X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
glycolysis (125) 125
pfkfb3 (120) 120
index medicus (108) 108
humans (83) 83
metabolism (66) 66
animals (56) 56
phosphofructokinase-2 - metabolism (55) 55
expression (53) 53
biochemistry & molecular biology (51) 51
cancer (46) 46
6-phosphofructo-2-kinase (40) 40
cell biology (37) 37
fructose 2,6-bisphosphate (33) 33
fructose (32) 32
hypoxia (32) 32
phosphofructokinase-2 - genetics (32) 32
oncology (31) 31
inhibition (30) 30
cell line, tumor (29) 29
proliferation (29) 29
6-phosphofructo-2-kinase pfkfb3 (28) 28
glucose metabolism (28) 28
growth (28) 28
mice (28) 28
phosphorylation (28) 28
glucose-metabolism (27) 27
angiogenesis (26) 26
apoptosis (26) 26
cell proliferation (26) 26
enzymes (25) 25
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (23) 23
kinases (22) 22
glucose (21) 21
physiological aspects (21) 21
phosphofructokinase-2 - antagonists & inhibitors (20) 20
glucose - metabolism (19) 19
inflammation (19) 19
biophysics (17) 17
analysis (16) 16
endothelial cells (16) 16
female (16) 16
pfkfb3 gene (16) 16
signal transduction (16) 16
activation (15) 15
aerobic glycolysis (15) 15
tumors (15) 15
gene (14) 14
glycolysis - drug effects (14) 14
oxidative stress (14) 14
health aspects (13) 13
metastasis (13) 13
gene expression (12) 12
gene-expression (12) 12
neoplasms - metabolism (12) 12
phosphofructokinase (12) 12
antineoplastic agents - pharmacology (11) 11
cell cycle (11) 11
cell growth (11) 11
cell proliferation - drug effects (11) 11
development and progression (11) 11
dextrose (11) 11
endothelium (11) 11
gene expression regulation, neoplastic (11) 11
proteins (11) 11
research (11) 11
activated protein-kinase (10) 10
article (10) 10
cancer-cells (10) 10
cell metabolism (10) 10
chemotherapy (10) 10
gene expression regulation, enzymologic (10) 10
glutamine (10) 10
immunology (10) 10
neoplasms - pathology (10) 10
pharmacology & pharmacy (10) 10
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene pfkfb3 (9) 9
apoptosis - drug effects (9) 9
breast cancer (9) 9
cells, cultured (9) 9
enzyme inhibitors - pharmacology (9) 9
fructose-2,6-bisphosphatase (9) 9
glycolysis - genetics (9) 9
hematology (9) 9
inhibitors (9) 9
lactates (9) 9
male (9) 9
neurosciences (9) 9
survival (9) 9
autophagy (8) 8
cell line (8) 8
cells (8) 8
endothelial cells - metabolism (8) 8
glycolysis - physiology (8) 8
lactic acid (8) 8
medicine, research & experimental (8) 8
pathway (8) 8
pentose phosphate pathway (8) 8
pfkfb4 (8) 8
research paper (8) 8
vascular endothelial growth factor (8) 8
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Oncotarget, ISSN 1949-2553, 09/2017, Volume 8, Issue 37, pp. 62793 - 62802
6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatases (PFKFBs) are bifunctional enzymes which regulate the transformation between fructose-2, 6-bisphosphate... 
Glycolysis | Hematologic malignancies | PFKFB3 | Solid tumors | Autophagy | autophagy | glycolysis | 6-PHOSPHOFRUCTO-2-KINASE PFKFB3 | CELL-GROWTH | 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE GENE PFKFB3 | HYPOXIA | solid tumors | CELL BIOLOGY | hematologic malignancies | INHIBITION | GLUCOSE-METABOLISM | FRUCTOSE 2,6-BISPHOSPHATE | ENERGY-METABOLISM | TUMOR-GROWTH | EXPRESSION
Journal Article
Expert Opinion on Therapeutic Targets, ISSN 1472-8222, 08/2018, Volume 22, Issue 8, pp. 659 - 674
Journal Article
Journal of Neuropathology & Experimental Neurology, ISSN 0022-3069, 08/2019, Volume 78, Issue 9, pp. 865 - 870
A hallmark of glioblastoma is the high level of aerobic glycolysis. PFKFB3 and PFKFB4 are regulatory glycolytic enzymes, which are overexpressed in... 
