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Journal of Immunological Methods, ISSN 0022-1759, 09/2015, Volume 424, pp. 43 - 52
The therapeutic monoclonal antibody (mAb) TGN1412 (anti-CD28 superagonist) caused near-fatal cytokine release syndrome (CRS) in all six volunteers during a... 
Whole blood | Group size | TGN1412 | Cytokine release assay | PBMC | Therapeutic mAb | REVEALS WORRYING DIFFERENCES | BIOCHEMICAL RESEARCH METHODS | MONOCLONAL-ANTIBODY TGN1412 | IMMUNOLOGY | VITRO ASSAYS | FC-GAMMA-RIIB | T-CELL RESPONSES | MULTIPLE-SCLEROSIS | RITUXIMAB | CD28 | CHRONIC LYMPHOCYTIC-LEUKEMIA | SYNDROME IN-VIVO | Antibodies, Monoclonal, Humanized - adverse effects | Leukocytes, Mononuclear - metabolism | Glycophorin - metabolism | Antibodies, Monoclonal, Humanized - therapeutic use | Leukocytes, Mononuclear - drug effects | Cytokines - metabolism | Humans | Immunoglobulin G - therapeutic use | Antineoplastic Agents - therapeutic use | Alemtuzumab | Daclizumab | Fluoroimmunoassay - methods | Antibodies, Monoclonal - administration & dosage | Antineoplastic Agents - adverse effects | Antibodies, Monoclonal, Humanized - pharmacology | Erythrocytes - metabolism | Immunoglobulin G - pharmacology | Cytokines - blood | Cytokines | Monoclonal antibodies | Health aspects | GYPA, glycophorin A | mAb, monoclonal antibody | WBC, white blood cells | IFNγ, interferon gamma | TNFα, tumor necrosis factor alpha | HDC, high density culture | SP, Solid Phase | RBCs, Red Blood Cells | PBMCs, peripheral blood mononuclear cells | CRS, cytokine release syndrome | IL-2, interleukin-2 | AQ, Aqueous Phase | WB, whole blood | PBS, phosphate buffered saline | IL-8, interleukin-8 | IL-13, interleukin-13 | CRA, cytokine release assay | IL-2R, interleukin-2 receptor | IL-17, interleukin-17 | TCR, T cell receptor
Journal Article
Journal Article
Advanced Materials, ISSN 0935-9648, 03/2013, Volume 25, Issue 11, pp. 1547 - 1551
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Circulation, ISSN 0009-7322, 05/2007, Volume 115, Issue 17, pp. 2271 - 2281
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Hypertension, ISSN 0194-911X, 07/2019, Volume 74, Issue 1, pp. 26 - 28
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Journal of Neuroscience, ISSN 0270-6474, 01/2010, Volume 30, Issue 2, pp. 573 - 582
The cytokine interleukin-1 beta(IL-1 beta) released by spinal microglia in enhanced response states contributes significantly to neuronal mechanisms of chronic... 
PERIPHERAL-NERVE INJURY | PANNEXIN 1 CHANNELS | NEUROPATHIC PAIN | ACTIVATED PROTEIN-KINASE | MOLECULAR PLATFORM | P2X RECEPTOR | TACTILE ALLODYNIA | INFLAMMATORY CASPASES | MICROGLIAL CATHEPSIN-S | PERMEATION PORE INHIBITION | NEUROSCIENCES
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Journal Article