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1. Full Text Enhanced pro‐protein convertase subtilisin/kexin type 9 expression by C‐reactive protein through p38MAPK‐HNF1α pathway in HepG2 cells
by Cui, Chuan‐Jue and Li, Sha and Zhu, Cheng‐Gang and Sun, Jing and Du, Ying and Zhang, Yan and Wu, Na‐Qiong and Guo, Yuan‐Lin and Xu, Rui‐Xia and Gao, Ying and Li, Jian‐Jun
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 12/2016, Volume 20, Issue 12, pp. 2374 - 2383
Plasma C‐reactive protein (CRP) concentration is associated positively with cardiovascular risk, including dyslipidemia. We suggested a regulating role of CRP... 
pro‐protein convertase subtilisin/kexin type 9 | mitogen‐activated protein kinase | C‐reactive protein | mitogen-activated protein kinase | pro-protein convertase subtilisin/kexin type 9 | C-reactive protein | CRP | MEDICINE, RESEARCH & EXPERIMENTAL | LOW-DENSITY-LIPOPROTEIN | ATHEROSCLEROSIS | CIRCULATING PCSK9 | CELL BIOLOGY | INFLAMMATION | RELEVANCE | CARDIOVASCULAR-DISEASE | OUTCOMES | LDLR | CORONARY-ARTERY-DISEASE | Signal Transduction | Humans | RNA, Messenger - genetics | Receptors, LDL - metabolism | Proprotein Convertase 9 - genetics | Proprotein Convertase 9 - metabolism | Hepatocyte Nuclear Factor 1-alpha - metabolism | RNA, Messenger - metabolism | Promoter Regions, Genetic - genetics | Hep G2 Cells | C-Reactive Protein - metabolism | Time Factors | Models, Biological | Protein Binding | Lipoproteins, LDL - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | RNA, Small Interfering - metabolism | pro‐protein convertase subtilisin | kexin type 9 | Original
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2. Full Text First Food-Derived Peptide Inhibitor of the Protein–Protein Interaction between Gain-of-Function PCSK9D374Y and the Low-Density Lipoprotein Receptor
by Grazioso, Giovanni and Bollati, Carlotta and Sgrignani, Jacopo and Arnoldi, Anna and Lammi, Carmen
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 10/2018, Volume 66, Issue 40, pp. 10552 - 10557
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is involved in cholesterol homeostasis, because it induces the low-density lipoprotein receptor (LDLR)... 
bioactive peptides | functional foods | PCSK9 inhibitors | HepG2 cells | LDLR
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3. Full Text Hepatic Overexpression of Idol Increases Circulating Protein Convertase Subtilisin/Kexin Type 9 in Mice and Hamsters via Dual Mechanisms: Sterol Regulatory Element–Binding Protein 2 and Low-Density Lipoprotein Receptor–Dependent Pathways
by Sasaki, Makoto and Terao, Yoshio and Ayaori, Makoto and Uto-Kondo, Harumi and Iizuka, Maki and Yogo, Makiko and Hagisawa, Kosuke and Takiguchi, Shunichi and Yakushiji, Emi and Nakaya, Kazuhiro and Ogura, Masatsune and Komatsu, Tomohiro and Ikewaki, Katsunori
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 06/2014, Volume 34, Issue 6, pp. 1171 - 1178
OBJECTIVE—Low-density lipoprotein receptor (LDLR) is degraded by inducible degrader of LDLR (Idol) and protein convertase subtilisin/kexin type 9 (PCSK9),... 
