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Molecular Cell, ISSN 1097-2765, 05/2019, Volume 74, Issue 4, pp. 635 - 636
In this issue of , define a feedforward kinetic pathway consisting of a cycle of oligoadenylation and deadenylation that regulates the production of mature... 
PARN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | RNA | Telomerase
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 10/2008, Volume 382, Issue 4, pp. 827 - 834
Poly(A)-specific ribonuclease (PARN) is a processive 3′-exoribonuclease involved in the decay of eukaryotic mRNAs. Interestingly, PARN interacts not only with... 
PARN | mRNA | cap | RRM | deadenylation
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2019, Volume 73, Issue 6, pp. 1204 - 1216.e4
PARN loss-of-function mutations cause a severe form of the hereditary disease dyskeratosis congenita (DC). PARN deficiency affects the stability of non-coding... 
dyskeratosis congenita | PAPD5 | DIS3L | PARN | miRNA | 3′ end modification | cancer | non-coding RNA degradation | p53 | DIS3L2
Journal Article
Cell Reports, ISSN 2211-1247, 04/2018, Volume 23, Issue 3, pp. 888 - 898
Poly(A)-specific ribonuclease (PARN) and target of EGR1 protein 1 (TOE1) are nuclear granule-associated deadenylases, whose mutations are linked to multiple... 
TOE1 | adenylation | TERC | PARN | scaRNA | deadenylase | deadenylation | 3′ end maturation | CAF1Z | CANCER-CELLS | MESSENGER-RNA | CYTOPLASMIC POLYADENYLATION | SMALL NUCLEOLAR RNAS | POLY(A)-SPECIFIC RIBONUCLEASE PARN | QUALITY CONTROL | RIBOSOMAL-RNA | HUMAN TELOMERASE RNA | PULMONARY-FIBROSIS | POLY(A) TAIL | CELL BIOLOGY
Journal Article
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 07/2017, Volume 196, Issue 1, pp. 82 - 93
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 01/2019, Volume 47, Issue 1, pp. 391 - 405
Abstract In human cells, telomeres are elongated by the telomerase complex that contains the reverse transcriptase hTERT and RNA template TERC/hTR.... 
BIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLY(A)-SPECIFIC RIBONUCLEASE PARN | DYSKERATOSIS-CONGENITA | POLY(A) REMOVAL | PONTOCEREBELLAR HYPOPLASIA | HOYERAAL-HREIDARSSON SYNDROME | COMPONENT | MUTATIONS | MATURATION | CAJAL BODIES | Index Medicus | RNA Prot Comp
Journal Article
Molecular Cell, ISSN 1097-2765, 05/2019, Volume 74, Issue 4, pp. 688 - 700.e3
Mutations in RNA-processing enzymes are increasingly linked to human disease. Telomerase RNA and related noncoding RNAs require 3′ end-processing steps,... 
U1 SNRNA | CAJAL BODY LOCALIZATION | H/ACA | BIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SMALL NUCLEAR | PARN | TRAFFICKING | DEGRADATION | COMPONENT | MUTATIONS | CELL BIOLOGY | Medical colleges | RNA | Gene mutations | Respiratory tract diseases | Genetic transcription | Ribonuclease | Telomerase
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5430 - 5430
Human telomerase RNA (hTR) is transcribed as a precursor that is then posttranscriptionally modified and processed. A fraction of the transcripts is... 
SMALL NUCLEOLAR | MESSENGER-RNA | RECOGNITION | BIOGENESIS | MULTIDISCIPLINARY SCIENCES | POLY(A)-SPECIFIC RIBONUCLEASE PARN | EXOSOME | HELIX | DEGRADATION | MATURATION | HUMAN TELOMERASE RNA | Degradation | Kinetics | Ribonucleic acid--RNA | Precursors | Telomerase | Assembly | Index Medicus
Journal Article
Pediatric Neurology, ISSN 0887-8994, 2016, Volume 56, pp. 62 - 68.e1
Journal Article