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1. Full Text Non-peptide ligand binding to the formyl peptide receptor FPR2—A comparison to peptide ligand binding modes
by Stepniewski, Tomasz M and Filipek, Slawomir
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2015, Volume 23, Issue 14, pp. 4072 - 4081
Ligands of the FPR2 receptor initiate many signaling pathways including activation of phospholipase C, protein kinase C, the mitogen-activated protein kinase,... 
Non-peptide ligands | Ligand binding | FPR2 | GPCRs | Formyl peptide receptors | ACTIVATION | CHEMISTRY, MEDICINAL | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MONOCYTES | CHEMISTRY, ORGANIC | PROTEIN-COUPLED RECEPTORS | FORMYL-PEPTIDE-RECEPTOR-LIKE-1 | GLIAL-CELLS | IDENTIFICATION | AGONISTS | SERUM AMYLOID-A | SIGNAL-TRANSDUCTION | Receptors, Formyl Peptide - antagonists & inhibitors | Receptors, Lipoxin - antagonists & inhibitors | Receptors, Lipoxin - agonists | Structure-Activity Relationship | Benzimidazoles - chemistry | Receptors, Lipoxin - chemistry | Phenylurea Compounds - chemistry | Receptors, Formyl Peptide - agonists | Receptors, Formyl Peptide - metabolism | Pyrazolones - metabolism | Pyridazines - metabolism | Phenylurea Compounds - metabolism | Binding Sites | Receptors, Lipoxin - metabolism | Pyrazolones - chemistry | Models, Molecular | Pyridazines - chemistry | Benzimidazoles - metabolism | Hydrophobic and Hydrophilic Interactions | Receptors, Formyl Peptide - chemistry | Ligands | Protein Conformation | Molecular Docking Simulation | Phenylurea Compounds - pharmacology | Quinazolinones - chemistry | Quinazolinones - metabolism | Peptides | Analysis
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2. Full Text The Thermodynamics of Protein–Ligand Interaction and Solvation: Insights for Ligand Design
by Olsson, Tjelvar S.G and Williams, Mark A and Pitt, William R and Ladbury, John E
Journal of Molecular Biology, ISSN 0022-2836, 12/2008, Volume 384, Issue 4, pp. 1002 - 1017
Isothermal titration calorimetry is able to provide accurate information on the thermodynamic contributions of enthalpy and entropy changes to free energies of... 
protein structure | thermodynamics | isothermal titration calorimetry | solvent-accessible surface | protein–ligand interaction | protein-ligand interaction | VANT-HOFF | ENTROPY-ENTHALPY COMPENSATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYSTAL-STRUCTURES | PEPTIDE BINDING | BIOMOLECULAR INTERACTIONS | BINDING THERMODYNAMICS | SCORING FUNCTIONS | FREE-ENERGY | MAXIMAL AFFINITY | Protein Binding | Thermodynamics | Ligands | Proteins - metabolism | Protein Structure, Quaternary | Proteins | Protein binding
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3. Full Text Deriving Ligand Orientation in Weak Protein–Ligand Complexes by DEEP‐STD NMR Spectroscopy in the Absence of Protein Chemical‐Shift Assignment
by Nepravishta, Ridvan and Walpole, Samuel and Tailford, Louise and Juge, Nathalie and Angulo, Jesus
ChemBioChem, ISSN 1439-4227, 02/2019, Volume 20, Issue 3, pp. 340 - 344
Differential epitope mapping saturation transfer difference (DEEP‐STD) NMR spectroscopy is a recently developed powerful approach for elucidating the structure... 