cholesterol ester transfer proteins | Idol protein, mouse | receptors, LDL | Pcsk9 protein, mouse | Cricetinae | Signal Transduction | Cholesterol Ester Transfer Proteins - physiology | Humans | Liver - metabolism | Mice, Inbred C57BL | Serine Endopeptidases - physiology | Ubiquitin-Protein Ligases - physiology | Sterol Regulatory Element Binding Protein 2 - physiology | Hep G2 Cells | Proprotein Convertases - physiology | Animals | Liver X Receptors | Orphan Nuclear Receptors - physiology | Serine Endopeptidases - blood | Mesocricetus | Proprotein Convertases - blood | Lipoproteins, LDL - metabolism | Mice | Receptors, LDL - physiology | Proprotein Convertase 9
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4. Full Text Inhibition of PCSK9D374Y/LDLR Protein-Protein Interaction by Computationally Designed T9 Lupin Peptide
by Lammi, Carmen and Sgrignani, Jacopo and Roda, Gabriella and Arnoldi, Anna and Grazioso, Giovanni
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 2018, Volume 10, Issue 4, pp. 425 - 430
Alanine scanning | bioactive peptides | PCSK9 inhibitors | HepG2 cells | LDL-R | MM-GBSA
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5. Full Text First Food-Derived Peptide Inhibitor of the Protein-Protein Interaction between Gain-of-Function PCSK9(D374Y) and the Low-Density Lipoprotein Receptor
by Grazioso, G and Bollati, C and Sgrignani, J and Arnoldi, A and Lammi, C
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, ISSN 0021-8561, 10/2018, Volume 66, Issue 40, pp. 10552 - 10557
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is involved in cholesterol homeostasis, because it induces the low-density lipoprotein receptor (LDLR)... 
PCSK9 inhibitors | MOLECULAR-DYNAMICS | LUPIN PROTEIN | FOOD SCIENCE & TECHNOLOGY | HepG2 cells | DECREASES | bioactive peptides | functional foods | AGRICULTURE, MULTIDISCIPLINARY | CHEMISTRY, APPLIED | LDLR | EXPRESSION | BINDING | PCSK9 GENE
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6. Full Text G-Protein Estrogen Receptor as a Regulator of Low-Density Lipoprotein Cholesterol Metabolism: Cellular and Population Genetic Studies
by Hussain, Yasin and Ding, Qingming and Connelly, Philip W and Brunt, J Howard and Ban, Matthew R and McIntyre, Adam D and Huff, Murray W and Gros, Robert and Hegele, Robert A and Feldman, Ross D
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2015, Volume 35, Issue 1, pp. 213 - 221
OBJECTIVE—Estrogen deficiency is linked with increased low-density lipoprotein (LDL) cholesterol. The hormone receptor mediating this effect is unknown.... 
PCSK9 protein | receptors | LDL | human | Cholesterol | GPER protein | receptors, LDL | LDL-CHOLESTEROL | cholesterol, LDL | BLOOD-PRESSURE | DIABETES-MELLITUS | HEART-DISEASE | PLASMA-LEVELS | LIPID-LEVELS | CARDIOVASCULAR-DISEASE | GPER protein, human | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | PCSK9 protein, human | UP-REGULATION | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | Receptors, Estrogen - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Middle Aged | Male | Mutation, Missense | Proprotein Convertases - genetics | Dose-Response Relationship, Drug | Young Adult | Transfection | RNA Interference | Serine Endopeptidases - genetics | Adult | Cholesterol, LDL - blood | Female | Receptors, G-Protein-Coupled - drug effects | Genetics, Population | Receptors, LDL - genetics | European Continental Ancestry Group - genetics | Receptors, Estrogen - genetics | Gene Frequency | Proprotein Convertases - metabolism | Gene Expression Regulation | Receptors, LDL - metabolism | Hep G2 Cells | Canada | Homozygote | Phenotype | Receptors, Estrogen - drug effects | Adolescent | Heterozygote | Aged | Receptors, G-Protein-Coupled - genetics | Serine Endopeptidases - metabolism | Proprotein Convertase 9
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7. Full Text Suppressor of cytokine signaling-3 (SOCS-3) induces proprotein convertase subtilisin kexin type 9 (PCSK9) expression in hepatic HepG2 cell line
by Ruscica, Massimiliano and Ricci, Chiara and Macchi, Chiara and Magni, Paolo and Cristofani, Riccardo and Liu, Jingwen and Corsini, Alberto and Ferri, Nicola
Journal of Biological Chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 7, pp. 3508 - 3519
The suppressor of cytokine signaling (SOCS) proteins are negative regulators of the JAK/STAT pathway activated by proinflammatory cytokines, including the... 
