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1. Full Text Combatting bacterial persister cells
by Wood, Thomas K
Biotechnology and Bioengineering, ISSN 0006-3592, 03/2016, Volume 113, Issue 3, pp. 476 - 483
ABSTRACT Most bacterial cells lead lives of quiet desperation in biofilms, combatting stress; yet, their prevalence attests to their ability to alter gene... 
antimicrobial tolerance | cell signaling | persister cells | Antimicrobial tolerance | Persister cells | Cell signaling | MITOMYCIN-C | STRESS-RESPONSE | MESSENGER-RNA | INDOLE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PSEUDOMONAS-AERUGINOSA | MULTIDRUG TOLERANCE | ESCHERICHIA-COLI K-12 | GENE-EXPRESSION | TOXIN YAFQ | BIOFILM FORMATION | Bacteria - growth & development | Bacteria - metabolism | Signal Transduction | Bacterial Physiological Phenomena | Anti-Bacterial Agents - pharmacology | Microbial Viability | Gene Expression Regulation, Bacterial | Stresses | Biofilms | Pathways | Antibiotics | Genetics | Bacteria | Indoles | Gene expression
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2. Full Text Staphylococcus aureus chronic and relapsing infections: Evidence of a role for persister cells: An investigation of persister cells, their formation and their role in S. aureus disease
by Conlon, Brian P
BioEssays, ISSN 0265-9247, 10/2014, Volume 36, Issue 10, pp. 991 - 996
Staphylococcus aureus is an opportunistic pathogen capable of causing a variety of diseases including osteomyelitis, endocarditis, infections of indwelling... 
Relapse | Antibiotics | Biofilm | Tolerance | Persister | Toxin-antitoxin (TA) | Staphylococcus aureus | toxin-antitoxin (TA) | BACTERIAL PERSISTENCE | relapse | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | persister | VANCOMYCIN PENETRATION | STREPTOCOCCUS-PNEUMONIAE | RESISTANT STAPHYLOCOCCI | biofilm | IN-VIVO | BIOLOGY | JOINT INFECTIONS | CYSTIC-FIBROSIS | antibiotics | tolerance | TREATMENT FAILURE | BIOFILM FORMATION | Biofilms - drug effects | Anti-Bacterial Agents - therapeutic use | Recurrence | Staphylococcal Infections - drug therapy | Animals | Staphylococcus aureus - physiology | Humans | Staphylococcus aureus - cytology | Anti-Bacterial Agents - pharmacology | Staphylococcal Infections - microbiology | Staphylococcus aureus - drug effects | Chronic Disease
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3. Full Text Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells
by Pu, Yingying and Zhao, Yanna and Zhao, Zhilun and Li, Yingxing and Zou, Jin and Ma, Qi and Ke, Yuehua and Zhu, Yun and Chen, Huiyi and Baker, Matthew A.B and Ge, Hao and Sun, Yujie and Xie, Xiaoliang Sunney and Bai, Fan
Molecular Cell, ISSN 1097-2765, 04/2016, Volume 62, Issue 2, pp. 284 - 294
Natural variations in gene expression provide a mechanism for multiple phenotypes to arise in an isogenic bacterial population. In particular, a sub-group... 
HETEROGENEITY | OMPF | STOCHASTIC GENE-EXPRESSION | PERSISTER CELLS | INFECTIONS | PUMPS | PSEUDOMONAS-AERUGINOSA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | ANTIBIOTIC-RESISTANCE | PROTEINS | CELL BIOLOGY | Optical Imaging | Up-Regulation | Escherichia coli - drug effects | Colony Count, Microbial | Dose-Response Relationship, Drug | Biological Transport | Penicillins - metabolism | Time Factors | Membrane Transport Proteins - genetics | Escherichia coli - metabolism | Membrane Transport Proteins - metabolism | Escherichia coli - growth & development | Drug Resistance, Bacterial - genetics | Penicillins - pharmacology | Bacterial Outer Membrane Proteins - genetics | Boron Compounds - pharmacology | Boron Compounds - metabolism | Microbial Viability - drug effects | Anti-Bacterial Agents - metabolism | Escherichia coli Proteins - metabolism | Genotype | Phenotype | Bacterial Outer Membrane Proteins - metabolism | Escherichia coli - genetics | Escherichia coli Proteins - genetics | Anti-Bacterial Agents - pharmacology | High-Throughput Nucleotide Sequencing | Mutation | Gene Expression Regulation, Bacterial | Gene expression | Beta lactamases | Genes
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4. Full Text Targeting Cancer Cell Dormancy
by Recasens, Ariadna and Munoz, Lenka
Trends in Pharmacological Sciences, ISSN 0165-6147, 02/2019, Volume 40, Issue 2, pp. 128 - 141
Cancer cell dormancy is a process whereby cells enter reversible cell cycle arrest, termed quiescence. Quiescence is essential for cancer cells to acquire... 