DEEP-STD | NMR spectroscopy | TEMPOL | mixed molecular dynamics | CHEMISTRY, MEDICINAL | TRANSFER DIFFERENCE NMR | BIOCHEMISTRY & MOLECULAR BIOLOGY | SURFACE ACCESSIBILITY | IDENTIFICATION | BINDING HOT-SPOTS | Molecular dynamics | Nuclear magnetic resonance spectroscopy | Sexually transmitted diseases | Antigenic determinants | Protein binding | Residues | Spectroscopy | Saturation | Pharmacology | Mapping | Peptide mapping | Proteins | Magnetic resonance spectroscopy | Organic chemistry | Spectrum analysis | Epitope mapping | Ligands | Coordination compounds | Binding sites | Communications | Communication
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4. Full Text Mapping of the ligand-binding site on the b' domain of human PDI: Interaction with peptide ligands and the x-linker region
by Bryne, Lee J and Sidhu, Ateesh and Wallis, A. Katrine and Ruddock, Lloyd W and Freedman, Robert B and Howard, Mark J and Williamson, Richard A
Biochemical Journal, ISSN 0264-6021, 10/2009, Volume 423, Issue 2, pp. 209 - 217
PDI (protein disulfide-isomerase) catalyses the formation of native disulfide bonds of secretory proteins in the endoplasmic reticulum. PDI consists of four... 
b′ domain | Ligand-binding site | Nuclear magnetic resonance (NMR) | Protein disulfide-isomerase (PDI) | PROTEIN-DISULFIDE-ISOMERASE | BB DOMAINS | ligand-binding site | nuclear magnetic resonance (NMR) | CRYSTAL-STRUCTURE | NMR-SPECTROSCOPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein disulfide-isomerase (PDI) | ERP57 | BONDS | b ' domain | FAMILY | Peptide Fragments - metabolism | Protein Structure, Secondary | Peptide Fragments - isolation & purification | Protein Disulfide-Isomerases - metabolism | Humans | Models, Molecular | Protein Interaction Mapping | Peptide Fragments - chemistry | Ligands | Protein Disulfide-Isomerases - chemistry | Protein Disulfide-Isomerases - isolation & purification | Somatostatin - chemistry | Binding Sites | Somatostatin - metabolism | Protein Structure, Tertiary - physiology
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5. Full Text Mutations in a TGF-β Ligand, TGFB3, Cause Syndromic Aortic Aneurysms and Dissections
by Bertoli-Avella, Aida M., MD, PhD and Gillis, Elisabeth, MSc and Morisaki, Hiroko, MD, PhD and Verhagen, Judith M.A., MD and de Graaf, Bianca M., BSc and van de Beek, Gerarda, BSc and Gallo, Elena, PhD and Kruithof, Boudewijn P.T., PhD and Venselaar, Hanka, PhD and Myers, Loretha A., BSc and Laga, Steven, MD and Doyle, Alexander J., MD, PhD and Oswald, Gretchen, MS, CGC and van Cappellen, Gert W.A., PhD and Yamanaka, Itaru, PhD and van der Helm, Robert M., BSc and Beverloo, Berna, PhD and de Klein, Annelies, PhD and Pardo, Luba, MD, PhD and Lammens, Martin, MD, PhD and Evers, Christina, MD and Devriendt, Koenraad, MD, PhD and Dumoulein, Michiel, MD and Timmermans, Janneke, MD and Bruggenwirth, Hennie T., PhD and Verheijen, Frans, PhD and Rodrigus, Inez, MD and Baynam, Gareth, MD and Kempers, Marlies, MD, PhD and Saenen, Johan, MD, PhD and Van Craenenbroeck, Emeline M., MD, PhD and Minatoya, Kenji, MD, PhD and Matsukawa, Ritsu, MD, PhD and Tsukube, Takuro, MD, PhD and Kubo, Noriaki, MD, PhD and Hofstra, Robert, PhD and Goumans, Marie Jose, PhD and Bekkers, Jos A., MD, PhD and Roos-Hesselink, Jolien W., MD, PhD and van de Laar, Ingrid M.B.H., MD, PhD and Dietz, Harry C., MD and Van Laer, Lut, PhD and Morisaki, Takayuki, MD, PhD and Wessels, Marja W., MD, PhD and Loeys, Bart L., MD, PhD
Journal of the American College of Cardiology, ISSN 0735-1097, 2015, Volume 65, Issue 13, pp. 1324 - 1336
Abstract Background Aneurysms affecting the aorta are a common condition associated with high mortality as a result of aortic dissection or rupture.... 
