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Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 124, pp. 82 - 102
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2015, Volume 23, Issue 13, pp. 3426 - 3435
A new series of selective PDE4D inhibitors has been designed and synthesized by replacing 3-methoxy group with 3-difluoromethoxy isoster moiety in our... 
Pharmacokinetic properties | Phosphodiesterases type 4D inhibitors | cAMP enhancers | Microwave-assisted reaction | PDE4D | CAMP enhancers | CHEMISTRY, MEDICINAL | ANTIDEPRESSANT-LIKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DESIGN | CHEMISTRY, ORGANIC | KNOCK-DOWN | ROLIPRAM | MEMORY | MOUSE MODEL | IMPROVED SAFETY | CAMP | PHOSPHODIESTERASE-4 | Catechols - chemical synthesis | Humans | Motor Activity - drug effects | Male | Neurons - cytology | Isoenzymes - chemistry | Structure-Activity Relationship | Diazepam - pharmacokinetics | Isoenzymes - metabolism | Phosphodiesterase Inhibitors - chemical synthesis | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Neurons - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Cell Survival - drug effects | Gene Expression | Phosphodiesterase Inhibitors - pharmacokinetics | Nootropic Agents - pharmacokinetics | Catechols - pharmacokinetics | Enzyme Assays | Nootropic Agents - blood | Nootropic Agents - chemical synthesis | Rolipram - blood | Phosphodiesterase Inhibitors - blood | Animals | Rolipram - pharmacokinetics | Neurons - enzymology | Halogenation | Catechols - blood | Cell Line, Tumor | Diazepam - blood | Mice | Mice, Inbred BALB C | Isoenzymes - antagonists & inhibitors | Analysis | Pharmacy | Cyclic adenylic acid | Adenylic acid | Cyclic guanylic acid | Alzheimer's disease | Antianxiety agents | Protein binding | Index Medicus
Journal Article
Nature Genetics, ISSN 1061-4036, 10/2003, Volume 35, Issue 2, pp. 131 - 138
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 04/2003, Volume 14, Issue 4, pp. 1392 - 1404
Journal Article
Best Practice & Research Clinical Endocrinology & Metabolism, ISSN 1521-690X, 12/2018, Volume 32, Issue 6, pp. 941 - 954
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 10/2002, Volume 27, Issue 4, pp. 587 - 595
Pharmacological inhibition of type 4 cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase (PDE4) produces antidepressant-like effects in animals;... 
Antidepressant | Cyclic AMP | Mice | Rolipram | Gene knockout | Phosphodiesterase 4D (PDE4D) | CELLS | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | PSYCHIATRY | antidepressant | phosphodiesterase 4D (PDE4D) | rolipram | BINDING PROTEIN CREB | FORCED SWIMMING TEST | mice | NEUROSCIENCES | gene knockout | ADENOSINE-MONOPHOSPHATE | cyclic AMP | PHARMACOLOGY & PHARMACY | RAT-BRAIN | AMP PHOSPHODIESTERASE | EXPRESSION | ADMINISTRATION INCREASES | CAMP | Motor Activity - physiology | Cyclic Nucleotide Phosphodiesterases, Type 4 | Drug Tolerance - genetics | Brain - enzymology | Motor Activity - drug effects | Male | Depressive Disorder, Major - enzymology | Behavior, Animal - drug effects | Antidepressive Agents - pharmacology | Protein Isoforms - deficiency | 3',5'-Cyclic-AMP Phosphodiesterases - deficiency | Rolipram - pharmacology | Cyclic AMP - metabolism | Depressive Disorder, Major - drug therapy | Depressive Disorder, Major - physiopathology | Brain - physiopathology | Adrenergic beta-Agonists - pharmacology | Behavior, Animal - physiology | Genotype | 3',5'-Cyclic-AMP Phosphodiesterases - genetics | Down-Regulation - drug effects | Mice, Knockout | Brain - drug effects | Down-Regulation - physiology | Animals | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | Drug Interactions - physiology | Protein Isoforms - genetics
Journal Article
Journal Article
Genes, Brain and Behavior, ISSN 1601-1848, 07/2012, Volume 11, Issue 5, pp. 614 - 622
Phosphodiesterases (PDEs) are a superfamily of intracellular second messenger cyclic nucleotide hydrolyzing enzymes composed of 12 families. The Pde4 family... 
Cincinnati water maze | fear conditioning | Morris water maze | Pde4 | Pde4d | locomotor activity | Acoustic startle | F344 rats | phosphodiesterase | Locomotor activity | Fear conditioning | Phosphodiesterase | MICE DEFICIENT | BEHAVIOR | NEUROSCIENCES | ROLIPRAM | ELEVATED PLUS | WATER MAZE | MEMORY | BEHAVIORAL SCIENCES | MAJOR DEPRESSIVE DISORDER | PHOSPHODIESTERASE INHIBITOR | EXPRESSION | (+)-METHAMPHETAMINE | Cyclic Nucleotide Phosphodiesterases, Type 3 - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 | Maze Learning - physiology | Brain - enzymology | Rats | Behavior, Animal - physiology | Reflex, Startle - genetics | Depression - genetics | Fear - physiology | Conditioning, Classical - physiology | Depression - enzymology | Exploratory Behavior - physiology | Motor Activity - genetics | Animals | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Extinction, Psychological - physiology | Disease Models, Animal | Genotype & phenotype | Animal behavior | Antidepressants | Rodents | Animal memory | Enzymes | Animal models | Hyperreactivity | Mental disorders | Extinction | Exploratory behavior | Memory | Spatial discrimination learning | spatial memory | Cognitive ability | Data processing | Depression | Habituation | Learning | Second messengers | Sensorimotor gating | Enhancers | Cyclic nucleotides | Acoustic startle response | Tonic immobility
Journal Article
Genes, brain, and behavior, ISSN 1601-1848, 7/2012, Volume 11, Issue 5, pp. 614 - 622
Phosphodiesterases (PDEs) are a superfamily of intracellular second messenger cyclic nucleotide hydrolyzing enzymes composed of 12 families. The Pde4 family... 
Morris water maze | fear conditioning | Cincinnati water maze | Pde4 | Pde4d | locomotor activity | F344 rats | Phosphodiesterase | acoustic startle
Journal Article
Journal Article