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The Journal of allergy and clinical immunology, ISSN 0091-6749, 9/2014, Volume 134, Issue 3, pp. 698 - 705.e5
Journal Article
Frontiers in Physiology, ISSN 1664-042X, 09/2019, Volume 10
Endothelial dysfunction, which leads to ischemic events under atherosclerotic conditions, can be attenuated by antagonizing the thromboxane-prostanoid receptor... 
atherosclerosis | endothelium | contraction | PGI2 | relaxation | prostanoid receptors
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 08/2016, Volume 14, Issue 32, pp. 7715 - 7721
A novel formal synthesis of Beraprost (1) is described. The tricyclic cyclopent[b]benzofuran core is efficiently prepared from (-)-Corey lactone diol in 12... 
Journal Article
MOLECULAR METABOLISM, ISSN 2212-8778, 12/2014, Volume 3, Issue 9, pp. 834 - 847
Objective: Brite adipocytes are inducible energy-dissipating cells expressing UCP1 which appear within white adipose tissue of healthy adult individuals.... 
PGE2 | Polyunsaturated fatty acids | PGI2 | ENDOCRINOLOGY & METABOLISM | UCP1 | Calcium oscillation | PGF2 alpha
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2016, Volume 14, Issue 32, pp. 7715 - 7721
A novel formal synthesis of Beraprost (1) is described. The tricyclic cyclopent[b]benzofuran core is efficiently prepared from (-)-Corey lactone diol in 12... 
BENZOPROSTACYCLINS | PREPARATIVE RESOLUTION | METABOLITES | ACID | PROSTAGLANDINS | PGI2 | CHEMISTRY | CHEMISTRY, ORGANIC | PROSTACYCLIN-ANALOGS | PHENYLENE PGI DERIVATIVES
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 07/2018, Volume 351, pp. 46 - 56
Cardiac fibroblasts (CF) are key cells for maintaining extracellular matrix (ECM) protein homeostasis in the heart, and for cardiac repair through... 
Cardiac Fibroblast | PGI2 | TLR4 | Kinin Receptors | Collagen | SYSTEM | NO | ACTIVATION | MECHANISM | PROSTACYCLIN | CYTOKINE | PATHWAY | KININ B-1 RECEPTOR | GENE-EXPRESSION | LIPOPOLYSACCHARIDE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | GROWTH-FACTOR | Index Medicus
Journal Article
by Wen, Q and Lee, KO and Sim, SZ and Xu, XG and Sim, MK
EUROPEAN JOURNAL OF PHARMACOLOGY, ISSN 0014-2999, 12/2015, Volume 768, pp. 173 - 181
DAA-I (des-aspartate-angiotensin I), an endogenous angiotensin, had been shown earlier to ameliorate animal models of cardiovascular diseases via the... 
SYNTHASE | PGE2 | Prostaglandins | INTERCELLULAR-ADHESION MOLECULE-1 | Des-a spartate-angiotensin I | COX-2 | PGI2 | Losartan | ENDOTHELIAL-CELLS | HUVEC | PHARMACOLOGY & PHARMACY | EXPRESSION
Journal Article
Pharmaceutical Biology, ISSN 1388-0209, 01/2017, Volume 55, Issue 1, pp. 663 - 672
Context: Astaxanthin (ASTX) is a xanthophyll carotenoid that reduces hemostasis in hyperlipidemic organisms. Its antihemostatic mechanisms remain unclear.... 
TXA2/PGI2 balance | NO/ROS balance | Carotenoid | antioxidant activity | t-PA/PAI-1 balance | T-PA/PAI-1 balance | Antioxidant activity | OXIDATIVE STRESS | ACTIVATION | LOW-DENSITY-LIPOPROTEIN | DIABETIC-RATS | VASCULAR-DISEASE | PLANT SCIENCES | OBESE MICE | NRF2 | NITRIC-OXIDE | CARDIOVASCULAR-DISEASE | PHARMACOLOGY & PHARMACY | MEDICAL LABORATORY TECHNOLOGY | INTERVENTION | Fibrinolysis - drug effects | Hyperlipidemias - genetics | Hyperlipidemias - blood | Prothrombin Time | Male | Dose-Response Relationship, Drug | Plasminogen Activator Inhibitor 1 - metabolism | Time Factors | Diet, High-Fat | Lipids - blood | Lipid Peroxidation - drug effects | Platelet Function Tests | Platelet Aggregation Inhibitors - pharmacology | Platelet Aggregation - drug effects | Plasminogen Activator Inhibitor 1 - genetics | Disease Models, Animal | Nitric Oxide - blood | Hyperlipidemias - drug therapy | Biomarkers - blood | Nitric Oxide Synthase Type III - genetics | Rats, Sprague-Dawley | Tissue Plasminogen Activator - blood | Fibrinolytic Agents - pharmacology | Nitric Oxide Synthase Type III - blood | Animals | Blood Coagulation - drug effects | Partial Thromboplastin Time | Anticoagulants - pharmacology | Hyperlipidemias - etiology | P-Selectin - blood | Xanthophylls - pharmacology | Thromboxane B2 - blood | 6-Ketoprostaglandin F1 alpha - blood | Proteins | Blood platelets | Coronary vessels | Rodents
Journal Article
Cardiovascular and Hematological Disorders - Drug Targets, ISSN 1871-529X, 2012, Volume 12, Issue 2, pp. 98 - 105
Journal Article
Clinical Science, ISSN 0143-5221, 02/2009, Volume 116, Issue 3, pp. 219 - 230
Healthy vascular function is primarily regulated by several factors including EDRF (endothelium-dependent relaxing factor), EDCF (endothelium-dependent... 