Cardiovascular | Internal Medicine | Loeys-Dietz syndrome | TGF-β pathway | thoracic aortic aneurysm | gene | Gene | Thoracic aortic aneurysm | CARDIAC & CARDIOVASCULAR SYSTEMS | DE-NOVO MUTATION | PHENOTYPE | MARFAN | REFERENCE VALUES | PREDICTION | FEATURES | PATHOGENESIS | GROWTH-FACTOR-BETA | OVERGROWTH | TGF-beta pathway | PEPTIDE DOMAIN | MIM, Mendelian Inheritance in Man | TGF, transforming growth factor | TGFBR, transforming growth factor beta receptor | LOF, loss of function | SNP, single nucleotide polymorphism | LDS, Loeys-Dietz syndrome | TAAD, thoracic aortic aneurysms and dissections | Original Investigation | LAP, latency-associated peptide | MFS, Marfan syndrome
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6. Full Text Priming of Qualitatively Superior Human Effector CD8(+) T Cells Using TLR8 Ligand Combined with FLT3 Ligand
by Lissina, A and Briceno, O and Afonso, G and Larsen, M and Gostick, E and Price, DA and Mallone, R and Appay, V
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 01/2016, Volume 196, Issue 1, pp. 256 - 263
The quality of Ag-specific CD8(+) T cell responses is central to immune efficacy in infectious and malignant settings. Inducing effector CD8(+) T cells with... 
LONG PEPTIDES | ACTIVATION | DENDRITIC CELLS | RECOGNITION | HIGH-FREQUENCY | ANTIGEN SENSITIVITY | IMMUNOLOGY | NAIVE | CANCER | INNATE IMMUNITY | VACCINES | T-Lymphocytes, Cytotoxic - immunology | Immunotherapy, Adoptive - methods | Coculture Techniques | Dendritic Cells - immunology | Humans | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Membrane Proteins - pharmacology | Signal Transduction - immunology | Toll-Like Receptor 8 - immunology | Interleukin-4 - pharmacology | Lymphocyte Activation - immunology | Interleukin-12 Subunit p35 - immunology | T-Lymphocytes, Cytotoxic - transplantation | Leukocytes, Mononuclear - immunology | Cell Line, Tumor | Toll-Like Receptor 8 - agonists | Life Sciences | Immunology
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7. Full Text Generation of Signaling Specificity in Arabidopsis by Spatially Restricted Buffering of Ligand—Receptor Interactions
by Emily B. Abrash and Kelli A. Davies and Dominique C. Bergmann
The Plant Cell, ISSN 1040-4651, 8/2011, Volume 23, Issue 8, pp. 2864 - 2879
Core signaling pathways function in multiple programs during multicellular development. The mechanisms that compartmentalize pathway function or confer process... 
Receptors | Phenotypes | Cotyledons | Hypocotyls | Developmental biology | Ligands | Plants | Pedicels | Genotypes | Plant cells | PROTEIN | STOMATAL DEVELOPMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | SECRETORY PEPTIDE | MOUTHS | PLANT SCIENCES | CELL BIOLOGY | MUTANTS | THALIANA | TOO | GENE-EXPRESSION | ERECTA | Arabidopsis - growth & development | Hypocotyl - genetics | Molecular Sequence Data | Plant Epidermis - genetics | Plant Epidermis - ultrastructure | Plant Epidermis - metabolism | Arabidopsis Proteins - metabolism | Plant Stomata - ultrastructure | Meristem - genetics | Plants, Genetically Modified | Body Patterning | Gene Expression Regulation, Plant | Meristem - metabolism | Cell Differentiation | Hypocotyl - metabolism | Protein-Serine-Threonine Kinases - metabolism | Plant Epidermis - growth & development | Amino Acid Sequence | Hypocotyl - ultrastructure | Arabidopsis Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Arabidopsis - ultrastructure | Hypocotyl - growth & development | Receptors, Cell Surface - metabolism | Plant Stomata - growth & development | Meristem - ultrastructure | Meristem - growth & development | Arabidopsis - metabolism | Arabidopsis - genetics | Phenotype | Models, Biological | Signal Transduction - physiology | Mutation | Receptors, Cell Surface - genetics | Arabidopsis thaliana | Physiological aspects | Research | Plant physiology | Ligands (Biochemistry)
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8. Full Text The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200 - Dependent pathway in mice
by Yang, Yanan and Ahn, Young-Ho and Gibbons, Don L and Zang, Yi and Lin, Wei and Thilaganathan, Nishan and Alvarez, Cristina A and Moreira, Daniel C and Creighton, Chad J and Gregory, Philip A and Goodall, Gregory J and Kurie, Jonathan M
Journal of Clinical Investigation, ISSN 0021-9738, 04/2011, Volume 121, Issue 4, pp. 1373 - 1385
Epithelial tumor cells transit to a mesenchymal state in response to extracellular cues, in a process known as epithelial-to-mesenchymal transition (EMT). The... 
