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phenylacetylglycine (14) 14
index medicus (6) 6
rats (6) 6
animals (5) 5
glycine - analogs & derivatives (5) 5
glycine - urine (5) 5
liver (5) 5
phospholipidosis (5) 5
metabolism (4) 4
toxicology (4) 4
biomarker (3) 3
biotechnology & applied microbiology (3) 3
glycine (3) 3
glycine - blood (3) 3
glycine - metabolism (3) 3
hippurates - urine (3) 3
humans (3) 3
metabolomics (3) 3
metabonomics (3) 3
oxidative stress (3) 3
toxicity (3) 3
urinary (3) 3
urine (3) 3
amino-acids (2) 2
amiodarone (2) 2
amiodarone-treated rats (2) 2
ammonia (2) 2
amphiphilic cationic drugs (2) 2
biomarkers - blood (2) 2
biomarkers - metabolism (2) 2
biomarkers - urine (2) 2
body weight (2) 2
citric acid cycle (2) 2
coenzyme q (2) 2
drug-induced phospholipidosis (2) 2
female (2) 2
h nmr (2) 2
h-1 nmr (2) 2
heart failure (2) 2
hippurate (2) 2
hippuric acid (2) 2
hyperammonemia - drug therapy (2) 2
hyperammonemia - metabolism (2) 2
induced lipidosis (2) 2
l-ornithine-phenylacetate (2) 2
liquid chromatography (2) 2
male (2) 2
mass spectrometry (2) 2
mechanism (2) 2
mediterranean diet (2) 2
metabolites (2) 2
methylmalonic acid (2) 2
nmr (2) 2
ornithine - analogs & derivatives (2) 2
phenylacetic acid (2) 2
plasma (2) 2
quantification (2) 2
rats, sprague-dawley (2) 2
spectroscopy (2) 2
time factors (2) 2
urinalysis (2) 2
1h nmr (1) 1
5-oxazolone (1) 1
6-apa, 6-aminopenicillanic acid (1) 1
8-isoprostane (1) 1
abridged index medicus (1) 1
accumulation (1) 1
acetic acid (1) 1
acid (1) 1
acids (1) 1
acute liver-failure (1) 1
aged (1) 1
aging - genetics (1) 1
aging - metabolism (1) 1
alanine (1) 1
alkoxyresorufin o-dealkylation (1) 1
alveolar macrophages (1) 1
amino acids (1) 1
amiodarone - pharmacology (1) 1
ammonia - blood (1) 1
ammonia - metabolism (1) 1
amphiphilic drugs (1) 1
amphiphilics (1) 1
analytical validation (1) 1
anesthesia (1) 1
antioxidants - administration & dosage (1) 1
atherosclerosis (1) 1
beta carotene - blood (1) 1
biochemical research methods (1) 1
biochemistry & molecular biology (1) 1
biochemistry, general (1) 1
biomarkers (1) 1
biomarkers - analysis (1) 1
biomedicine (1) 1
bodies (1) 1
brain - drug effects (1) 1
brain - metabolism (1) 1
brain edema (1) 1
cancer patients (1) 1
cardiomyopathy (1) 1
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1. Full Text 1H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure
by Kang, Seok-Min and Park, Jong-Chul and Shin, Min-Jeong and Lee, Hyeran and Oh, Jaewon and Ryu, Do Hyun and Hwang, Geum-Sook and Chung, Ji Hyung
Clinical Biochemistry, ISSN 0009-9120, 2011, Volume 44, Issue 4, pp. 293 - 299
We sought to identify metabolic pathways characterizing human heart failure (HF) using NMR based urinary metabolomic analysis in conjunction with multivariate... 
Heart failure | Phenylacetylglycine | Citric acid cycle | Methylmalonic acid | Metabolism
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2. Full Text Effects of the Mediterranean Diet Supplemented With Coenzyme Q(10) on Metabolomic Profiles in Elderly Men and Women
by Gonzalez-Guardia, L and Yubero-Serrano, EM and Delgado-Lista, J and Perez-Martinez, P and Garcia-Rios, A and Marin, C and Camargo, A and Delgado-Casado, N and Roche, HM and Perez-Jimenez, F and Brennan, L and Lopez-Miranda, J
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, ISSN 1079-5006, 01/2015, Volume 70, Issue 1, pp. 78 - 84
Background. Characterization of the variations in the metabolomic profiles of elderly people is a necessary step to understand changes associated with aging.... 
