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Glia, ISSN 0894-1491, 03/2018, Volume 66, Issue 3, pp. 562 - 575
Amyloid β (Aβ)‐induced neuroinflammation plays an important part in Alzheimer's disease (AD). Emerging evidence supports a role for the transient receptor... 
TRPM2 channel | PARP‐1 | Aβ42 | TNF‐α | ROS | microglial activation | TNF-α | PARP-1
Journal Article
Cancer Cell, ISSN 1535-6108, 06/2019, Volume 35, Issue 6, pp. 851 - 867.e7
We demonstrate that concurrent administration of poly(ADP-ribose) polymerase (PARP) and WEE1 inhibitors is effective in inhibiting tumor growth but poorly... 
WEE1 inhibitor | sequential therapy | replication stress | PARP inhibitor | Sugars | Monosaccharides | Ovarian cancer
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 09/2019, Volume 62, Issue 17, pp. 7897 - 7909
Tankyrases 1 and 2 (TNKS1/2) are promising pharmacological targets that recently gained interest for anticancer therapy in Wnt pathway dependent tumors.... 
TARGETS | POLY(ADP-RIBOSE) | DESIGN | AXIN | CHEMISTRY, MEDICINAL | PARP
Journal Article
Oncotarget, ISSN 1949-2553, 12/2018, Volume 9, Issue 96, p. 36867
Cancer cells often accumulate spontaneous and treatment-induced DNA damage i.e. potentially lethal DNA double strand breaks (DSBs). Targeting DSB repair... 
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 07/2018, Volume 9, Issue 53, pp. 30115 - 30127
Basal-like breast cancer (BLBC) is an aggressive breast cancer subtype with features similar to the basal cells surrounding the mammary ducts. Treatment of... 
Xenograft | HORMAD1 | Basal-like breast cancer | PARP inhibitor
Journal Article
Journal of Palliative Medicine, ISSN 1096-6218, 08/2019, Volume 22, Issue 8, pp. 977 - 980
Background: Chemotherapy-induced peripheral neuropathy is characterized by pain, numbness, and tingling in the hands and feet and by diminished quality of... 
Brief Reports | OXIDATIVE STRESS | PARP inhibitors | chemotherapy-induced peripheral neuropathy | PARP INHIBITION | MUTATION | HEALTH CARE SCIENCES & SERVICES | meta-analysis | DOUBLE-BLIND | SEROUS OVARIAN | VELIPARIB ABT-888 | OLAPARIB MAINTENANCE THERAPY | CANCER
Journal Article
Experimental Cell Research, ISSN 0014-4827, 11/2019, Volume 384, Issue 1, p. 111547
Traumatic brain injury (TBI) is common and often fatal in current times. The role of poly(adenosine diphosphate-ribose) polymerase (PARP)-induced cell death... 
PARP | Traumatic brain injury | p53-MDM2 pathway | Parthanatos | Iduna | AIF
Journal Article
Amino Acids, ISSN 0939-4451, 05/2012, Volume 42, Issue 5, pp. 1735 - 1747
Journal Article
Hematology/Oncology Clinics of North America, ISSN 0889-8588, 12/2018, Volume 32, Issue 6, pp. 997 - 1010
Large-scale genomic studies have demonstrated that ovarian cancer is characterized by frequent genetic and epigenetic alterations of gene members of the... 
Platinum agents | Homologous recombination deficiency | DNA repair deficiency | PARP-inhibitors | Ovarian cancer | BRCA2 MUTATIONS | HYPERMETHYLATION | COMBINATION | SOMATIC MUTATIONS | GEMCITABINE | PARP INHIBITOR | WOMEN | OLAPARIB | ONCOLOGY | HEMATOLOGY | CARCINOMA | ASSOCIATION
Journal Article
Critical Reviews in Biochemistry and Molecular Biology, ISSN 1040-9238, 7/2013, Volume 48, Issue 4, pp. 397 - 408
Journal Article
Journal Article
Annals of Oncology, ISSN 0923-7534, 01/2018, Volume 29, Issue 1, pp. 154 - 161
Abstract Background Homologous recombination defects in BRCA1/2-mutated tumors result in sensitivity to poly(ADP-ribose) polymerase inhibitors, which interfere... 
Metastatic breast cancer | Temozolomide | Platinum | PARP inhibitors | temozolomide | TRIAL | platinum | ONCOLOGY | CATALYTIC INHIBITION | DNA | metastatic breast cancer | MUTATION | OVARIAN | POLY(ADP-RIBOSE) POLYMERASE INHIBITOR | Original
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2019, Volume 167, pp. 58 - 63
Abnormal protein aggregation is a common pathological feature of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD),... 
α-Synuclein | PARP | TDP-43 | Phase separation | hnRNP A1 | Nervous system diseases | Glycoproteins | Alzheimer's disease | Sugars | Monosaccharides
Journal Article
Clinical Science, ISSN 0143-5221, 2015, Volume 129, Issue 11, pp. 951 - 962
Our laboratory established a role for poly(ADP-ribose) polymerase (PARP) in asthma. To increase the clinical significance of our studies, it is imperative to... 
Olaparib (AZD2281) | House dust mite | Poly(adenosine 5'-diphosphate-ribose)polymerase (PARP) inhibition | Eosinophilia | T helper 2 (Th2) cytokines | T-CELL FUNCTION | MEDICINE, RESEARCH & EXPERIMENTAL | POLY(ADP-RIBOSE) POLYMERASE-1 INHIBITOR | house dust mite | poly(adenosine 5 '-diphosphate-ribose)polymerase (PARP) inhibition | GENE KNOCKOUT | ALLERGIC AIRWAY INFLAMMATION | DEFICIENCY | MURINE MODEL | eosinophilia | olaparib (AZD2281) | NF-KAPPA-B | EXPRESSION | LUNG INFLAMMATION | REQUIREMENT | Asthma - prevention & control | Humans | Th2 Cells - immunology | Anti-Allergic Agents - pharmacology | Th2 Cells - drug effects | Lung - enzymology | T-Lymphocytes, Regulatory - immunology | Antigens, Dermatophagoides | Asthma - immunology | Inflammation Mediators - metabolism | Disease Models, Animal | Anti-Asthmatic Agents - pharmacology | Asthma - physiopathology | Cytokines - metabolism | Receptors, Antigen, T-Cell - metabolism | Asthma - enzymology | Mice, Inbred C57BL | Cells, Cultured | Lung - physiopathology | Piperazines - pharmacology | Mice, Knockout | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | T-Lymphocytes, Regulatory - drug effects | Animals | Poly(ADP-ribose) Polymerases - genetics | Signal Transduction - drug effects | Lymphocyte Activation - drug effects | Lung - drug effects | Poly(ADP-ribose) Polymerases - deficiency | Cell Proliferation - drug effects | Enzyme Activation | Poly (ADP-Ribose) Polymerase-1 | Th2 Cells - enzymology | Lung - immunology | T-Lymphocytes, Regulatory - enzymology | poly(adenosine 5′-diphosphate-ribose)polymerase (PARP) inhibition | Original Papers | Original Paper
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 03/2009, Volume 156, Issue 5, pp. 713 - 727
Journal Article
Cell Reports, ISSN 2211-1247, 08/2018, Volume 24, Issue 9, pp. 2493 - 2505.e4
ADP-ribosylation (ADPr) is a reversible posttranslational modification involved in a range of cellular processes. Here, we report system-wide identification of... 
proteomics | DNA damage | serine ADP-ribosylation | PARP inhibitor | PTM | mass spectrometry | ADPr | post-translational modification | phosphorylation | oxidative stress | ADP-ribosylation | INTRINSIC DISORDER | DISSOCIATION | RIBOSE ACCEPTOR SITES | PARP INHIBITION | DNA-DAMAGE | INTERACTION NETWORKS | NUCLEAR PROTEINS | TANDEM MASS-SPECTROMETRY | PROTEIN-PHOSPHORYLATION | IDENTIFICATION | CELL BIOLOGY
Journal Article