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Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | SUBSTRATE-SPECIFICITY | HYDROPHOBIC MOTIF PHOSPHORYLATION | cancer | serum and glucocorticoid protein kinase (SGK) | COMPLEX 2 | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | Index Medicus | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2005, Volume 385, Issue 2, pp. 399 - 408
We developed a high-throughput HTRF (homogeneous time-resolved fluorescence) assay for Akt kinase activity and screened approx. 270000 compounds for their... 
Allosteric inhibitor | Protein kinase B (PKB) | Inhibitor | Pleckstrin homology domain | Akt | Kinase | PROTEIN-KINASE-B | INDUCED APOPTOSIS | TYROSINE KINASE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | pleckstrin homology domain | allosteric inhibitor | COWDEN-DISEASE | kinase | inhibitor | STRUCTURAL BASIS | protein kinase B (PKB) | TUMOR-SUPPRESSOR | MOLECULAR-CLONING | CELL-LINE LNCAP | HUMAN CANCER | Phosphoproteins - immunology | Prostatic Neoplasms - chemistry | Humans | Peptides - genetics | Blood Proteins - immunology | Male | Isoenzymes - chemistry | Phosphoproteins - chemistry | Carcinoma - chemistry | Peptides - metabolism | TNF-Related Apoptosis-Inducing Ligand | Blood Proteins - genetics | Adenosine Triphosphate - metabolism | Phosphorylation - drug effects | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Peptides - immunology | Enzyme Inhibitors - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Cell Line, Tumor | Prostatic Neoplasms - metabolism | Uterine Cervical Neoplasms - pathology | Quinoxalines - pharmacology | Caspases - metabolism | Uterine Cervical Neoplasms - metabolism | Cloning, Molecular | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Molecular Structure | Carcinoma - pathology | Binding, Competitive | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Prostatic Neoplasms - pathology | Proto-Oncogene Proteins - antagonists & inhibitors | Peptides - chemistry | Membrane Glycoproteins - pharmacology | Blood Proteins - chemistry | Phosphoproteins - genetics | Enzyme Activation - drug effects | Proto-Oncogene Proteins c-akt | Sequence Homology, Amino Acid | Apoptosis Regulatory Proteins | Signal Transduction - physiology | Uterine Cervical Neoplasms - chemistry | Carcinoma - metabolism | Benzylamines - pharmacology | Isoenzymes - antagonists & inhibitors | Index Medicus | cdk2, cyclin-dependent kinase 2 | FGFR, fibroblast growth factor receptor | MEK, MAPK | SH, Src homology | PI3K, phosphoinositide 3-kinase | DOPS, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine | ERK kinase | DOPC, 1,2-dioleoyl-sn-glycero-3-phosphocholine | DTT, dithiothreitol | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | PEG, poly(ethylene glycol) | PKC, protein kinase C | FLT, Fms-related tyrosine kinase | lymphoma 1 | GSK3, glycogen synthase kinase 3 | TRAIL, tumour-necrosis-factor-related apoptosis-inducing ligand | HTRF, homogeneous time-resolved fluorescence | PH, pleckstrin homology | MAPKK1, MAPK kinase 1 | FBS, foetal bovine serum | PDK, phosphoinositide-dependent kinase | TCL1, T-cell leukaemia | MAPK, mitogen-activated protein kinase | PKA, protein kinase A | SGK, serum- and glucocorticoid-inducible kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2003, Volume 373, Issue 2, pp. 583 - 591
Journal Article
FEBS Letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
The specificity of 4,5,6,7‐tetrabromo‐2‐azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase‐2 (CK2), has been examined... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | DRB, 1-(β | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | ribofuranosyl)-5,6-dichlorobenzimidazole | PKA, cAMP-dependent protein kinase | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | CATALYTIC SUBUNIT | ZEA-MAYS | TYROSINE KINASE | CRYSTAL-STRUCTURE | COMPETITIVE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein phosphorylation | IMMUNOPHILIN FPR3 | SACCHAROMYCES-CEREVISIAE | protein kinase | CELL BIOLOGY | casein kinase | BIOPHYSICS | inhibitor | CELL-CYCLE | BETA-SUBUNIT | casein kinase-2 | MAMMARY-GLAND | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects | Index Medicus
Journal Article
by Lin, HJ and Hsieh, FC and Song, H and Lin, J
BRITISH JOURNAL OF CANCER, ISSN 0007-0920, 12/2005, Volume 93, Issue 12, pp. 1372 - 1381
Activation of kinases signalling pathways contributes to various malignant phenotypes in human cancers, including breast tumour. To examine the possible... 
