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1. Full Text Silencing of microRNA‐21 in vivo ameliorates autoimmune splenomegaly in lupus mice
by Garchow, Barry G and Bartulos Encinas, Oscar and Leung, Yiu Tak and Tsao, Patricia Y and Eisenberg, Robert A and Caricchio, Roberto and Obad, Susanna and Petri, Andreas and Kauppinen, Sakari and Kiriakidou, Marianthi
EMBO Molecular Medicine, ISSN 1757-4676, 10/2011, Volume 3, Issue 10, pp. 605 - 615
MicroRNAs (miRNAs) have been implicated in B cell lineage commitment, regulation of T cell differentiation, TCR signalling, regulation of IFN signalling, and... 
autoimmunity | miR‐21/PDCD4 | SLE | splenomegaly | TRANSFORMATION | MEDICINE, RESEARCH & EXPERIMENTAL | miR-21/PDCD4 | SIGNALING PROTEINS | TUMOR-SUPPRESSOR PDCD4 | PROGRAMMED CELL-DEATH-4 | PATHOGENESIS | GENETIC DISSECTION | THERAPEUTIC TARGETS | MIR-21 | EXPRESSION | T-CELLS | Transcription, Genetic - drug effects | Lupus Erythematosus, Systemic - complications | Gene Silencing - drug effects | Aging - drug effects | MicroRNAs - metabolism | Gene Expression Profiling | Splenomegaly - pathology | fas Receptor - metabolism | Lymphocyte Subsets - immunology | Autoimmune Diseases - genetics | Splenomegaly - complications | CD4-CD8 Ratio | Oligonucleotides - pharmacology | Lupus Erythematosus, Systemic - immunology | Lymphocytes - metabolism | Splenomegaly - genetics | Lymphocyte Subsets - drug effects | Mice, Inbred C57BL | Splenomegaly - immunology | Autoimmune Diseases - immunology | Aging - pathology | Apoptosis Regulatory Proteins - metabolism | Gene Expression Regulation - drug effects | B-Lymphocytes - drug effects | Animals | B-Lymphocytes - immunology | Lupus Erythematosus, Systemic - genetics | Lymphocytes - drug effects | Mice | MicroRNAs - genetics | RNA-Binding Proteins - metabolism | Lupus | Immunology | Autoimmune diseases | Lymphocytes | Index Medicus | PDCD4 | miR-21
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2. Full Text PDCD4 suppresses proliferation, migration, and invasion of endometrial cells by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway
by Li, Yue and Wang, Xiaoyan and Wang, Xishuang and Wan, Lu and Liu, Yanping and Shi, Yongyu and Zhang, Lining and Fang, Zhenghui and Wei, Zengtao
Biology of Reproduction, ISSN 0006-3363, 08/2018, Volume 99, Issue 2, pp. 360 - 372
Abstract Endometriosis (EM) is a kind of estrogen-dependent disease in reproductive-age women. Ovarian EM is the most common type. Although EM is a benign... 
Endometriosis | Proliferation | Programmed cell death 4 (PDCD4) | Migration | Invasion | DEATH 4 PDCD4 | proliferation | DEPENDENT TRANSCRIPTION | endometriosis | DOWN-REGULATION | GENE PDCD4 | MESENCHYMAL TRANSITION | REPRODUCTIVE BIOLOGY | invasion | EPITHELIAL-CELLS | migration | TISSUE INHIBITOR | STROMAL CELLS | NF-KAPPA-B | EXPRESSION | programmed cell death 4 (PDCD4)
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3. Full Text Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase-3 axis
by White, Kevin and Dempsie, Yvonne and Caruso, Paola and Wallace, Emma and McDonald, Robert A and Stevens, Hannah and Hatley, Mark E and Van Rooij, Eva and Morrell, Nicholas W and MacLean, Margaret R and Baker, Anew H
Hypertension, ISSN 0194-911X, 07/2014, Volume 64, Issue 1, pp. 185 - 94
Pulmonary endothelial cell apoptosis is a transient, yet defining pathogenic event integral to the onset of many pulmonary vascular diseases such as pulmonary... 
