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Nature (London), ISSN 1476-4687, 2017, Volume 547, Issue 7664, pp. 413 - 418
Immunotherapy with PD-1 checkpoint blockade is effective in only a minority of patients with cancer, suggesting that additional treatment strategies are... 
CELLS | GENE | MULTIDISCIPLINARY SCIENCES | CD94/NKG2A | BLOCKADE | EXPRESSION | PD-1 | HLA-E | Tumor Escape - drug effects | Immunotherapy - methods | Loss of Function Mutation | Tumor Escape - genetics | Genomics | Humans | NF-kappa B - metabolism | Interferons - immunology | Melanoma, Experimental - immunology | T-Lymphocytes - drug effects | Tumor Escape - immunology | Melanoma, Experimental - therapy | Melanoma, Experimental - pathology | Antigen Presentation - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - deficiency | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Antigen Presentation - immunology | Unfolded Protein Response | CRISPR-Cas Systems - genetics | Gene Editing | Xenograft Model Antitumor Assays | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism | Animals | Melanoma, Experimental - genetics | T-Lymphocytes - immunology | Mice | Care and treatment | Analysis | Immunotherapy | Diagnosis | Genetic screening | Methods | Cancer | Animal models | PD-1 protein | Genes | Genomes | Synergism | Proteins | Signal transduction | Clonal deletion | Lymphocytes | Protein folding | Tyrosine | Antigen presentation | NF-κB protein | CRISPR | Melanoma | Medical screening | Patients | Screening | Signaling | Immune checkpoint | PD-L1 protein | Interferon | Genetic testing | Tumors | Protein-tyrosine-phosphatase | PTPN2 protein
Journal Article
Nature immunology, ISSN 1529-2916, 2019, Volume 20, Issue 7, pp. 835 - 851
...). LINK-A expression facilitated crosstalk between phosphatidylinositol-(3,4,5)-trisphosphate and inhibitory G-protein-coupled receptor (GPCR... 
COMPLEX | PHOSPHORYLATION | IMMUNOTHERAPY | G-PROTEINS | MUTATION | RESISTANCE | T-CELL | IMMUNOLOGY | NEGATIVE BREAST-CANCER | TRANSGENIC MICE | P53 | Neoplasms - metabolism | Phosphorylation | Cell Proliferation | Tumor Escape - genetics | Adenoma - genetics | Humans | Gene Expression Regulation, Neoplastic | Adenoma - metabolism | Ubiquitination | Tumor Microenvironment - genetics | Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Oncogenes | Disease Models, Animal | Tumor Escape - immunology | Cyclic AMP-Dependent Protein Kinases - metabolism | Tumor Suppressor Protein p53 - metabolism | RNA, Long Noncoding - genetics | Antigen Presentation - immunology | Cell Transformation, Neoplastic - metabolism | Disease Progression | Tumor Microenvironment - immunology | Xenograft Model Antitumor Assays | Animals | Neoplasms - immunology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Line, Tumor | Mice | Neoplasms - pathology | Antigens | Peptides | Ligases | Immunotherapy | Antisense RNA | Metastasis | Tumor proteins | Protein kinases | Cancer | Breast cancer | Prognosis | Research | Cancer cells | Apoptosis | Ubiquitin | Protein kinase A | G protein-coupled receptors | PD-1 protein | p53 Protein | Crosstalk | Kinases | Metastases | Proteins | Phosphatidylinositol | Antigenicity | Mammary gland | Ubiquitin-protein ligase | Antigen presentation | Tumor cells | Mammary glands | Nucleic acids | Ribonucleic acid--RNA | Gene expression | Suppressors | Immune checkpoint | Tumors
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 549, Issue 7670, pp. 106 - 110
Journal Article
Angewandte Chemie (International ed.), ISSN 1433-7851, 2017, Volume 56, Issue 44, pp. 13732 - 13735
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 5, p. e19664
T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) is a newly identified negative immunomodulator that is up-regulated on dysfunctional T cells during viral infections... 
