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ph domain (548) 548
biochemistry & molecular biology (497) 497
animals (440) 440
humans (429) 429
cell biology (299) 299
pleckstrin homology domain (236) 236
protein structure, tertiary (214) 214
amino acid sequence (212) 212
molecular sequence data (208) 208
protein binding (179) 179
signal transduction (178) 178
mice (170) 170
activation (166) 166
phosphorylation (164) 164
proteins (158) 158
binding (151) 151
binding sites (142) 142
biophysics (136) 136
models, molecular (118) 118
crystal-structure (116) 116
pleckstrin homology domains (115) 115
sequence homology, amino acid (115) 115
ph domains (103) 103
blood proteins - chemistry (96) 96
cell line (96) 96
cell membrane - metabolism (95) 95
phosphatidylinositols - metabolism (90) 90
mutation (86) 86
phosphatidylinositol phosphates - metabolism (85) 85
plasma-membrane (79) 79
protein conformation (78) 78
research article (77) 77
phosphatidylinositol 3-kinases - metabolism (76) 76
brutons tyrosine kinase (74) 74
ph, pleckstrin homology (71) 71
lipids (70) 70
phosphoproteins (70) 70
structural basis (69) 69
identification (68) 68
beta-gamma-subunits (67) 67
cells (67) 67
recombinant fusion proteins - metabolism (67) 67
x-linked agammaglobulinemia (66) 66
kinase (65) 65
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research (65) 65
protein-tyrosine kinases - metabolism (64) 64
expression (62) 62
phosphatidylinositol 3-kinase (61) 61
akt (60) 60
cos cells (60) 60
transfection (59) 59
enzyme activation (58) 58
inositol phosphates (58) 58
phosphatidylinositol 4,5-bisphosphate (56) 56
phosphoproteins - chemistry (55) 55
rats (55) 55
membrane (54) 54
phosphoinositides (54) 54
phosphoinositide 3-kinase (52) 52
blood proteins - metabolism (51) 51
family (51) 51
protein-tyrosine kinases - genetics (51) 51
sequence alignment (51) 51
analysis (50) 50
guanine nucleotide exchange factors - metabolism (50) 50
oncology (50) 50
membrane proteins - metabolism (49) 49
ph-domain (49) 49
phosphatidylinositol 4,5-diphosphate - metabolism (49) 49
signal-transduction (49) 49
crystallography, x-ray (48) 48
protein structure, secondary (48) 48
protein-kinase-c (48) 48
phosphoproteins - metabolism (47) 47
base sequence (46) 46
endocytosis (46) 46
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signal transduction - physiology (46) 46
multidisciplinary sciences (45) 45
phosphoinositide (45) 45
receptor (45) 45
mutagenesis, site-directed (44) 44
pleckstrin (44) 44
actin (43) 43
proto-oncogene proteins c-akt - metabolism (43) 43
tyrosine kinase (43) 43
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biology (41) 41
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apoptosis (40) 40
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The Journal of cell biology, ISSN 0021-9525, 5/2001, Volume 153, Issue 4, pp. 795 - 809
We show that cells lacking two Dictyostelium class I phosphatidylinositol (PI) 3′ kinases (PI3K and pi3k1/2-null cells) or wild-type cells treated with the... 
Chemotactic factors | Phenotypes | Lymphocytes | Actins | Cell membranes | Gene expression regulation | Kinetics | Physiological regulation | Chemotaxis | Cells | Dictyostelium | Actin polymerization | PI3 kinase | PH domain | SYNTHASE KINASE-3 | PHOSPHOINOSITIDE 3-KINASE | CELL-DEATH | CELL BIOLOGY | actin polymerization | BRUTONS TYROSINE KINASE | ADENYLYL-CYCLASE | LEADING-EDGE | CHEMOATTRACTANT | MEDIATED ACTIVATION | ACTIN CYTOSKELETON | chemotaxis | Protein-Serine-Threonine Kinases | Actins - metabolism | Molecular Sequence Data | Microscopy, Video | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Protozoan Proteins - genetics | Phosphoproteins - chemistry | Chemotaxis - physiology | Protozoan Proteins - metabolism | Blood Proteins - genetics | Dictyostelium - enzymology | Protozoan Proteins - chemistry | Dictyostelium - cytology | Chromones - pharmacology | Folic Acid | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Proto-Oncogene Proteins - genetics | Blood Proteins - chemistry | Chemotaxis - drug effects | Phosphoproteins - genetics | Phosphatidylinositol 3-Kinases - genetics | Proto-Oncogene Proteins c-akt | Animals | Mutagenesis, Insertional - physiology | Polymers - metabolism | Phosphatidylinositol | Cell research | Analysis | Physiological aspects | Polymerization
Journal Article
Journal of molecular biology, ISSN 0022-2836, 2018, Volume 430, Issue 3, pp. 372 - 388
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2011, Volume 286, Issue 21, pp. 18650 - 18657
Journal Article
Biochemical journal, ISSN 0264-6021, 10/2000, Volume 351, Issue 1, pp. 19 - 31
Journal Article
Journal Article
PLoS computational biology, ISSN 1553-734X, 01/2015, Volume 11, Issue 1, p. e1004021
Journal Article
Biochemical journal, ISSN 1470-8728, 2003, Volume 375, Issue 3, pp. 531 - 538
.... It possesses an N-terminal pleckstrin homology (PH) domain that interacts with equal affinity with the second messengers PtdIns(3,4,5)P3 and PtdIns(3,4... 
Journal Article
Journal Article