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09/2000, Volume 39, Issue 3, 17
Obesity is a worldwide problem, with major health, social and economic implications. The adaptation of drug dosages to obese patients is a subject of concern,... 
Beta adrenoceptor antagonists, pharmacokinetics | Bisoprolol, pharmacokinetics | Propranolol, pharmacokinetics | Gentamicin, pharmacokinetics | Dexfenfluramine, pharmacokinetics | Clinical pharmacokinetics | Nicotine, pharmacokinetics | Sotalol, pharmacokinetics | Antineoplastics, pharmacokinetics | Remifentanil, pharmacokinetics | Antihyperglycaemics, pharmacokinetics | Vecuronium bromide, pharmacokinetics | Theophylline, pharmacokinetics | Phenytoin, pharmacokinetics | Antibacterials, pharmacokinetics | Anaesthetics, pharmacokinetics | Doxorubicin, pharmacokinetics | Propofol, pharmacokinetics | Rocuronium bromide, pharmacokinetics | Anticonvulsants, pharmacokinetics | Carbamazepine, pharmacokinetics | Nebivolol, pharmacokinetics | Obesity | Sufentanil, pharmacokinetics | Vancomycin, pharmacokinetics | Anorectics, pharmacokinetics | Neuropsychotherapeutics, pharmacokinetics | Caffeine, pharmacokinetics | Interferon alpha, pharmacokinetics | Neuromuscular blocking agents, pharmacokinetics | Antifungals, pharmacokinetics | Cyclophosphamide, pharmacokinetics | Xanthines, pharmacokinetics | Ciprofloxacin, pharmacokinetics | General anaesthesia | Glibenclamide, pharmacokinetics | Labetalol, pharmacokinetics | Busulfan, pharmacokinetics | Glipizide, pharmacokinetics | Ifosfamide, pharmacokinetics | Lithium, pharmacokinetics | Opioids, pharmacokinetics | Carboplatin, pharmacokinetics | Phenazone, pharmacokinetics | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | LEAN BODY-MASS | VANCOMYCIN | METABOLISM | NORMAL VOLUNTEERS | PHARMACOLOGY & PHARMACY | PHARMACODYNAMICS | PATIENT | CLINICAL PHARMACOKINETICS | SIGNIFICANT WEIGHT-REDUCTION | CREATININE CLEARANCE | DISPOSITION | Adrenergic beta-Antagonists - pharmacokinetics | Anesthetics - pharmacokinetics | Anticonvulsants - pharmacokinetics | Hypoglycemic Agents - pharmacokinetics | Obesity - drug therapy | Antifungal Agents - pharmacokinetics | Humans | Anti-Bacterial Agents - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Obesity - metabolism
Book Review
Clinical Pharmacokinetics, ISSN 0312-5963, 05/2000, Volume 38, Issue 5, pp. 377 - 392
Effective use of the growing number of nonsteroidal anti-inflammatory drugs (NSAIDs), a group that has recently been augmented by the introduction of the... 
Research and development | Suprofen, pharmacokinetics | Sulindac, pharmacokinetics | Mefenamic acid, pharmacokinetics | Carprofen, pharmacokinetics | Indobufen, pharmacokinetics | Ketorolac, pharmacokinetics | Pirprofen, pharmacokinetics | Celecoxib, pharmacokinetics | Oxaprozin, pharmacokinetics | Oxyphenbutazone, pharmacokinetics | Azapropazone, pharmacokinetics | Nabumetone, pharmacokinetics | Bermoprofen, pharmacokinetics | Diclofenac, pharmacokinetics | Ibuprofen, pharmacokinetics | Benoxaprofen, pharmacokinetics | Diflunisal, pharmacokinetics | Flunoxaprofen, pharmacokinetics | Ketoprofen, pharmacokinetics | Loxoprofen, pharmacokinetics | Alminoprofen, pharmacokinetics | Flobufen, pharmacokinetics | Ximoprofen, pharmacokinetics | Butibufen, pharmacokinetics | Tenoxicam, pharmacokinetics | Meloxicam, pharmacokinetics | Naproxen, pharmacokinetics | Rofecoxib, pharmacokinetics | Piroxicam, pharmacokinetics | Tiaprofenic acid, pharmacokinetics | Flurbiprofen, pharmacokinetics | Indomethacin, pharmacokinetics | Pranoprofen, pharmacokinetics | Fenoprofen, pharmacokinetics | Indoprofen, pharmacokinetics | Etodolac, pharmacokinetics | Nonsteroidal antiinflammatories, pharmacokinetics | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | RHEUMATOID-ARTHRITIS | SYNOVIAL-FLUID | HEALTHY-SUBJECTS | NAPROXEN PHARMACOKINETICS | CIRCADIAN CHANGES | ELDERLY PATIENTS | PHARMACOLOGY & PHARMACY | CLINICAL PHARMACOKINETICS | ANTIINFLAMMATORY DRUGS | INTESTINAL PERMEABILITY | PURE ENANTIOMERS | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Pharmacokinetics | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Humans | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Journal Article
2001, Volume 15, Issue 6, 26
Many psychiatric patients smoke, and are believed to be heavier smokers than those without psychiatric disorders. Cigarette smoking is one of the environmental... 