EPITHELIAL-MESENCHYMAL TRANSITION | MEDICINE, RESEARCH & EXPERIMENTAL | BREAST-CANCER CELLS | STEM-CELLS | ZEB1 | K-RAS ONCOGENE | TUMOR PROGRESSION | GATA3 EXPRESSION | E-CADHERIN | DIFFERENTIATION | MIR-200 FAMILY | GATA3 Transcription Factor - genetics | Adenocarcinoma - pathology | Receptors, Notch - metabolism | Epithelial-Mesenchymal Transition - physiology | Humans | Lung Neoplasms - metabolism | Glycoproteins - metabolism | Lung Neoplasms - pathology | MicroRNAs - metabolism | Gene Expression Profiling | Mice, 129 Strain | Epithelial-Mesenchymal Transition - genetics | Antigens, CD - metabolism | Adenocarcinoma - metabolism | Peptides - metabolism | Jagged-2 Protein | Adenocarcinoma - genetics | Membrane Proteins - metabolism | GATA3 Transcription Factor - metabolism | Lung Neoplasms - genetics | Signal Transduction | Membrane Proteins - genetics | AC133 Antigen | Adenocarcinoma - secondary | Animals | Cell Line, Tumor | Ligands | Mice | MicroRNAs - genetics | Adenocarcinoma | Genetic aspects | Metastasis | Research
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9. Full Text Programmed Death (PD)-1:PD-Ligand 1/PD-Ligand 2 Pathway Inhibits T Cell Effector Functions during Human Tuberculosis
by Jurado, Javier O and Alvarez, Ivana B and Pasquinelli, Virginia and Martinez, Gustavo J and Quiroga, Maria F and Abbate, Eduardo and Musella, Rosa M and Chuluyan, H. Eduardo and Garcia, Veronica E
The Journal of Immunology, ISSN 0022-1767, 07/2008, Volume 181, Issue 1, pp. 116 - 125
Protective immunity against Mycobacterium tuberculosis requires the generation of cell-mediated immunity. We investigated the expression and role of programmed... 
