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BBA - Proteins and Proteomics, ISSN 1570-9639, 2010, Volume 1804, Issue 8, pp. 1676 - 1683
Mammals possess an intricate regulatory system for controlling flux through fuel utilization pathways in response to the dietary availability of particular... 
GCN5 | PGC-1α | Sirt1 | Acetylation
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 07/2019, Volume 115, p. 108930
Backgroud Icariin, a major bioactive pharmaceutical component of the Chinese herbal medicine Epimedii Herba, has demonstrated lipid-lowering and anti-obesity... 
FNDC5 | Icariin | Irisin | AMPK | PGC-1α
Journal Article
Journal of Physiology and Pharmacology, ISSN 0867-5910, 12/2008, Volume 59, Issue 7, pp. 5 - 18
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2013, Volume 430, Issue 2, pp. 653 - 658
► p21 HCT116 cells exhibited an increase in mitochondrial mass. ► The expression levels of PGC-1α and AMPK were upregulated in p21 HCT116 cells. ► The... 
AMPK | Mitochondria | PGC-1α | p21 | P21
Journal Article
Neuropharmacology, ISSN 0028-3908, 12/2019, Volume 160, p. 107755
Poly(ADP-ribose) polymerase-1 (PARP1) is a ubiquitous nuclear enzyme that regulates DNA repair and genomic stability. In oxidative genotoxic conditions, PARP1... 
NAD | TFAM | PARP | PGC-1α | SIRT1 | NRF-1
Journal Article
Pharmacological Research, ISSN 1043-6618, 10/2019, Volume 148, p. 104414
Atherosclerosis (AS) is one of the major causes leading to mortality of dysfunctional cardiovascular events in the menopausal women, which has long-term... 
Postmenopausal atherosclerosis | Dioscin | PGC-1α | ERα | Autophagy
Journal Article
Phytomedicine, ISSN 0944-7113, 11/2019, Volume 64, p. 153074
Although the results of our and other studies show that baicalin can enhance glucose uptake and insulin sensitivity in skeletal muscle and adipocytes of mice,... 
Hyperglycemia | PGC-1α | p38 MAPK | Baicalin | Gluconeogenesis
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2018, Volume 500, Issue 4, pp. 952 - 957
Impairment of mitochondrial biogenesis has been associated with vascular pathophysiology. The G-protein–coupled receptor (TGR5) is an important mediator of... 
TGR5 | PGC-1α | Mitochondrial biogenesis | CREB | Endothelial cells
Journal Article
ISSN 0925-4439, 2018
Parkinson's disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantia nigra compacta (SNc). Although mitochondrial... 
Mitochondrial fusion | Mfn2 | PGC-1α | Parkinson's disease | MitoQ
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 07/2011, Volume 301, Issue 1, pp. G119 - G127
Journal Article
Biological psychiatry, ISSN 0006-3223, 4/2017, Volume 81, Issue 7, pp. 564 - 572
Journal Article
Science and Sports, ISSN 0765-1597, 04/2017, Volume 32, Issue 2, pp. 82 - 90
Objectives This study aims to determine the effects of 10 weeks of high intensity interval training besides green tea supplementation on Sirtuin-1 (SIRT1) and... 
Catechins | PGC-1α | HIIT | SRIT1
Journal Article
04/2011
The importance of dietary fat in the expression of multiple genes is clear. In the case of beef cattle, lipid in the form of fatty acids (saturated or... 
beef cattle | dietary fat | Metabolismo energético, PGC-1?, grasa dietaria, bovinos de engorda | PGC-1α | energy metabolism
Web Resource
Pharmacological Reports, ISSN 1734-1140, 10/2018, Volume 70, Issue 5, pp. 988 - 992
Parkinson’s disease (PD) is a progressive neurodegenerative process leading to the loss of dopaminergic neurons and their projections.... 
PGC-1α | MPTP | PEPCK | Parkinson’s disease | Octanoic acid
Journal Article
Nephrology, ISSN 1320-5358, 2019
Muscle weakness is commonly among chronic kidney disease (CKD) patients. Muscle mitochondrial dysfunction and decreased pyruvate dehydrogenase (PDH) activity... 
pyruvate dehydrogenase | PGC-1Α | handgrip strength | MFN-1 | DRP1
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 07/2019, Volume 854, pp. 328 - 337
Cancer metabolism is an attractive target of the therapeutic strategy for cancer. The present study identified bouchardatine ( ) as a potent suppressor of... 
Energy metabolism | PGC-1α | Bouchardatine | SIRT1 | UCP2 | REGULATOR | PGC-1 alpha | LACTATE | PHARMACOLOGY & PHARMACY | UNCOUPLING PROTEIN-2
Journal Article
Journal of Experimental Biology, ISSN 0022-0949, 2019, Volume 222, Issue 10, p. jeb198424
The hypothalamus controls metabolism and feeding behaviour via several signals with other tissues. Exercise and supplements can change hypothalamic signalling... 
HMB supplement | Exercise | Muscle strength | Energy homeostasis | Hypothalamus | Tissue crosstalk | PGC-1α signalling pathway
Journal Article
Pharmacological Research, ISSN 1043-6618, 09/2019, Volume 147, p. 104381
The Mitochondrial-derived peptide MOTS-c has recently been reported as a 16-amino acid peptide regulating metabolism and homeostasis in different cells.... 
NF-κ B | MOTS-c | inflammation | ROS | AMPK | osteoclast | PGC-1 α | osteolysis
Journal Article
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