MAMMALIAN TARGET | p70S6K | 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 | PHOSPHATIDYLINOSITOL 3-KINASE | breast cancer | AKT | PHOSPHOINOSITIDE 3-KINASE | P70 S6 KINASE | RAPAMYCIN MTOR | PDK-I | ONCOLOGY | SIGNALING PATHWAY | EPIDERMAL-GROWTH-FACTOR | mTOR | C-JUN | phosphorylation | MAMMARY EPITHELIAL-CELLS
Journal Article
Molecular and Cellular Biochemistry, ISSN 0300-8177, 6/2007, Volume 300, Issue 1, pp. 113 - 127
Recent work has highlighted a role for PDK1 in adaptive immunity, however its contribution to innate immunity has not been addressed. We have investigated the... 
Life Sciences | Biochemistry, general | NF-κB | TPCK | PDK | PKB | Oncology | Medical Biochemistry | Cardiology | IL-1β | KINASE-ALPHA | TRANSCRIPTIONAL ACTIVATION | SIGNALING PATHWAYS | PROTEIN KINASE-1 | 3-PHOSPHOINOSITIDE-DEPENDENT KINASE-1 | IKK-BETA | CHLOROMETHYL KETONE | IL-1 beta | CELL BIOLOGY | P65 SUBUNIT | NF-kappa B | TOLL-LIKE RECEPTORS | GENE-EXPRESSION
Journal Article
International Journal of Experimental Pathology, ISSN 0959-9673, 02/2019, Volume 100, Issue 1, pp. 32 - 40
Journal Article
2003, Volume 546, Issue 1, 7
Phosphoinositides (PIs) play an essential role in diverse cellular functions. Their intracellular level is strictly regulated by specific PI kinases,... 
Bacterial infection | Myotubular myopathy | Lowe syndrome | Phosphoinositides | Charcot–Marie–Tooth neuropathy | Cancer | PLC, phospholipase C | FYVE, Fab1p/YOTB/Vac1p/EEA1 | CMT4B, Charcot–Marie–Tooth disease type 4B | MTMR, myotubular myopathy-related protein | SNX, sorting nexin | SHIP, Src homology 2-containing inositol-5-phosphatase | EEA1, early endosome antigen 1 | SBF2, SET binding factor 2 | MTM1, myotubularin | PDK, 3-phosphoinositide-dependent kinase | ENTH, epsin N-terminal homology | PKC, protein kinase C | DAG, diacylglycerol | PTEN, phosphatase and tensin homolog deleted on chromosome ten | PX, phox homology | OCRL, oculocerebrorenal syndrome of Lowe phosphatase | XLMTM, X-linked myotubular myopathy | PtdIns, phosphatidylinositol | PH, pleckstrin homology | SET, Survar 3-9, Enhancer-of-zeste, Trithorax | Inl, internalin | FERM, band 4.1/ezrin/radixin/moesin | NFκB, nuclear factor-κB | IpgD, entry-mediating invasin phosphatase | PIs, phosphoinositides | Charcot-Marie-Tooth neuropathy | MARIE-TOOTH-DISEASE | LOWE-SYNDROME | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPID PHOSPHATASE SHIP2 | PTEN | bacterial infection | phosphoinositides | CELL BIOLOGY | SHIGELLA-FLEXNERI | MYOTUBULARIN-RELATED PROTEIN-2 | PHOSPHATIDYLINOSITOL 3-PHOSPHATE | BIOPHYSICS | myotubular myopathy | EPITHELIAL-CELLS | GENE | TUMOR-SUPPRESSOR | cancer | Neoplasms - metabolism | Bacteria - metabolism | Phosphoric Monoester Hydrolases - genetics | Tumor Suppressor Proteins - metabolism | Signal Transduction | Humans | Phosphatidylinositol 3-Kinases - metabolism | Diabetes Mellitus, Type 2 - metabolism | 1-Phosphatidylinositol 4-Kinase - metabolism | Animals | PTEN Phosphohydrolase | Models, Biological | Phospholipases - metabolism | Phosphatidylinositols - metabolism | Bacteria - pathogenicity | Genetic Diseases, Inborn - metabolism | Phosphoric Monoester Hydrolases - metabolism | Index Medicus
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