X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (1500) 1500
pgc-1-alpha (1391) 1391
animals (1051) 1051
humans (751) 751
mice (686) 686
male (614) 614
metabolism (519) 519
biochemistry & molecular biology (442) 442
mitochondria (438) 438
cell biology (432) 432
exercise (415) 415
skeletal-muscle (409) 409
peroxisome proliferator-activated receptor gamma coactivator 1-alpha (405) 405
expression (400) 400
mitochondrial biogenesis (382) 382
physiology (370) 370
muscle, skeletal - metabolism (339) 339
gene expression (323) 323
gene-expression (320) 320
endocrinology & metabolism (318) 318
oxidative stress (291) 291
transcription factors - metabolism (286) 286
physiological aspects (275) 275
mitochondria - metabolism (273) 273
muscles (273) 273
rats (259) 259
transcriptional coactivator pgc-1-alpha (256) 256
skeletal muscle (243) 243
female (242) 242
proteins (238) 238
transcription factors - genetics (231) 231
mice, inbred c57bl (230) 230
activation (229) 229
rodents (223) 223
insulin-resistance (216) 216
biosynthesis (209) 209
obesity (203) 203
phosphorylation (200) 200
article (195) 195
musculoskeletal system (194) 194
pgc-1 alpha (193) 193
pgc-1α (192) 192
sirt1 (187) 187
glucose (186) 186
research (181) 181
transcription factors (177) 177
signal transduction (175) 175
activated protein-kinase (170) 170
insulin resistance (163) 163
multidisciplinary sciences (158) 158
gene expression regulation (155) 155
energy metabolism (154) 154
mitochondrial dna (154) 154
mice, knockout (150) 150
energy-metabolism (147) 147
transcription (147) 147
neurosciences (141) 141
adult (137) 137
cells (137) 137
apoptosis (136) 136
human skeletal-muscle (136) 136
transcriptional coactivator (135) 135
research article (134) 134
genes (133) 133
pgc-1 (133) 133
disease (131) 131
analysis (130) 130
cells, cultured (129) 129
dysfunction (128) 128
cell line (127) 127
diabetes (126) 126
fatty-acid oxidation (126) 126
muscle (126) 126
homeostasis (125) 125
biology (124) 124
biogenesis (123) 123
medicine (123) 123
ampk (122) 122
medicine, research & experimental (121) 121
pharmacology & pharmacy (121) 121
rna, messenger - metabolism (119) 119
sirtuin 1 - metabolism (119) 119
health aspects (117) 117
genetic aspects (116) 116
liver (115) 115
disease models, animal (114) 114
kinases (114) 114
sport sciences (111) 111
mitochondria - drug effects (110) 110
amp-activated protein kinases - metabolism (108) 108
inflammation (107) 107
fatty acids (106) 106
insulin (104) 104
genetics & heredity (97) 97
middle aged (97) 97
oxidation-reduction (97) 97
peroxisome proliferator-activated receptor gamma coactivator 1-alpha - metabolism (97) 97
science (95) 95
nutrition & dietetics (94) 94
rats, sprague-dawley (94) 94
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Biological Chemistry, ISSN 0021-9258, 03/2011, Volume 286, Issue 12, pp. 10605 - 10617
Journal Article
CELL METABOLISM, ISSN 1550-4131, 05/2015, Volume 21, Issue 5, pp. 731 - 738
"Browning,'' the appearance and activation of brown-in-white (brite) adipose cells within inguinal white adipose tissue (iWAT), and induction of uncoupling... 
THERMOGENESIS | OBESITY | PROTEIN | METABOLISM | PGC-1-ALPHA | ENDOCRINOLOGY & METABOLISM | UCP1 | EXPRESSION | CELL BIOLOGY
Journal Article
DIABETES, ISSN 0012-1797, 05/2014, Volume 63, Issue 5, pp. 1605 - 1611
Abnormal conditions during early development adversely affect later health. We investigated whether maternal exercise could protect offspring from adverse... 
OBESITY | DNA METHYLATION | PGC-1-ALPHA | ENDOCRINOLOGY & METABOLISM | RATS | RECEPTOR | INSULIN SENSITIVITY
Journal Article
ACTA PHYSIOLOGICA, ISSN 1748-1708, 06/2017, Volume 220, Issue 2, pp. 181 - 183
Journal Article
by Liu, C and Li, SM and Liu, TH and Borjigin, J and Lin, JD
NATURE, ISSN 0028-0836, 05/2007, Volume 447, Issue 7143, pp. 477 - U4
The mammalian clock regulates major aspects of energy metabolism, including glucose and lipid homeostasis and mitochondrial oxidative metabolism(1,2). The... 
CELLS | GLUCOSE-HOMEOSTASIS | RHYTHMS | OSCILLATORS | PGC-1-ALPHA | MULTIDISCIPLINARY SCIENCES | LIVER | COMPONENT | MICE | CONTROLLING MITOCHONDRIAL BIOGENESIS | CIRCADIAN GENE-EXPRESSION
Journal Article
Nature, ISSN 0028-0836, 07/2008, Volume 454, Issue 7203, pp. 463 - 469
Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional... 
SKELETAL-MUSCLE | OXIDATIVE-PHOSPHORYLATION | TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA | METABOLIC SYNDROME | ANTIOXIDANT DEFENSE | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | NECROSIS-FACTOR-ALPHA | PHYSICAL-ACTIVITY | MUSCLE FIBER-TYPE | PARKINSONS-DISEASE
Journal Article
Rapid Communications in Mass Spectrometry, ISSN 0951-4198, 03/2018, Volume 32, Issue 6, pp. 480 - 488
Rationale: A novel benzimidazole compound ZLN005 was previously identified as a transcriptional activator of peroxisome proliferator-activated receptor.... 