Macrovascular circulation | Microvascular circulation | Inflammation | Nitric oxide | Tumour Necrosis factor-α (TNF-α) | Reactive oxygen species (ROS) | RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | nitric oxide | IMPROVES ENDOTHELIAL FUNCTION | SUPEROXIDE-PRODUCTION | NITRIC-OXIDE SYNTHASE | microvascular circulation | reactive oxygen species (ROS) | macrovascular circulation | tumour necrosis factor-alpha (TNF-alpha) | TUMOR-NECROSIS-FACTOR | MESSENGER-RNA | inflammation | SMOOTH-MUSCLE-CELLS | CONGESTIVE-HEART-FAILURE | NF-KAPPA-B | MARROW PROGENITOR CELLS | Dietary Fats - adverse effects | Reactive Oxygen Species - metabolism | Humans | Endothelium, Vascular - physiopathology | Vascular Diseases - physiopathology | Animals | Tumor Necrosis Factor-alpha - physiology | Stem Cells - physiology | Exercise - physiology | Dietary Carbohydrates - adverse effects | Lipid Metabolism - physiology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Aging - metabolism | EET, epoxyeicosatrienoic acid | AMI, acute myocardial infarction | eNOS, endothelial NOS | DC, dendritic cell | RA, rheumatoid arthritis | IKK, IκB kinase | TNF, tumour necrosis factor | EPC, endothelial progenitor cell | iNOS, inducible NOS | RAGE, receptor for AGEs | Review | HMG-CoA, 3-hydroxy-3-methylglutaryl-CoA | ICAM-1, intercellular adhesion molecule-1 | SCF, stem cell factor | XO, xanthine oxidase | R, ischaemia | cNOS, constitutive NOS | ZOF rat, Zucker Obese Fatty rat | ROS, reactive oxygen species | IκB, inhibitor of NF-κB | PGI2, prostacyclin | reperfusion | nNOS, neuronal NOS | NOS, NO synthase | IHD, ischaemic heart disease | O2•−, superoxide radical | NF-κB, nuclear factor κB | ONOO−, peroxynitrite | tumour necrosis factor-α (TNF-α) | HUVEC, human umbilical vein EC | VCAM-1, vascular cell adhesion molecule-1 | SK1, sphingosine kinase 1 | EDHF, endothelium-dependent hyperpolarizing factor | EC, endothelial cell | Sph1P, sphingosine-1-phosphate | IL, interleukin | t-PA, tissue plasminogen activator | ASS, argininosuccinate synthase | ACEI, angiotensin-converting enzyme inhibitor | CRP, C-reactive protein | AGE, advanced glycation end-product | HDL, high-density lipoprotein | TNFR, TNF receptor
Journal Article
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, ISSN 1044-1549, 05/2019, Volume 60, Issue 5, pp. 499 - 500
Journal Article
Vascular Pharmacology, ISSN 1537-1891, 2011, Volume 55, Issue 1, pp. 50 - 58
Activation of the trigeminal nerve terminals around cerebral and meningeal arteries is thought to be an important patho-mechanism in migraine. Vasodilatation... 
IP receptor | PGI 2 | Craniovascular system | PGI 2 receptor antagonist | Migraine | PGI2 receptor antagonist | PGI2 | GASTROINTESTINAL TOXICITY | ACTIVATION | PEPTIDE RELEASE | PROSTACYCLIN RECEPTOR | PROSTANOID RECEPTORS | ARTERIES | PGI | RELEVANCE | NITRIC-OXIDE | PGI receptor antagonist | PHARMACOLOGY & PHARMACY | ANTAGONISTS
Journal Article