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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2009, Volume 106, Issue 27, pp. 11137 - 11142
Peutz-Jeghers syndrome (PJS) is a familial cancer disorder due to inherited loss of function mutations in the LKB1/ STK11 serine/threonine kinase. PJS patients... 
Peutz Jeghers syndrome | Stomach | Tuberous sclerosis | Hypoxia | Mice | Gene expression regulation | Genetic mutation | Cyclins | Tumors | Cancer | FDG-PET | Glycolysis | AMPK | Polyposis | Hamartoma | MAMMALIAN TARGET | CANCER-CELLS | RAPAMYCIN | MULTIDISCIPLINARY SCIENCES | glycolysis | KINASE | CELL-GROWTH | TUBEROUS SCLEROSIS COMPLEX | MESSENGER-RNA | STK11 DELETIONS | hamartoma | polyposis | GROWTH-FACTOR EXPRESSION | Biological Sciences
Journal Article
Endocrine Reviews, ISSN 0163-769X, 02/2012, Volume 33, Issue 1, pp. 109 - 144
Journal Article
Journal Article
Nature, ISSN 0028-0836, 12/2010, Volume 468, Issue 7324, pp. 653 - 658
Little is known about metabolic regulation in stem cells and how this modulates tissue regeneration or tumour suppression. We studied the Lkb1 tumour... 
MAINTENANCE | ACTIVATED PROTEIN-KINASE | DROSOPHILA LKB1 | GENE | SERINE-THREONINE KINASE | PATHWAY | PEUTZ-JEGHERS-SYNDROME | MULTIDISCIPLINARY SCIENCES | MICE | TRANSCRIPTION FACTOR | DEFICIENCY | Protein-Serine-Threonine Kinases - deficiency | AMP-Activated Protein Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Multiprotein Complexes | Hematopoietic Stem Cells - pathology | Aneuploidy | Male | AMP-Activated Protein Kinases - deficiency | Mechanistic Target of Rapamycin Complex 1 | Cell Division | Gene Deletion | Cell Death | Female | Energy Metabolism - physiology | Protein-Serine-Threonine Kinases - metabolism | Hematopoietic Stem Cells - drug effects | Signal Transduction | Cell Survival | Mice, Inbred C57BL | Catalytic Domain - genetics | Protein-Serine-Threonine Kinases - genetics | Spindle Apparatus - pathology | Hematopoietic Stem Cells - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Sirolimus - pharmacology | AMP-Activated Protein Kinases - chemistry | Regeneration | Animals | Proteins - metabolism | Centrosome - pathology | Hematopoietic Stem Cells - cytology | Cell Cycle - physiology | Mice | Enzyme Activation | Pancytopenia - genetics | AMP-Activated Protein Kinases - genetics | Energy metabolism | Bioenergetics | Cell cycle | Tumor suppressor genes | Research | Properties | Hematopoietic stem cells | Kinases | Metabolism | Stem cells | Tumors
Journal Article
JOURNAL OF INVESTIGATIVE DERMATOLOGY, ISSN 0022-202X, 01/2016, Volume 136, Issue 1, pp. 15 - 23
A number of critical signaling pathways are required for homeostatic regulation of cell survival, differentiation, and proliferation during organogenesis. One... 
PROTEIN-KINASE-B | EPIDERMAL-NEVI | PEUTZ-JEGHERS-SYNDROME | NEVI CLOVE-SYNDROME | GERMLINE MUTATIONS | TUMOR-SUPPRESSOR | FIBROADIPOSE HYPERPLASIA | FACIAL-ANGIOFIBROMAS | TUBEROUS-SCLEROSIS | CONGENITAL LIPOMATOUS OVERGROWTH | DERMATOLOGY
Journal Article
Science, ISSN 0036-8075, 12/2005, Volume 310, Issue 5754, pp. 1642 - 1646
The Peutz-Jegher syndrome tumor-suppressor gene encodes a protein-threonine kinase, LKB1, which phosphorylates and activates AMPK [adenosine mono-phosphate... 
Blood glucose | Phosphorylation | Fasting | Liver | Adenoviruses | Medical treatment | Mice | Gene expression regulation | Research Articles | Genotypes | Gluconeogenesis | RAT-TISSUES | HEPATIC GLUCONEOGENESIS | ACTIVATED PROTEIN-KINASE | AMP | FOOD-INTAKE | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | PGC-1 | CREB COACTIVATOR TORC2 | UPSTREAM KINASES | SNF1-ACTIVATING KINASES | Liver - enzymology | Metformin - therapeutic use | Humans | Homeostasis | Multienzyme Complexes - metabolism | Male | Diabetes Mellitus, Type 2 - metabolism | Hyperglycemia - drug therapy | AMP-Activated Protein Kinases | Lipogenesis - genetics | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Trans-Activators - genetics | Female | Protein-Serine-Threonine Kinases - metabolism | Hypoglycemic Agents - therapeutic use | Blood Glucose - analysis | Signal Transduction | Liver - metabolism | Metformin - pharmacology | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Hypoglycemic Agents - pharmacology | Hyperglycemia - metabolism | Animals | Gluconeogenesis - genetics | Glucose - metabolism | Mice, Obese | Trans-Activators - metabolism | Transcription Factors | Enzyme Activation | HeLa Cells | Diabetes Mellitus, Type 2 - drug therapy | Tumor suppressor genes | Dosage and administration | Research | Metformin | Analysis | Peutz-Jeghers syndrome | Proteins | Glucose | Gene expression | Rodents | Binding sites
Journal Article
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, ISSN 1540-1405, 09/2019, Volume 17, Issue 9, pp. 1109 - 1133
Small bowel adenocarcinoma (SBA) is a rare malignancy of the gastrointestinal tract that has increased in incidence across recent years. Often diagnosed at an... 
DOUBLE-BALLOON ENTEROSCOPY | LYNCH-SYNDROME | CYTOREDUCTIVE SURGERY | ONCOLOGY | PEUTZ-JEGHERS-SYNDROME | COLORECTAL-CANCER SURVIVORS | QUALITY-OF-LIFE | HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY | MICROSATELLITE-INSTABILITY | HELICAL CT-ENTEROCLYSIS | CAPSULE ENDOSCOPY
Journal Article
World Chinese Journal of Digestology, ISSN 1009-3079, 2015, Volume 23, Issue 2, pp. 332 - 337
Journal Article
The American Journal of Surgical Pathology, ISSN 0147-5185, 11/2015, Volume 39, Issue 11, pp. 1449 - 1457
Journal Article
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, ISSN 1542-3565, 07/2014, Volume 12, Issue 7, pp. 1059 - 1068
Although 30% of individuals diagnosed with colorectal cancer (CRC) report a family history of the disease, only 5% to 6% carry germline mutations in genes... 
COLORECTAL-CANCER RISK | LYNCH-SYNDROME | Genetic Testing | Lynch Syndrome | PEUTZ-JEGHERS-SYNDROME | MUTATION CARRIERS | Colorectal Cancer | Genetic Counseling | HEREDITARY | RECOMMENDATIONS | GERMLINE MUTATIONS | FAMILIAL COLON-CANCER | SESSILE SERRATED ADENOMAS | GASTROENTEROLOGY & HEPATOLOGY | HYPERPLASTIC POLYPOSIS SYNDROME
Journal Article