drug-tolerant persister cells | disseminated tumor cells | epigenetic inhibitors | cancer dormancy | HUMAN CARCINOMA | HEMATOPOIETIC STEM-CELLS | IMMUNE-MEDIATED DORMANCY | BONE-MARROW NICHE | TUMOR DORMANCY | UROKINASE RECEPTOR | PHARMACOLOGY & PHARMACY | DRUG-RESISTANCE | GOVERNING METASTATIC DORMANCY | ESTROGEN-RECEPTOR | DREAM COMPLEX
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5. Full Text Antibiotic Susceptibility of Escherichia coli Cells during Early-Stage Biofilm Formation
by Gu, H and Lee, SW and Carnicelli, J and Jiang, ZW and Ren, DC
JOURNAL OF BACTERIOLOGY, ISSN 0021-9193, 09/2019, Volume 201, Issue 18, p. 1
Bacteria form complex multicellular structures on solid surfaces known as biofilms, which allow them to survive in harsh environments. A hallmark... 
SYSTEM | BACTERIA | cell-cell interaction | TOLERANCE | antibiotic tolerance | MICROBIOLOGY | STRATEGIES | ADHESION | patterned biofilm | PERSISTER CELLS | biofilm | cell-surface interaction | RESISTANCE | DYNAMICS | MOLECULAR-MECHANISMS | SURFACES | Cell culture | Sonication | Planktonic cells | Cell interactions | Ofloxacin | Cell surface | Cell adhesion & migration | Solid surfaces | Biofilms | Antibiotics | E coli | Ampicillin | Antibiotic tolerance | Cell adhesion | Clusters | Harsh environments | Bacteria | Cell size | Antifouling substances
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6. Full Text Synchrotron IR spectromicroscopy: Chemistry of living cells
by Holman, Hoi-Ying N and Bechtel, Hans A and Hao, Zhao and Martin, Michael C
Analytical Chemistry, ISSN 0003-2700, 11/2010, Volume 82, Issue 21, pp. 8757 - 8765
Advanced analytical capabilities of synchrotron IR spectromicroscopy meet the demands of modern biological research for studying molecular reactions in... 
HETEROGENEITY | CHEMISTRY, ANALYTICAL | PERSISTER CELLS | ENERGY | TRANSFORM INFRARED-SPECTROSCOPY | BIOFILMS | ENVIRONMENT | DISEASE | MICROSPECTROSCOPY | RADIATION | FTIR SPECTROMICROSCOPY | Bacteria - chemistry | Microfluidic Analytical Techniques - instrumentation | Water - analysis | Micrasterias - cytology | Equipment Design | Hydrogen Bonding | Microscopy - instrumentation | Bacteria - cytology | Chlamydomonas - cytology | Chlamydomonas - chemistry | Micrasterias - chemistry | Spectrophotometry, Infrared - instrumentation | Synchrotrons - instrumentation
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7. Full Text A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
by Sharma, Sreenath V and Lee, Diana Y and Li, Bihua and Quinlan, Margaret P and Takahashi, Fumiyuki and Maheswaran, Shyamala and McDermott, Ultan and Azizian, Nancy and Zou, Lee and Fischbach, Michael A and Wong, Kwok-Kin and Brandstetter, Kathleyn and Wittner, Ben and Ramaswamy, Sridhar and Classon, Marie and Settleman, Jeff
Cell, ISSN 0092-8674, 2010, Volume 141, Issue 1, pp. 69 - 80
Accumulating evidence implicates heterogeneity within cancer cell populations in the response to stressful exposures, including drug treatments. While modeling... 
CELLBIO | DNA | HUMDISEASE | Cellbio | Humdisease | INSULIN | STEM-CELLS | HISTONE MODIFICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | THERAPEUTIC RESISTANCE | GROWTH | DISEASE | SENSITIVITY | MECHANISMS | RETREATMENT | INHIBITORS | CELL BIOLOGY | Neoplasms - metabolism | Chromatin - metabolism | Receptor, IGF Type 1 - metabolism | Humans | Drug Resistance, Neoplasm | Chromatin - pathology | Jumonji Domain-Containing Histone Demethylases - genetics | Neoplasms - drug therapy | Histone Demethylases - metabolism | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Cell Line, Tumor | Histone Deacetylase Inhibitors - pharmacology | DNA Damage | Neoplasms - pathology | Jumonji Domain-Containing Histone Demethylases - metabolism | KDM5A | cancer | bacterial persisters | drug resistance | IGF-1R | chromatin
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8. Full Text Persister cells and tolerance to antimicrobials
by Keren, Iris and Kaldalu, Niilo and Spoering, Amy and Wang, Yipeng and Lewis, Kim
FEMS Microbiology Letters, ISSN 0378-1097, 2004, Volume 230, Issue 1, pp. 13 - 18
Abstract Bacterial populations produce persister cells that neither grow nor die in the presence of microbicidal antibiotics. Persisters are largely... 
