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Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 2, pp. 645 - 652
PARylation [poly(ADP-ribosyl)ation] is involved in the maintenance of genomic methylation patterns through its control of Dram 1 [DNA... 
DNA methylation | Epigenetics | Poly(ADP-ribosyl)ation (PARylation) | DNA methyltranferase 1 (Dnmt1) | CCCTC-binding factor (Ctcf) | Poly(ADP-ribose) polymerase 1 (Parp1) | POLY(ADP-RIBOSYL)ATION REACTIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | poly(ADP-ribosyl)ation (PARylation) | epigenetics | HUMAN GENOME | GENE | EMBRYONIC STEM-CELLS | INSULATOR PROTEIN CTCF | UNMETHYLATED STATE | TUMOR-SUPPRESSOR | poly(ADP-ribose) polymerase 1 (Parp1) | CPG ISLANDS | BINDING | DNA (Cytosine-5-)-Methyltransferases - metabolism | Multiprotein Complexes - metabolism | DNA Methylation | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | DNA (Cytosine-5-)-Methyltransferase 1 | CCCTC-Binding Factor | Epigenesis, Genetic | CpG Islands - physiology | Repressor Proteins - metabolism | poly(ADP-ribose) polymerase 1 | DNMT1 protein | genomics | Promoters | ADP-ribosylation | CpG islands | Life Sciences | Poly(ADP-ribose) Polymerases | DNA (Cytosine-5-)-Methyltransferase | Multiprotein Complexes | Repressor Proteins | Biochemistry, Molecular Biology | CpG Islands | Poly Adenosine Diphosphate Ribose | Molecular biology | DMR1, differentially methylated region 1 | Ab, antibody | poly(ADPribosyl)ation (PARylation) | H2B, histone 2B | PARG, poly(ADP-ribose) glycohydrolase | Ctcf, CCCTC-binding factor | IP, immunoprecipitation | DTT, dithiothreitol | ChIP, chromatin immunoprecipitation | TBST, Tris-buffered saline plus 0.05% Tween 20 | Dnmt1, DNA (cytosine-5)-methyltransferase 1 | Parp1, poly(ADP-ribose) polymerase 1 | H1, histone 1 | CGI, CpG island | dsDNA, double-stranded DNA | PARylation, poly(ADP-ribosyl)ation | PARs, poly(ADP-ribose) polymers | RE-ChIP, sequential ChIP
Journal Article
International Journal of Biomedicine, ISSN 2158-0510, 06/2019, Volume 9, Issue Suppl_1, pp. S24 - S25
Background: Cisplatin (Fig. 1) is a low molecular weight platinum-containing compound with a square planar geometry. It is widely used for the treatment of... 
spFRET | PARP1 | nucleosomes | Cisplatin
Journal Article
Nature Communications, ISSN 2041-1723, 07/2016, Volume 7, Issue 1, p. 12235
Although SIRT7 is a member of sirtuin family proteins that are described as NAD(+)-dependent class III histone deacetylases, the intrinsic enzymatic activity... 
RNA-POLYMERASE-I | LATERAL SURFACE | REPAIR | DNA-DAMAGE RESPONSE | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | PARP1 ACTIVATION | DOUBLE-STRAND BREAKS | LYSINE MALONYLATION | STRESS | NUCLEOSOME
Journal Article
International Journal of Cancer, ISSN 0020-7136, 03/2015, Volume 136, Issue 6, pp. 1263 - 1275
Journal Article
SDÜ Sağlık Bilimleri Dergisi, ISSN 2146-1937, 04/2017, pp. 1 - 1
Journal Article
Oncotarget, ISSN 1949-2553, 05/2018, Volume 9, Issue 34, pp. 23349 - 23365
Y-box-binding protein 1 (YB-1) is a multifunctional cellular factor overexpressed in tumors resistant to chemotherapy. An intrinsically disordered structure... 
PARP1 inhibitors | Poly(ADP-ribose) (PAR) | Poly(ADP-ribose) polymerase 1 (PARP1) | Olaparib | Y-box binding protein 1 (YB-1)
Journal Article
Oncotarget, ISSN 1949-2553, 10/2018, Volume 9, Issue 78, pp. 34821 - 34837
Poly-ADP ribose polymerase 1 ( ) is clinically important because of its synthetic lethality with breast cancer allele 1 and 2 mutations, which are causative... 
Telomeres | NHEJ | PARP1 | Gene editing | HDR
Journal Article
Oncotarget, ISSN 1949-2553, 12/2018, Volume 9, Issue 101, pp. 37549 - 37563
Telomeric crisis is the final replicative barrier to cell immortalisation; it is characterised by genome instability and cell death and is triggered when... 
Genome instability | PARP1 | Telomere | Cancer | Crisis
Journal Article
Oncotarget, ISSN 1949-2553, 09/2018, Volume 9, Issue 69, pp. 33056 - 33058
Journal Article
Molecular Oncology, ISSN 1574-7891, 02/2019, Volume 13, Issue 2, pp. 153 - 170
Poly(ADP‐ribose) polymerase 1 inhibitors alone or in combination with DNA damaging agents are promising clinical drugs in the treatment of cancer. However,... 
HMGA2 | PARP1 | olaparib | PARP1 trapping | PARylation | IDENTIFICATION | STEM | REPAIR | ONCOLOGY | ROLES | DNA | PROTECTS CANCER-CELLS | NAD(+) | POLY(ADP-RIBOSE) POLYMERASE-1 | PROTEINS | EXPRESSION
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 8/2013, Volume 19, Issue 15, pp. 4067 - 4078
Journal Article
Cancers, ISSN 2072-6694, 09/2019, Volume 11, Issue 9, p. 1373
Myelodysplastic syndromes (MDS) are highly heterogeneous myeloid diseases, characterized by frequent genetic/chromosomal aberrations. Olaparib is a potent,... 
AML | PARP1 | MDS | PARP inhibitors | olaparib | hematopoietic differentiation
Journal Article
Cell Cycle, ISSN 1538-4101, 08/2016, Volume 15, Issue 15, pp. 2042 - 2052
ADP-ribosylation is involved in a variety of biological processes, many of which are chromatin-dependent and linked to important functions during the cell... 
cyclin E | p27 | PARP1 | E2F-1 | cell cycle regulation | gene expression
Journal Article
DNA Repair, ISSN 1568-7864, 09/2019, Volume 81, p. 102650
All organisms must protect their genome from constantly occurring DNA damage. To this end, cells have evolved complex pathways for repairing sites of DNA... 
Laser microirradiation | PARP1 | Q-FADD | Kinetic modelling | Recruitment to DNA damage sites | DNA repair protein | Accumulation
Journal Article