X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (8) 8
biochemistry & molecular biology (7) 7
akt (6) 6
phosphorylation (5) 5
pkc, protein kinase c (5) 5
animals (4) 4
cell biology (4) 4
gsk3, glycogen synthase kinase 3 (4) 4
mapk, mitogen-activated protein kinase (4) 4
ph, pleckstrin homology (4) 4
research article (4) 4
3-phosphoinositide-dependent protein kinases (3) 3
ampk, amp-activated protein kinase (3) 3
erk, extracellular-signal-regulated kinase (3) 3
life sciences (3) 3
p70 s6 kinase (3) 3
pdk (3) 3
phosphoinositide 3-kinase (3) 3
pkb, protein kinase b (3) 3
protein kinase b (3) 3
protein-serine-threonine kinases - metabolism (3) 3
activation (2) 2
biophysics (2) 2
cancer (2) 2
cell line (2) 2
chk, checkpoint kinase (2) 2
ck, casein kinase (2) 2
crystal-structure (2) 2
csk, c-terminal src kinase (2) 2
dtt, dithiothreitol (2) 2
enzyme inhibitors - pharmacology (2) 2
fbs, foetal bovine serum (2) 2
gene expression regulation - drug effects (2) 2
gst, glutathione transferase (2) 2
inhibitor (2) 2
jnk, c-jun n-terminal kinase (2) 2
kinase (2) 2
mammalian target (2) 2
mitogen-activated protein kinases - metabolism (2) 2
msk, mitogen- and stress-activated protein kinase (2) 2
oncology (2) 2
pdk, 3-phosphoinositide-dependent kinase (2) 2
pdk, 3-phosphoinositide-dependent protein kinase (2) 2
phk, phosphorylase kinase (2) 2
phosphorylation - drug effects (2) 2
pi3k, phosphoinositide 3-kinase (2) 2
pka, camp-dependent protein kinase (2) 2
protein kinase (2) 2
protein-kinase-b (2) 2
protein-serine-threonine kinases - antagonists & inhibitors (2) 2
proteins (2) 2
proto-oncogene proteins - metabolism (2) 2
proto-oncogene proteins c-akt (2) 2
pten, phosphatase and tensin homologue deleted on chromosome 10 (2) 2
rock, rho-dependent protein kinase (2) 2
sgk, serum- and glucocorticoid-induced kinase (2) 2
signal transduction (2) 2
tumor-suppressor (2) 2
tyrosine kinase (2) 2
1-phosphatidylinositol 4-kinase - metabolism (1) 1
2 isoforms (1) 1
2-chloroethylethyl sulfide (1) 1
2-chloroethylethyl sulphide (1) 1
2‐chloroethylethyl sulphide (1) 1
3-phosphoinositide-dependent kinase-1 (1) 1
3-phosphoinositide-dependent protein kinase-1 (1) 1
4e-bp1, eif4e-binding protein 1 (1) 1
activated protein-kinase (1) 1
active transport, cell nucleus (1) 1
adenosine triphosphate (1) 1
adenosine triphosphate - metabolism (1) 1
adipocytes (1) 1
agc family, protein kinase a (1) 1
agc family, protein kinase a/protein kinase g/protein kinase c family (1) 1
aicar, aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (1) 1
akt/protein kinase b (1) 1
allosteric inhibitor (1) 1
amino acid sequence (1) 1
amino acid substitution (1) 1
androstadienes - pharmacology (1) 1
anti-cancer drugs (1) 1
antineoplastic agents - pharmacology (1) 1
antioxidant (1) 1
antioxidants (1) 1
antioxidants - pharmacology (1) 1
apoptosis (1) 1
apoptosis - drug effects (1) 1
apoptosis regulatory proteins (1) 1
ask (1) 1
atf2, activating transcription factor 2 (1) 1
atm, ataxia telangiectasia mutated (1) 1
bacteria - metabolism (1) 1
bacteria - pathogenicity (1) 1
bacterial infection (1) 1
bad phosphorylation (1) 1
bcl (1) 1
benzylamines - pharmacology (1) 1
beta-subunit (1) 1
binding (1) 1
binding partner (1) 1
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
... (protein kinase A/protein kinase G/protein kinase Q family kinases such as Akt (protein kinase 13), S6K (p70 ribosomal S6 kinase... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | HYDROPHOBIC MOTIF | cancer | serum and glucocorticoid protein kinase (SGK) | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical journal, ISSN 0264-6021, 01/2005, Volume 385, Issue 2, pp. 399 - 408
We developed a high-throughput HTRF (homogeneous time-resolved fluorescence) assay for Akt kinase activity and screened approx... 
