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CHEMMEDCHEM, ISSN 1860-7179, 07/2019, Volume 14, Issue 14, pp. 1349 - 1358
Recently, investigations of the complex mechanisms of allostery have led to a deeper understanding of G protein-coupled receptor (GPCR) activation and... 
M1 MUSCARINIC AGONISTS | ACTIVATION | CHEMISTRY, MEDICINAL | ALLOSTERIC MODULATORS | BITOPIC LIGANDS | ALZHEIMERS-DISEASE | OPPORTUNITIES | dualsteric ligands | TARGET MAJOR HALLMARKS | partial agonists | STRATEGIES | muscarinic receptors | GPCRs | PHARMACOLOGY | EMPHASIS | PHARMACOLOGY & PHARMACY | allostery
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 03/2018, Volume 26, Issue 5, pp. 1069 - 1075
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 12/2014, Volume 34, Issue 50, pp. 16865 - 16876
Journal Article
Nature Neuroscience, ISSN 1097-6256, 09/2009, Volume 12, Issue 9, pp. 1114 - 1120
Journal Article
Journal Article
ChemMedChem, ISSN 1860-7179, 07/2019, Volume 14, Issue 14, pp. 1349 - 1358
Recently, investigations of the complex mechanisms of allostery have led to a deeper understanding of G protein‐coupled receptor (GPCR) activation and... 
muscarinic receptors | dualsteric ligands | GPCRs | allostery | partial agonists | G proteins | Carbachol | Cardiotonic agents | Membrane proteins | Cardiac glycosides | Proteins | Signaling | Receptors | Allosteric properties | G protein-coupled receptors | Acetylcholine receptors (muscarinic) | Ligands | Derivatives | Carboxylic acids
Journal Article
Journal Article
Biophysical Journal, ISSN 0006-3495, 01/2015, Volume 108, Issue 2, pp. 286a - 286a
NMDA receptors are ligand-gated ion channels that mediate excitatory synaptic transmission in the central nervous system. Partial agonists elicit submaximal... 
Protein Structure, Tertiary | Drug Partial Agonism | Receptors, N-Methyl-D-Aspartate - chemistry | Computer Simulation | Receptors, N-Methyl-D-Aspartate - agonists | Receptors, N-Methyl-D-Aspartate - metabolism | Models, Molecular | Protein Binding | Ligands | Binding Sites | Methyl aspartate
Journal Article