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Journal Article
Journal Article
生物学前沿:英文版, ISSN 1674-7984, 2016, Volume 11, Issue 5, pp. 376 - 386
BACKGROUND: Long-term exposure to drugs of abuse causes an upregulation of the cAMP-signaling pathway in the nucleus accumbens and other forebrain regions,... 
药物成瘾 | 抑制剂 | 治疗 | 磷酸二酯酶 | 药物滥用 | 中枢神经系统 | PubMed | 行为模型 | Life Sciences | Biochemistry, general | Genetics and Population Dynamics | VTA | PDE4 | PDE4 inhibitors | Proteomics | Neurobiology | drug addiction | nucleus accumbens | Developmental Biology | Cell Biology | Illegal drugs | Drug abuse | Neurosciences | Health aspects | Analysis
Journal Article
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2010, Volume 635, Issue 1, pp. 198 - 203
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2010, Volume 643, Issue 1, pp. 113 - 120
The affinities of genistein on phosphodiesterase (PDE)1–4 and cause of gastrointestinal adverse effects of genistein remain unclear. Female BALB/c mice were... 
Allergic asthma | High-affinity rolipram binding site | Phosphodiesterase isozymes 1–4 inhibition | Genistein | Cytokine | Gastrointestinal adverse effect | Phosphodiesterase isozymes 1-4 inhibition | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | TYROSINE KINASE | PROTEIN-KINASE | CARDIAC-MUSCLE | GUINEA-PIG | PDE4 INHIBITORS | IN-VITRO | SELECTIVE INHIBITORS | ASTHMA | PHARMACOLOGY & PHARMACY | T-CELLS | Phosphodiesterase Inhibitors - therapeutic use | Phosphodiesterase Inhibitors - adverse effects | Brain - enzymology | Male | Dose-Response Relationship, Drug | Cyclic Nucleotide Phosphodiesterases, Type 1 - antagonists & inhibitors | Respiratory Hypersensitivity - drug therapy | Anesthesia | Female | Genistein - therapeutic use | Radioligand Assay | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Rolipram - pharmacology | Binding Sites | Cell Membrane - drug effects | Disease Models, Animal | Genistein - adverse effects | Binding, Competitive | Guinea Pigs | Phosphodiesterase Inhibitors - pharmacology | Gastrointestinal Tract - drug effects | Respiratory Hypersensitivity - immunology | Brain - drug effects | Cell Membrane - enzymology | Animals | Genistein - pharmacology | Protein Binding | Mice | Mice, Inbred BALB C | Medical colleges | Complications and side effects | Lung diseases, Obstructive | Isoenzymes | Albumin | Cell membranes | Chemical properties | Angiogenesis inhibitors | Biological response modifiers | Isoflavones
Journal Article
Journal of Biomedical Science, ISSN 1021-7770, 2011, Volume 18, Issue 1, pp. 84 - 84
Background: Hesperetin was reported to selectively inhibit phosphodiesterase 4 (PDE4). While hesperetin-7,3'-Odimethylether (HDME) is a synthetic liposoluble... 
cytokine | hesperetin-7,3'-O-dimethylether | allergic asthma | phosphodiesterase-4 inhibitor | Airway hyperresponsiveness | chronic obstructive pulmonary disease | MEDICINE, RESEARCH & EXPERIMENTAL | ASTHMA MODEL | CARDIAC-MUSCLE | GUINEA-PIG | RANDOMIZED CLINICAL-TRIALS | AMIDE AWD 12-281 | CELL DEVELOPMENT | PDE4 INHIBITORS | CELL BIOLOGY | OBSTRUCTIVE PULMONARY-DISEASE | SMOOTH-MUSCLE | hesperetin-7,3 '-O-dimethylether | ALLERGEN CHALLENGE | Bronchoalveolar Lavage Fluid | Guinea Pigs | Asthma - physiopathology | Ovalbumin - immunology | Bronchial Hyperreactivity - drug therapy | Cytokines - analysis | Cyclic Nucleotide Phosphodiesterases, Type 1 - metabolism | Male | Immunoglobulins - analysis | Blood Cell Count | Cyclic Nucleotide Phosphodiesterases, Type 1 - antagonists & inhibitors | Animals | Phosphodiesterase 4 Inhibitors - administration & dosage | Hesperidin - administration & dosage | Female | Hesperidin - analogs & derivatives | Mice | Mice, Inbred BALB C | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Rolipram - pharmacology | Binding Sites | Disease Models, Animal | Pulmonary Disease, Chronic Obstructive - drug therapy | Cytokines | Biological response modifiers | Health aspects | Immunoglobulin G | Enzyme-linked immunosorbent assay | Asthma | Respiratory therapy | Medicine | Chinese medicine | Nuclear magnetic resonance--NMR | Hospitals | Lymphocytes | Rodents | Mortality | Fluorides | Kinases | Binding sites
Journal Article