PLASMA PCSK9 | tumor necrosis factor (TNF) | ACTIVATION | hepatocyte | proprotein convertase subtilisin | PROTEIN | insulin | CHOLESTEROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | APOLIPOPROTEIN-B | HUMAN ENDOTHELIAL-CELLS | INSULIN-RESISTANCE | stat-3 | HepG2 | kexin type 9 (PCSK9) | SMOOTH-MUSCLE-CELLS | MUTATIONS | suppressor of cytokine signaling 3 (SOCS3) | Proprotein Convertases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Humans | STAT3 Transcription Factor - agonists | Tumor Necrosis Factor-alpha - genetics | Male | Janus Kinases - metabolism | Hepatocytes - metabolism | Proprotein Convertases - genetics | Recombinant Fusion Proteins - metabolism | RNA Interference | Serine Endopeptidases - genetics | Lipogenesis | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Recombinant Proteins - metabolism | Janus Kinases - chemistry | Signal Transduction | Mice, Inbred C57BL | Proprotein Convertases - metabolism | Insulin Resistance | Enzyme Induction | Suppressor of Cytokine Signaling Proteins - genetics | Serine Endopeptidases - chemistry | Proprotein Convertases - chemistry | Hep G2 Cells | Obesity - metabolism | Suppressor of Cytokine Signaling 3 Protein | Animals | Suppressor of Cytokine Signaling Proteins - antagonists & inhibitors | Suppressor of Cytokine Signaling Proteins - agonists | Obesity - enzymology | Protein Processing, Post-Translational | Serine Endopeptidases - metabolism | Mutation | Suppressor of Cytokine Signaling Proteins - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Hepatocytes - enzymology | Proprotein Convertase 9 | Cell Biology
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8. Full Text The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding
by Maretzky, Thorsten and Evers, Astrid and Gall, Sylvain Le and Alabi, Rolake O and Speck, Nancy and Reiss, Karina and Blobel, Carl P
Journal of Biological Chemistry, ISSN 0021-9258, 03/2015, Volume 290, Issue 12, pp. 7416 - 7425
Background: Release of membrane proteins from the cell surface by the metalloproteinase ADAM10 is post-translationally regulated. Results: The cytoplasmic... 
Shedding | GROWTH-FACTOR-RECEPTOR | Kexin Type 9 (PCSK9) | Cytoplasmic Domain | BIOCHEMISTRY & MOLECULAR BIOLOGY | NOTCH ACTIVATION | Metalloprotease | TACE | NECROSIS-FACTOR-ALPHA | Cell Surface Enzyme | AMYLOID PRECURSOR PROTEIN | CALCIUM INFLUX | ADAM | Proprotein Convertase Subtilisin | MOUSE MODEL | SUBSTRATE SELECTIVITY | Protein Ectodomain Shedding | CONVERTING-ENZYME | SECRETASE ADAM10 | Amino Acid Sequence | Amyloid Precursor Protein Secretases - genetics | Cytoplasm - enzymology | ADAM Proteins - physiology | Amyloid Precursor Protein Secretases - physiology | ADAM Proteins - chemistry | Membrane Proteins - genetics | Cells, Cultured | ADAM10 Protein | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | DNA Primers | Amyloid Precursor Protein Secretases - chemistry | Mice, Knockout | Animals | Membrane Proteins - chemistry | Membrane Proteins - physiology | Proteolysis | Base Sequence | Mice | ADAM Proteins - genetics | Real-Time Polymerase Chain Reaction | Cell Biology
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9. Full Text Amyloid precursor-like protein 2 and sortilin do not regulate the PCSK9 convertase-mediated low density lipoprotein receptor degradation but interact with each other
by Butkinaree, Chutikarn and Canuel, Maryssa and Essalmani, Rachid and Poirier, Steve and Benjannet, Suzanne and Asselin, Marie-Claude and Roubtsova, Anna and Hamelin, Josée and Marcinkiewicz, Jadwiga and Chamberland, Ann and Guillemot, Johann and Mayer, Gaétan and Sisodia, Sangram S and Jacob, Yves and Prat, Annik and Seidah, Nabil G
Journal of Biological Chemistry, ISSN 0021-9258, 07/2015, Volume 290, Issue 30, pp. 18609 - 18620
Amyloid precursor-like protein 2 (APLP2) and sortilin were reported to individually bind the proprotein convertase subtilisin/kexin type 9 (PCSK9) and regulate... 