MYCOBACTERIUM-TUBERCULOSIS | IMMUNITY | ACTIVATION | IFN-GAMMA PRODUCTION | VIRUS-INFECTION | CYTOKINE RESPONSES | INTERFERON-GAMMA | PD-L2 EXPRESSION | B7 FAMILY | IMMUNOLOGY | MOLECULE-ASSOCIATED PROTEIN | Antigens, CD - immunology | Apoptosis Regulatory Proteins - immunology | B7-H1 Antigen | Humans | Programmed Cell Death 1 Ligand 2 Protein | Cells, Cultured | Mycobacterium tuberculosis - immunology | Receptors, Cell Surface - metabolism | Receptors, Cell Surface - immunology | Antigens, CD - metabolism | Tuberculosis - immunology | Signal Transduction - immunology | Lymphocyte Activation - immunology | Signaling Lymphocytic Activation Molecule Family Member 1 | T-Lymphocytes - metabolism | Interferon-gamma - immunology | Protein Binding | Antigens - immunology | Programmed Cell Death 1 Receptor | T-Lymphocytes - immunology | Tuberculosis - metabolism | Intercellular Signaling Peptides and Proteins - immunology | Interferon-gamma - biosynthesis
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10. Full Text [177Lu]Lutetium-labelled PSMA ligand-induced remission in a patient with metastatic prostate cancer
by Kratochwil, Clemens and Giesel, Frederik L and Eder, Matthias and Afshar-Oromieh, Ali and Benešová, Martina and Mier, Walter and Kopka, Klaus and Haberkorn, Uwe
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 04/2015, Volume 42, Issue 6, pp. 987 - 988
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | MEMBRANE ANTIGEN | Prostatic Neoplasms - radiotherapy | Humans | Peptides - pharmacokinetics | Organometallic Compounds - pharmacokinetics | Male | Tomography, X-Ray Computed | Positron-Emission Tomography | Multimodal Imaging | Neoplasm Metastasis | Glutamate Carboxypeptidase II - metabolism | Antigens, Surface - metabolism | Organometallic Compounds - therapeutic use | Prostatic Neoplasms - diagnostic imaging | Peptides - therapeutic use | Radiopharmaceuticals - therapeutic use | Rare earth metals | Cancer patients | Metastasis | Prostate cancer | Index Medicus
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11. Full Text Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell-mediated injury in the heart
by Grabie, Nir and Gotsman, Israel and DaCosta, Rosa and Pang, Hong and Stavrakis, George and Butte, Manish J and Keir, Mary E and Freeman, Gordon J and Sharpe, Arlene H and Lichtman, Andrew H
Circulation, ISSN 0009-7322, 10/2007, Volume 116, Issue 18, pp. 2062 - 2071
Background - PD-L1 and PD-L2 are ligands for the inhibitory receptor programmed death-1 (PD-1), which is an important regulator of immune responses. PD-L1 is... 
Myocarditis | Inflammation | Lymphocytes | Endothelium | Immune system | endothelium | CARDIAC & CARDIOVASCULAR SYSTEMS | lymphocytes | myocarditis | IFN-GAMMA | INDUCIBLE COSTIMULATOR LIGAND | AUTOIMMUNE MYOCARDITIS | DILATED CARDIOMYOPATHY | CARDIAC ALLOGRAFTS | RECEPTOR-DEFICIENT MICE | RESPONSES | INTERFERON-GAMMA | EPITHELIAL-CELLS | inflammation | immune system | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | Inflammation - pathology | B7-1 Antigen - genetics | CD8-Positive T-Lymphocytes - pathology | Membrane Glycoproteins - biosynthesis | Peptides - genetics | Signal Transduction - immunology | Inflammation - metabolism | Membrane Glycoproteins - physiology | Inflammation Mediators - metabolism | CD8-Positive T-Lymphocytes - metabolism | B7-1 Antigen - biosynthesis | Inflammation Mediators - physiology | Myocarditis - immunology | Neutrophils - metabolism | Neutrophils - pathology | B7-H1 Antigen | Endothelial Cells - metabolism | Peptides - physiology | Mice, Inbred C57BL | Neutrophils - immunology | B7-1 Antigen - physiology | Mice, Transgenic | Inflammation - immunology | Membrane Glycoproteins - genetics | Animals | Myocarditis - metabolism | Mice | Myocarditis - pathology | Endothelial Cells - pathology | CD8 lymphocytes | Physiological aspects | Development and progression | Vascular endothelium | Research | Cell-mediated lympholysis | Apoptosis
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12. Full Text Transfer of the human NKG2D ligands UL16 binding proteins (ULBP) 1–3 is related to lytic granule release and leads to ligand retransfer and killing of ULBP‐recipient natural killer cells
by López‐Cobo, Sheila and Romera‐Cárdenas, Gema and García‐Cuesta, Eva M and Reyburn, Hugh T and Valés‐Gómez, Mar
Immunology, ISSN 0019-2805, 09/2015, Volume 146, Issue 1, pp. 70 - 80
After immune interactions, membrane fragments can be transferred between cells. This fast transfer of molecules is transient and shows selectivity for certain... 