ACTIVATION | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | ELEVATED FREQUENCIES | HEPATITIS-C-VIRUS | CD4(+) | T-CELL IMMUNOGLOBULIN | GENE FAMILY | CORE PROTEIN | CONTAINING MOLECULE-3 TIM-3 | PD-1 EXPRESSION | Up-Regulation | Phosphorylation | Hepacivirus - immunology | Coculture Techniques | Humans | Middle Aged | Hepatitis C, Chronic - virology | Suppressor of Cytokine Signaling 1 Protein | Male | Monocytes - metabolism | Hepatocytes - metabolism | Complement C1q - metabolism | Antigens, CD - metabolism | Lipopolysaccharide Receptors - metabolism | STAT1 Transcription Factor - metabolism | Mitochondrial Proteins - metabolism | Viral Core Proteins - metabolism | Adult | Membrane Proteins - metabolism | Interleukin-12 Subunit p40 - biosynthesis | Interleukin-12 Subunit p40 - metabolism | Signal Transduction | Macrophage Activation - immunology | Down-Regulation | Gene Silencing | Suppressor of Cytokine Signaling Proteins - genetics | Hepatitis A Virus Cellular Receptor 2 | Apoptosis Regulatory Proteins - metabolism | Macrophages - metabolism | Carrier Proteins - metabolism | Hepatitis C, Chronic - immunology | Hepatocytes - virology | Protein Binding | Programmed Cell Death 1 Receptor | Infection | Medical research | Cytokines | Immunotherapy | Medicine, Experimental | T cells | Hepatitis C virus | Gene expression | Health aspects | Mitogens | Health care | Multiple sclerosis | PD-1 protein | Veterans | Crosstalk | Lymphocytes T | Arthritis | Infections | Macrophages | CD14 antigen | Lipopolysaccharides | Proteins | Hepatitis | Lymphocytes | Toll-like receptors | Inhibition | Stat1 protein | Immune system | Antigens | Immunoglobulins | Immune response | TLR7 protein | Internal medicine | Immunoregulation | Melanoma | Blocking | Interleukin 12 | T cell receptors | Inflammation | TLR4 protein | Medicine | Complement component C1q | Signaling | Monocytes | Hospitals | Infectious diseases | Mucin | Core protein | Hepatocytes | Ligands | Human behavior | Viral infections
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 553, Issue 7686, pp. 91 - 95
Treatments that target immune checkpoints, such as the one mediated by programmed cell death protein 1 (PD-1... 
CELLS | THERAPY | IMMUNOTHERAPY | STABILIZATION | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | RETINOBLASTOMA-PROTEIN | SPOP | DEPENDENT KINASES | BREAST | REQUIREMENT | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Immunologic Surveillance | Phosphorylation | Humans | Male | Prostatic Neoplasms - immunology | Proteolysis | Cullin Proteins - metabolism | Female | Protein Stability | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Repressor Proteins - metabolism | Tumor Escape - immunology | Cdh1 Proteins - metabolism | Lymphocytes, Tumor-Infiltrating - cytology | Cell Line | Repressor Proteins - chemistry | Programmed Cell Death 1 Receptor - metabolism | Nuclear Proteins - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Nuclear Proteins - chemistry | 14-3-3 Proteins - metabolism | B7-H1 Antigen - metabolism | Animals | Cell Cycle | Neoplasms - immunology | B7-H1 Antigen - biosynthesis | Mice | Proteasome Endopeptidase Complex - metabolism | Cyclin D - metabolism | Lymphocytes, Tumor-Infiltrating - immunology | Animal models | PD-1 protein | Kinases | Cyclin-dependent kinase 4 | Cullin | Degradation | Proteins | Ubiquitination | Cell growth | Lymphocytes | Immunotherapy | Cell cycle | Cyclin D | Ubiquitin-protein ligase | Cyclin-dependent kinases | L1 protein | Immunosurveillance | Anaphase-promoting complex | Patients | Molecular modelling | Immune checkpoint | Cell death | Medical prognosis | PD-L1 protein | Ligands | Mutation | Anaphase | Prostate cancer | Prostate | Tumors | Apoptosis | Cancer
Journal Article
Current topics in medicinal chemistry, ISSN 1568-0266, 2018, Volume 18, Issue 8, pp. 674 - 699
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2001, Volume 98, Issue 24, pp. 13866 - 13871
PD-1 is an immunoreceptor that belongs to the immunoglobulin (Ig) superfamily and contains two tyrosine residues in the cytoplasmic region. Studies on... 