FAMILIAL HYPERCHOLESTEROLEMIA | LDL RECEPTOR | AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA | LIVER-REGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEPG2 CELLS | COMPLEMENTATION ASSAY | MOUSE-LIVER | ADAPTER PROTEIN | SECRETED PCSK9 | CHONDROITIN SULFATE GLYCOSAMINOGLYCAN | Receptors, LDL - genetics | Adaptor Proteins, Vesicular Transport - biosynthesis | Humans | Liver - metabolism | Proprotein Convertases - metabolism | Adaptor Proteins, Vesicular Transport - genetics | Gene Expression Regulation | Hepatocytes - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Nerve Tissue Proteins - genetics | Proprotein Convertases - genetics | Hep G2 Cells | Nerve Tissue Proteins - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Proteolysis | Receptors, LDL - biosynthesis | Amyloid beta-Protein Precursor - metabolism | Proprotein Convertases - secretion | Serine Endopeptidases - genetics | Mice | Serine Endopeptidases - metabolism | Serine Endopeptidases - secretion | Proprotein Convertase 9 | low-density lipoprotein receptor (LDLR) degradation | cardiovascular disease | proprotein convertase subtilisin | Sortilin (SORT1) | APLP2 | Protein Synthesis and Degradation | lipoprotein metabolism | kexin type 9 (PCSK9) | dyslipidemia | low-density lipoprotein (LDL)
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10. Full Text The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2
by Hong, Cynthia and Duit, Sarah and Jalonen, Pilvi and Out, Ruud and Scheer, Lilith and Sorrentino, Vincenzo and Boyadjian, Rima and Rodenburg, Kees C. W and Foley, Edan and Korhonen, Laura and Lindholm, Dan and Nimpf, Johannes and van Berkel, Theo J. C and Tontonoz, Peter and Zelcer, Noam
Journal of biological chemistry, ISSN 0021-9258, 2010, Volume 285, Issue 26, pp. 19720 - 19726
We have previously identified the E3-ubiquitin ligase Inducible Degrader of the LDLR (Idol)1 as a post-translational modulator of LDLR levels. Idol is a direct... 
GENE | LDL RECEPTOR | REELIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | PCSK9 | MICE | HYPERCHOLESTEROLEMIA | MUTATIONS | LIVER-X-RECEPTORS | LEUCINE ZIPPER PROTEIN | BRAIN | NIH 3T3 Cells | Phosphorylation | LDL-Receptor Related Proteins | Humans | Hydrocarbons, Fluorinated - pharmacology | Immunoblotting | Orphan Nuclear Receptors - metabolism | Receptors, Lipoprotein - metabolism | Ubiquitination | Transfection | Liver X Receptors | Serine Endopeptidases - genetics | Cell Adhesion Molecules, Neuronal - metabolism | Extracellular Matrix Proteins - metabolism | Cell Line | Receptors, LDL - genetics | Extracellular Matrix Proteins - genetics | Mice, Inbred C57BL | Receptors, Lipoprotein - genetics | Ubiquitin-Protein Ligases - metabolism | Receptors, LDL - metabolism | Sulfonamides - pharmacology | Nerve Tissue Proteins - genetics | Orphan Nuclear Receptors - genetics | Cell Adhesion Molecules, Neuronal - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Signal Transduction - drug effects | Benzoates - pharmacology | Cell Line, Tumor | Protein Binding | Mice | Serine Endopeptidases - metabolism | Ubiquitin-Protein Ligases - genetics | Benzylamines - pharmacology | Cholesterol Metabolism | Lipoprotein Receptor | Protein Synthesis and Degradation | LXR | Ubiquitin Ligase | Metabolism | Nuclear Receptors
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11. Full Text Inhibition of PCSK9 transcription by Berberine involves down-regulation of hepatic HNF1α protein expression through the ubiquitin-proteasome degradation pathway
by Dong, Bin and Li, Hai and Singh, Amar Bahadur and Cao, Aiqin and Liu, Jingwen
Journal of Biological Chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 7, pp. 4047 - 4058
Our previous in vitro studies have identified hepatocyte nuclear factor 1 alpha (HNF1 alpha) as an obligated trans-activator for PCSK9 gene expression and... 