Antimicrobial tolerance | Pseudomonas aeruginosa | Escherichia coli | Staphylococcus aureus | Persisters | AFFECTS LETHALITY | AFFECTS FREQUENCY | BIOFILMS | MICROBIOLOGY | DNA-SYNTHESIS | antimicrobial tolerance | BETA-LACTAM | MUREIN SYNTHESIS | INHIBITION | PSEUDOMONAS-AERUGINOSA | ESCHERICHIA-COLI K-12 | RESISTANCE | persisters | Culture Media | Escherichia coli - drug effects | Pseudomonas aeruginosa - growth & development | Drug Tolerance | Anti-Bacterial Agents - pharmacology | Colony Count, Microbial | Escherichia coli - growth & development | Pseudomonas aeruginosa - drug effects | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development
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9. Full Text Interactions of nanosilver with Escherichia coli cells in planktonic and biofilm cultures
by Choi, Okkyoung and Yu, Chang-Ping and Esteban Fernández, G and Hu, Zhiqiang
Water Research, ISSN 0043-1354, 2010, Volume 44, Issue 20, pp. 6095 - 6103
Biofilms are often more resistant to toxic chemicals such as heavy metals and antimicrobial agents than planktonic cells. Nanosilver has a broad range of... 
Fluorescence-based microrespirometry | Nanosilver | Spatial distribution | Nanoparticle aggregation | Biofilm resistance | BACTERIA | MICROBIAL BIOFILMS | TOLERANCE | ANTIBIOTIC-RESISTANCE | WATER RESOURCES | TOXICITY | SILVER NANOPARTICLES | ENVIRONMENTAL SCIENCES | PERSISTER CELLS | SPATIAL DISTRIBUTIONS | ENGINEERING, ENVIRONMENTAL | PSEUDOMONAS-AERUGINOSA | HEAVY-METAL RESISTANCE | Biofilms - drug effects | Plankton - drug effects | Escherichia coli - drug effects | Metal Nanoparticles - chemistry | Plankton - microbiology | Silver - chemistry | Silver - toxicity | Index Medicus | Silver | Biofilms | Nanocomposites | Toxic | Nanomaterials | Bacteria | Nanostructure | Agglomeration | Culture
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10. Full Text Cover Picture: Identification of N‐Arylated NH125 Analogues as Rapid Eradicating Agents against MRSA Persister Cells and Potent Biofilm Killers of Gram‐Positive Pathogens (ChemBioChem 4/2017)
by Abouelhassan, Yasmeen and Basak, Akash and Yousaf, Hussain and Huigens, Robert W
ChemBioChem, ISSN 1439-4227, 02/2017, Volume 18, Issue 4, pp. 336 - 336
The cover picture shows the destruction of a bacterial membrane by a new NH125 analogue. Through chemical synthesis and biological evaluation, the authors have... 
drug-resistant bacteria | biofilms | antibacterial agents | MRSA | persister cells | Biofilms
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11. Full Text Persister cells: Molecular mechanisms related to antibiotic tolerance
by Lewis, Kim
Handbook of Experimental Pharmacology, ISSN 0171-2004, 2012, Volume 211, Issue 211, pp. 121 - 133
It is a given that new antibiotics are needed to combat drug-resistant pathogens. However, this is only a part of the need-we actually never had antibiotics... 
