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PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 11, pp. e0207399 - e0207399
PARP inhibitors target BRCA mutations and defective homologous recombination repair (HRR) for the treatment of epithelial ovarian cancer (EOC). However, the... 
HOMOLOGOUS RECOMBINATION REPAIR | PEGYLATED LIPOSOMAL DOXORUBICIN | MULTIDISCIPLINARY SCIENCES | 3-AMINOPYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONE 3-AP | CERVICAL-CANCER | OPEN-LABEL | ANTITUMOR-ACTIVITY | CELL-LINES | RIBONUCLEOTIDE REDUCTASE-ACTIVITY | ENDOTHELIAL GROWTH-FACTOR | TUMOR-CELL | Humans | Mice, SCID | Breast Neoplasms - drug therapy | Piperazines - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Breast Neoplasms - metabolism | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Mice, Nude | BRCA1 Protein - metabolism | Cell Line, Tumor | Female | Pyridines - pharmacology | Thiosemicarbazones - pharmacology | Quinazolines - pharmacology | Drug Resistance, Neoplasm - drug effects | Enzyme inhibitors | BRCA mutations | Patient outcomes | Development and progression | Genetic aspects | Drug therapy, Combination | Drug therapy | Health aspects | Methods | Ovarian cancer | Animal models | Severe combined immunodeficiency | Ovarian carcinoma | Xenotransplantation | Homologous recombination | Homology | AKT protein | Kinases | Homologous recombination repair | Ribonucleotide reductase | Xenografts | Protein-tyrosine kinase receptors | Vascular endothelial growth factor | Growth factors | Protein-tyrosine kinase | Tyrosine | Effectiveness | Poly(ADP-ribose) polymerase | Breast cancer | Survival | Inhibitors | Cell lines | Mice | Mutation | Prolongation | Cancer | Tumors | Apoptosis | Reductase | Index Medicus
Journal Article
Journal of Veterinary Medical Science, ISSN 0916-7250, 2018
Cerebral ischemia is a neurological disorder with high mortality. Quercetin is a flavonoid compound that is abundant in vegetables and fruits. It exerts... 
neuroprotection | quercetin | PARP | caspase-3
Journal Article
European Urology, ISSN 0302-2838, 10/2019, Volume 76, Issue 4, pp. 452 - 458
Poly ADP-ribose polymerase (PARP) inhibitors, such as olaparib, are being explored as a treatment option for metastatic castration-resistant prostate cancer... 
ATM | Olaparib | BRCA2 | Prostate cancer | PARP inhibitor
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 05/2012, Volume 166, Issue 2, pp. 617 - 636
GaQ | ROS | PARP | Ca | p53
Journal Article
Microbes and Infection, ISSN 1286-4579, 2019
Protein ADP-ribosylation is a reversible post-translational modification, which alters protein activity, localization, interactome or stability, leading to... 
Infection | Bacteria | PARP | Immunity | ADP-ribosylation | ARTD
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2016, Volume 30, Issue 4, pp. 637 - 650
Poly (ADP-ribose) polymerase inhibitors (PARPis) are clinically effective predominantly for BRCA-mutant tumors. We introduce a mechanism-based strategy to... 
AML | DNMT inhibitor | DNMT1 | PARP trapping | DNA damage | PARP inhibitor | breast cancer | PARP | DNA double-strand break | DNA repair | POLY(ADP-RIBOSE) POLYMERASE | DECITABINE | METHYLATION | BASE EXCISION-REPAIR | LETHALITY | ONCOLOGY | DOUBLE-STRAND BREAKS | ACUTE MYELOID-LEUKEMIA | MYELODYSPLASTIC SYNDROME | MAMMALIAN-CELLS | ADP-RIBOSE POLYMERS | CELL BIOLOGY | Chromatin - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Male | Poly (ADP-Ribose) Polymerase-1 - metabolism | Triple Negative Breast Neoplasms - drug therapy | DNA Breaks, Double-Stranded | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Drug Synergism | Xenograft Model Antitumor Assays | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Animals | Triple Negative Breast Neoplasms - genetics | Mice, Nude | Triple Negative Breast Neoplasms - metabolism | Cell Line, Tumor | Leukemia, Myeloid, Acute - drug therapy | Female | Mice, Inbred NOD | Mice | DNA Methylation - drug effects | Leukemia, Myeloid, Acute - genetics | Medical colleges | Care and treatment | Chromatin | Leukemia | Epidemiology | Monosaccharides | Gerontology | Methyltransferases | Analysis | DNA | Genetic aspects | Health aspects | Sugars | Cancer | Index Medicus
Journal Article
Future Oncology, ISSN 1479-6694, 02/2017, Volume 13, Issue 4, pp. 307 - 320
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 6/2017, Volume 23, Issue 12, pp. 3097 - 3108
Journal Article
Expert Opinion on Therapeutic Targets, ISSN 1472-8222, 09/2019, Volume 23, Issue 9, pp. 773 - 785
Introduction: The implementation of poly-ADP-ribose polymerase (PARP) inhibitors for therapy has created potential treatments for a wide spectrum of... 