Allosteric inhibitor | Protein kinase B (PKB) | Inhibitor | Pleckstrin homology domain | Akt | Kinase | PROTEIN-KINASE-B | INDUCED APOPTOSIS | TYROSINE KINASE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | pleckstrin homology domain | allosteric inhibitor | COWDEN-DISEASE | kinase | inhibitor | STRUCTURAL BASIS | protein kinase B (PKB) | TUMOR-SUPPRESSOR | MOLECULAR-CLONING | CELL-LINE LNCAP | HUMAN CANCER | Phosphoproteins - immunology | Prostatic Neoplasms - chemistry | Humans | Peptides - genetics | Blood Proteins - immunology | Male | Isoenzymes - chemistry | Phosphoproteins - chemistry | Carcinoma - chemistry | Peptides - metabolism | TNF-Related Apoptosis-Inducing Ligand | Blood Proteins - genetics | Adenosine Triphosphate - metabolism | Phosphorylation - drug effects | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Peptides - immunology | Enzyme Inhibitors - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Cell Line, Tumor | Prostatic Neoplasms - metabolism | Uterine Cervical Neoplasms - pathology | Quinoxalines - pharmacology | Caspases - metabolism | Uterine Cervical Neoplasms - metabolism | Cloning, Molecular | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Molecular Structure | Carcinoma - pathology | Binding, Competitive | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Prostatic Neoplasms - pathology | Proto-Oncogene Proteins - antagonists & inhibitors | Peptides - chemistry | Membrane Glycoproteins - pharmacology | Blood Proteins - chemistry | Phosphoproteins - genetics | Enzyme Activation - drug effects | Proto-Oncogene Proteins c-akt | Sequence Homology, Amino Acid | Apoptosis Regulatory Proteins | Signal Transduction - physiology | Uterine Cervical Neoplasms - chemistry | Carcinoma - metabolism | Benzylamines - pharmacology | Isoenzymes - antagonists & inhibitors | cdk2, cyclin-dependent kinase 2 | FGFR, fibroblast growth factor receptor | MEK, MAPK | SH, Src homology | PI3K, phosphoinositide 3-kinase | DOPS, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine | ERK kinase | DOPC, 1,2-dioleoyl-sn-glycero-3-phosphocholine | DTT, dithiothreitol | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | PEG, poly(ethylene glycol) | PKC, protein kinase C | FLT, Fms-related tyrosine kinase | lymphoma 1 | GSK3, glycogen synthase kinase 3 | TRAIL, tumour-necrosis-factor-related apoptosis-inducing ligand | HTRF, homogeneous time-resolved fluorescence | PH, pleckstrin homology | MAPKK1, MAPK kinase 1 | FBS, foetal bovine serum | PDK, phosphoinositide-dependent kinase | TCL1, T-cell leukaemia | MAPK, mitogen-activated protein kinase | PKA, protein kinase A | SGK, serum- and glucocorticoid-inducible kinase
Journal Article
FEBS letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
The specificity of 4,5,6,7-tetrabromo-2-azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase-2 (CK2... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | PKA, cAMP-dependent protein kinase | DRB, 1-(β-D-ribofuranosyl)-5,6-dichlorobenzimidazole | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | CATALYTIC SUBUNIT | ZEA-MAYS | TYROSINE KINASE | CRYSTAL-STRUCTURE | COMPETITIVE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein phosphorylation | IMMUNOPHILIN FPR3 | SACCHAROMYCES-CEREVISIAE | protein kinase | CELL BIOLOGY | casein kinase | BIOPHYSICS | inhibitor | CELL-CYCLE | BETA-SUBUNIT | casein kinase-2 | MAMMARY-GLAND | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects
Journal Article
2003, Volume 546, Issue 1, 7
Phosphoinositides (PIs) play an essential role in diverse cellular functions. Their intracellular level is strictly regulated by specific PI kinases, phosphatases and phospholipases... 
