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Clinical science (London, England : 1979), ISSN 0143-5221, 06/2015, Volume 128, Issue 11, pp. 805 - 823
Pigment epithelium-derived factor (PEDF) is a broadly expressed multifunctional member of the serine proteinase inhibitor (serpin) family. This widely studied... 
Angiogenesis | PEDF receptor | Serpin | Hypoxia | Diabetes | Tissue distribution | Pigment epithelium-derived factor (PEDF) | MEDICINE, RESEARCH & EXPERIMENTAL | hypoxia | OXIDATIVE STRESS | angiogenesis | PIGMENT-EPITHELIUM | tissue distribution | EPITHELIUM-DERIVED FACTOR | VITREOUS FLUID | serpin | NONINHIBITORY SERPIN | GENE-EXPRESSION | OSTEOGENESIS IMPERFECTA | diabetes | NF-KAPPA-B | pigment epithelium-derived factor (PEDF) | PULMONARY-FIBROSIS | ENDOTHELIAL GROWTH-FACTOR | Serpins - genetics | Diabetes Mellitus - genetics | Neovascularization, Physiologic - genetics | Humans | Gene Expression Profiling | Signal Transduction - genetics | Eye Proteins - therapeutic use | Serpins - therapeutic use | Serpins - physiology | Nerve Growth Factors - therapeutic use | Neovascularization, Physiologic - physiology | Diabetes Mellitus - physiopathology | Neovascularization, Pathologic - drug therapy | Nerve Growth Factors - genetics | Angiogenesis Inhibitors - therapeutic use | Adult | Neovascularization, Pathologic - genetics | Neovascularization, Pathologic - physiopathology | Signal Transduction - physiology | Eye Proteins - physiology | Eye Proteins - genetics | Nerve Growth Factors - physiology | PEDF-tg, transgenic overexpression of PEDF | RXR, retinoid X receptor | Flt-1, FMS-like tyrosine kinase 1 | ERK, extracellular-signal-regulated kinase | ERK kinase 5 | ATGL, adipose triglyceride lipase | IGF, insulin-like growth factor | FasL, Fas ligand | HUVEC, human umbilical vein endothelial cell | PAI-1, plaminogen activator inhibitor-1 | LR, laminin receptor | PEDF, pigment epithelium-derived factor | PPAR-γ, peroxisome proliferator-activated receptor γ | JNK, c-Jun N-terminal kinases | NF-κB, nuclear factor κB | VEGF, vascular endothelial growth factor | RARE, retinoic acid-response element | bFGF, basic fibroblast growth factor | LRP, low-density lipoprotein receptor-related protein | DR, diabetic retinopathy, E, embryonic day | AGE, advanced glycation end-product | MMP, matrix metalloproteinase | OIR, oxygen-induced retinopathy | PDGF, platelet-derived growth factor | MAPK, mitogen-activated protein kinase | PKA, protein kinase A | MEK5, MAPK | serpin, serine proteinase inhibitor | Review | RCL, reactive centre loop | IκB, inhibitor of κB kinase | PEDF-R, PEDF receptor | NFATc2, nuclear factor of activated T-cells cytoplasmic 2 | CK2, casein kinase 2 | NFAT, nuclear factor of activated T-cells | HIF-1, hypoxia-inducible factor 1 | c-FLIP, cellular FLICE-like inhibitory protein | ER, oestrogen receptor | KDR, kinase insert domain receptor | RPE, retinal pigment epithelial | RAR, retinoic acid receptor | ATRA, all-trans retinoic acid
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 47, pp. 82824 - 82834
miRNA dysregulation is associated with many human diseases, including cancer. This study explored the effects of miR-93-3p on clear cell renal cell carcinoma... 
PEDF | ccRCC | MiR-93-3p | Migration | Apoptosis | CANCER CELLS | PAZOPANIB | apoptosis | CELL BIOLOGY | EPITHELIUM-DERIVED FACTOR | REGULATOR | FACTOR PEDF | IN-VIVO | migration | SUNITINIB | miR-93-3p | EXPRESSION | PROMOTES
Journal Article
Experimental Eye Research, ISSN 0014-4835, 08/2019, Volume 185, p. 107678
Age-related meibomian gland (MG) atrophy, characterized by decreased meibocyte proliferation, is one of the causes of meibomian gland dysfunction (MGD), which... 