Oxidative stress | METABONOMICS | ACID | METAANALYSIS | Mediterranean diet | HEART-FAILURE | Phenylacetylglycine | HUMANS | Coenzyme Q | Hippurate | URINARY | GERIATRICS & GERONTOLOGY | CARDIOVASCULAR-DISEASE | GERONTOLOGY | URINALYSIS | CONSUMPTION
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3. Full Text Metabolomics analysis of alloxan-induced diabetes in mice using UPLC–Q-TOF-MS after Crassostrea gigas polysaccharide treatment
by Zhao, Guanhua and Hou, Xilong and Li, Xingyao and Li, Wei and Qu, Min and Tong, Changqing
International Journal of Biological Macromolecules, ISSN 0141-8130, 03/2018, Volume 108, pp. 550 - 557
Diabetes has become a global and serious health issues which causes a variety of complications. This study aims to explore the hypoglycemic effect of... 
Metabolomics | Polysaccharides | Diabetes | Crassostrea gigas | METABOLITES | POLYMER SCIENCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | ATHEROSCLEROSIS | MELLITUS | TANDEM MASS-SPECTROMETRY | PHENYLACETYLGLYCINE | LIVER-INJURY | URINE | SERUM METABOLOMICS | CHEMISTRY, APPLIED | INTERVENTION
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4. Full Text Increased levels of urinary phenylacetylglycine associated with mitochondrial toxicity in a model of drug-induced phospholipidosis
by Doessegger, Lucette and Schmitt, Georg and Lenz, Barbara and Fischer, Holger and Schlotterbeck, Götz and Atzpodien, Elke-Astrid and Senn, Hans and Suter, Laura and Csato, Miklos and Evers, Stefan and Singer, Thomas
Therapeutic Advances in Drug Safety, ISSN 2042-0986, 6/2013, Volume 4, Issue 3, pp. 101 - 114
Background: Phospholipidosis (PLD) is a lysosomal storage disorder induced by a class of cationic amphiphilic drugs. However, drug-induced PLD is reversible.... 
Biomarker | Urinary phenylacetylglycine | Phospholipidosis | phospholipidosis | urinary phenylacetylglycine | biomarker | Original Research
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5. Full Text H-1 nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure
by Kang, SM and Park, JC and Shin, MJ and Lee, H and Oh, J and Ryu, DH and Hwang, GS and Chung, JH
CLINICAL BIOCHEMISTRY, ISSN 0009-9120, 03/2011, Volume 44, Issue 4, pp. 293 - 299
Objectives: We sought to identify metabolic pathways characterizing human heart failure (HF) using (NMR)-N-1 based urinary metabolomic analysis in conjunction... 
Heart failure | CANCER PATIENTS | MYOCARDIAL-INFARCTION | Phenylacetylglycine | SERUM | Metabolism | Methylmalonic acid | PEROXISOME PROLIFERATION | FAILING HEART | DISEASE | MODIFIED NUCLEOSIDES | GENE-EXPRESSION | Citric acid cycle | MEDICAL LABORATORY TECHNOLOGY | PLASMA HOMOCYSTEINE | REVEALS
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6. Full Text Method development and validation for simultaneous quantitation of endogenous hippuric acid and phenylacetylglycine in rat urine using liquid chromatography coupled with electrospray ionization tandem mass spectrometry
by Kamiguchi, Hidenori and Yamaguchi, Masashi and Murabayashi, Mika and Mori, Ikuo and Horinouchi, Akira
Journal of Chromatography B, ISSN 1570-0232, 11/2016, Volume 1035, pp. 76 - 83
Urinary hippuric acid (HA) and phenylacetylglycine (PAG) are biomarker candidates for drug-induced phospholipidosis (PLD). To confirm their utility in... 
Phenylacetylglycine | Drug-induced phospholipidosis | Hippuric acid | Analytical validation | LC/MS/MS | CHEMISTRY, ANALYTICAL | AMIODARONE-TREATED RATS | BIOMARKER | QUANTIFICATION | MONITOR | BIOCHEMICAL RESEARCH METHODS | NIEMANN-PICK-DISEASE | AMPHIPHILIC CATIONIC DRUGS | LIPIDOSIS | ACCUMULATION | SAMPLES | Glycine - analogs & derivatives | Reference Standards | Animals | Spectrometry, Mass, Electrospray Ionization - methods | Glycine - urine | Rats | Chromatography, Liquid - methods | Rats, Sprague-Dawley | Hippurates - urine | Liquid chromatography | Pharmaceutical industry | Mass spectrometry | Methods | Index Medicus
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7. Full Text Effects of the mediterranean diet supplemented with coenzyme Q10 on metabolomic profiles in elderly men and women
by González-Guardia, Lorena and Yubero-Serrano, Elena María and Delgado-Lista, Javier and Perez-Martinez, Pablo and Garcia-Rios, Antonio and Marin, Carmen and Camargo, Antonio and Delgado-Casado, Nieves and Roche, Helen M and Perez-Jimenez, Francisco and Brennan, Lorraine and López-Miranda, José
Journals of Gerontology - Series A Biological Sciences and Medical Sciences, ISSN 1079-5006, 01/2015, Volume 70, Issue 1, pp. 78 - 84
Characterization of the variations in the metabolomic profiles of elderly people is a necessary step to understand changes associated with aging. This study... 