microRNAs | hypertension, pulmonary | endothelium | apoptosis | PDCD4 protein, human | TARGET | METASTASIS | TUMOR-SUPPRESSOR PDCD4 | pulmonary | PROLIFERATION | MICRORNA MIR-21 | BREAST-CANCER CELLS | CHRONIC HYPOXIA | ARTERIAL-HYPERTENSION | DISEASE | PERIPHERAL VASCULAR DISEASE | hypertension | PDCD4 protein | human | EXPRESSION | Cell Proliferation | Endothelial Cells - metabolism | Humans | Caspase 3 - metabolism | MicroRNAs - metabolism | Hypertension, Pulmonary - metabolism | Apoptosis Regulatory Proteins - metabolism | Animals | Cell Line, Tumor | Mice | MicroRNAs - genetics | Apoptosis - physiology | RNA-Binding Proteins - metabolism | Index Medicus
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4. Full Text Clinicopathological and prognostic significance of PDCD4 and microRNA-21 in human gastric cancer
by Motoyama, Kazuo and Inoue, Hiroshi and Mimori, Koshi and Tanaka, Fumiaki and Kojima, Kazuyuki and Uetake, Hiroyuki and Sugihara, Kenichi and Mori, Masaki
International Journal of Oncology, ISSN 1019-6439, 05/2010, Volume 36, Issue 5, pp. 1089 - 1095
MicroRNA | Prognosis | PDCD4 | miR-21 | Gastric cancer
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5. Full Text A feedback loop between microRNA 155 (miR-155), programmed cell death 4, and activation protein 1 modulates the expression of miR-155 and tumorigenesis in tongue cancer
by Zargar, Shabir and Tomar, Vivek and Shyamsundar, Vidyarani and Vijayalakshmi, Ramshankar and Somasundaram, Kumaravel and Karunagaran, Devarajan
Molecular and Cellular Biology, ISSN 0270-7306, 03/2019, Volume 39, Issue 6
MicroRNA 155 (miR-155) is an oncomir, generated as a noncoding RNA from the BIC gene whose promoter activity is mainly controlled via activation protein 1... 
Tumor xenografts | MiR-155 sponge | NF-B | Pdcd4 | AP-1 | BIC | Apoptosis | MiR-155 | miR-155 sponge | TUMOR PROGRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | tumor xenografts | BINDING-PROTEIN | apoptosis | PROLIFERATION | HUMAN GLIOMA | CELL BIOLOGY | BREAST-CANCER | PDCD4 EXPRESSION | NF-kappa B | TARGETING PDCD4 | miR-155 | TRANSFORMATION SUPPRESSOR | NF-KAPPA-B | Index Medicus
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6. Full Text Tumor suppressor Pdcd4attenuates Sin1 translation to inhibit invasion in colon carcinoma
by Wang, Qing and Zhu, Jiang and Wang, Ya-Wen and Dai, Yong and Wang, Yanlei and Wang, Chi and Liu, Jinpeng and Baker, Alyson and Colburn, Nancy H and Yang, Hsin-Sheng
Oncogene, ISSN 0950-9232, 11/2017, Volume 36, Issue 45, pp. 6225 - 6234
Programmed cell death 4 (Pdcd4), a tumor invasion suppressor, is frequently down-regulated in colorectal cancer and other cancers. In this study, we find that... 
Pdcd4 | Akt | invasion | mTORC2 | Sin1 | eIF4A
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7. Full Text Silencing of microR6-21 in vivo ameliorates autoimmune splenomegaly in lupus mice
by Garchow, Barry G and Encinas, Oscar Bartulos and Leung, Yiu Tak and Tsao, Patricia Y and Eisenberg, Robert A and Caricchio, Roberto and Obad, Susanna and Petri, Andreas and Kauppinen, Sakari and Kiriakidou, Marianthi
EMBO Molecular Medicine, ISSN 1757-4676, 10/2011, Volume 3, Issue 10, pp. 605 - 615
Autoimmunity | Splenomegaly | SLE | MiR-21/PDCD4
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8. Full Text Role of the TGFβ/PDCD4/AP-1 Signaling Pathway in Nasopharyngeal Carcinoma and Its Relationship to Prognosis
by Ma, Jie and Xuan, Shu-Hong and Li, Yan and Zhang, Zhi-Ping and Li, Xin-Hua
Cellular Physiology and Biochemistry, ISSN 1015-8987, 11/2017, Volume 43, Issue 4, pp. 1392 - 1401
Background: The objective of the present study was to evaluate the role of the TGFβ/PDCD4/AP-1 pathway in nasopharyngeal carcinoma (NPC) and its relationship... 
