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Journal of Investigative Dermatology, ISSN 0022-202X, 04/2018, Volume 138, Issue 4, pp. 979 - 981
Journal Article
Oncotarget, ISSN 1949-2553, 10/2018, Volume 9, Issue 79, p. 34996
As a multi-kinase inhibitor, sorafenib is beneficial in around 30% of hepatocellular carcinoma (HCC) patients; however, HCC patients develop acquired drug... 
Journal Article
Blood, ISSN 0006-4971, 03/2017, Volume 129, Issue 9, pp. 1113 - 1123
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy caused by the accumulation of genomic lesions that affect the development of T cells.... 
PATHWAY ACTIVATION | CLONAL SELECTION | ACUTE LYMPHOBLASTIC-LEUKEMIA | SECRETASE INHIBITOR PF-03084014 | TUMOR-SUPPRESSOR | OF-FUNCTION MUTATIONS | CELL LEUKEMIA | HEMATOLOGY | CHILDRENS ONCOLOGY GROUP | ACTIVATING MUTATIONS | SIGNATURES DEFINE | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Humans
Journal Article
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 05/2019, Volume 294, Issue 21, pp. 8543 - 8554
Prostate cancer is the second leading cause of cancer death among men in the United States. The androgen receptor (AR) antagonist enzalutamide is a Food and... 
PF-03084014 | Notch pathway | anticancer drug | DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOCETAXEL | ADAM | prostate cancer | androgen receptor | STEM-LIKE CELLS | INHIBITION | Notch1 | PATHWAY | drug resistance | CASTRATION-RESISTANT | EXPRESSION | enzalutamide | Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 12/2018, Volume 379, Issue 25, pp. 2417 - 2428
Journal Article
by Shao, FY and Sun, H and Deng, CX
ONCOTARGET, ISSN 1949-2553, 09/2017, Volume 8, Issue 42, pp. 73329 - 73344
Triple-negative breast cancer (TNBC) is an aggressive subgroup of human breast cancer, which is characterized as estrogen receptor (ER) negative, progesterone... 
MOLECULAR SUBTYPES | MAMMARY STEM-CELLS | OPEN-LABEL | PRECISION MEDICINE | CELL BIOLOGY | TNBC subtype | TUMOR-INFILTRATING LYMPHOCYTES | cancer therapy | NEOADJUVANT CHEMOTHERAPY | RANDOMIZED PHASE-II | SECRETASE INHIBITOR PF-03084014 | STEM/PROGENITOR CELLS | drug resistance | cancer targets | HOMOLOGOUS RECOMBINATION | CSCs
Journal Article
Cancer, ISSN 0008-543X, 11/2015, Volume 121, Issue 22, pp. 3933 - 3937
The biology of inhibiting Notch and potentially other targets of -secretase in desmoid tumors is examined. 
PF-03084014 | CELLS | FIBROMATOSIS | ONCOLOGY | SARCOMA | TISSUE | TUMORS | CD44 | Signal Transduction - physiology | Receptors, Notch - antagonists & inhibitors | Humans | Fibromatosis, Aggressive - drug therapy
Journal Article
Journal Article
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, ISSN 1756-9966, 11/2019, Volume 38, Issue 1, pp. 1 - 15
Background NOTCH1 gene mutations in mantle cell lymphoma (MCL) have been described in about 5-10% of cases and are associated with significantly shorter... 
PROTEIN | T-CELL | CANCER | Delta-like ligand | DLL4 | Angiogenesis | B-CELL | ONCOLOGY | Notch1 | Mantle cell lymphoma | OMP-52 M51 | SECRETASE INHIBITOR PF-03084014 | MUTATIONS | LEUKEMIA CELLS | PHASE-I | OMP-52 M51
Journal Article
Annals of Surgical Oncology, ISSN 1068-9265, 06/2018, Volume 25, Issue 6, pp. 1544 - 1554
Journal Article
Cancer Letters, ISSN 0304-3835, 2013, Volume 335, Issue 1, pp. 41 - 51
Highlights ► Pancreatic cancer is a devastating disease with an extremely poor life expectancy. ► We investigated the efficacy of Notch signaling pathway... 
Hematology, Oncology and Palliative Medicine | PF-03084014 | Gamma-secretase inhibitor | Pancreatic cancer | Notch | INITIATING CELLS | STEM-CELLS | ACTIVATION | DOWN-REGULATION | COMBINATION | GEMCITABINE | ONCOLOGY | GROWTH | RESISTANCE | Carcinoma, Pancreatic Ductal - secondary | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Receptors, Notch - metabolism | Humans | Lung Neoplasms - metabolism | Carcinoma, Pancreatic Ductal - metabolism | Valine - administration & dosage | Molecular Targeted Therapy | Antigens, CD - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Pancreatic Neoplasms - drug therapy | Receptors, Notch - antagonists & inhibitors | Lung Neoplasms - secondary | Neoplastic Stem Cells - metabolism | Tetrahydronaphthalenes - administration & dosage | Female | Tumor Cells, Cultured | Liver Neoplasms - secondary | Liver Neoplasms - prevention & control | Deoxycytidine - administration & dosage | Pancreatic Neoplasms - pathology | Valine - analogs & derivatives | Disease Progression | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Lung Neoplasms - prevention & control | Signal Transduction - drug effects | Tumor Burden - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Liver Neoplasms - metabolism | Cell Proliferation - drug effects | Mice | Deoxycytidine - analogs & derivatives | Studies | Medical prognosis | Stem cells | Clinical trials | Metastasis | Laboratory animals | Drug dosages | Cancer therapies | Patients | Tumors | Apoptosis | pancreatic cancer | gamma-secretase inhibitor
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 3340 - 12
Journal Article