PLASMA PCSK9 | TARGET | CHOLESTEROL | MECHANISM | LDL RECEPTOR | FENOFIBRATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER | BINDING | DENSITY-LIPOPROTEIN RECEPTOR | ATORVASTATIN | Proprotein Convertases - antagonists & inhibitors | Transcription, Genetic - drug effects | Hepatocyte Nuclear Factor 1-alpha - genetics | Humans | Ubiquitin - metabolism | Hepatocyte Nuclear Factor 1-alpha - antagonists & inhibitors | Male | Hepatocyte Nuclear Factor 1-alpha - metabolism | Promoter Regions, Genetic - genetics | Proprotein Convertases - genetics | Proteasome Endopeptidase Complex - drug effects | Liver - drug effects | HEK293 Cells | Mesocricetus | Serine Endopeptidases - genetics | Real-Time Polymerase Chain Reaction | Cricetinae | Liver - metabolism | Proprotein Convertases - metabolism | RNA, Messenger - genetics | Cells, Cultured | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Hep G2 Cells | Gene Expression Regulation - drug effects | Berberine - pharmacology | Animals | Mice | Serine Endopeptidases - metabolism | Proprotein Convertase 9 | Kexin Type 9 (PCSK9) | Proprotein Convertase Subtilisin | Dyslipidemia | Nuclear Receptor | Lipids | Lipid Metabolism | LDL Receptor | Ubiquitylation (Ubiquitination) | HNF1a | Proteasome
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12. Full Text Inhibition of PCSK9(D374Y)/LDLR Protein-Protein Interaction by Computationally Designed T9 Lupin Peptide
by Lammi, C and Sgrignani, J and Roda, G and Arnoldi, A and Grazioso, G
ACS MEDICINAL CHEMISTRY LETTERS, ISSN 1948-5875, 04/2019, Volume 10, Issue 4, pp. 425 - 425
The inhibition of the PCSK9/LDLR protein protein interaction is a promising strategy for developing new hypocholesterolemic agents. Familial... 
THERAPEUTICS | PCSK9 inhibitors | CHEMISTRY, MEDICINAL | CHOLESTEROL | DRUG DESIGN | PCSK9 | HepG2 cells | HYPERCHOLESTEROLEMIA | bioactive peptides | LDL | MM-GBSA | LDL-R | Alanine scanning | RECEPTORS | BINDING
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13. Full Text Endoplasmic reticulum stress and Ca2+ depletion differentially modulate the sterol regulatory protein PCSK9 to control lipid metabolism
by Lebeau, Paul and Al-Hashimi, Ali and Sood, Sudesh and Lhoták, Šárka and Yu, Pei and Gyulay, Gabriel and Paré, Guillaume and Wayne Chen, S.R and Trigatti, Bernardo and Prat, Annik and Seidah, Nabil G and Austin, Richard C
Journal of Biological Chemistry, ISSN 0021-9258, 01/2017, Volume 292, Issue 4, pp. 1510 - 1523
Accumulating evidence implicates endoplasmic reticulum (ER) stress as a mediator of impaired lipid metabolism, thereby contributing to fatty liver disease and... 