Biofilm | Persister | High-persister mutants | Drug tolerance | Toxin/antitoxins | Drug Resistance, Microbial | Candida albicans - drug effects | Cystic Fibrosis - microbiology | Escherichia coli - drug effects | Humans | Pseudomonas aeruginosa - drug effects | Cystic Fibrosis - complications
Conference Proceeding
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12. Full Text Contact‐dependent growth inhibition induces high levels of antibiotic‐tolerant persister cells in clonal bacterial populations
by Ghosh, Anirban and Baltekin, Özden and Wäneskog, Marcus and Elkhalifa, Dina and Hammarlöf, Disa L and Elf, Johan and Koskiniemi, Sanna and Teknisk-naturvetenskapliga vetenskapsområdet and Biologiska sektionen and Uppsala universitet and Institutionen för cell- och molekylärbiologi and Molekylär systembiologi and Mikrobiologi
The EMBO Journal, ISSN 0261-4189, 05/2018, Volume 37, Issue 9, p. n/a
Bacterial populations can use bet‐hedging strategies to cope with rapidly changing environments. One example is non‐growing cells in clonal bacterial... 
bet‐hedging | persisters | contact‐dependent growth inhibition | toxin | contact-dependent growth inhibition | bet-hedging | SYSTEM | PROTEIN | (P)PPGPP | BIOCHEMISTRY & MOLECULAR BIOLOGY | PPGPP | CELL BIOLOGY | PSEUDOMONAS-AERUGINOSA | STRINGENT RESPONSE | ESCHERICHIA-COLI K-12 | DEGRADATION | REQUIRES | EXPRESSION | Biodegradation | Populations | Stringent response | Changing environments | Immunity | Degradation | Proteins | Signaling | Antibiotics | Bacteria | Toxins | Stochasticity | Contact stresses | Inhibition | Feedforward | Population density | Genotypes | Fitness | Index Medicus | Signal Transduction | Microbiology, Virology & Host Pathogen Interaction | Biological Sciences | Naturvetenskap | Biokemi och molekylärbiologi | Biologiska vetenskaper | Biochemistry and Molecular Biology | Natural Sciences
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13. Full Text Pharmacodynamics of ciprofloxacin against Pseudomonas aeruginosa planktonic and biofilm‐derived cells
by Marques, C.N.H and Nelson, S.M
Letters in Applied Microbiology, ISSN 0266-8254, 04/2019, Volume 68, Issue 4, pp. 350 - 359
The influence of growth phase and state on the survival and recovery of Pseudomonas aeruginosa exposed to ciprofloxacin was investigated using batch culture... 
Pseudomonads | microbial physiology | antibiotics | biofilms | resistance | NALIDIXIC-ACID | VARIANTS | ESCHERICHIA-COLI | GROWTH-RATE | SUSCEPTIBILITY | ANTIBIOTIC-RESISTANCE | MICROBIOLOGY | LUX GENES | PERSISTER CELLS | LIGHT OUTPUT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DNA GYRASE | Microbial Sensitivity Tests | Plankton - drug effects | Pseudomonas aeruginosa - growth & development | Biofilms - growth & development | Ciprofloxacin - pharmacology | Anti-Bacterial Agents - pharmacology | Pseudomonas aeruginosa - drug effects | Physiological aspects | Drug resistance in microorganisms | Pseudomonas aeruginosa | Ciprofloxacin | Cell culture | Batch culture | Pharmacodynamics | Cell survival | Populations | Planktonic cells | Disaggregation | Antimicrobial agents | Regrowth | Pharmacology | Exposure | Infections | Metabolism | Recovery | Antiinfectives and antibacterials | Resilience | Reduction | Biofilms | Antibiotics | Viability | Stationary phase
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14. Full Text Biofilm-Grown Burkholderia cepacia Complex Cells Survive Antibiotic Treatment by Avoiding Production of Reactive Oxygen Species
by Van Acker, Heleen and Sass, Andrea and Bazzini, Silvia and De Roy, Karen and Udine, Claudia and Messiaen, Thomas and Riccardi, Giovanna and Boon, Nico and Nelis, Hans J and Mahenthiralingam, Eshwar and Coenye, Tom
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e58943
The presence of persister cells has been proposed as a factor in biofilm resilience. In the present study we investigated whether persister cells are present... 
PERSISTER CELLS | IN-VITRO | BACTERIA | PSEUDOMONAS-AERUGINOSA | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | CENOCEPACIA | PLASMID | RESISTANCE | MECHANISMS | CYSTIC-FIBROSIS | Biofilms - drug effects | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Burkholderia cepacia - metabolism | Reactive Oxygen Species - metabolism | Burkholderia cepacia - drug effects | Tobramycin - pharmacology | Biofilms - growth & development | Burkholderia cepacia - cytology | Anti-Bacterial Agents - pharmacology | Drug Resistance, Bacterial - drug effects | Burkholderia cepacia - physiology | Antibacterial agents | Analysis | Tricarboxylic acid cycle | Flow cytometry | Dehydrogenases | Laboratories | Genes | Infections | Genomes | Isocitrate lyase | Proteins | Electron transport chain | E coli | Catalase | Bacteria | Burkholderia | Pretreatment | Drug dosages | Detoxification | Cystic fibrosis | Antimicrobial agents |