Articles

UofT Libraries is getting a new library services platform in January 2021.
Learn more about the change.

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
science & technology (737) 737
life sciences & biomedicine (731) 731
pcsk9 (633) 633
humans (533) 533
cholesterol (282) 282
lipids (271) 271
cardiovascular system & cardiology (264) 264
proprotein convertase 9 (255) 255
male (244) 244
low density lipoproteins (242) 242
hypercholesterolemia (224) 224
cardiac & cardiovascular systems (220) 220
animals (206) 206
female (204) 204
statins (202) 202
atherosclerosis (182) 182
cholesterol, ldl - blood (169) 169
middle aged (155) 155
biochemistry & molecular biology (148) 148
cardiovascular disease (132) 132
pharmacology & pharmacy (127) 127
serine endopeptidases - genetics (125) 125
cardiovascular (124) 124
lipoproteins (122) 122
pcsk9 inhibitors (121) 121
peripheral vascular disease (120) 120
familial hypercholesterolemia (118) 118
cardiovascular diseases (109) 109
receptors, ldl - metabolism (103) 103
adult (101) 101
aged (99) 99
mutation (99) 99
hypercholesterolemia - drug therapy (94) 94
risk factors (94) 94
ldl receptor (88) 88
proprotein convertase 9 - antagonists & inhibitors (87) 87
ldlr (86) 86
serine endopeptidases - metabolism (86) 86
anticholesteremic agents - therapeutic use (84) 84
low density lipoprotein (82) 82
kexin (81) 81
monoclonal antibodies (80) 80
receptors, ldl - genetics (80) 80
ezetimibe (77) 77
dyslipidemia (76) 76
mice (76) 76
analysis (75) 75
cardiology (73) 73
hydroxymethylglutaryl-coa reductase inhibitors - therapeutic use (73) 73
genetic aspects (70) 70
proprotein convertases (70) 70
antibodies, monoclonal - therapeutic use (68) 68
medicine & public health (68) 68
ldl-c (67) 67
alirocumab (66) 66
evolocumab (66) 66
care and treatment (65) 65
biological and medical sciences (63) 63
proprotein convertase 9 - metabolism (63) 63
endocrinology & metabolism (62) 62
biomarkers - blood (61) 61
ldl cholesterol (60) 60
medical sciences (59) 59
proprotein convertases - genetics (59) 59
hyperlipoproteinemia type ii - genetics (58) 58
blood cholesterol (55) 55
diabetes (55) 55
cardiovascular diseases - prevention & control (54) 54
coronary heart disease (54) 54
subtilisin (54) 54
cholesterol - blood (53) 53
health aspects (53) 53
proprotein convertases - metabolism (53) 53
treatment outcome (52) 52
proteins (51) 51
cell biology (50) 50
physiological aspects (50) 50
clinical trials (49) 49
hypercholesterolemia - blood (48) 48
ldl (48) 48
proprotein convertase 9 - genetics (47) 47
cardiology. vascular system (45) 45
ldl-cholesterol (45) 45
cardiovascular agents (44) 44
internal medicine (44) 44
liver (43) 43
metabolism (43) 43
research (43) 43
cholesterol, ldl - metabolism (42) 42
hypercholesterolemia - genetics (42) 42
apolipoproteins (41) 41
low-density lipoprotein cholesterol (41) 41
proprotein convertase subtilisin/kexin type 9 (41) 41
abridged index medicus (40) 40
enzymes (40) 40
hep g2 cells (40) 40
lipid metabolism (40) 40
blood and lymphatic vessels (39) 39
dyslipidemias - drug therapy (39) 39
gene expression (39) 39
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (956) 956
German (18) 18
Russian (8) 8
Chinese (7) 7
French (6) 6
Portuguese (5) 5
Japanese (4) 4
Spanish (4) 4
Italian (1) 1
Korean (1) 1
Norwegian (1) 1
Polish (1) 1
Slovak (1) 1
Swedish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text In Silico Insights into Protein-Protein Interaction Disruptive Mutations in the PCSK9-LDLR Complex
by Martin, William R and Lightstone, Felice C and Cheng, Feixiong
International journal of molecular sciences, ISSN 1422-0067, 03/2020, Volume 21, Issue 5, p. 1550
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Index Medicus | protein–protein interaction (ppi) | ppi disruptive mutation | pcsk9 | residue interaction network | ldlr | molecular dynamics | mm/pbsa
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text First Food-Derived Peptide Inhibitor of the Protein–Protein Interaction between Gain-of-Function PCSK9D374Y and the Low-Density Lipoprotein Receptor
by Grazioso, Giovanni and Bollati, Carlotta and Sgrignani, Jacopo and Arnoldi, Anna and Lammi, Carmen
Journal of agricultural and food chemistry, ISSN 0021-8561, 10/2018, Volume 66, Issue 40, pp. 10552 - 10557
bioactive peptides | functional foods | PCSK9 inhibitors | HepG2 cells | LDLR | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Inhibition of PCSK9D374Y/LDLR Protein–Protein Interaction by Computationally Designed T9 Lupin Peptide
by Lammi, Carmen and Sgrignani, Jacopo and Roda, Gabriella and Arnoldi, Anna and Grazioso, Giovanni
ACS medicinal chemistry letters, ISSN 1948-5875, 04/2019, Volume 10, Issue 4, pp. 425 - 430
Alanine scanning | bioactive peptides | PCSK9 inhibitors | HepG2 cells | LDL-R | MM-GBSA
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Proprotein Convertase Subtilisin/Kexin Type 9, Angiopoietin-Like Protein 8, Sortilin, and Cholesteryl Ester Transfer Protein-Friends of Foes for Psoriatic Patients at the Risk of Developing Cardiometabolic Syndrome?
