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Journal of Pharmaceutical Sciences, ISSN 0022-3549, 01/2019, Volume 108, Issue 1, pp. 603 - 619
The minipig continues to build a reputation as a viable alternative large animal model to predict humans in dermatology and toxicology studies. Therefore, it... 
topical | transdermal | discovery | IVIVE | pharmacokinetics | in silico | PBPK modeling | tissue composition | VITRO | MECHANISTIC TOOL | CHEMISTRY, MEDICINAL | GOTTINGEN MINIPIG | MEMBRANE | CHEMISTRY, MULTIDISCIPLINARY | MOLECULES | IN-VIVO | PHARMACOLOGY & PHARMACY | ALBUMIN | BINDING | LIPIDS
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 2/2018, Volume 81, Issue 2, pp. 291 - 304
Zoptarelin doxorubicin is a fusion molecule of the chemotherapeutic doxorubicin and a luteinizing hormone-releasing hormone receptor (LHRHR) agonist, designed... 
Medicine & Public Health | AN-152 | Drug–drug interaction | Targeted chemotherapy | Oncology | Cancer Research | Pharmacology/Toxicology | AEZS-108 | Doxorubicin | PBPK modeling | EXPRESSING LHRH RECEPTORS | EFFICACY | CANCERS | CYTOTOXIC ANALOGS | ADRIAMYCIN CONCENTRATIONS | DISPOSITION | ONCOLOGY | ANION-TRANSPORTING POLYPEPTIDE | ENDOMETRIAL | OVARIAN | PHARMACOLOGY & PHARMACY | Drug-drug interaction | Octamer Transcription Factor-2 | Solute Carrier Organic Anion Transporter Family Member 1B3 - metabolism | Humans | Middle Aged | Male | Gonadotropin-Releasing Hormone - analogs & derivatives | Gonadotropin-Releasing Hormone - pharmacokinetics | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Drug Interactions | Antineoplastic Agents - adverse effects | Biotransformation | Computer Simulation | Doxorubicin - analogs & derivatives | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacokinetics | Hypoglycemic Agents - pharmacokinetics | Metformin - pharmacokinetics | Gonadotropin-Releasing Hormone - adverse effects | Simvastatin - pharmacokinetics | Doxorubicin - pharmacokinetics | Models, Biological | Aged | Doxorubicin - adverse effects | Anthracyclines | Pituitary hormones | Metabolites | Drug interactions | Luteinizing hormone | Models | Glycoproteins | Product development | Drugs | Organic cation transporter | Computer simulation | Simvastatin | Data processing | Pharmacology | Oct-2 protein | Substrates | Organic anion transporting polypeptide | Luteinizing hormone-releasing hormone | Drug interaction | Metformin | Transporter | Tumors
Journal Article
Journal of Pharmacokinetics and Pharmacodynamics, ISSN 1567-567X, 8/2018, Volume 45, Issue 4, pp. 537 - 555
In this paper we present a framework for the reduction and linking of physiologically based pharmacokinetic (PBPK) models with models of systems biology to... 
Biomedical Engineering | Biochemistry, general | Veterinary Medicine/Veterinary Science | Biomedicine | Pharmacy | PBPK | Model reduction | Pharmacology/Toxicology | Systems pharmacology | Mathematical pharmacology | Original Paper
Journal Article
Clinical Pharmacology and Therapeutics, ISSN 0009-9236, 2017, Volume 101, Issue 5, pp. 646 - 656
Patient groups prone to polypharmacy and special subpopulations are susceptible to suboptimal treatment. Refined dosing in special populations is imperative to... 
TRIAL | PHARMACOKINETIC MODEL | VANCOMYCIN | MORPHINE | INFANTS | PBPK | MORBIDLY OBESE | PHARMACOLOGY & PHARMACY | PRETERM | DOSAGE | CHILDREN | Delivery of Health Care, Integrated | Models, Biological | Cost-Benefit Analysis | Humans | Precision Medicine - trends | Pharmaceutical Preparations - administration & dosage | Forecasting | Index Medicus | Abridged Index Medicus
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 12/2013, Volume 458, Issue 1, pp. 156 - 168
Journal Article
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, ISSN 1567-567X, 08/2018, Volume 45, Issue 4, pp. 537 - 555
Journal Article
Drug Discovery Today, ISSN 1359-6446, 07/2019, Volume 24, Issue 7, pp. 1344 - 1354
Model-informed drug discovery and development (MID3) is an umbrella term under which sit several computational approaches: quantitative systems pharmacology... 
XENOBIOTIC LEVELS | HEPATIC ELIMINATION | VAPOR ABSORPTION | IN-VITRO | METABOLISM | RAT | RENAL CLEARANCE | PHARMACOLOGY & PHARMACY | PBPK MODELS | DISPERSION MODEL | FLOW | Drugs | Medical colleges | Metabolites | Analysis | Pharmacology | Models | Drug discovery | Index Medicus
Journal Article
Journal Article