Bacterial infection | Myotubular myopathy | Lowe syndrome | Phosphoinositides | Charcot–Marie–Tooth neuropathy | Cancer | PLC, phospholipase C | FYVE, Fab1p/YOTB/Vac1p/EEA1 | CMT4B, Charcot–Marie–Tooth disease type 4B | MTMR, myotubular myopathy-related protein | SNX, sorting nexin | SHIP, Src homology 2-containing inositol-5-phosphatase | EEA1, early endosome antigen 1 | SBF2, SET binding factor 2 | MTM1, myotubularin | PDK, 3-phosphoinositide-dependent kinase | ENTH, epsin N-terminal homology | PKC, protein kinase C | DAG, diacylglycerol | PTEN, phosphatase and tensin homolog deleted on chromosome ten | PX, phox homology | OCRL, oculocerebrorenal syndrome of Lowe phosphatase | XLMTM, X-linked myotubular myopathy | PtdIns, phosphatidylinositol | PH, pleckstrin homology | SET, Survar 3-9, Enhancer-of-zeste, Trithorax | Inl, internalin | FERM, band 4.1/ezrin/radixin/moesin | NFκB, nuclear factor-κB | IpgD, entry-mediating invasin phosphatase | PIs, phosphoinositides | Charcot-Marie-Tooth neuropathy | MARIE-TOOTH-DISEASE | LOWE-SYNDROME | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPID PHOSPHATASE SHIP2 | PTEN | bacterial infection | phosphoinositides | CELL BIOLOGY | SHIGELLA-FLEXNERI | MYOTUBULARIN-RELATED PROTEIN-2 | PHOSPHATIDYLINOSITOL 3-PHOSPHATE | BIOPHYSICS | myotubular myopathy | EPITHELIAL-CELLS | GENE | TUMOR-SUPPRESSOR | cancer | Neoplasms - metabolism | Bacteria - metabolism | Phosphoric Monoester Hydrolases - genetics | Tumor Suppressor Proteins - metabolism | Signal Transduction | Humans | Phosphatidylinositol 3-Kinases - metabolism | Diabetes Mellitus, Type 2 - metabolism | 1-Phosphatidylinositol 4-Kinase - metabolism | Animals | PTEN Phosphohydrolase | Models, Biological | Phospholipases - metabolism | Phosphatidylinositols - metabolism | Bacteria - pathogenicity | Genetic Diseases, Inborn - metabolism | Phosphoric Monoester Hydrolases - metabolism
Book Review
Biochemical journal, ISSN 0264-6021, 07/2003, Volume 373, Issue 2, pp. 583 - 591
Journal Article
Molecular and Cellular Biochemistry, ISSN 0300-8177, 6/2007, Volume 300, Issue 1, pp. 113 - 127
Recent work has highlighted a role for PDK1 in adaptive immunity, however its contribution to innate immunity has not been addressed. We have investigated the... 
Life Sciences | Biochemistry, general | NF-κB | TPCK | PDK | PKB | Oncology | Medical Biochemistry | Cardiology | IL-1β | KINASE-ALPHA | TRANSCRIPTIONAL ACTIVATION | SIGNALING PATHWAYS | PROTEIN KINASE-1 | 3-PHOSPHOINOSITIDE-DEPENDENT KINASE-1 | IKK-BETA | CHLOROMETHYL KETONE | IL-1 beta | CELL BIOLOGY | P65 SUBUNIT | NF-kappa B | TOLL-LIKE RECEPTORS | GENE-EXPRESSION
Journal Article
by Lin, HJ and Hsieh, FC and Song, H and Lin, J
BRITISH JOURNAL OF CANCER, ISSN 0007-0920, 12/2005, Volume 93, Issue 12, pp. 1372 - 1381
.... To examine the possible activation of these signalling molecules, we examined the phosphorylation status in 12 protein kinases and transcription factors in normal primary human mammary epithelial... 
MAMMALIAN TARGET | p70S6K | 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 | breast cancer | AKT | PHOSPHOINOSITIDE 3-KINASE | P70 S6 KINASE | RAPAMYCIN MTOR | PDK-I | ONCOLOGY | SIGNALING PATHWAY | EPIDERMAL-GROWTH-FACTOR | mTOR | MAXIMAL ACTIVATION | C-JUN | phosphorylation | MAMMARY EPITHELIAL-CELLS
Journal Article
11.