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animals (8) 8
biochemistry & molecular biology (7) 7
humans (6) 6
phk, phosphorylase kinase (6) 6
phosphorylase kinase (6) 6
phosphorylation (5) 5
mice (4) 4
pkc, protein kinase c (4) 4
activation (3) 3
inhibitor (3) 3
male (3) 3
models, molecular (3) 3
phk (3) 3
protein kinase (3) 3
amino acid substitution (2) 2
ampk, amp-activated protein kinase (2) 2
cancer (2) 2
cell biology (2) 2
cell line (2) 2
chk, checkpoint kinase (2) 2
ck, casein kinase (2) 2
crystal-structure (2) 2
csk, c-terminal src kinase (2) 2
electron-microscopy (2) 2
em, electron microscopy (2) 2
female (2) 2
genes (2) 2
genetics & heredity (2) 2
gsk3, glycogen synthase kinase 3 (2) 2
jnk, c-jun n-terminal kinase (2) 2
mapk, mitogen-activated protein kinase (2) 2
mbp, myelin basic protein (2) 2
msk, mitogen- and stress-activated protein kinase (2) 2
oa, okadaic acid (2) 2
oncology (2) 2
phosphorylase kinase - antagonists & inhibitors (2) 2
phosphorylase kinase - chemistry (2) 2
phosphorylase kinase - genetics (2) 2
phosphotransferases (2) 2
pka, camp-dependent protein kinase (2) 2
pkb, protein kinase b (2) 2
pkd, protein kinase d (2) 2
protein kinases (2) 2
protein phosphorylation (2) 2
rabbits (2) 2
rock, rho-dependent protein kinase (2) 2
saxs, small‐angle x‐ray scattering (2) 2
sgk, serum- and glucocorticoid-induced kinase (2) 2
small-angle x-ray scattering (2) 2
1-phosphatidylinositol 4-kinase - genetics (1) 1
1-phosphatidylinositol 4-kinase - metabolism (1) 1
active site (1) 1
adenosine triphosphate (1) 1
administration, oral (1) 1
adult (1) 1
afm, atomic force microscopy (1) 1
aged (1) 1
aged, 80 and over (1) 1
aicar, aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (1) 1
ak, autophosphorylation-activated protein kinase (1) 1
albumin (1) 1
alleles (1) 1
alpha-subunit (1) 1
amino acid sequence (1) 1
amp-pnp (1) 1
analysis (1) 1
angiogenesis (1) 1
angiogenesis inhibitors - isolation & purification (1) 1
angiogenesis inhibitors - pharmacology (1) 1
angstrom resolution (1) 1
animals, genetically modified (1) 1
anti-cancer drugs (1) 1
antiangiogenic compounds (1) 1
apoptosis (1) 1
apoptosis regulatory proteins - antagonists & inhibitors (1) 1
apoptosis regulatory proteins - chemistry (1) 1
apoptosis regulatory proteins - genetics (1) 1
aspartate (1) 1
atf2, activating transcription factor 2 (1) 1
atm, ataxia telangiectasia mutated (1) 1
autoinhibition (1) 1
b kinase (1) 1
basic biological sciences (1) 1
benign (1) 1
beta-subunit (1) 1
binding sites - drug effects (1) 1
binding sites - genetics (1) 1
binding, competitive (1) 1
binding, competitive - drug effects (1) 1
biological products (1) 1
biomarkers, tumor - analysis (1) 1
biomarkers, tumor - genetics (1) 1
biophysics (1) 1
blood platelets - enzymology (1) 1
bovine serum albumin (1) 1
brsk, brain-specific kinase (1) 1
bsa (1) 1
ca2 (1) 1
cak, cyclin-dependent kinase-activating kinase (1) 1
calc, calphostin c (1) 1
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Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Journal Article
FEBS letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
...) only CK2 was drastically inhibited (>85%) whereas three kinases (phosphorylase kinase, glycogen synthase kinase 3β... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | PKA, cAMP-dependent protein kinase | DRB, 1-(β-D-ribofuranosyl)-5,6-dichlorobenzimidazole | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | CATALYTIC SUBUNIT | ZEA-MAYS | TYROSINE KINASE | CRYSTAL-STRUCTURE | COMPETITIVE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein phosphorylation | IMMUNOPHILIN FPR3 | SACCHAROMYCES-CEREVISIAE | protein kinase | CELL BIOLOGY | casein kinase | BIOPHYSICS | inhibitor | CELL-CYCLE | BETA-SUBUNIT | casein kinase-2 | MAMMARY-GLAND | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects
Journal Article
Protein science, ISSN 0961-8368, 04/2005, Volume 14, Issue 4, pp. 1039 - 1048
Journal Article
Journal of molecular biology, ISSN 0022-2836, 06/2011, Volume 409, Issue 3, pp. 369 - 383
The death-associated protein kinase (DAPK) family has been characterized as a group of pro-apoptotic serine/threonine kinases that share specific structural features in their catalytic kinase domain... 
dimerization | crystallography | autoinhibition | small-angle X-ray scattering | active site | ZIPK | ESRF | CaMK | MLCK | DAPK | zipper-interacting protein kinase | EMBL/DESY | calmodulin | EDTA | European Molecular Biology Laboratory/Deutsches Elektronen Synchrotron | myosin light chain kinase | CaM | SAXS | BSA | PhK | European Synchrotron Radiation Facility | ethylenediaminetetraacetic acid | CaM-dependent protein kinase | denosine 5'-(beta,gamma-imido) triphosphate | phosphorylase kinase | death-associated protein kinase | AMP-PNP | bovine serum albumin | ACTIVATION | MECHANISM | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | CATALYTIC DOMAIN | CANCER | DISCOVERY | CELL-DEATH | DIFFERENTIATION | INHIBITOR | Catalytic Domain | Phosphorylation | Calcium-Calmodulin-Dependent Protein Kinases - genetics | Apoptosis Regulatory Proteins - chemistry | Models, Molecular | Crystallography, X-Ray | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors | Sequence Homology, Amino Acid | Calcium-Calmodulin-Dependent Protein Kinases - chemistry | Animals | Apoptosis Regulatory Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - genetics | Protein Conformation | Mice | Protein Interaction Domains and Motifs | Death-Associated Protein Kinases | Dimerization | Apoptosis | Oligomers | Particle accelerators | Analysis | Myosin | Crystals | Albumin | Nucleotides | Muscle proteins | Structure | Protein kinases | Calmodulin | Protein binding
Journal Article
Journal Article
Molecular genetics and metabolism, ISSN 1096-7192, 06/2013, Volume 109, Issue 2, pp. 179 - 182
Journal Article
FEBS letters, ISSN 0014-5793, 1984, Volume 169, Issue 2, pp. 224 - 228
The ability of homogeneous glycogen phorphorylase kinase (Phk) from rabbit skeletal muscle to phosphorylate bovine brain myelin basic protein (MBP) was investigated... 
Mylein basic protein | Rabbit skeletal muscle | cAMP-dependent protein kinase | Glycogen phosphorylase kinase | protein kinase A, cAMP-dependent protein kinase | HPLC, high-performance liquid chromatography | MBP, myelin basic protein | Phk, glycogen phosphorylase kinase
Journal Article
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