Chlordiazepoxide, pharmacokinetics | Risperidone, pharmacokinetics | Amitriptyline, pharmacokinetics | Lorazepam, pharmacokinetics | Serotonin reuptake inhibitors, pharmacokinetics | Amfebutamone, pharmacokinetics | Haloperidol, pharmacokinetics | Fluphenazine, pharmacokinetics | Diazepam, pharmacokinetics | Trazodone, pharmacokinetics | Imipramine, pharmacokinetics | Clozapine, pharmacokinetics | Trifluoperazine, pharmacokinetics | Tricyclic antidepressants, pharmacokinetics | Clomipramine, pharmacokinetics | Zotepine, pharmacokinetics | Tiotixene, pharmacokinetics | Alprazolam, pharmacokinetics | Nortriptyline, pharmacokinetics | Fluvoxamine, pharmacokinetics | Venlafaxine, pharmacokinetics | Antidepressants, pharmacokinetics | Triazolam, pharmacokinetics | Chlorpromazine, pharmacokinetics | Olanzapine, pharmacokinetics | Antipsychotics, pharmacokinetics | Anxiolytics, pharmacokinetics | Smoking | Pharmacotherapy | Neurology | Neurosciences | Medicine & Public Health | Psychiatry | Psychopharmacology | VARIABILITY FACTORS | TOBACCO SMOKING | CIGARETTE-SMOKING | REDUCED HALOPERIDOL | PSYCHIATRIC POPULATION | DEPRESSED-PATIENTS | PLASMA-CONCENTRATIONS | DRUG-INTERACTIONS | CYP1A2 GENE | PHARMACOLOGY & PHARMACY | TARDIVE-DYSKINESIA | NEUROSCIENCES | Smoking - metabolism | Animals | Drug Interactions | Mental Disorders - drug therapy | Psychotropic Drugs - pharmacokinetics | Humans | Mental Disorders - metabolism | Smoking - psychology
Book Review
Clinical Pharmacokinetics, ISSN 0312-5963, 2008, Volume 47, Issue 10, pp. 635 - 654
Journal Article
2003, Volume 42, Issue 14, 30
Modifications to bodily functions and physiology are known to occur with age. These changes can have a considerable impact on the pharmacokinetic processes of... 
Melphalan, pharmacokinetics | Vinblastine, pharmacokinetics | Cytarabine, pharmacokinetics | Antimetabolites, pharmacokinetics | Gemcitabine, pharmacodynamics | Vinca alkaloids, pharmacodynamics | Fluorouracil, pharmacokinetics | Ifosfamide, pharmacodynamics | Methotrexate, pharmacokinetics | Topotecan, pharmacodynamics | Capecitabine, pharmacodynamics | Irinotecan, pharmacokinetics | Vinca alkaloids, pharmacokinetics | Alkylating agents, pharmacokinetics | Chlorambucil, pharmacokinetics | Cyclophosphamide, pharmacodynamics | Vincristine, pharmacokinetics | Carboplatin, pharmacodynamics | Fludarabine, pharmacodynamics | Cisplatin, pharmacokinetics | Vinorelbine, pharmacodynamics | Capecitabine, pharmacokinetics | Platinum complexes, pharmacokinetics | Topotecan, pharmacokinetics | Cytarabine, pharmacodynamics | DNA topoisomerase inhibitors, pharmacodynamics | Chlorambucil, pharmacodynamics | Fluorouracil, pharmacodynamics | Fludarabine, pharmacokinetics | Cyclophosphamide, pharmacokinetics | Antimetabolites, pharmacodynamics | Gemcitabine, pharmacokinetics | Melphalan, pharmacodynamics | Oxaliplatin, pharmacokinetics | Vinblastine, pharmacodynamics | Vinorelbine, pharmacokinetics | Cisplatin, pharmacodynamics | Vincristine, pharmacodynamics | Oxaliplatin, pharmacodynamics | Irinotecan, pharmacodynamics | Ifosfamide, pharmacokinetics | Methotrexate, pharmacodynamics | Alkylating agents, pharmacodynamics | Platinum complexes, pharmacodynamics | Carboplatin, pharmacokinetics | Elderly | DNA topoisomerase inhibitors, pharmacokinetics | Cancer | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | CELL LUNG-CANCER | LEUKEMIA GROUP-B | DOXORUBICIN-BASED CHEMOTHERAPY | COLONY-STIMULATING FACTOR | RANDOMIZED PHASE-III | METASTATIC BREAST-CANCER | NON-HODGKINS-LYMPHOMA | CHRONIC LYMPHOCYTIC-LEUKEMIA | PHARMACOLOGY & PHARMACY | ACUTE MYELOID-LEUKEMIA | PLASMA-PROTEIN BINDING | Drug Interactions | Antineoplastic Agents - adverse effects | Humans | Aged, 80 and over | Aging | Aged | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Frail Elderly | Patient Compliance | Neoplasms - drug therapy | Randomized Controlled Trials as Topic
Book Review
2004, Volume 43, Issue 12, 18
Topiramate is a new antiepileptic drug (AED) that has been approved worldwide (in more than 80 countries) for the treatment of various kinds of epilepsy. It is... 
Haloperidol, drug interactions | Topiramate, drug interactions | Carbamazepine, drug interactions | Risperidone, pharmacokinetics | Valproic acid, drug interactions | Topiramate, pharmacokinetics | Propranolol, pharmacokinetics | Sumatriptan, pharmacokinetics | Valproic acid, pharmacokinetics | Haloperidol, pharmacokinetics | Phenytoin, drug interactions | Antimigraines, drug interactions | Phenytoin, pharmacokinetics | Lithium, drug interactions | Carbamazepine, pharmacokinetics | Antiepileptic drugs, drug interactions | Drug interactions | Risperidone, drug interactions | Antimigraines, pharmacokinetics | Sumatriptan, drug interactions | Antiepileptic drugs, pharmacokinetics | Antipsychotics, drug interactions | Lithium, pharmacokinetics | Propranolol, drug interactions | Antipsychotics, pharmacokinetics | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | STEADY-STATE PHARMACOKINETICS | NORETHINDRONE | ETHINYL ESTRADIOL | COMBINATION THERAPY | LAMOTRIGINE | CARBAMAZEPINE | VALPROATE | PHARMACOLOGY & PHARMACY | EPILEPSY | BIOAVAILABILITY | REPETITIVE MONOTHERAPY | Anticonvulsants - pharmacokinetics | Fructose - pharmacokinetics | Area Under Curve | Psychotropic Drugs - pharmacokinetics | Humans | Sumatriptan - therapeutic use | Lithium - pharmacokinetics | Anticonvulsants - therapeutic use | Half-Life | Metabolic Clearance Rate | Fructose - therapeutic use | Fructose - analogs & derivatives | Serotonin Receptor Agonists - therapeutic use | Drug Interactions | Lithium - metabolism | Serotonin Receptor Agonists - pharmacokinetics | Sumatriptan - pharmacokinetics | Epilepsy - drug therapy | Contraceptives, Oral - pharmacokinetics
Book Review
British Journal of Clinical Pharmacology, ISSN 0306-5251, 08/2012, Volume 74, Issue 2, pp. 336 - 345
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • In healthy subjects, GSK2248761 was shown to be safe and well tolerated with single doses up to 1200 mg once daily... 
NNRTI | HIV‐1 infection | antiretroviral therapy | drug‐drug interaction | HIV-1 infection | Drug-drug interaction | Antiretroviral therapy | PHARMACOKINETICS | TOLERABILITY | PHARMACOLOGY & PHARMACY | ATAZANAVIR | SIMVASTATIN | drug-drug interaction | PROTEASE INHIBITORS | Fluorobenzenes - pharmacokinetics | Pyrroles - pharmacokinetics | Darunavir | Ethinyl Estradiol - pharmacokinetics | Humans | Pyrrolidinones - pharmacokinetics | Male | Fluorobenzenes - administration & dosage | Indoles - administration & dosage | Lopinavir - pharmacokinetics | Anti-HIV Agents - administration & dosage | Pyrrolidinones - administration & dosage | Tenofovir | Deoxycytidine - pharmacokinetics | Drug Interactions | Pyrroles - administration & dosage | Contraceptives, Oral - administration & dosage | Patient Safety | Atazanavir Sulfate | Contraceptives, Oral - pharmacokinetics | Phosphinic Acids - administration & dosage | Raltegravir Potassium | Emtricitabine | Adenine - analogs & derivatives | Pyridines - administration & dosage | Risk Assessment | Simvastatin - administration & dosage | Deoxycytidine - administration & dosage | Phosphinic Acids - pharmacokinetics | Rosuvastatin Calcium | Adenine - pharmacokinetics | Sulfonamides - pharmacokinetics | Cross-Over Studies | Cytochrome P-450 CYP3A - metabolism | Atorvastatin | Cytochrome P-450 CYP2D6 - metabolism | Least-Squares Analysis | Lopinavir - administration & dosage | Pyrimidines - pharmacokinetics | Oligopeptides - administration & dosage | Deoxycytidine - analogs & derivatives | Sulfonamides - administration & dosage | Cytochrome P-450 CYP2D6 Inhibitors | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Heptanoic Acids - pharmacokinetics | Pyridines - pharmacokinetics | Reverse Transcriptase Inhibitors - administration & dosage | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Reverse Transcriptase Inhibitors - pharmacokinetics | Heptanoic Acids - administration & dosage | Female | Ethinyl Estradiol - administration & dosage | Androstenes - pharmacokinetics | Double-Blind Method | Ritonavir - administration & dosage | Pyrimidines - administration & dosage | Oligopeptides - pharmacokinetics | Linear Models | Simvastatin - pharmacokinetics | Androstenes - administration & dosage | Adenine - administration & dosage | Organophosphonates - pharmacokinetics | Organophosphonates - administration & dosage | Cytochrome P-450 CYP3A Inhibitors | Ritonavir - pharmacokinetics | Anti-HIV Agents - pharmacokinetics | Indoles - pharmacokinetics | Drug Combinations | Urine | Simvastatin | Drug interactions | Cytochrome P-450 | HIV (Viruses) | Complications and side effects | Analysis | Electrocardiogram | Electrocardiography | DNA polymerases | Ethinyl estradiol | Dosage and administration | EKG | Antiviral agents | Urinalysis | Ritonavir | tenofovir | Cytochrome P450 | Lopinavir | ethinylestradiol | Blood | Infection | non-nucleoside reverse transcriptase inhibitors | Antiviral activity | Drug interaction | Probes | CYP2D6 protein
Journal Article
07/1998, Volume 35, Issue 1, 28
Stimulating cardiac -adrenoceptors with oxyfedrine causes dilatation of coronary vessels and positive inotropic effects on the myocardium. -adrenergic agonists... 
Reviews-on-treatment | Hypertension | Calcium-antagonists, pharmacokinetics | Clinical-pharmacokinetics | Alpha-blockers, pharmacokinetics | ACE-inhibitors, pharmacokinetics | Phosphodiesterase-inhibitors, pharmacokinetics | Bioavailability | Pregnancy | Xanthines, pharmacokinetics | Coronary-disorders | Children | Angiotensin-antagonists, pharmacokinetics | Vasodilators, pharmacokinetics | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | THEOPHYLLINE PHARMACOKINETICS | INTRAVENOUS NITROGLYCERIN | POPULATION PHARMACOKINETICS | RENAL-FAILURE | ISOSORBIDE DINITRATE | PHARMACOLOGY & PHARMACY | ESSENTIAL-HYPERTENSION | CONGESTIVE-HEART-FAILURE | ARTERIAL OCCLUSIVE DISEASE | CHRONIC CARDIAC-FAILURE | BLOOD-PRESSURE | Nitroprusside - pharmacokinetics | Enoximone - pharmacokinetics | Isosorbide Dinitrate - analogs & derivatives | Labetalol - pharmacokinetics | Vasodilator Agents - pharmacokinetics | Humans | Milrinone | Imidazoles - pharmacokinetics | Propanolamines - pharmacokinetics | Theophylline - pharmacokinetics | Nitroglycerin - pharmacokinetics | Prazosin - pharmacokinetics | Female | Adrenergic alpha-Antagonists - pharmacokinetics | Piperazines - pharmacokinetics | Isosorbide Dinitrate - pharmacokinetics | Indoramin - pharmacokinetics | Alprostadil - pharmacokinetics | Phosphodiesterase Inhibitors - pharmacokinetics | Pyridones - pharmacokinetics | Iloprost - pharmacokinetics | Pentaerythritol Tetranitrate - pharmacokinetics | Adrenergic beta-Agonists - pharmacokinetics | Amrinone - pharmacokinetics | Oxyfedrine - pharmacokinetics | Molsidomine - pharmacokinetics | Carbazoles - pharmacokinetics | Trapidil - pharmacokinetics
Book Review