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Molecular Biology of the Cell, ISSN 1059-1524, 12/2008, Volume 19, Issue 12, pp. 5360 - 5372
Class III phosphatidylinositol 3-kinase (PI3-kinase) regulates multiple membrane trafficking. In yeast, two distinct PI3-kinase complexes are known: complex I... 
PRE-AUTOPHAGOSOMAL STRUCTURE | LATE ENDOSOMES | MOLECULAR MACHINERY | PROTEIN-KINASE | TRANS-GOLGI NETWORK | TUMOR-SUPPRESSOR | VPS34 PTDINS 3-KINASE | SACCHAROMYCES-CEREVISIAE | SELECTIVE AUTOPHAGY | SELF-DIGESTION | CELL BIOLOGY | Autophagy-Related Proteins | Adaptor Proteins, Vesicular Transport - classification | Humans | Adaptor Proteins, Vesicular Transport - genetics | Molecular Sequence Data | rab GTP-Binding Proteins - genetics | Autophagy - physiology | Phosphatidylinositol 3-Kinases - metabolism | Phylogeny | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Adaptor Proteins, Vesicular Transport - metabolism | Recombinant Fusion Proteins - metabolism | Multiprotein Complexes - metabolism | RNA Interference | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Phagosomes - ultrastructure | Cell Membrane - metabolism | Membrane Proteins - metabolism | Androstadienes - metabolism | Beclin-1 | rab GTP-Binding Proteins - metabolism | Amino Acid Sequence | Cell Line | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Phagosomes - metabolism | Apoptosis Regulatory Proteins - metabolism | Endocytosis - physiology | Phosphatidylinositol 3-Kinases - genetics | Multiprotein Complexes - chemistry | Sequence Alignment | Animals | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Mice
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 3, pp. 528 - 534.e3
The class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) is required for the initiation of essentially all macroautophagic processes. PI3KC3-C1... 
protein structure | crosslinking mass spectrometry | autophagy | lipid kinase | protein dynamics | electron microscopy | pseudokinase | protein kinase | phosphoinositide | allostery | BECLIN 1 | MONITORING AUTOPHAGY | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RUBICON | ARCHITECTURE | PHOSPHATIDYLINOSITOL | IDENTIFICATION | MATURATION | MICROSCOPY | ATG14L | CELL BIOLOGY | Saccharomyces cerevisiae - genetics | Allosteric Regulation | Humans | Adaptor Proteins, Vesicular Transport - genetics | Structure-Activity Relationship | Adaptor Proteins, Vesicular Transport - metabolism | Autophagy | HEK293 Cells | Class III Phosphatidylinositol 3-Kinases - chemistry | Protein Interaction Domains and Motifs | Autophagy-Related Proteins - genetics | Vacuolar Sorting Protein VPS15 - genetics | Signal Transduction | Class III Phosphatidylinositol 3-Kinases - metabolism | Saccharomyces cerevisiae Proteins - genetics | Vacuolar Sorting Protein VPS15 - chemistry | Vacuolar Sorting Protein VPS15 - metabolism | Class III Phosphatidylinositol 3-Kinases - genetics | Saccharomyces cerevisiae Proteins - metabolism | Beclin-1 - genetics | Saccharomyces cerevisiae - enzymology | Mutation | Beclin-1 - metabolism | Autophagy-Related Proteins - metabolism | Mass Spectrometry - methods | Saccharomyces cerevisiae Proteins - chemistry | Enzymes | Crosslinked polymers | Molecular biology | Mass spectrometry | Protein kinases | Cells
Journal Article
Journal Article
JOURNAL OF CELL SCIENCE, ISSN 0021-9533, 01/2006, Volume 119, Issue 2, pp. 259 - 270
Beclin 1 was originally identified as a novel Bcl-2-interacting protein, but co-immunoprecipitation studies suggest that the major physiological partner for... 
MALIGNANT GLIOMA-CELLS | autophagy | cell death | RAT HEPATOCYTES | phosphatidylinositol-3-kinase | PHOSPHATIDYLINOSITOL 3-KINASE | Vps34 | Beclin | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | MULTIVESICULAR BODY MORPHOGENESIS | glioblastoma | endocytosis | TUMOR-SUPPRESSOR | CATHEPSIN-D | MEMBRANE-TRANSPORT | AUTOPHAGIC VACUOLE | MOLECULAR-MECHANISMS
Journal Article
Journal Article
Autophagy, ISSN 1554-8627, 06/2013, Volume 9, Issue 6, pp. 933 - 935
Journal Article
Annual Review of Biochemistry, ISSN 0066-4154, 6/2017, Volume 86, Issue 1, pp. 225 - 244
Autophagy is the process of cellular self-eating by a double-membrane organelle, the autophagosome. A range of signaling processes converge on two protein... 
COPII | Atg1 | membrane remodeling | vesicle | tethering complex | nanoscale biology | ULK1 | Vps34 | membrane fusion | phosphatidylinositol 3-kinase | Vesicle | Membrane fusion | Membrane remodeling | Phosphatidylinositol 3-kinase | Nanoscale biology | Tethering complex | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHAGOPHORE ASSEMBLY SITE | PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES | REGULATES AUTOPHAGY | MAMMALIAN AUTOPHAGY | BECLIN 1 PHOSPHORYLATION | SACCHAROMYCES-CEREVISIAE | SELECTIVE AUTOPHAGY | ATG1 KINASE COMPLEX | ENDOPLASMIC-RETICULUM | ULK1 COMPLEX | Humans | Protein Multimerization | Eukaryotic Cells - metabolism | Autophagy-Related Protein-1 Homolog - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Eukaryotic Cells - ultrastructure | Class III Phosphatidylinositol 3-Kinases - chemistry | Phagosomes - ultrastructure | Cell Membrane - metabolism | Autophagy - genetics | Intracellular Signaling Peptides and Proteins - genetics | Phosphatidylinositol 3-Kinase - metabolism | COP-Coated Vesicles - ultrastructure | Gene Expression | Signal Transduction | Phagosomes - metabolism | Gene Expression Regulation | COP-Coated Vesicles - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Cell Membrane - ultrastructure | Autophagy-Related Protein-1 Homolog - chemistry | Phosphatidylinositol 3-Kinase - chemistry | Phosphatidylinositol 3-Kinase - genetics | Class III Phosphatidylinositol 3-Kinases - genetics | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | Autophagy-Related Protein-1 Homolog - genetics | Physiological aspects | Autophagy (Cytology) | Genetic aspects | Research | Gene expression
Journal Article