Original Paper | Nasopharyngeal carcinoma | TGF?/PDCD4/AP-1 signaling pathway pathway | Activator protein-1 | Prognosis | Programmed cell death 4 | Transforming growth factor-? receptor I | PHYSIOLOGY | TGF-BETA | METASTASIS | TGF beta/PDCD4/AP-1 signaling pathway pathway | CELL-GROWTH | AP-1 | CELL BIOLOGY | Transforming growth factor-beta receptor I | PDCD4 EXPRESSION | INVASION | NF-KAPPA-B | TUMORIGENESIS | PROGRESSION | Nasopharyngeal Neoplasms - metabolism | Follow-Up Studies | Humans | Middle Aged | Apoptosis Regulatory Proteins - analysis | Male | Transcription Factor AP-1 - metabolism | Nasopharyngeal Neoplasms - pathology | Transforming Growth Factor beta - analysis | Adult | Female | Carcinoma - pathology | Nasopharyngeal Neoplasms - diagnosis | Nasopharynx - pathology | Nasopharynx - metabolism | RNA-Binding Proteins - analysis | Nasopharyngeal Carcinoma | Transcription Factor AP-1 - analysis | Signal Transduction | Kaplan-Meier Estimate | Carcinoma - diagnosis | Apoptosis Regulatory Proteins - metabolism | Disease-Free Survival | Cell Line, Tumor | Aged | Carcinoma - metabolism | Transforming Growth Factor beta - metabolism | RNA-Binding Proteins - metabolism | Index Medicus | Transforming growth factor-β receptor I | TGFβ/PDCD4/AP-1 signaling pathway pathway
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9. MiRNA-182 regulates the cardiomyocyte apoptosis in heart failure
by Zhou, F and Fu, W.-D and Chen, L
European Review for Medical and Pharmacological Sciences, ISSN 1128-3602, 2019, Volume 23, Issue 11, pp. 4917 - 4923
OBJECTIVE: To investigate the effect of miRNA-182 on cardiomyocyte apoptosis of heart failure (HF). MATERIALS AND METHODS: HF model in rats was established by... 
Heart failure | PDCD4 | PACS2 | MiRNA-182 | Apoptosis | TRANSFORMATION | SUPPRESSOR PDCD4 | PHARMACOLOGY & PHARMACY | MODEL
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10. Full Text Involvement of programmed cell death 4 in transforming growth factor-β1-induced apoptosis in human hepatocellular carcinoma
by Zhang, H and Ozaki, I and Mizuta, T and Hamajima, H and Yasutake, T and Eguchi, Y and Ideguchi, H and Yamamoto, K and Matsuhashi, S
Oncogene, ISSN 0950-9232, 10/2006, Volume 25, Issue 45, pp. 6101 - 6112
PDCD4 gene | HCC | TGF-β1 | Smad | Tumor suppressor
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11. Full Text Turning 21: induction of miR-21 as a key swith in the inflammatory response
by Sheedy, FJ
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 01/2015, Volume 6
miR-21 is one of the most highly expressed members of the small non-coding microRNA family in many mammalian cell types. Its expression is further enhanced in... 
CELLS | REGULATES EXPRESSION | ACTIVATION | PTEN | INJURY | macrophage | IMMUNOLOGY | MICRORNA-21 | IDENTIFICATION | TARGET GENES | inflammation | PDCD4 | cancer | miR-21
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12. Full Text Petal abscission in roses is associated with the activation of a truncated version of the animal PDCD4 homologue, RbPCD1
by Singh, Amar Pal and Singh, Priya and Tripathi, Siddharth Kaushal and Kumar, Vinod and Sane, Aniruddha P
Plant Science, ISSN 0168-9452, 11/2019, Volume 288
Abscission is a developmental process that leads to shedding of organs not needed by the plant. Apart from wall hydrolysis, the cells of the abscission zone... 