ELUCIDATION | CHEMISTRY, ANALYTICAL | SPECTROSCOPY | PGC-1-ALPHA | ENZYMES | BIOCHEMICAL RESEARCH METHODS | SIRT1
Journal Article
ENDOCRINE REVIEWS, ISSN 0163-769X, 12/2006, Volume 27, Issue 7, pp. 728 - 735
Many biological programs are regulated at the transcriptional level. This is generally achieved by the concerted actions of several transcription factors.... 
HEPATIC GLUCONEOGENESIS | SKELETAL-MUSCLE | OXIDATIVE-PHOSPHORYLATION | MITOCHONDRIAL BIOGENESIS | INSULIN-RESISTANCE | PROTEIN-KINASE | ADAPTIVE THERMOGENESIS | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | TRANSCRIPTIONAL COACTIVATOR | PGC-1-ALPHA EXPRESSION
Journal Article
Immunity, ISSN 1074-7613, 08/2016, Volume 45, Issue 2, pp. 374 - 388
Although tumor-specific T cells recognize cancer cells, they are often rendered dysfunctional due to an immunosuppressive microenvironment. Here we showed that... 
PGC-1-ALPHA | INFLAMMATION | TRANSCRIPTION | IMMUNOLOGY | NF-KAPPA-B | CANCER | EXPRESSION | PD-1 | EXHAUSTION | LYMPHOCYTES | COACTIVATORS | Biosynthesis | T cells | Cells | Cancer | Antigens | Medical research | Flow cytometry | Cytokines | Cytotoxicity | Kinases | Metabolism | Experiments | Genotype & phenotype | Mitochondria | Microscopy | Lymphocytes | Oxidation | Immune system | Tumors | Index Medicus
Journal Article
Pharmacological Research, ISSN 1043-6618, 01/2016, Volume 103, pp. 158 - 166
Exercise and diet are powerful interventions to prevent and ameliorate various pathologies. The development of pharmacological agents that confer exercise- or... 
Exercise | Diet | Mimetics | Resveratrol | AMPK | PGC-1α | PPARβ/δ | Skeletal muscle | Caloric restriction | PPAR beta/delta | 1-ALPHA PGC-1-ALPHA | LIFE-SPAN | TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA | MUSCLE MITOCHONDRIAL-FUNCTION | PGC-1 alpha | SKELETAL-MUSCLE | CARDIOVASCULAR HEALTH | GLUCOSE-HOMEOSTASIS | FATTY-ACID OXIDATION | REV-ERB-ALPHA | PHARMACOLOGY & PHARMACY | SMALL-MOLECULE ACTIVATORS
Journal Article
PLOS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6
Peroxisome proliferator-activated receptor (PPAR). coactivator 1a (PGC-1a) is a coactivator of various nuclear receptors and other transcription factors whose... 
COACTIVATOR 1-ALPHA PGC-1-ALPHA | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | INCREASES | TRANSCRIPTIONAL COACTIVATOR | IONIZATION MASS-SPECTROMETRY | EXERCISE METABOLISM
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2019, Volume 62, Issue 12, pp. 5844 - 5862
The NAD(+)-dependent deacetylase SIRT2 represents an attractive target for drug development. Here, we designed and synthesized drug-like SIRT2-selective... 
GLUCOSE-HOMEOSTASIS | ACTIVATION | CHEMISTRY, MEDICINAL | PROTEIN | HISTONE DEACETYLASE SIRT6 | ACETYLATION | PGC-1-ALPHA | CHROMAN-4-ONE | TUMOR-SUPPRESSOR | CANCER | PROMOTES
Journal Article
JOURNAL OF PHYSIOLOGY-LONDON, ISSN 0022-3751, 05/2010, Volume 588, Issue 10, pp. 1779 - 1790
Skeletal muscle contraction increases intracellular ATP turnover, calcium flux, and mechanical stress, initiating signal transduction pathways that modulate... 
PHYSIOLOGY | ENERGY-EXPENDITURE | MITOCHONDRIAL BIOGENESIS | ERR-ALPHA | PROTEIN-KINASE | GENE-EXPRESSION | METABOLIC ADAPTATIONS | GAMMA COACTIVATOR-1-ALPHA | PGC-1-ALPHA TRANSCRIPTION | TRANSCRIPTION FACTOR | NEUROSCIENCES | HISTONE DEACETYLASE-5
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 06/2019, Volume 10
The coactivator PGC-1 alpha 1 is activated by exercise training in skeletal muscle and promotes fatigue-resistance. In exercised muscle, PGC-1 alpha 1 enhances... 
TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA | ACID | INHIBITION | MESSENGER-RNA | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIA | DISEASE | EXPRESSION | EXERCISE | SHUTTLE
Journal Article
Cell Metabolism, ISSN 1550-4131, 09/2008, Volume 8, Issue 3, pp. 249 - 256
Neuromuscular disorders with defects in the mitochondrial ATP-generating system affect a large number of children and adults worldwide, but remain without... 
HUMDISEASE | CELLS | TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA | LACKING | RECEPTOR-GAMMA | BIOGENESIS | ERR-ALPHA | C-OXIDASE DEFICIENCY | DNA | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | MUSCLE | CELL BIOLOGY
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2009, Volume 284, Issue 21, pp. 14476 - 14484
Oxidative stress is a hallmark of metabolism-related diseases and a risk factor for atherosclerosis. FoxO factors have been shown to play a key role in... 
REGULATOR | TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA | ACTIVATION | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTHELIAL-CELLS | INVOLVEMENT | NEURODEGENERATION | DYSFUNCTION | EXPRESSION | FORKHEAD PROTEINS
Journal Article