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Journal Article
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 10/2018, Volume 66, Issue 40, pp. 10552 - 10557
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is involved in cholesterol homeostasis, because it induces the low-density lipoprotein receptor (LDLR)... 
bioactive peptides | functional foods | PCSK9 inhibitors | HepG2 cells | LDLR
Journal Article
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 2018, Volume 10, Issue 4, pp. 425 - 430
Journal Article
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, ISSN 0021-8561, 10/2018, Volume 66, Issue 40, pp. 10552 - 10557
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is involved in cholesterol homeostasis, because it induces the low-density lipoprotein receptor (LDLR)... 
PCSK9 inhibitors | MOLECULAR-DYNAMICS | LUPIN PROTEIN | FOOD SCIENCE & TECHNOLOGY | HepG2 cells | DECREASES | bioactive peptides | functional foods | AGRICULTURE, MULTIDISCIPLINARY | CHEMISTRY, APPLIED | LDLR | EXPRESSION | BINDING | PCSK9 GENE
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2015, Volume 35, Issue 1, pp. 213 - 221
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 7, pp. 3508 - 3519
The suppressor of cytokine signaling (SOCS) proteins are negative regulators of the JAK/STAT pathway activated by proinflammatory cytokines, including the... 
PLASMA PCSK9 | tumor necrosis factor (TNF) | ACTIVATION | hepatocyte | proprotein convertase subtilisin | PROTEIN | insulin | CHOLESTEROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | APOLIPOPROTEIN-B | HUMAN ENDOTHELIAL-CELLS | INSULIN-RESISTANCE | stat-3 | HepG2 | kexin type 9 (PCSK9) | SMOOTH-MUSCLE-CELLS | MUTATIONS | suppressor of cytokine signaling 3 (SOCS3) | Proprotein Convertases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Humans | STAT3 Transcription Factor - agonists | Tumor Necrosis Factor-alpha - genetics | Male | Janus Kinases - metabolism | Hepatocytes - metabolism | Proprotein Convertases - genetics | Recombinant Fusion Proteins - metabolism | RNA Interference | Serine Endopeptidases - genetics | Lipogenesis | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Recombinant Proteins - metabolism | Janus Kinases - chemistry | Signal Transduction | Mice, Inbred C57BL | Proprotein Convertases - metabolism | Insulin Resistance | Enzyme Induction | Suppressor of Cytokine Signaling Proteins - genetics | Serine Endopeptidases - chemistry | Proprotein Convertases - chemistry | Hep G2 Cells | Obesity - metabolism | Suppressor of Cytokine Signaling 3 Protein | Animals | Suppressor of Cytokine Signaling Proteins - antagonists & inhibitors | Suppressor of Cytokine Signaling Proteins - agonists | Obesity - enzymology | Protein Processing, Post-Translational | Serine Endopeptidases - metabolism | Mutation | Suppressor of Cytokine Signaling Proteins - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Hepatocytes - enzymology | Proprotein Convertase 9 | Cell Biology
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2015, Volume 290, Issue 30, pp. 18609 - 18620
Journal Article
Journal of biological chemistry, ISSN 0021-9258, 2010, Volume 285, Issue 26, pp. 19720 - 19726
We have previously identified the E3-ubiquitin ligase Inducible Degrader of the LDLR (Idol)1 as a post-translational modulator of LDLR levels. Idol is a direct... 
GENE | LDL RECEPTOR | REELIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | PCSK9 | MICE | HYPERCHOLESTEROLEMIA | MUTATIONS | LIVER-X-RECEPTORS | LEUCINE ZIPPER PROTEIN | BRAIN | NIH 3T3 Cells | Phosphorylation | LDL-Receptor Related Proteins | Humans | Hydrocarbons, Fluorinated - pharmacology | Immunoblotting | Orphan Nuclear Receptors - metabolism | Receptors, Lipoprotein - metabolism | Ubiquitination | Transfection | Liver X Receptors | Serine Endopeptidases - genetics | Cell Adhesion Molecules, Neuronal - metabolism | Extracellular Matrix Proteins - metabolism | Cell Line | Receptors, LDL - genetics | Extracellular Matrix Proteins - genetics | Mice, Inbred C57BL | Receptors, Lipoprotein - genetics | Ubiquitin-Protein Ligases - metabolism | Receptors, LDL - metabolism | Sulfonamides - pharmacology | Nerve Tissue Proteins - genetics | Orphan Nuclear Receptors - genetics | Cell Adhesion Molecules, Neuronal - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Signal Transduction - drug effects | Benzoates - pharmacology | Cell Line, Tumor | Protein Binding | Mice | Serine Endopeptidases - metabolism | Ubiquitin-Protein Ligases - genetics | Benzylamines - pharmacology | Cholesterol Metabolism | Lipoprotein Receptor | Protein Synthesis and Degradation | LXR | Ubiquitin Ligase | Metabolism | Nuclear Receptors
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 7, pp. 4047 - 4058
Journal Article
ACS MEDICINAL CHEMISTRY LETTERS, ISSN 1948-5875, 04/2019, Volume 10, Issue 4, pp. 425 - 425
The inhibition of the PCSK9/LDLR protein protein interaction is a promising strategy for developing new hypocholesterolemic agents. Familial... 
THERAPEUTICS | PCSK9 inhibitors | CHEMISTRY, MEDICINAL | CHOLESTEROL | DRUG DESIGN | PCSK9 | HepG2 cells | HYPERCHOLESTEROLEMIA | bioactive peptides | LDL | MM-GBSA | LDL-R | Alanine scanning | RECEPTORS | BINDING
Journal Article
Journal Article
Cardiology in Review, ISSN 1061-5377, 07/2019, Volume 27, Issue 4, pp. 211 - 217
Angiopoietin-like 3 protein (ANGPTL3) is an inhibitor of both lipoprotein lipase and endothelial lipase in humans. Population studies indicate a relationship... 
CARDIAC & CARDIOVASCULAR SYSTEMS | CHOLESTEROL | LOW-DENSITY-LIPOPROTEIN | AMERICAN-COLLEGE | RISK | MONOCLONAL-ANTIBODY | evinacumab | lipid-lowering | STATIN THERAPY | lipoprotein lipase | ANGPTL3 | LIPASE | ANGPTL3 DEFICIENCY | MUTATIONS | PCSK9 INHIBITORS
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2014, Volume 289, Issue 2, pp. 942 - 955
Journal Article
Journal Article
Structure, ISSN 0969-2126, 04/2012, Volume 20, Issue 4, pp. 582 - 592
Journal Article