Proteins | Molecules | Biological Sciences | Phosphorylation | Receptors | Phosphatases | B lymphocytes | Cell lines | Ligands | Chimeras | Growth retardation | P62(DOK) | ACTIVATION | PROTEIN | MULTIDISCIPLINARY SCIENCES | ANTIGEN-RECEPTOR | MICE | SHP-1 | EXPRESSION | MEMBER | FAMILY | LYMPHOCYTES | Protein Tyrosine Phosphatase, Non-Receptor Type 11 | Calcium - metabolism | Humans | Protein Tyrosine Phosphatases - metabolism | Receptors, Antigen, B-Cell - metabolism | Antigens, CD - genetics | Receptors, IgG - metabolism | Antigens, CD - metabolism | Phosphotyrosine - metabolism | Receptors, IgG - genetics | Cell Division | Antigens, Surface - metabolism | Tumor Cells, Cultured | Protein Phosphatase 2 | Signal Transduction | Receptors, KIR | Antigens, Surface - genetics | Intracellular Signaling Peptides and Proteins | src Homology Domains | Tyrosine - metabolism | Animals | Apoptosis Regulatory Proteins | SH2 Domain-Containing Protein Tyrosine Phosphatases | Programmed Cell Death 1 Receptor | Mice | Receptors, Immunologic - genetics | Mitogen-Activated Protein Kinase 3 | Protein Tyrosine Phosphatase, Non-Receptor Type 6 | Receptors, Immunologic - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Physiological aspects | Protein tyrosine kinase | Immunoglobulins | Cellular signal transduction | B cells | phosphotyrosine | thyrosine phosphatase | Fc receptors | SH2 domain | PD-1 protein
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2019, Volume 176, Issue 1-2, pp. 334 - 347.e12
Journal Article
Nature (London), ISSN 1476-4687, 2019, Volume 567, Issue 7749, pp. 530 - 534
T cells expressing chimeric antigen receptors (CAR T cells) targeting human CD19 (hCD19) have shown clinical efficacy against B cell malignancies(1,2). CAR T... 
ELEMENTS | CHROMATIN | RNA-SEQ | IMMUNOTHERAPY | CD19 | MULTIDISCIPLINARY SCIENCES | INFECTION | CHIMERIC ANTIGEN RECEPTOR | DIFFERENTIATION | DYSFUNCTION | EXHAUSTION | Chromatin - metabolism | CD8-Positive T-Lymphocytes - pathology | Receptors, Steroid - metabolism | Humans | Transcription Factors - deficiency | Male | NF-kappa B - metabolism | Gene Expression Profiling | Adoptive Transfer | Transcription Factor AP-1 - metabolism | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Melanoma, Experimental - immunology | Neoplasms - genetics | CD8-Positive T-Lymphocytes - metabolism | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Receptors, Steroid - deficiency | Antigens, CD19 - immunology | Mice, Inbred C57BL | Melanoma, Experimental - pathology | Survival Rate | Nuclear Receptor Subfamily 4, Group A, Member 1 - deficiency | Nuclear Receptor Subfamily 4, Group A, Member 2 - deficiency | Receptors, Thyroid Hormone - metabolism | Transcription Factors - metabolism | Animals | Melanoma, Experimental - genetics | Lymphocytes, Tumor-Infiltrating - pathology | Neoplasms - immunology | Receptors, Chimeric Antigen - immunology | Cell Line, Tumor | Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism | Receptors, Thyroid Hormone - deficiency | Mice | Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism | CD8-Positive T-Lymphocytes - immunology | Neoplasms - pathology | Chromatin - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Transcription factors | Antigen receptors, T cell | Receptors | Causes of | Physiological aspects | Development and progression | Observations | T cells | Tumors | Antigens | Chromatin | DNA binding proteins | Gene expression | Accessibility | PD-1 protein | CD8 antigen | Genomics | Nur77 protein | Effector cells | Genomes | Activation | NF-AT protein | Bearing | Consortia | Cell activation | Lymphocytes | Transcription activation | Immunotherapy | DNA methylation | Deoxyribonucleic acid--DNA | Binding |