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International journal of molecular sciences, ISSN 1422-0067, 03/2020, Volume 21, Issue 5, p. 1550
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Index Medicus | protein–protein interaction (ppi) | ppi disruptive mutation | pcsk9 | residue interaction network | ldlr | molecular dynamics | mm/pbsa
Journal Article
Journal of agricultural and food chemistry, ISSN 0021-8561, 10/2018, Volume 66, Issue 40, pp. 10552 - 10557
Journal Article
ACS medicinal chemistry letters, ISSN 1948-5875, 04/2019, Volume 10, Issue 4, pp. 425 - 430
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 05/2020, Volume 21, Issue 10, p. 3682
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Psoriasis | Disease | Cytokines | Angiopoietin | Liver | Homeostasis | Lipids | Subtilisin | Inflammation | Gene expression | Metabolic syndrome | Patients | Cholesteryl ester transfer protein | Proteins | Lipoproteins | Kexin | Pathways | Atherosclerosis | Tumor necrosis factor-TNF | Metabolic disorders | Immune system | Index Medicus | metabolic syndrome | atherosclerosis | PCSK9 | CEPT | psoriasis | ANGPTL8
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 01/2015, Volume 35, Issue 1, pp. 213 - 221
PCSK9 protein | receptors | LDL | human | Cholesterol | GPER protein | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Receptors, Estrogen - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Middle Aged | Male | Mutation, Missense | Proprotein Convertases - genetics | Dose-Response Relationship, Drug | Young Adult | Transfection | RNA Interference | Serine Endopeptidases - genetics | Adult | Cholesterol, LDL - blood | Female | Receptors, G-Protein-Coupled - drug effects | Genetics, Population | Receptors, LDL - genetics | European Continental Ancestry Group - genetics | Receptors, Estrogen - genetics | Gene Frequency | Proprotein Convertases - metabolism | Gene Expression Regulation | Receptors, LDL - metabolism | Hep G2 Cells | Canada | Homozygote | Phenotype | Receptors, Estrogen - drug effects | Adolescent | Heterozygote | Aged | Receptors, G-Protein-Coupled - genetics | Serine Endopeptidases - metabolism | Proprotein Convertase 9 | Index Medicus
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 06/2014, Volume 34, Issue 6, pp. 1171 - 1178
cholesterol ester transfer proteins | Idol protein, mouse | receptors, LDL | Pcsk9 protein, mouse | Cricetinae | Signal Transduction | Cholesterol Ester Transfer Proteins - physiology | Humans | Liver - metabolism | Mice, Inbred C57BL | Serine Endopeptidases - physiology | Ubiquitin-Protein Ligases - physiology | Sterol Regulatory Element Binding Protein 2 - physiology | Hep G2 Cells | Proprotein Convertases - physiology | Animals | Liver X Receptors | Orphan Nuclear Receptors - physiology | Serine Endopeptidases - blood | Mesocricetus | Proprotein Convertases - blood | Lipoproteins, LDL - metabolism | Mice | Receptors, LDL - physiology | Proprotein Convertase 9 | Index Medicus
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 03/2015, Volume 290, Issue 12, pp. 7416 - 7425
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Amyloid Precursor Protein Secretases - genetics | Cytoplasm - enzymology | ADAM Proteins - physiology | Amyloid Precursor Protein Secretases - physiology | ADAM Proteins - chemistry | Membrane Proteins - genetics | Cells, Cultured | ADAM10 Protein | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | DNA Primers | Amyloid Precursor Protein Secretases - chemistry | Mice, Knockout | Animals | Membrane Proteins - chemistry | Membrane Proteins - physiology | Proteolysis | Base Sequence | Mice | ADAM Proteins - genetics | Real-Time Polymerase Chain Reaction | Index Medicus | ADAM | Shedding | Kexin Type 9 (PCSK9) | Cytoplasmic Domain | Proprotein Convertase Subtilisin | Metalloprotease | Cell Surface Enzyme | Protein Ectodomain Shedding | Cell Biology
Journal Article
Cell chemical biology, ISSN 2451-9456, 11/2016, Volume 23, Issue 11, pp. 1362 - 1371
secretion | anti-secretagogue | LDL | R-IMPP | translation | high throughput screen (HTS) | PCSK9 | ribosome | phenotypic screening | LDL receptor | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Isoquinolines - chemistry | Small Molecule Libraries - chemistry | Small Molecule Libraries - pharmacology | Isoquinolines - pharmacology | Proprotein Convertase 9 - antagonists & inhibitors | Humans | Ribosomes - drug effects | Cell Line, Tumor | Ribosomes - metabolism | Protein Biosynthesis - drug effects | Proprotein Convertase 9 - metabolism
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 7, pp. 4047 - 4058