LDL RECEPTOR | VENTRICULAR-TACHYCARDIA | LIVER-REGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MICE LACKING PCSK9 | CHOLESTEROL EFFLUX | CONVERTASE SUBTILISIN/KEXIN TYPE-9 | DENSITY-LIPOPROTEIN-RECEPTOR | CLEAVAGE-ACTIVATING PROTEIN | CARDIAC RYANODINE RECEPTOR | ELEMENT-BINDING PROTEINS | Receptors, LDL - genetics | Calcium - metabolism | Humans | Lipid Metabolism | Male | Proprotein Convertase 9 - biosynthesis | Proprotein Convertase 9 - genetics | Hepatocytes - metabolism | Hep G2 Cells | Gene Expression Regulation, Enzymologic | Animals | Proteolysis | Endoplasmic Reticulum Stress | Mice | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | hepatocyte | proprotein convertase subtilisin | low density lipoprotein (LDL) | ER calcium | SREBP2 | cholesterol | endoplasmic reticulum stress (ER stress) | kexin type 9 (PCSK9) | hepatocytes | Cell Biology
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14. Full Text Angiopoietin-Like 3 Protein Inhibition: A New Frontier in Lipid-Lowering Treatment
by Lang, William and Frishman, William H
Cardiology in Review, ISSN 1061-5377, 07/2019, Volume 27, Issue 4, pp. 211 - 217
Angiopoietin-like 3 protein (ANGPTL3) is an inhibitor of both lipoprotein lipase and endothelial lipase in humans. Population studies indicate a relationship... 
CARDIAC & CARDIOVASCULAR SYSTEMS | CHOLESTEROL | LOW-DENSITY-LIPOPROTEIN | AMERICAN-COLLEGE | RISK | MONOCLONAL-ANTIBODY | evinacumab | lipid-lowering | STATIN THERAPY | lipoprotein lipase | ANGPTL3 | LIPASE | ANGPTL3 DEFICIENCY | MUTATIONS | PCSK9 INHIBITORS
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15. Full Text Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor
by Zhang, Yingnan and Eigenbrot, Charles and Zhou, Lijuan and Shia, Steven and Li, Wei and Quan, Clifford and Tom, Jeffrey and Moran, Paul and Lello, Paola Di and Skelton, Nicholas J and Kong-Beltran, Monica and Peterson, Andrew and Kirchhofer, Daniel
Journal of Biological Chemistry, ISSN 0021-9258, 01/2014, Volume 289, Issue 2, pp. 942 - 955
PCSK9 (proprotein convertase subtilisin/kexin type 9) is a negative regulator of the hepatic LDL receptor, and clinical studies with PCSK9-inhibiting... 
COMPLEX | DESIGN | LDL-RECEPTOR | CHOLESTEROL | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIBODY | DEGRADATION | C-TERMINAL DOMAIN | ANTAGONISTS | SECRETED PCSK9 | Cricetulus | Humans | Crystallography, X-Ray | Peptide Library | Proprotein Convertases - genetics | Receptors, LDL - chemistry | Dose-Response Relationship, Drug | Enzyme Inhibitors - chemistry | Protein Binding - drug effects | Serine Endopeptidases - genetics | Binding Sites | Oligopeptides - chemistry | CHO Cells | Protein Structure, Tertiary | Amino Acid Sequence | Receptors, LDL - genetics | Cricetinae | Enzyme Inhibitors - metabolism | Magnetic Resonance Spectroscopy | Protein Structure, Secondary | Proprotein Convertases - metabolism | Enzyme Inhibitors - pharmacology | Models, Molecular | Receptors, LDL - metabolism | Serine Endopeptidases - chemistry | Oligopeptides - metabolism | Proprotein Convertases - chemistry | Hep G2 Cells | Binding, Competitive - drug effects | Animals | Serine Endopeptidases - metabolism | Oligopeptides - pharmacology | Proprotein Convertase 9 | Protein Structure and Folding | Crystal Structure | Peptides | Protease | LDL Receptor | PCSK9 | Phage Display | Protein-Protein Interactions
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16. Full Text Circulating Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Regulates VLDLR Protein and Triglyceride Accumulation in Visceral Adipose Tissue
by Roubtsova, Anna and Munkonda, Mercedes Nancy and Awan, Zuhier and Marcinkiewicz, Jadwiga and Chamberland, Ann and Lazure, Claude and Cianflone, Katherine and Seidah, Nabil G and Prat, Annik
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2011, Volume 31, Issue 4, pp. 785 - 791
OBJECTIVE—Proprotein convertase subtilisin/kexin 9 (PCSK9) promotes the degradation of the low-density lipoprotein receptor (LDLR), and its gene is the third... 