Senescence | Inflorescence | Ethylene | PDCD4 | MA3 domain | Repression | Heat shock
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13. Full Text Beneficial treatment effects of dietary nitrate supplementation on testicular injury in streptozotocin-induced diabetic male rats
by Keyhanmanesh, Rana and Hamidian, Gholamreza and Alipour, Mohammad Reza and Oghbaei, Hajar
Reproductive BioMedicine Online, ISSN 1472-6483, 09/2019, Volume 39, Issue 3, pp. 357 - 371
Do low doses of dietary nitrate help to attenuate the progression of diabetic reproductive disorders in streptozotocin-induced diabetic male rats? Fifty male... 
Pdcd4 | Diabetes | Pacs2 | MiR-449a | Sodium nitrate | P53 | Index Medicus
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14. Full Text Clinicopathological and prognostic significance of PDCD4 and microRNA-21 in human gastric cancer
by Motoyama, K and Inoue, H and Mimori, K and Tanaka, F and Kojima, K and Uetake, H and Sugihara, K and Mori, M
INTERNATIONAL JOURNAL OF ONCOLOGY, ISSN 1019-6439, 05/2010, Volume 36, Issue 5, pp. 1089 - 1095
Recent studies have demonstrated that the novel tumor suppressor protein programmed cell death 4 (PDCD4) is downregulated in several human solid cancel types... 
gastric cancer | TUMOR-SUPPRESSOR PDCD4 | prognosis | PROGRAMMED CELL-DEATH | ONCOLOGY | INITIATION-FACTOR 4A | COLORECTAL-CANCER | PDCD4 | GENE-EXPRESSION | microRNA | EUKARYOTIC TRANSLATION | INHIBITS TRANSLATION | miR-21 | TRANSFORMATION SUPPRESSOR | CARCINOMA | CLINICAL-SIGNIFICANCE
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15. Full Text Serum microRNA-21 negatively relates to expression of programmed cell death-4 in patients with Epithelial ovarian cancer
by Mahmoud, Enas H and Fawzy, Amal and Elshimy, Reham A.A
Asian Pacific Journal of Cancer Prevention, ISSN 1513-7368, 01/2018, Volume 19, Issue 1, pp. 33 - 38
Background: Ovarian cancer is the third most common cancer of the female genital tract and the leading cause of cancer death associated with gynecologic... 
MiR-21 | PDCD4 | Ovarian cancer | miR-21
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16. Full Text The unique evolution of the programmed cell death 4 protein in plants
by Cheng, Shijun and Liu, Renyi and Gallie, Daniel R
BMC Evolutionary Biology, ISSN 1471-2148, 2013, Volume 13, Issue 1, pp. 199 - 199
Background: The programmed cell death 4 (PDCD4) protein is induced in animals during apoptosis and functions to inhibit translation and tumor promoter-induced... 
MA3 domain PDCD4 eIF4G | Domain duplication | eIF4A | Translation initiation | Hormone signaling | EIFISO4G | POLY(A) BINDING-PROTEIN | DOMAIN | eIF4G | TUMOR-SUPPRESSOR PDCD4 | MA3 domain | EVOLUTIONARY BIOLOGY | EUKARYOTIC TRANSLATION INITIATION | HELICASE ACTIVITY | STRUCTURAL BASIS | GENETICS & HEREDITY | PDCD4 | INHIBITS TRANSLATION | TRANSFORMATION SUPPRESSOR | Protein Structure, Tertiary | Amino Acid Sequence | Protein Biosynthesis | Signal Transduction | Apoptosis Regulatory Proteins - chemistry | Molecular Sequence Data | RNA, Messenger - metabolism | Apoptosis Regulatory Proteins - metabolism | Plant Proteins - genetics | Eukaryotic Initiation Factor-4F | Plants - metabolism | Sequence Alignment | Plants - genetics | Plant Proteins - chemistry | Chlamydomonas - genetics | Apoptosis Regulatory Proteins - genetics | Plant Proteins - metabolism | Apoptosis | Evolution, Molecular | Apoptotic proteins | Composition | Physiological aspects | Protein biosynthesis | Evolution | Genetic aspects | Research | Plants | Prasinophytes | Natural history | Evolutionary biology | Proteins | Competition | Algae | Colleges & universities | Phylogenetics | Genomes | Kinases | Comparative analysis | Index Medicus
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17. Programmed Cell Death 4 is a Direct Target of miR-21 and Regulates Invasion in Oral Squamous Cell Carcinoma
by Tomenson, Miranda
11/2009
Programmed Cell Death 4 (PDCD4) is a known tumour suppressor, lost in carcinomas of the breast, prostate, colon, lung and ovary. This study found significantly... 