Acinar atrophy | PEDF | Regenerative medicine | Meibomian gland dysfunction | Aging | Meibomian glands | Dry eye disease | Evaporative dry eye | STEM-CELL FATE | TEAR FILM | RECEPTOR | EVAPORATION | FACTOR PEDF | MEIBOCYTE DIFFERENTIATION | OPHTHALMOLOGY | DYSFUNCTION | EXPRESSION | PROMOTES | DRY-EYE
Journal Article
Oncotarget, ISSN 1949-2553, 04/2018, Volume 9, Issue 27, pp. 19192 - 19202
Pigment epithelial derived factor (PEDF) is a secreted glycoprotein that is a non-inhibitory member of the serine protease inhibitor (serpin) family. PEDF... 
PEDF | Colorectal cancer | Metastases | Pigment epithelial derived factor
Journal Article
Bone, ISSN 8756-3282, 07/2019, Volume 124, pp. 103 - 117
Pigment epithelium-derived factor (PEDF) is known for its osteogenic properties, but its effects against primary and secondary bone tumors have not... 
PEDF | Bone | Metastasis | Doxorubicin | Cancer | Zoledronic acid | Anthracyclines | Bone tumors | Pregnant women | Analysis
Journal Article
Experimental Eye Research, ISSN 0014-4835, 11/2019, Volume 188, p. 107798
Abnormal migration and proliferation of endothelial cells (EC) drive neovascular retinopathies. While anti-VEGF treatment slows progression, pathology is often... 
Macular degeneration | Angiogenesis | Laminin receptor | PEDF | Retinopathy | Choroidal neovascularization | Peptides | YIGSR
Journal Article
Disease models & mechanisms, ISSN 1754-8403, 01/2019, Volume 12, Issue 1, p. dmm035642
Dysfunction and loss of the retinal pigment epithelium (RPE) are hallmarks of retinal degeneration, but the underlying pathogenetic processes are only... 
Retina | PEDF | MITF | Neurodegeneration | RPE | RETINAL DEGENERATION | APOPTOSIS-INDUCING FACTOR | ROYAL-COLLEGE | PATHOLOGY | CELL BIOLOGY | FACTOR PEDF | MOUSE MODEL | GROWTH | GENE-TRANSFER | TRANSCRIPTION FACTOR | EYE DEVELOPMENT | CELL
Journal Article
Stem cells (Dayton, Ohio), ISSN 1066-5099, 5/2018, Volume 36, Issue 5, pp. 775 - 784
Macrophages are crucial drivers of inflammatory corneal neovascularization and thus are potential targets for immunomodulatory therapies. We hypothesized that... 
Angiogenesis | Cornea | PEDF | Mesenchymal Stromal Cells | Inflammation | Macrophages | Pigment Epithelial Derived Factor
Journal Article
Journal Article
2018, Advances in Experimental Medicine and Biology, Volume 1074, 8
Oxidative stress has been implicated in neurodegenerative diseases, such as age-related macular degeneration. Hydrogen peroxide and sodium iodate can mediate... 
MEDICINE, RESEARCH & EXPERIMENTAL | Oxidative stress | Toxicity | INTERPHOTORECEPTOR MATRIX | DEATH | PREVALENCE | Sodium iodate (NaIO3) | DAMAGE | DEGENERATION | CELL BIOLOGY | ARPE-19 cells | Retinal pigment epithelium (RPE) | PEDF | Age-related macular degeneration | OPHTHALMOLOGY | DYSFUNCTION | Pigment epithelium-derived factor (PEDF) | SODIUM-IODATE | Viability
Book Chapter
FEBS JOURNAL, ISSN 1742-464X, 05/2010, Volume 277, Issue 9, pp. 2192 - 2205
Pigment epithelium-derived factor (PEDF), a potent blocker of angiogenesis in vivo, and of endothelial cell migration and tubule formation, binds with high... 
F1-ATPase | endothelial cells | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEDIATED GENE-TRANSFER | F1Fo-ATP synthase | CHOROIDAL NEOVASCULARIZATION | IDENTIFICATION | BOVINE EYES | PEDF | ATP SYNTHASE | FACTOR PEDF | surface plasmon resonance | ANGIOSTATIN | ENDOTHELIAL-CELLS | TUMOR-GROWTH
Journal Article
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