PFKFB4 | PFKFB3 | Glioblastoma | 6-PHOSPHOFRUCTO-2-KINASE PFKFB3 | PROLIFERATION | PATHOLOGY | Survival | TUMORS | LOCUS | NEUROSCIENCES | CLINICAL NEUROLOGY | METABOLISM | Loss of heterozygosity | Glycolysis | EXPRESSION
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2019, Volume 513, Issue 3, pp. 642 - 650
Hepatocellular carcinoma (HCC) is a prevalent malignancy with increasing incidence and extremely poor prognosis worldwide. The multi-kinase inhibitor sorafenib... 
Hepatocellular carcinoma | Sorafenib resistance | HIF-1α | PFKFB3 | Positive feedback loop | HIF-1 alpha | METASTASIS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | GLYCOLYSIS | INHIBITION | BIOPHYSICS | GLUCOSE-METABOLISM | ENDOTHELIUM | TARGETING PFKFB3 | HIF-1-ALPHA | EXPRESSION
Journal Article
Atherosclerosis, ISSN 0021-9150, 08/2018, Volume 275, pp. e127 - e127
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 2019, Volume 10, Issue 4, pp. 577 - 583
Human endothelial cells (ECs) have been employed to monitor the protein changes induced' by [3-(3-pyridiny1)-1-(4-pyridiny1)-2-propen-1-one] (3PO), a compound... 
mass spectrometry | 3PO | Quantitative proteomics | cell pathway modulation | inflammation | PFKFB3 inhibitor | CHEMISTRY, MEDICINAL | PFKFB3 | ENDOTHELIAL DYSFUNCTION | ANGIOGENESIS | RISK | MODEL | GLYCOLYSIS | INHIBITION | FREE QUANTIFICATION | NORMALIZATION
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 46, pp. 80909 - 80922
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3), is a critical enzyme for glycolysis and highly expressed in cancer cells. It plays an... 
Glycolysis | AMPK | Nuclear localization | PFKFB3 | Autophagy | CANCER-CELLS | autophagy | ACTIVATED PROTEIN-KINASE | MECHANISM | PHOSPHORYLATION | glycolysis | 6-PHOSPHOFRUCTO-2-KINASE PFKFB3 | METABOLIC REQUIREMENTS | CELL-PROLIFERATION | CELL BIOLOGY | CROSS-TALK | MONITORING AUTOPHAGY | nuclear localization
Journal Article
Chinese Journal of Cancer Prevention and Treatment, ISSN 1673-5269, 02/2018, Volume 25, Issue 4, pp. 250 - 257
Journal Article
Journal Article
Open Biology, ISSN 2046-2441, 2017, Volume 7, Issue 12, p. 170219
Endothelial cell (EC) metabolism has lately emerged as a novel and promising therapeutic target to block vascular dysregulation associated with diseases like... 
Angiogenesis | ASNS | CPT1a | Endothelial cell metabolism | GLS1 | PFKFB3 | VASCULAR DEVELOPMENT | FORKHEAD TRANSCRIPTION FACTOR | HUMAN ASPARAGINE SYNTHETASE | GLUTAMINE | angiogenesis | BIOCHEMISTRY & MOLECULAR BIOLOGY | PFKFB3 BLOCKADE | PROLIFERATION | endothelial cell metabolism | CANCER | FATTY-ACID | AEROBIC GLYCOLYSIS | MOLECULAR-MECHANISMS
Journal Article
International Journal of Cancer, ISSN 0020-7136, 01/2019, Volume 144, Issue 1, pp. 178 - 189
Metabolic alterations are increasingly recognized as important novel anti‐cancer targets. Among several regulators of metabolic alterations, fructose 2,6... 
lipid droplet | PFKFB3 | ovarian and cervical cancer | lipophagy | Chemoresistance | CELLS | APOPTOSIS | PHOSPHORYLATION | 6-PHOSPHOFRUCTO-2-KINASE PFKFB3 | OVARIAN-CANCER | AUTOPHAGY | ONCOLOGY | RESISTANCE | HSULF-1 | LIPID DROPLETS | ADIPOSE-TISSUE | Lipid Droplets - drug effects | Apoptosis - drug effects | Humans | Enzyme Inhibitors - pharmacology | Ovarian Neoplasms - pathology | Phosphofructokinase-2 - antagonists & inhibitors | Carboplatin - administration & dosage | Glycolysis - drug effects | Autophagy - drug effects | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Phosphofructokinase-2 - metabolism | Mice, Nude | Cell Line, Tumor | Female | Ovarian Neoplasms - metabolism | Lipid Droplets - metabolism | Paclitaxel - administration & dosage | Ovarian Neoplasms - drug therapy | Drug Resistance, Neoplasm - drug effects | Antimitotic agents | Care and treatment | Antineoplastic agents | Health aspects | Analysis | Cancer | Regulators | Immunoprecipitation | Bafilomycin A | Lipids | Metabolism | Fructose | Metastases | Proteins | Alterations | Chemotherapy | Transmission electron microscopy | Inhibitors | Paclitaxel | Weight reduction | Glycolysis | Carboplatin | Lactic acid | Immunofluorescence | Ascites | Tumors | Apoptosis | Cancer Therapy and Prevention
Journal Article
Cancer research, ISSN 0008-5472, 8/2018, Volume 78, Issue 16, pp. 4524 - 4532
Long non-coding RNA (lncRNA) have yet to be linked to cancer metabolism. Here we report that upregulation of the lncRNA LINC00538 (YIYA) promotes glycolysis,... 