PCSK9 | proprotein convertase | adipose tissue metabolism | fatty acid uptake | VLDL receptor | CHOLESTEROL | HYPERCHOLESTEROLEMIA | DECREASES | SECRETED PCSK9 | LIVER-REGENERATION | DENSITY-LIPOPROTEIN-RECEPTOR | DEGRADATION | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | HEMATOLOGY | EXPRESSION | Immunohistochemistry | Liver - enzymology | Age Factors | Homeostasis | Adipocytes - enzymology | Male | Receptors, LDL - deficiency | Serine Endopeptidases - genetics | Female | Proprotein Convertases | Receptors, LDL - genetics | Oleic Acid - metabolism | Serine Endopeptidases - deficiency | Mice, Inbred C57BL | Receptors, LDL - metabolism | Cholesterol - metabolism | Adipocytes - pathology | Adiposity - genetics | Mice, Knockout | Triglycerides - metabolism | Hydrolysis | Animals | Serine Endopeptidases - blood | Sex Factors | Mice | Serine Endopeptidases - metabolism | Intra-Abdominal Fat - enzymology | Intra-Abdominal Fat - pathology | Hypertrophy | Proprotein Convertase 9
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17. Full Text Fabs Enable Single Particle cryoEM Studies of Small Proteins
by Wu, Shenping and Avila-Sakar, Agustin and Kim, JungMin and Booth, David S and Greenberg, Charles H and Rossi, Andrea and Liao, Maofu and Li, Xueming and Alian, Akram and Griner, Sarah L and Juge, Narinobu and Yu, Yadong and Mergel, Claudia M and Chaparro-Riggers, Javier and Strop, Pavel and Tampé, Robert and Edwards, Robert H and Stroud, Robert M and Craik, Charles S and Cheng, Yifan
Structure, ISSN 0969-2126, 04/2012, Volume 20, Issue 4, pp. 582 - 592
In spite of its recent achievements, the technique of single particle electron cryomicroscopy (cryoEM) has not been widely used to study proteins smaller than... 
NONHUMAN-PRIMATES | BIOPHYSICS | HIV-1 INTEGRASE | CRYOELECTRON MICROSCOPY | SYNTHETIC ANTIBODIES | RECONSTRUCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELECTRON-MICROSCOPY | PCSK9 | VIRUS CORE ANTIGEN | SUBUNIT | CELL BIOLOGY | Molecular Weight | Escherichia coli | Humans | Peptide Library | Proprotein Convertases - genetics | Immunoglobulin Fab Fragments - metabolism | Serine Endopeptidases - genetics | Recombinant Proteins - metabolism | Immunoglobulin Fab Fragments - genetics | Proprotein Convertases - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Escherichia coli Proteins - metabolism | Serine Endopeptidases - chemistry | Recombinant Proteins - genetics | Proprotein Convertases - chemistry | Vesicular Glutamate Transport Proteins - metabolism | Vesicular Glutamate Transport Proteins - genetics | Image Processing, Computer-Assisted | Vesicular Glutamate Transport Proteins - chemistry | Immunoglobulin Fab Fragments - chemistry | Escherichia coli Proteins - genetics | Protein Conformation | Serine Endopeptidases - metabolism | Escherichia coli Proteins - chemistry | Cryoelectron Microscopy - methods | Proprotein Convertase 9 | Proteins | Antigens | Universities and colleges | Semiconductor industry | Binding | Alignment | Images | Strategy | Fragmentation | Three dimensional
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