prostate cancer | DNA damage response | BRCA mutations | ovarian cancer | PARP inhibitors | breast cancer | BRCAness | PARP enzymes | Index Medicus
Journal Article
Cell Cycle, ISSN 1538-4101, 08/2019, Volume 18, Issue 15, pp. 1770 - 1783
Although improvements in radiation therapy were made over the years, radioresistance is still a major challenge. Cancer cells are often deficient for DNA... 
proton radiation | PARP | RAD51 | delayed cell death | cell cycle arrest | synthetic lethality | LUNG | APOPTOSIS | INCREASES | INDUCED SENESCENCE | CANCER | CELL BIOLOGY | THERAPY | RADIOSENSITIZATION | CISPLATIN | PARP INHIBITION | HOMOLOGOUS RECOMBINATION
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2010, Volume 16, Issue 18, pp. 4532 - 4542
Tumor cells are often deficient in DNA repair and damage response (DDR) pathways, and anticancer therapies are commonly based on genotoxic treatments using... 
indenoisoquinolines | PARP | poly(ADP-ribose) | DNA repair | γH2AX | pharmacodynamics
Journal Article
Journal of Biomolecular Structure and Dynamics, ISSN 0739-1102, 09/2019, Volume 37, Issue 14, pp. 3637 - 3648
The Wnt/β-catenin pathway plays an important regulatory role in cancer signaling and cell regenerative mechanisms. Its suppression has long been considered as... 
PARP | colorectal cancer | virtual screening | molecular dynamics | tankyrase | BIOPHYSICS | MECHANISM | DATABASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PARP INHIBITORS | BINDING
Journal Article
GYNECOLOGIC ONCOLOGY, ISSN 0090-8258, 05/2019, Volume 153, Issue 2, pp. 416 - 424
Purpose. PARP inhibitor maintenance therapy in platinum sensitive sporadic ovarian cancers improves progression free survival. However, biomarker for synthetic... 
LUNG | Biomarker | Synthetic lethality | DNA repair | MAINTENANCE THERAPY | Ovarian cancer | OBSTETRICS & GYNECOLOGY | CISPLATIN | ONCOLOGY | ERCC1 | Predictive | XPF: PARP | PARP INHIBITORS | EXPRESSION | Index Medicus
Journal Article
CANCER SCIENCE, ISSN 1349-7006, 01/2018, Volume 109, pp. 559 - 559
Conference Proceeding
Journal of the National Cancer Institute, ISSN 0027-8874, 2018, Volume 110, Issue 8, pp. 914 - 917
Heat shock proteins (HSPs) are molecular chaperones that maintain proteins in their correct conformation to ensure stability and protect carcinoma cells from... 
RESISTANCE | CELLS | ONCOLOGY | BREAST | PARP INHIBITOR | Index Medicus
Journal Article
Neuropharmacology, 09/2019, pp. 107755 - 107755
Journal Article
The Journal of Pathology, ISSN 0022-3417, 02/2013, Volume 229, Issue 3, pp. 422 - 429
Journal Article
by Lu, HY and Bai, L and Zhou, YP and Lu, YP and Jiang, ZL and Shi, JY
CURRENT TOPICS IN MEDICINAL CHEMISTRY, ISSN 1568-0266, 2019, Volume 19, Issue 12, pp. 1041 - 1050
The occurrence and development of tumors are closely related to epigenetic instability which modulates gene expression through DNA methylation, histone... 
HDAC INHIBITORS | CANCER-CELLS | APOPTOSIS | HISTONE DEACETYLASE INHIBITOR | CHEMISTRY, MEDICINAL | STRAND-BREAK REPAIR | PARP | COMBINATION | PARP INHIBITOR | Dual inhibitors | Epigenetics | Tumor | Synergy | DNA-REPAIR | PHASE-I | DERIVATIVES | HDAC
Journal Article
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