Glycolysis | Glucose metabolism | long non-coding RNA | CDK6 | PFKFB3 | Fructose Bisphosphatase 2
Journal Article
International Journal of Oncology, ISSN 1019-6439, 03/2018, Volume 52, Issue 3, pp. 945 - 954
6-Phosphofructo 2-kinase/fructose 2, 6-bisphos-phatase 3 (PFKFB3) has been reported to be overexpressed in human cancer tissues and to promote the... 
Angiogenesis | Breast cancer | PFKFB3 | Prognosis | CELL GLYCOLYSIS | THERAPEUTIC STRATEGY | angiogenesis | 6-PHOSPHOFRUCTO-2-KINASE PFKFB3 | breast cancer | prognosis | OVEREXPRESSION | ONCOLOGY | GLUCOSE-METABOLISM | CDK INHIBITOR P27 | GROWTH | GENE-EXPRESSION | TUMOR-ASSOCIATED MACROPHAGES | 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE
Journal Article
Experimental Cell Research, ISSN 0014-4827, 12/2019, Volume 385, Issue 2, p. 111689
Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) are widely involved in cell... 
Ubiquitination | PFKFB3 | Proliferation | ROCK2 | Migration | Invasion | KINASE | BETA-CATENIN | CELL BIOLOGY | HEPATOCELLULAR-CARCINOMA | INHIBITION | ONCOLOGY | CELL-MIGRATION | EXPRESSION
Journal Article
International Journal of Cancer, ISSN 0020-7136, 09/2019, Volume 145, Issue 5, pp. 1358 - 1370
Tumor angiogenesis is critical for tumor progression as the new blood vessels supply nutrients and facilitate metastasis. Previous studies indicate tumor... 
lymphotoxin | PFKFB3 | NF‐κB | angiogenesis | glycolysis | NF-κB | HEAD | HOMEOSTASIS | 6-PHOSPHOFRUCTO-2-KINASE PFKFB3 | CANCER | TNF | NF-kappa B | ONCOLOGY | INFLAMMATION | ENDOTHELIAL-CELLS | GROWTH | LYMPHANGIOGENESIS | T-CELLS | Human Umbilical Vein Endothelial Cells | Immunohistochemistry | Squamous Cell Carcinoma of Head and Neck - metabolism | Up-Regulation | Coculture Techniques | Humans | Squamous Cell Carcinoma of Head and Neck - pathology | Lymphotoxin-alpha - metabolism | RNA, Messenger - metabolism | Lymphotoxin-alpha - biosynthesis | Head and Neck Neoplasms - metabolism | Neovascularization, Pathologic - pathology | Lymphotoxin-alpha - genetics | Heterografts | Lymphocytes, Tumor-Infiltrating | T-Lymphocytes - metabolism | Squamous Cell Carcinoma of Head and Neck - blood supply | Female | B-Lymphocytes - metabolism | RNA, Messenger - genetics | Head and Neck Neoplasms - pathology | Head and Neck Neoplasms - blood supply | Animals | Phosphofructokinase-2 - metabolism | Mice, Nude | Cell Cycle - physiology | Glycolysis | Mice | Mice, Inbred BALB C | Neovascularization, Pathologic - metabolism | Lymphotoxin | Cell proliferation | Tumor necrosis factor receptors | Leukocyte migration | Xenotransplantation | Lymphocytes T | Density | Blood | Metastases | Angiogenesis | Signal transduction | Lymphocytes | Xenografts | Nutrients | Squamous cell carcinoma | Tumor cells | Blood vessels | Pharmacology | Endothelial cells | Lymphocytes B | Head and neck cancer | Infiltration | Umbilical vein | Cell migration | Tumors
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2013, Volume 452, Issue 3, pp. 531 - 543
Journal Article