Phenylacetylglycine | Oxidative stress | Coenzyme Q | Mediterranean diet | Hippurate | Biomarkers - metabolism | beta Carotene - blood | Glycine - analogs & derivatives | Metabolomics | Gene Expression | Ubiquinone - administration & dosage | Diet, Mediterranean | Oxidative Stress | Glycine - urine | Humans | Ubiquinone - analogs & derivatives | Male | Hippurates - urine | Cross-Over Studies | Aging - genetics | Antioxidants - administration & dosage | Dietary Fats - administration & dosage | Female | Aged | Dietary Supplements | Aging - metabolism
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8. Full Text L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: A novel ammonia-lowering pathway
by Kristiansen, Rune Gangsøy and Rose, Christopher F and Fuskevåg, Ole-Martin and Mæhre, Hanne and Revhaug, Arthur and Jalan, Rajiv and Ytrebø, Lars Marius
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 11/2014, Volume 307, Issue 10, pp. G1024 - G1031
Glycine is an important ammoniagenic amino acid, which is increased in acute liver failure (ALF). We have previously shown that L-ornithine phenylacetate (OP)... 
L-ornithine-phenylacetate | Phenylacetylglycine | Ammonia | Glycine | PHYSIOLOGY | phenylacetylglycine | HYPERAMMONEMIA | INTERORGAN AMMONIA | ammonia | RATS | ENCEPHALOPATHY | METABOLISM | glycine | AMINO-ACIDS | GLUTAMATE | FULMINANT HEPATIC-FAILURE | GASTROENTEROLOGY & HEPATOLOGY | N-ACYLTRANSFERASE | Glycine - analogs & derivatives | Glycine - metabolism | Liver Failure, Acute - complications | Hyperammonemia - metabolism | Glycine - urine | Ornithine - analogs & derivatives | Brain - metabolism | Hyperammonemia - drug therapy | Kidney - metabolism | Time Factors | Swine | Female | Liver Failure, Acute - drug therapy | Hyperammonemia - etiology | Disease Models, Animal | Biomarkers - metabolism | Glycine - blood | Kidney - drug effects | Ammonia - metabolism | Ammonia - blood | Ornithine - pharmacology | Liver Failure, Acute - metabolism | Random Allocation | Brain - drug effects | Animals
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9. Full Text Biomarker discovery for drug-induced phospholipidosis: phenylacetylglycine to hippuric acid ratio in urine and plasma as potential markers
by Kamiguchi, Hidenori and Murabayashi, Mika and Mori, Ikuo and Horinouchi, Akira and Higaki, Kazutaka
Biomarkers, ISSN 1354-750X, 02/2017, Volume 22, Issue 2, pp. 178 - 188
Context: Drug-induced phospholipidosis is one of the significant concerns in drug development, especially in safety assessment and noninvasive diagnostic tool... 
Phenylacetylglycine | drug-induced phospholipidosis | hippuric acid | phenylalanine metabolism | AMIODARONE-TREATED RATS | MECHANISM | TOXICITY | AMPHIPHILIC CATIONIC DRUGS | INHIBITION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | LIVER | BODIES | TOXICOLOGY | INDUCED LIPIDOSIS | Glycine - analogs & derivatives | Glycine - blood | Biomarkers - urine | Glycine - urine | Biomarkers - analysis | Rats | Hippurates - analysis | Phospholipids | Biomarkers - blood | Drug Monitoring - methods | Metabolomics - methods | Hippurates - urine | Lipidoses - chemically induced | Animals | Hippurates - blood | Glycine - analysis | Lipidoses - diagnosis | Index Medicus
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10. Full Text Nuclear magnetic resonance‐ and mass spectrometry‐based metabolomics to study maleic acid toxicity from repeated dose exposure in rats
by Wu, Charlene and Chen, Chi‐Hung and Chen, Hsin‐Chang and Liang, Hao‐Jan and Chen, Shu‐Ting and Lin, Wan‐Yu and Wu, Kuen‐Yuh and Chiang, Su‐Yin and Lin, Ching‐Yu
Journal of Applied Toxicology, ISSN 0260-437X, 12/2017, Volume 37, Issue 12, pp. 1493 - 1506
Maleic acid (MA), a chemical intermediate used in many consumer and industrial products, was intentionally adulterated in a variety of starch‐based foods and... 