by Krahel, Julita Anna and Baran, Anna and Kaminski, Tomasz W and Flisiak, Iwona
International journal of molecular sciences, ISSN 1422-0067, 05/2020, Volume 21, Issue 10, p. 3682
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Psoriasis | Disease | Cytokines | Angiopoietin | Liver | Homeostasis | Lipids | Subtilisin | Inflammation | Gene expression | Metabolic syndrome | Patients | Cholesteryl ester transfer protein | Proteins | Lipoproteins | Kexin | Pathways | Atherosclerosis | Tumor necrosis factor-TNF | Metabolic disorders | Immune system | Index Medicus | metabolic syndrome | atherosclerosis | PCSK9 | CEPT | psoriasis | ANGPTL8
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text G-Protein Estrogen Receptor as a Regulator of Low-Density Lipoprotein Cholesterol Metabolism: Cellular and Population Genetic Studies
by Hussain, Yasin and Ding, Qingming and Connelly, Philip W and Brunt, J Howard and Ban, Matthew R and McIntyre, Adam D and Huff, Murray W and Gros, Robert and Hegele, Robert A and Feldman, Ross D
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 01/2015, Volume 35, Issue 1, pp. 213 - 221
PCSK9 protein | receptors | LDL | human | Cholesterol | GPER protein | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Receptors, Estrogen - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Middle Aged | Male | Mutation, Missense | Proprotein Convertases - genetics | Dose-Response Relationship, Drug | Young Adult | Transfection | RNA Interference | Serine Endopeptidases - genetics | Adult | Cholesterol, LDL - blood | Female | Receptors, G-Protein-Coupled - drug effects | Genetics, Population | Receptors, LDL - genetics | European Continental Ancestry Group - genetics | Receptors, Estrogen - genetics | Gene Frequency | Proprotein Convertases - metabolism | Gene Expression Regulation | Receptors, LDL - metabolism | Hep G2 Cells | Canada | Homozygote | Phenotype | Receptors, Estrogen - drug effects | Adolescent | Heterozygote | Aged | Receptors, G-Protein-Coupled - genetics | Serine Endopeptidases - metabolism | Proprotein Convertase 9 | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Hepatic Overexpression of Idol Increases Circulating Protein Convertase Subtilisin/Kexin Type 9 in Mice and Hamsters via Dual Mechanisms: Sterol Regulatory Element–Binding Protein 2 and Low-Density Lipoprotein Receptor–Dependent Pathways
by Sasaki, Makoto and Terao, Yoshio and Ayaori, Makoto and Uto-Kondo, Harumi and Iizuka, Maki and Yogo, Makiko and Hagisawa, Kosuke and Takiguchi, Shunichi and Yakushiji, Emi and Nakaya, Kazuhiro and Ogura, Masatsune and Komatsu, Tomohiro and Ikewaki, Katsunori
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 06/2014, Volume 34, Issue 6, pp. 1171 - 1178
cholesterol ester transfer proteins | Idol protein, mouse | receptors, LDL | Pcsk9 protein, mouse | Cricetinae | Signal Transduction | Cholesterol Ester Transfer Proteins - physiology | Humans | Liver - metabolism | Mice, Inbred C57BL | Serine Endopeptidases - physiology | Ubiquitin-Protein Ligases - physiology | Sterol Regulatory Element Binding Protein 2 - physiology | Hep G2 Cells | Proprotein Convertases - physiology | Animals | Liver X Receptors | Orphan Nuclear Receptors - physiology | Serine Endopeptidases - blood | Mesocricetus | Proprotein Convertases - blood | Lipoproteins, LDL - metabolism | Mice | Receptors, LDL - physiology | Proprotein Convertase 9 | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding
by Maretzky, Thorsten and Evers, Astrid and Gall, Sylvain Le and Alabi, Rolake O and Speck, Nancy and Reiss, Karina and Blobel, Carl P
The Journal of biological chemistry, ISSN 0021-9258, 03/2015, Volume 290, Issue 12, pp. 7416 - 7425