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Proprotein Convertases - antagonists & inhibitors | Transcription, Genetic - drug effects | Hepatocyte Nuclear Factor 1-alpha - genetics | Humans | Ubiquitin - metabolism | Hepatocyte Nuclear Factor 1-alpha - antagonists & inhibitors | Male | Hepatocyte Nuclear Factor 1-alpha - metabolism | Promoter Regions, Genetic - genetics | Proprotein Convertases - genetics | Proteasome Endopeptidase Complex - drug effects | Liver - drug effects | HEK293 Cells | Mesocricetus | Serine Endopeptidases - genetics | Real-Time Polymerase Chain Reaction | Cricetinae | Liver - metabolism | Proprotein Convertases - metabolism | RNA, Messenger - genetics | Cells, Cultured | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Hep G2 Cells | Gene Expression Regulation - drug effects | Berberine - pharmacology | Animals | Mice | Serine Endopeptidases - metabolism | Proprotein Convertase 9 | Index Medicus | Kexin Type 9 (PCSK9) | Proprotein Convertase Subtilisin | Dyslipidemia | Nuclear Receptor | Lipids | Lipid Metabolism | LDL Receptor | Ubiquitylation (Ubiquitination) | HNF1a | Proteasome
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 7, pp. 3508 - 3519
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Proprotein Convertases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Humans | STAT3 Transcription Factor - agonists | Tumor Necrosis Factor-alpha - genetics | Male | Janus Kinases - metabolism | Hepatocytes - metabolism | Proprotein Convertases - genetics | Recombinant Fusion Proteins - metabolism | RNA Interference | Serine Endopeptidases - genetics | Lipogenesis | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Recombinant Proteins - metabolism | Janus Kinases - chemistry | Signal Transduction | Mice, Inbred C57BL | Proprotein Convertases - metabolism | Insulin Resistance | Enzyme Induction | Suppressor of Cytokine Signaling Proteins - genetics | Serine Endopeptidases - chemistry | Proprotein Convertases - chemistry | Hep G2 Cells | Obesity - metabolism | Suppressor of Cytokine Signaling 3 Protein | Animals | Suppressor of Cytokine Signaling Proteins - antagonists & inhibitors | Suppressor of Cytokine Signaling Proteins - agonists | Obesity - enzymology | Protein Processing, Post-Translational | Serine Endopeptidases - metabolism | Mutation | Suppressor of Cytokine Signaling Proteins - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Hepatocytes - enzymology | Proprotein Convertase 9 | Index Medicus | tumor necrosis factor (TNF) | hepatocyte | proprotein convertase subtilisin | insulin | stat-3 | HepG2 | kexin type 9 (PCSK9) | Cell Biology | suppressor of cytokine signaling 3 (SOCS3)
Journal Article
Atherosclerosis, ISSN 0021-9150, 2016, Volume 256, pp. 1 - 6
Cardiovascular | ABCA1 | PCSK9 | Cholesterol efflux | Macrophage | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Receptors, LDL - genetics | Down-Regulation | Mice, Inbred C57BL | Cells, Cultured | Macrophages, Peritoneal - enzymology | Lipoproteins, LDL - pharmacology | Genotype | Liver X Receptors - metabolism | Cholesterol - metabolism | Proprotein Convertase 9 - pharmacology | ATP Binding Cassette Transporter 1 - metabolism | Mice, Knockout | Phenotype | Animals | Biological Transport | Retinoid X Receptors - agonists | Liver X Receptors - agonists | Receptors, LDL - deficiency | Ligands | Macrophages, Peritoneal - drug effects | Retinoid X Receptors - metabolism | ATP Binding Cassette Transporter 1 - genetics | Macrophages | Cholesterol | Gene expression | Low density lipoproteins | Genes | Index Medicus
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 01/2014, Volume 289, Issue 2, pp. 942 - 955
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cricetulus | Humans | Crystallography, X-Ray | Peptide Library | Proprotein Convertases - genetics | Receptors, LDL - chemistry | Dose-Response Relationship, Drug | Enzyme Inhibitors - chemistry | Protein Binding - drug effects | Serine Endopeptidases - genetics | Binding Sites | Oligopeptides - chemistry | CHO Cells | Protein Structure, Tertiary | Amino Acid Sequence | Receptors, LDL - genetics | Cricetinae | Enzyme Inhibitors - metabolism | Magnetic Resonance Spectroscopy | Protein Structure, Secondary | Proprotein Convertases - metabolism | Enzyme Inhibitors - pharmacology | Models, Molecular | Receptors, LDL - metabolism | Serine Endopeptidases - chemistry | Oligopeptides - metabolism | Proprotein Convertases - chemistry | Hep G2 Cells | Binding, Competitive - drug effects | Animals | Serine Endopeptidases - metabolism | Oligopeptides - pharmacology | Proprotein Convertase 9 | Index Medicus | Protein Structure and Folding | Crystal Structure | Peptides | Protease | LDL Receptor | PCSK9 | Phage Display | Protein-Protein Interactions
Journal Article
Journal of agricultural and food chemistry, ISSN 0021-8561, 06/2018, Volume 66, Issue 24, pp. 6083 - 6093
Journal Article