liquid chromatography tandem mass spectrometry | metabolomics | urine | biomarkers | nuclear magnetic resonance | maleic acid | oxidative stress | GLYCINE | INDUCED FANCONI-SYNDROME | MECHANISM | PHOSPHOLIPIDOSIS | QUANTIFICATION | PHENYLACETYLGLYCINE | URINARY | 8-ISOPROSTANE | TOXICOLOGY | Safety and security measures | Metabolites | Liver | Body weight | Physiological aspects | Nuclear magnetic resonance spectroscopy | Mass spectrometry | High performance liquid chromatography | Food | Oxidative stress | Metabolomics | Energy metabolism | Nuclear magnetic resonance--NMR | Toxicity | Syngeneic grafts | Nuclear engineering | Statistical methods | Multivariate analysis | Magnetic resonance spectroscopy | Rodents | Maleic acid | Product safety | Hepatotoxicity | Urine | Spectroscopy | Alanine | Kidneys | Statistical analysis | Starch | Industrial products | Organs | Rats | Mass spectroscopy | Liquid chromatography | Exposure | Metabolism | Nuclear safety | Deoxyguanosine | Acids | Biomarkers | Organ weight | Scientific imaging | Resonance | Food safety | Acetic acid | Index Medicus
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11. Full Text A metabonomic approach to the investigation of drug-induced phospholipidosis: an NMR spectroscopy and pattern recognition study
by Andrew W. Nicholls, Jeremy K. Nicholson, John N. Haselden, Catherine J. Waterfield
Biomarkers, ISSN 1354-750X, 2000, Volume 5, Issue 6, pp. 410 - 423
1H NMR spectroscopy of urine and pattern recognition analysis have been used to study the metabolic perturbations caused following dosing of five novel drug... 
Phospholipidosis 1h Nmr Urinalysis Metabonomics Phenylacetylglycine Cationic Amphiphilics Phenylacetate | NMR | METABONOMICS | PHENYLACETATE | PHOSPHOLIPIDOSIS | CATIONIC | URINALYSIS | PHENYLACETYLGLYCINE | AMPHIPHILICS | Phenylacetate | Urinalysis | Metabonomics | Phenylacetylglycine | H NMR | Cationic amphiphilics | Phospholipidosis | metabonomics | phenylacetylglycine | RAT | PHENYLACETIC ACID | phospholipidosis | TOXICITY | MODEL | URINARY | DAMAGE | cationic amphiphilics | urinalysis | H-1 NMR | PLASMA | CHLORPROMAZINE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | LIVER | TOXICOLOGY | phenylacetate
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12. Full Text Glycine and hyperammonemia: potential target for the treatment of hepatic encephalopathy
by Kristiansen, Rune Gangsøy and Rose, Christopher F and Ytrebø, Lars Marius
Metabolic Brain Disease, ISSN 0885-7490, 12/2016, Volume 31, Issue 6, pp. 1269 - 1273
Hepatic encephalopathy (HE) is a neuropsychiatric disorder caused by hepatic dysfunction. Numerous studies dictate that ammonia plays an important role in the... 
Biochemistry, general | Neurology | Ammonia | Neurosciences | Biomedicine | Metabolic Diseases | L-ornithine-phenylacetate (OP) | Phenylacetylglycine | Oncology | Glycine | Glutamine | ACUTE LIVER-FAILURE | INTRACRANIAL HYPERTENSION | GLYCEROL PHENYLBUTYRATE | CLEAVAGE SYSTEM | NEUROSCIENCES | BRAIN EDEMA | NONKETOTIC HYPERGLYCINEMIA | CIRRHOTIC RATS | AMINO-ACIDS | ENDOCRINOLOGY & METABOLISM | GLUTAMINE-SYNTHETASE | ORNITHINE PHENYLACETATE | Hyperammonemia - epidemiology | Glycine - metabolism | Hepatic Encephalopathy - metabolism | Hyperammonemia - metabolism | Humans | Ornithine - analogs & derivatives | Treatment Outcome | Hepatic Encephalopathy - drug therapy | Hyperammonemia - drug therapy | Animals | Glycine - antagonists & inhibitors | Ornithine - administration & dosage | Drug Delivery Systems - trends | Hepatic Encephalopathy - epidemiology | Care and treatment | Nervous system diseases | Liver | Anesthesia | Amino acids | Hepatic encephalopathy
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13. Full Text Phenylacetylglycine, a putative biomarker of phospholipidosis: Its origins and relevance to phospholipid accumulation using amiodarone treated rats as a model
by Delaney, Jane and Neville, William A and Swain, Aubrey and Miles, Adam and Leonard, Michael S and Waterfield, Catherine J
Biomarkers, ISSN 1354-750X, 05/2004, Volume 9, Issue 3, pp. 271 - 290
Amiodarone was given to male Sprague-Dawley rats at a dose of 150 mg kg−1 day−1 for 7 consecutive days to induce phospholipidosis in the lungs of treated rats.... 