trogocytosis | glycosyl‐phosphatidyl‐inositol‐anchored proteins | NKG | immune synapse | human natural killer cells | Human natural killer cells | Glycosyl-phosphatidyl-inositol-anchored proteins | NKG2D | Immune synapse | Trogocytosis | INTERCELLULAR TRANSFER | TARGET-CELLS | RECEPTOR | IMMUNOLOGY | PLASMA-MEMBRANE | CUTTING EDGE | B-CELLS | NK CELLS | GLYCOPROTEIN UL16 | glycosyl-phosphatidyl-inositol-anchored proteins | T-CELLS | Cell Line | Cricetinae | Cricetulus | Humans | Histocompatibility Antigens Class I - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Cell Degranulation - immunology | Receptors, Natural Killer Cell - immunology | GPI-Linked Proteins - metabolism | Protein Transport | Intercellular Signaling Peptides and Proteins - metabolism | Glycosylphosphatidylinositols | Animals | Killer Cells, Natural - immunology | Cytotoxicity, Immunologic - immunology | CHO Cells | Inositol | Killer cells | Chemical properties | T cells | Binding proteins | Protein binding | Proteins | Antigens | Ligands | Original
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13. Full Text Ligand-promoted alkylation of C(sp3)-H and C(sp2)-H bonds
by Zhu, Ru-Yi and He, Jian and Wang, Xiao-Chen and Yu, Jin-Quan
Journal of the American Chemical Society, ISSN 0002-7863, 09/2014, Volume 136, Issue 38, pp. 13194 - 13197
9-Methylacridine was identified as a generally effective ligand to promote a Pd(II)-catalyzed C(sp(3))-H and C(sp(2))-H alkylation of simple amides with... 
HALIDES | CROSS-COUPLING REACTIONS | ACTIVATION | OLEFINATION | ARYLATION | ALPHA-AMINO-ACIDS | BROMIDES | CHEMISTRY, MULTIDISCIPLINARY | C-H BONDS | PALLADIUM-CATALYZED ALKYLATION | Acridines - chemistry | Acrylates - chemistry | Amides - chemistry | Acrylates - chemical synthesis | Ligands | Iodides - chemistry | Catalysis | Palladium - chemistry | Alkylation | Iodides | Acrylic acid | Chemical bonds | Amino acids | Amides | Communication
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14. Full Text Control of Notch-ligand endocytosis by ligand-receptor interaction
by Hansson, Emil M and Lanner, Fredrik and Das, Debashish and Mutvei, Anders and Marklund, Ulrika and Ericson, Johan and Farnebo, Filip and Stumm, Gabriele and Stenmark, Harald and Andersson, Emma R and Lendahl, Urban
Journal of Cell Science, ISSN 0021-9533, 09/2010, Volume 123, Issue 17, pp. 2931 - 2942
In Notch signaling, cell-bound ligands activate Notch receptors on juxtaposed cells, but the relationship between ligand endocytosis, ubiquitylation and... 
Mind bomb | Dynamin | Notch | MVB | Delta-like | Jagged | Endosome | UBIQUITIN LIGASE | CIS-INHIBITION | DROSOPHILA DEVELOPMENT | ACTIVATE NOTCH | DELTA-ENDOCYTOSIS | CELL BIOLOGY | PHOSPHATIDYLINOSITOL 3-PHOSPHATE | SIGNALING PATHWAY | MULTIVESICULAR ENDOSOMES | DSL LIGANDS | Immunohistochemistry | Receptors, Notch - metabolism | Humans | Male | Mutation, Missense | Gene Knockdown Techniques | Intercellular Signaling Peptides and Proteins - metabolism | Endocytosis | Transfection | Serrate-Jagged Proteins | HEK293 Cells | Female | Membrane Proteins - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Signal Transduction | Membrane Proteins - genetics | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Ubiquitin-Protein Ligases - metabolism | Animals | Ligands | Mice | Ubiquitin-Protein Ligases - genetics | Calcium-Binding Proteins - genetics
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