0760 | Biomarkers | PDCD4 | Oral Cancer | miR-21 | Metastasis | Invasion
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18. Full Text miR-499 protects cardiomyocytes from H2O2-induced apoptosis via its effects on Pdcd4 and Pacs2
by Wang, Jiaji and Jia, Zhuqing and Zhang, Chenguang and Sun, Min and Wang, Weiping and Chen, Ping and Ma, Kangtao and Zhang, Youyi and Li, Xianhui and Zhou, Chunyan
RNA Biology, ISSN 1547-6286, 2014, Volume 11, Issue 4, pp. 339 - 350
Background: microRNAs (miRNAs) are a class of small, non-coding endogenous RNAs that post-transcriptionally regulate some protein-coding genes. miRNAs play an... 
Mitochondrial apoptosis pathway | PDCD4 | c-Jun | miR-499 | PACS2 | BID | CELLS | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-TERMINAL KINASE | HEART-FAILURE | CASPASE 8 | PROLIFERATION | GENE ONTOLOGY | mitochondrial apoptosis pathway | ACUTE MYOCARDIAL-INFARCTION | SUPPRESSOR PDCD4 | MICRORNA EXPRESSION | Research Paper
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19. Full Text Clinicopathological and Prognostic Value of MicroRNA-21 and MicroRNA-155 in Colorectal Cancer
by Shibuya, Hajime and Iinuma, Hisae and Shimada, Ryu and Horiuchi, Atsushi and Watanabe, Toshiaki
Oncology, ISSN 0030-2414, 03/2011, Volume 79, Issue 3-4, pp. 313 - 320
Objective: The clinical significance of microRNA-21 (miR-21) and miR-155 in colorectal cancer (CRC) patients remains elusive. In this study, we established the... 
Clinical Translational Research | PDCD4 | Prognostic factor | MicroRNA-21 | MicroRNA-155 | Colorectal cancer | TP53INP1 | TRANSFORMATION | PROFILES | METASTASIS | TUMOR-SUPPRESSOR PDCD4 | FEATURES | GENE | ONCOLOGY | MIR-21 | MIRNAS | EXPRESSION | RNA-Binding Proteins - genetics | Prognosis | Neoplasm Invasiveness | Colorectal Neoplasms - genetics | Humans | Middle Aged | RNA, Messenger - genetics | Liver Neoplasms - drug therapy | Male | Survival Rate | Lymphatic Metastasis | Reverse Transcriptase Polymerase Chain Reaction | Carrier Proteins - genetics | Heat-Shock Proteins - genetics | Peritoneal Neoplasms - drug therapy | Aged, 80 and over | Apoptosis Regulatory Proteins - genetics | Adult | Female | Aged | MicroRNAs - genetics | Colorectal Neoplasms - pathology | Liver Neoplasms - secondary | Peritoneal Neoplasms - secondary | Biomarkers | Ribonucleic acid--RNA | Medical prognosis | Index Medicus
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20. MircoRNA-629 promotes proliferation, invasion and migration of nasopharyngeal carcinoma through targeting PDCD4
by Zheng, Y.-Q and Bai, Y.-F and Yang, S and Cui, Y.-R and Wang, Y.-P and Hu, W.-L
European Review for Medical and Pharmacological Sciences, ISSN 1128-3602, 2019, Volume 23, Issue 1, pp. 207 - 216
OBJECTIVE: MicroRNAs (miRNA) have been demonstrated to be involved in the development and progression of several tumors, including nasopharyngeal carcinoma... 
NPC | PDCD4 | MiR-629 | Proliferation | Migration | Invasion | EPITHELIAL-MESENCHYMAL TRANSITION | DIAGNOSIS | TUMOR-SUPPRESSOR PDCD4 | PHARMACOLOGY & PHARMACY | MICRORNAS | KNOCKDOWN
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