phospholipidosis | phenylacetylglycine | amiodarone | biomarker | validation | PAG | Validation | Phenylacetylglycine | Biomarker | Amiodarone | Phospholipidosis | CHROMATOGRAPHIC ANALYSIS | INDOLIC COMPOUNDS | PHENYLALANINE-HYDROXYLASE | PHENYLACETIC ACID | HUMAN LARGE-INTESTINE | NIEMANN-PICK DISEASE | ALKOXYRESORUFIN O-DEALKYLATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ALVEOLAR MACROPHAGES | TOXICOLOGY | N-DESETHYLAMIODARONE | INDUCED LIPIDOSIS | Phenobarbital - pharmacology | Glycine - analogs & derivatives | Glycine - blood | Glycine - metabolism | Biomarkers - urine | Body Weight | Glycine - urine | Liver - metabolism | Organ Size | Rats | Male | Lymphocytes - cytology | Biomarkers - blood | Chromatography, High Pressure Liquid | Rats, Sprague-Dawley | Tissue Distribution | Animals | Time Factors | Lipids - blood | Phospholipids - metabolism | Lipidoses - metabolism | Amiodarone - pharmacology
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14. Full Text Detection of in vivo biomarkers of phospholipidosis using NMR‐based metabonomic approaches
by Espina, J. Robert and Shockcor, John P and Herron, William J and Car, Bruce D and Contel, Nancy R and Ciaccio, Paul J and Lindon, John C and Holmes, Elaine and Nicholson, Jeremy K
Magnetic Resonance in Chemistry, ISSN 0749-1581, 09/2001, Volume 39, Issue 9, pp. 559 - 565
The application of high‐field 1H NMR spectroscopy to the analysis of biological fluids has proved to be a valuable approach to toxicological screening. Coupled... 
chloroquine | metabonomics | NMR | phenylacetylglycine | amiodarone | Fischer rat | phospholipidosis | 1H NMR | amphiphilic drugs | Amphiphilic drugs | Chloroquine | Phenylacetylglycine | Amiodarone | Phospholipidosis; metabonomics | H NMR | H-1-NMR | NUCLEAR-MAGNETIC-RESONANCE | CARDIOMYOPATHY | CHEMISTRY, PHYSICAL | DISORDERS | CHEMISTRY, MULTIDISCIPLINARY | H-1 NMR | PATTERN-RECOGNITION | PLASMA | SPECTROSCOPY | URINE | LIVER
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15. Full Text An efficient synthesis of aryl phenaceturates using acid catalyzed dicyclohexylcarbodiimide esterification and transient N-tert-butoxycarbonylation
by Cabaret, D and Liu, J and Wakselman, M
Synthesis, ISSN 0039-7881, 1994, Volume 1, Issue 5, pp. 480 - 482
Application of the Holmberg procedure (DCC/pyridine/p-TSA(cat)) improves the yield of the direct condensation of phenols with phenylacetylglycine (1).... 
5(4H)-OXAZOLONE | PHENACETURATES | ESTERIFICATION | HYDROLYSIS | CHEMISTRY, ORGANIC | TERT-BUTOXYCARBONYLATION | PHENYLACETYLGLYCINE
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16. Full Text Kinetics of the enzymatic synthesis of benzylpenicillin
by Švedas, Vytas K and Margolin, Alexei L and Borisov, Ivan L and Berezin, Ilya V
Enzyme and Microbial Technology, ISSN 0141-0229, 1980, Volume 2, Issue 4, pp. 313 - 317
In the reported experiments, the kinetics of the enzymatic synthesis of benzylpenicillin catalysed by penicillin amidase (EC 3. 5. 1. 11) from Escherichia coli... 
PAA, phenylacetic acid | PAG, phenylacetylglycine | 6-APA, 6-aminopenicillanic acid | PMSF, phenylmethyl-sulphonylfluoride
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