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Amyloid Precursor Protein Secretases - genetics | Cytoplasm - enzymology | ADAM Proteins - physiology | Amyloid Precursor Protein Secretases - physiology | ADAM Proteins - chemistry | Membrane Proteins - genetics | Cells, Cultured | ADAM10 Protein | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | DNA Primers | Amyloid Precursor Protein Secretases - chemistry | Mice, Knockout | Animals | Membrane Proteins - chemistry | Membrane Proteins - physiology | Proteolysis | Base Sequence | Mice | ADAM Proteins - genetics | Real-Time Polymerase Chain Reaction | Index Medicus | ADAM | Shedding | Kexin Type 9 (PCSK9) | Cytoplasmic Domain | Proprotein Convertase Subtilisin | Metalloprotease | Cell Surface Enzyme | Protein Ectodomain Shedding | Cell Biology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation
by Petersen, Donna N and Hawkins, Julie and Ruangsiriluk, Wanida and Stevens, Kimberly A and Maguire, Bruce A and O’Connell, Thomas N and Rocke, Benjamin N and Boehm, Markus and Ruggeri, Roger B and Rolph, Tim and Hepworth, David and Loria, Paula M and Carpino, Philip A
Cell chemical biology, ISSN 2451-9456, 11/2016, Volume 23, Issue 11, pp. 1362 - 1371
secretion | anti-secretagogue | LDL | R-IMPP | translation | high throughput screen (HTS) | PCSK9 | ribosome | phenotypic screening | LDL receptor | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Isoquinolines - chemistry | Small Molecule Libraries - chemistry | Small Molecule Libraries - pharmacology | Isoquinolines - pharmacology | Proprotein Convertase 9 - antagonists & inhibitors | Humans | Ribosomes - drug effects | Cell Line, Tumor | Ribosomes - metabolism | Protein Biosynthesis - drug effects | Proprotein Convertase 9 - metabolism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Inhibition of PCSK9 transcription by Berberine involves down-regulation of hepatic HNF1α protein expression through the ubiquitin-proteasome degradation pathway
by Dong, Bin and Li, Hai and Singh, Amar Bahadur and Cao, Aiqin and Liu, Jingwen
The Journal of biological chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 7, pp. 4047 - 4058
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Proprotein Convertases - antagonists & inhibitors | Transcription, Genetic - drug effects | Hepatocyte Nuclear Factor 1-alpha - genetics | Humans | Ubiquitin - metabolism | Hepatocyte Nuclear Factor 1-alpha - antagonists & inhibitors | Male | Hepatocyte Nuclear Factor 1-alpha - metabolism | Promoter Regions, Genetic - genetics | Proprotein Convertases - genetics | Proteasome Endopeptidase Complex - drug effects | Liver - drug effects | HEK293 Cells | Mesocricetus | Serine Endopeptidases - genetics | Real-Time Polymerase Chain Reaction | Cricetinae | Liver - metabolism | Proprotein Convertases - metabolism | RNA, Messenger - genetics | Cells, Cultured | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Hep G2 Cells | Gene Expression Regulation - drug effects | Berberine - pharmacology | Animals | Mice | Serine Endopeptidases - metabolism | Proprotein Convertase 9 | Index Medicus | Kexin Type 9 (PCSK9) | Proprotein Convertase Subtilisin | Dyslipidemia | Nuclear Receptor | Lipids | Lipid Metabolism | LDL Receptor | Ubiquitylation (Ubiquitination) | HNF1a | Proteasome
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Suppressor of cytokine signaling-3 (SOCS-3) induces proprotein convertase subtilisin kexin type 9 (PCSK9) expression in hepatic HepG2 cell line
by Ruscica, Massimiliano and Ricci, Chiara and Macchi, Chiara and Magni, Paolo and Cristofani, Riccardo and Liu, Jingwen and Corsini, Alberto and Ferri, Nicola
The Journal of biological chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 7, pp. 3508 - 3519
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Proprotein Convertases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Humans | STAT3 Transcription Factor - agonists | Tumor Necrosis Factor-alpha - genetics | Male | Janus Kinases - metabolism | Hepatocytes - metabolism | Proprotein Convertases - genetics | Recombinant Fusion Proteins - metabolism | RNA Interference | Serine Endopeptidases - genetics | Lipogenesis | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Recombinant Proteins - metabolism | Janus Kinases - chemistry | Signal Transduction | Mice, Inbred C57BL | Proprotein Convertases - metabolism | Insulin Resistance | Enzyme Induction | Suppressor of Cytokine Signaling Proteins - genetics | Serine Endopeptidases - chemistry | Proprotein Convertases - chemistry | Hep G2 Cells | Obesity - metabolism | Suppressor of Cytokine Signaling 3 Protein | Animals | Suppressor of Cytokine Signaling Proteins - antagonists & inhibitors | Suppressor of Cytokine Signaling Proteins - agonists | Obesity - enzymology | Protein Processing, Post-Translational | Serine Endopeptidases - metabolism | Mutation | Suppressor of Cytokine Signaling Proteins - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Hepatocytes - enzymology | Proprotein Convertase 9 | Index Medicus | tumor necrosis factor (TNF) | hepatocyte | proprotein convertase subtilisin | insulin | stat-3 | HepG2 | kexin type 9 (PCSK9) | Cell Biology | suppressor of cytokine signaling 3 (SOCS3)
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Inhibitory effect of PCSK9 on Abca1 protein expression and cholesterol efflux in macrophages
by Adorni, Maria Pia and Cipollari, Eleonora and Favari, Elda and Zanotti, Ilaria and Zimetti, Francesca and Corsini, Alberto and Ricci, Chiara and Bernini, Franco and Ferri, Nicola
Atherosclerosis, ISSN 0021-9150, 2016, Volume 256, pp. 1 - 6
Cardiovascular | ABCA1 | PCSK9 | Cholesterol efflux | Macrophage | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Receptors, LDL - genetics | Down-Regulation | Mice, Inbred C57BL | Cells, Cultured | Macrophages, Peritoneal - enzymology | Lipoproteins, LDL - pharmacology | Genotype | Liver X Receptors - metabolism | Cholesterol - metabolism | Proprotein Convertase 9 - pharmacology | ATP Binding Cassette Transporter 1 - metabolism | Mice, Knockout | Phenotype | Animals | Biological Transport | Retinoid X Receptors - agonists | Liver X Receptors - agonists | Receptors, LDL - deficiency | Ligands | Macrophages, Peritoneal - drug effects | Retinoid X Receptors - metabolism | ATP Binding Cassette Transporter 1 - genetics | Macrophages | Cholesterol | Gene expression | Low density lipoproteins | Genes | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor
by Zhang, Yingnan and Eigenbrot, Charles and Zhou, Lijuan and Shia, Steven and Li, Wei and Quan, Clifford and Tom, Jeffrey and Moran, Paul and Lello, Paola Di and Skelton, Nicholas J and Kong-Beltran, Monica and Peterson, Andrew and Kirchhofer, Daniel
The Journal of biological chemistry, ISSN 0021-9258, 01/2014, Volume 289, Issue 2, pp. 942 - 955
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cricetulus | Humans | Crystallography, X-Ray | Peptide Library | Proprotein Convertases - genetics | Receptors, LDL - chemistry | Dose-Response Relationship, Drug | Enzyme Inhibitors - chemistry | Protein Binding - drug effects | Serine Endopeptidases - genetics | Binding Sites | Oligopeptides - chemistry | CHO Cells | Protein Structure, Tertiary | Amino Acid Sequence | Receptors, LDL - genetics | Cricetinae | Enzyme Inhibitors - metabolism | Magnetic Resonance Spectroscopy | Protein Structure, Secondary | Proprotein Convertases - metabolism | Enzyme Inhibitors - pharmacology | Models, Molecular | Receptors, LDL - metabolism | Serine Endopeptidases - chemistry | Oligopeptides - metabolism | Proprotein Convertases - chemistry | Hep G2 Cells | Binding, Competitive - drug effects | Animals | Serine Endopeptidases - metabolism | Oligopeptides - pharmacology | Proprotein Convertase 9 | Index Medicus | Protein Structure and Folding | Crystal Structure | Peptides | Protease | LDL Receptor | PCSK9 | Phage Display | Protein-Protein Interactions
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text Pinostrobin Inhibits Proprotein Convertase Subtilisin/Kexin-type 9 (PCSK9) Gene Expression through the Modulation of FoxO3a Protein in HepG2 Cells
by Gao, Wan-Yun and Chen, Pei-Yi and Chen, Shih-Fen and Wu, Ming-Jiuan and Chang, Heng-Yuan and Yen, Jui-Hung
Journal of agricultural and food chemistry, ISSN 0021-8561, 06/2018, Volume 66, Issue 24, pp. 6083 - 6093
FoxO3a | PCSK9 | flavonoid | LDLR | pinostrobin | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Applied | Food Science & Technology | Agriculture, Multidisciplinary | Agriculture | Science & Technology | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights