2012, 1. Aufl., ISBN 0470599146, xx, 536 p., [4] p. of plates
Presents both the fundamental concepts and the most recent applications in solid-phase organic synthesisWith its emphasis on basic concepts, Solid-Phase...
Solid-phase synthesis | Chemistry | SCIENCE | Physical & Theoretical | Synthesis | Organic compounds
Solid-phase synthesis | Chemistry | SCIENCE | Physical & Theoretical | Synthesis | Organic compounds
Book
2003, Advances in polymer science, ISBN 3540005250, Volume 163., viii, 282
Book
Nature, ISSN 0028-0836, 12/2011, Volume 480, Issue 7378, pp. 471 - 479
One of the most important reactions in organic chemistry-amide bond formation-is often overlooked as a contemporary challenge because of the widespread...
TRACELESS STAUDINGER LIGATION | AMINO-ACID | POLYPEPTIDE-SYNTHESIS | FACILE SYNTHESIS | GENERAL-SOLUTION | AQUEOUS-MEDIUM | MULTIDISCIPLINARY SCIENCES | NATIVE CHEMICAL LIGATION | OXIDATIVE AMIDATION | PHASE PEPTIDE-SYNTHESIS | CARBOXYLIC-ACIDS | Amides - chemistry | Chemistry Techniques, Synthetic | Organic Chemistry Phenomena | Proteins | Amino acids | Chemical properties | Research | Health aspects
TRACELESS STAUDINGER LIGATION | AMINO-ACID | POLYPEPTIDE-SYNTHESIS | FACILE SYNTHESIS | GENERAL-SOLUTION | AQUEOUS-MEDIUM | MULTIDISCIPLINARY SCIENCES | NATIVE CHEMICAL LIGATION | OXIDATIVE AMIDATION | PHASE PEPTIDE-SYNTHESIS | CARBOXYLIC-ACIDS | Amides - chemistry | Chemistry Techniques, Synthetic | Organic Chemistry Phenomena | Proteins | Amino acids | Chemical properties | Research | Health aspects
Journal Article
Chemistry : A European Journal, ISSN 0947-6539, 2015, Volume 21, Issue 14, pp. 5311 - 5316
Macrocyclic natural products (NPs) and analogues thereof often show high affinity, selectivity, and metabolic stability, and methods for the synthesis of...
Research Support, Non-U.S. Gov't | Journal Article | cyclodepsipeptides | natural products | macrocycle | solid‐phase synthesis | relay‐ring‐closing metathesis | relay-ring-closing metathesis | solid-phase synthesis | PHOSPHATASE INHIBITORS | DRUG DISCOVERY | BIOLOGY-ORIENTED SYNTHESIS | SIMPLIFIED ANALOGS | OLEFIN METATHESIS | CHEMISTRY, MULTIDISCIPLINARY | MARINE SPONGE | RING-CLOSING METATHESIS | OLIGOSACCHARIDE SYNTHESIS | CYTOTOXIC PEPTIDES | ACTIN CYTOSKELETON | Solid-Phase Synthesis Techniques | Biological Products - chemical synthesis | Biological Products - chemistry | Cyclization | Depsipeptides - chemical synthesis | Depsipeptides - chemistry
Research Support, Non-U.S. Gov't | Journal Article | cyclodepsipeptides | natural products | macrocycle | solid‐phase synthesis | relay‐ring‐closing metathesis | relay-ring-closing metathesis | solid-phase synthesis | PHOSPHATASE INHIBITORS | DRUG DISCOVERY | BIOLOGY-ORIENTED SYNTHESIS | SIMPLIFIED ANALOGS | OLEFIN METATHESIS | CHEMISTRY, MULTIDISCIPLINARY | MARINE SPONGE | RING-CLOSING METATHESIS | OLIGOSACCHARIDE SYNTHESIS | CYTOTOXIC PEPTIDES | ACTIN CYTOSKELETON | Solid-Phase Synthesis Techniques | Biological Products - chemical synthesis | Biological Products - chemistry | Cyclization | Depsipeptides - chemical synthesis | Depsipeptides - chemistry
Journal Article
2002, 2nd, completely rev. and enl. ed., ISBN 352730603X, xxii, 530
Book
Angewandte Chemie International Edition, ISSN 1433-7851, 11/2011, Volume 50, Issue 46, pp. 10800 - 10826
Which compound classes are best suited as probes and tools for chemical biology research and as inspiration for medicinal chemistry programs? Chemical space is...
chemoinformatics | natural products | bioorganic chemistry | medicinal chemistry | synthesis design | SOLID-PHASE SYNTHESIS | DRUG DISCOVERY | TOPOISOMERASE-I | ALDOL REACTIONS | NATURAL-PRODUCT STRUCTURE | SIMILARITY CLUSTERING PSSC | CHEMISTRY, MULTIDISCIPLINARY | TYROSINE-PHOSPHATASE-B | COMBINATORIAL CHEMISTRY | CHEMICAL SPACE | COMPOUND LIBRARY DEVELOPMENT | Protein Structure, Tertiary | Biological Products - chemical synthesis | Small Molecule Libraries - chemistry | Biological Products - chemistry | Enzyme Inhibitors - chemistry | Proteins - chemistry | Enzyme Inhibitors - chemical synthesis | Proteins - antagonists & inhibitors | Chemistry, Pharmaceutical | Biology | Biological activity
chemoinformatics | natural products | bioorganic chemistry | medicinal chemistry | synthesis design | SOLID-PHASE SYNTHESIS | DRUG DISCOVERY | TOPOISOMERASE-I | ALDOL REACTIONS | NATURAL-PRODUCT STRUCTURE | SIMILARITY CLUSTERING PSSC | CHEMISTRY, MULTIDISCIPLINARY | TYROSINE-PHOSPHATASE-B | COMBINATORIAL CHEMISTRY | CHEMICAL SPACE | COMPOUND LIBRARY DEVELOPMENT | Protein Structure, Tertiary | Biological Products - chemical synthesis | Small Molecule Libraries - chemistry | Biological Products - chemistry | Enzyme Inhibitors - chemistry | Proteins - chemistry | Enzyme Inhibitors - chemical synthesis | Proteins - antagonists & inhibitors | Chemistry, Pharmaceutical | Biology | Biological activity
Journal Article
Progress in Polymer Science, ISSN 0079-6700, 2012, Volume 37, Issue 3, pp. 365 - 405
This review is written to fulfill the need of a comprehensive guide for the manufacture of porous polymer particles. The synthesis section discusses and for...
Porogen | Membrane/microchannel emulsification | Microgel | Porosity | Click chemistry | Beads | Microfluidics | Suspension–dispersion–precipitation–seeded polymerization | Suspension-dispersion-precipitation-seeded polymerization | chemistry | SEEDED DISPERSION POLYMERIZATION | POLYMER SCIENCE | CROSS-LINKED POLYMER | SOLID-PHASE SYNTHESIS | NARROW SIZE DISTRIBUTION | MOLECULARLY IMPRINTED MICROSPHERES | NONSPHERICAL COLLOIDAL PARTICLES | Click | STYRENE-DIVINYLBENZENE COPOLYMERS | PERFORMANCE LIQUID-CHROMATOGRAPHY | CO-ETHYLENE DIMETHACRYLATE | IN-WATER EMULSIONS | Ethylene glycol | Peptides | Siloxanes | Polymerization | Azo compounds | Liquid chromatography | Sulfates | Polymethylmethacrylate | Surface active agents | Heterocyclic compounds | Ethylene oxide | Chemical properties | Polymer industry | Precipitation (Meteorology)
Porogen | Membrane/microchannel emulsification | Microgel | Porosity | Click chemistry | Beads | Microfluidics | Suspension–dispersion–precipitation–seeded polymerization | Suspension-dispersion-precipitation-seeded polymerization | chemistry | SEEDED DISPERSION POLYMERIZATION | POLYMER SCIENCE | CROSS-LINKED POLYMER | SOLID-PHASE SYNTHESIS | NARROW SIZE DISTRIBUTION | MOLECULARLY IMPRINTED MICROSPHERES | NONSPHERICAL COLLOIDAL PARTICLES | Click | STYRENE-DIVINYLBENZENE COPOLYMERS | PERFORMANCE LIQUID-CHROMATOGRAPHY | CO-ETHYLENE DIMETHACRYLATE | IN-WATER EMULSIONS | Ethylene glycol | Peptides | Siloxanes | Polymerization | Azo compounds | Liquid chromatography | Sulfates | Polymethylmethacrylate | Surface active agents | Heterocyclic compounds | Ethylene oxide | Chemical properties | Polymer industry | Precipitation (Meteorology)
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 06/2015, Volume 21, Issue 26, pp. 9370 - 9379
A general and scalable access to the aeruginosin family of marine natural products, exhibiting potent inhibitory activity against serine proteases, is...
palladium catalysis | CH activation | aeruginosin | marine natural products | total synthesis | Aeruginosin | C-H activation | Palladium catalysis | Marine natural products | Total synthesis | C£H activation | MICROCYSTIS-AERUGINOSA | NATURAL-PRODUCTS | UNACTIVATED C(SP)-H | STRUCTURAL CONFIRMATION | CHEMISTRY, MULTIDISCIPLINARY | C-H BONDS | PROTEASE INHIBITORS | CH activation | PALLADIUM-CATALYZED ARYLATION | ENANTIOSELECTIVE SYNTHESES | STEREOSELECTIVE-SYNTHESIS | PHASE-TRANSFER REACTION | Stereoisomerism | Bacteriocins - chemistry | Indoles - chemical synthesis | Bacteriocins - chemical synthesis | Leucine - chemistry | Biological Products - chemical synthesis | Biological Products - chemistry | Leucine - chemical synthesis | Serine Proteases - chemistry | Molecular Structure | Catalysis | Indoles - chemistry | Leucine - analogs & derivatives | Palladium - chemistry | Marine | Synthesis | Natural products | Protease | Halogenated | Strategy | Activation | Palladium
palladium catalysis | CH activation | aeruginosin | marine natural products | total synthesis | Aeruginosin | C-H activation | Palladium catalysis | Marine natural products | Total synthesis | C£H activation | MICROCYSTIS-AERUGINOSA | NATURAL-PRODUCTS | UNACTIVATED C(SP)-H | STRUCTURAL CONFIRMATION | CHEMISTRY, MULTIDISCIPLINARY | C-H BONDS | PROTEASE INHIBITORS | CH activation | PALLADIUM-CATALYZED ARYLATION | ENANTIOSELECTIVE SYNTHESES | STEREOSELECTIVE-SYNTHESIS | PHASE-TRANSFER REACTION | Stereoisomerism | Bacteriocins - chemistry | Indoles - chemical synthesis | Bacteriocins - chemical synthesis | Leucine - chemistry | Biological Products - chemical synthesis | Biological Products - chemistry | Leucine - chemical synthesis | Serine Proteases - chemistry | Molecular Structure | Catalysis | Indoles - chemistry | Leucine - analogs & derivatives | Palladium - chemistry | Marine | Synthesis | Natural products | Protease | Halogenated | Strategy | Activation | Palladium
Journal Article