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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2019, Volume 29, Issue 17, pp. 2503 - 2510
Cancer cells reprogram their metabolism to support growth and to mitigate cellular stressors. The serine synthesis pathway has been identified as a metabolic... 
3-Phosphoglycerate dehydrogenase | PHGDH | PHGDH inhibitor | Inhibitor | Serine synthesis | Cancer metabolism | CHEMISTRY, MEDICINAL | ACID | BIOSYNTHESIS | CHEMISTRY, ORGANIC | IDENTIFICATION | DERIVATIVES | Enzymes | Medical colleges | Serine | Therapeutics | Cancer cells | Physiological aspects | Amides | Cancer | Homeopathy | Materia medica and therapeutics
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 17, pp. 13139 - 13153
3-Phosphoglycerate dehydrogenase (PHGDH) has recently been identified as an attractive target in cancer therapy as it links upregulated glycolytic flux to... 
Serine metabolism | Fragments | PHGDH | Drug discovery | Cancer metabolism
Journal Article
Cell Metabolism, ISSN 1550-4131, 06/2019, Volume 29, Issue 6, pp. 1410 - 1421.e4
Tumors exhibit altered metabolism compared to normal tissues. Many cancers upregulate expression of serine synthesis pathway enzymes, and some tumors exhibit... 
serine | melanoma | breast cancer | PHGDH | Medical research | Medical colleges | Analysis | Serine | Resveratrol | Melanoma | Medicine, Experimental | Development and progression | Research institutes | Cancer
Journal Article
Metabolism, ISSN 0026-0495, 01/2020, Volume 102, p. 154000
Supplementation with serine attenuates alcoholic fatty liver by regulating homocysteine metabolism and lipogenesis. However, little is known about serine... 
NRF2 | 3-Phosphoglycerate dehydrogenase (PHGDH) | SIRT1 | Serine | High-fat diet | Non-alcoholic fatty liver disease (NAFLD)
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2017, Volume 114, Issue 43, pp. 11404 - 11409
The enzyme serine hydroxymethyltransferse (SHMT) converts serine into glycine and a tetrahydrofolate-bound one-carbon unit. Folate one-carbon units support... 
DLBCL | SHMT | Cancer metabolism | Glycine | Folate | SERINE HYDROXYMETHYLTRANSFERASE | SPECIFICITY | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | DEHYDROGENASE | cancer metabolism | folate | glycine | PATHWAY | SUBSTRATE | SYNTHETASE | PHGDH | ONE-CARBON METABOLISM | Physiological aspects | Lymphomas | Methyltransferases | Health aspects | Biological Sciences
Journal Article
Journal Article
Gene, ISSN 0378-1119, 02/2018, Volume 642, pp. 43 - 50
To investigate the expression, clinical significance, biological function, and the potential mechanism of PHGDH in pancreatic cancer. The expression of PHGDH... 
Prognosis | Proliferation | Pancreatic cancer | Phosphoglycerate dehydrogenase (PHGDH) | PHOSPHOGLYCERATE DEHYDROGENASE | METASTASIS | STATISTICS | ADENOCARCINOMA | HIGH EXPRESSION | METABOLISM | GASTRIC-CANCER | POOR-PROGNOSIS | GENETICS & HEREDITY | CARCINOMA | Immunohistochemistry | Analysis
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 08/2019, Volume 376, pp. 9 - 16
Osteoporosis is manifested by reduced bone mass. Tanshinone has been shown to affect osteoclast differentiation, but its role in osteoporosis remains less... 
Aging | Osteoporosis | Tanshinone | Phosphoglycerate dehydrogenase (PHGDH) | Alveolar bone loss | SATB2 | STEMNESS | MAINTENANCE | INHIBITION | PHARMACOLOGY & PHARMACY | SENESCENCE | TOXICOLOGY | OSTEOCLAST DIFFERENTIATION | EXPRESSION | MARROW STROMAL CELLS | RNA
Journal Article
Turk Patoloji Dergisi, ISSN 1018-5615, 2018, Volume 34, Issue 3, pp. 259 - 261
The Neu-Laxova syndrome is a rare autosomal recessive condition associated with neuro-ectodermal abnormalities and other patterns of severe malformations... 
Neu-laxova syndrome | Kyphosis | Phgdh mutation | Lissencephaly | Neu-Laxova syndrome | PHGDH mutation
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 11/2019, Volume 129, Issue 11, pp. 4708 - 4723
Cancer-associated mutations in the spliceosome gene SF3B1 create a neomorphic protein that produces aberrant mRNA splicing in hundreds of genes, but the... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | CANCER GENES | PATHWAY | PHGDH | KEY | REVEALS | Energy metabolism | Ontology | Splicing | Anemia | Serine | Leukemia | Cloning | Genomics | Genes | Amino acids | Gene expression | Metabolism | Glycine | Kinases | Proteins | Mitochondria | Xenografts | Mutation | Cancer
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 06/2019, Volume 87, pp. 16 - 22
Serine plays critically important roles in tumorigenesis. Homo sapiens 3-phosphoglycerate dehydrogenase (PHGDH) catalyzes the first committed step for the... 
Natural product | Azacoccone E | PHGDH inhibitor | Cancer | Enzymes | Colon cancer | Growth | Gliomas | Pharmacy | Force and energy | Melanoma | Drugstores
Journal Article
FEBS Letters, ISSN 0014-5793, 04/2019, Volume 593, Issue 8, pp. 763 - 776
Differences in the metabolism of cancer cells or cancer stem cells (CSCs) as compared to normal cells have provided avenues to safely target cancers. To... 
cancer metabolism | mitochondrial inhibitors | serine biosynthesis | cancer stem cells | drug screen | tumourspheres | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARBON METABOLISM | MODEL | CANCER | CELL BIOLOGY | DETERMINES | BIOPHYSICS | NRF2 | PROFILING REVEALS | PHGDH | EXPRESSION
Journal Article
Cancer Research, ISSN 0008-5472, 11/2016, Volume 76, Issue 22, pp. 6458 - 6462
Phosphoglycerate dehydrogenase (PHGDH) is the metabolic enzyme responsible for shunting the glycolytic intermediate 3-phosphoglycerate to the serine synthesis... 
BREAST-CANCER | INDUCIBLE FACTORS | MAINTENANCE | HOMEOSTASIS | PHOSPHOGLYCERATE DEHYDROGENASE | TUMOR HYPOXIA | ONCOLOGY | BIOSYNTHESIS | PROLIFERATION | PHGDH EXPRESSION | IDENTIFICATION | Cell Hypoxia | Cell Proliferation | Neoplastic Stem Cells - metabolism | Oxidation-Reduction | Humans | Cell Line, Tumor | Serine - metabolism | Disease Progression
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2018, Volume 504, Issue 1, pp. 309 - 314
Serine is a nonessential amino acid and plays an important role in cellular metabolism. In mammalian serine biosynthesis, 3-phosphoglycerate dehydrogenase... 
Adipocyte | Obesity | PHGDH | Glucose intolerance | Serine | PROFILES | PHOSPHOGLYCERATE DEHYDROGENASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | D-ASPARTATE RECEPTOR | CANCER | 3-PHOSPHOGLYCERATE DEHYDROGENASE | AMINO-ACID | BIOPHYSICS | D-SERINE | METABOLISM | PATHWAY | EXPRESSION | Enzymes | Medical colleges | Physiological aspects | Amino acids | Glucose | Dextrose
Journal Article