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FEBS Letters, ISSN 0014-5793, 09/2012, Volume 586, Issue 19, pp. 3471 - 3476
► TPCK inhibits all tested AGC kinases with phenylalanine-directed, cysteine-containing activation loops, including RSK1, Akt1, S6K1, MSK1 and MSK2. ► Mass... 
Signal transduction | Reversible phosphorylation | Mass spectrometry | Kinase inhibitor | TPCK | MSK | mitogen and stress-activated protein kinase | phosphatidylinositol-3 kinase | related to protein kinase A, protein kinase G and protein kinase C | PKA | S6 kinase | S6K | RSK | N-alpha-tosyl-l-phenylalanyl chloromethyl ketone | PI3K | ribosomal S6 kinase | 3-phosphoinositide dependent protein kinase-1 | protein kinase A | AGC | PDK1 | ERK | extracellular signal regulated kinase | SIGNAL | PROTEIN KINASE-1 | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | CANCER | CELL BIOLOGY | BIOPHYSICS | PATHWAY | RESISTANCE | MURINE BRAIN | S6 KINASE | Amino Acid Sequence | Protein Kinases - genetics | Mutagenesis, Site-Directed | Proto-Oncogene Proteins c-akt - chemistry | Humans | Molecular Sequence Data | Protein Kinases - chemistry | DNA Primers - genetics | Cysteine - chemistry | Ribosomal Protein S6 Kinases, 90-kDa - chemistry | Proto-Oncogene Proteins c-akt - genetics | Amino Acid Motifs | Sequence Homology, Amino Acid | Phenylalanine - chemistry | Base Sequence | Ribosomal Protein S6 Kinases, 90-kDa - genetics | HEK293 Cells | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Conserved Sequence | Protein Kinase Inhibitors - pharmacology | Tosylphenylalanyl Chloromethyl Ketone - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Amino Acid Substitution | Amino acids | Thiols | Mitogens | Protein kinases
Journal Article
Molecular Medicine Reports, ISSN 1791-2997, 09/2018, Volume 18, Issue 3, pp. 2798 - 2806
Journal Article
Gynecologic Oncology, ISSN 0090-8258, 2010, Volume 120, Issue 1, pp. 121 - 127
Journal Article
FEBS Letters, ISSN 0014-5793, 2000, Volume 470, Issue 3, pp. 350 - 354
The molecular basis for the modulatory properties of CD99 is not well understood. Treatment of human Jurkat T lymphocytes with anti-CD99 antibody led to... 
Protein kinase/phosphatase | Signal transduction | Cell surface molecule | T lymphocyte | Cellular activation | BAPTA-AM, 1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetra(acetoxymethyl) ester | PKC, protein kinase C | mAb, monoclonal antibody | JNK, c-jun N-terminal kinase | ERK, extracellular signal-regulated kinase | MEK, MAPK kinase | PI-3K, phosphatidylinositol-3 kinase | MAPK, mitogen-activated protein kinase | APOPTOSIS | cell surface molecule | signal transduction | MOLECULE | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYTOHESIN-1 | THYMOCYTES | CELL BIOLOGY | ADHESION | protein kinase/phosphatase | cellular activation | INHIBITION | BIOPHYSICS | PATHWAY | T-CELLS | LYMPHOCYTES | Phosphorylation | T-Lymphocytes - enzymology | Calcium - metabolism | Humans | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | MAP Kinase Kinase 1 | MAP Kinase Signaling System | Calcium - antagonists & inhibitors | Mitogen-Activated Protein Kinase Kinases - metabolism | Protein Kinase C - metabolism | Egtazic Acid - analogs & derivatives | Hyaluronan Receptors - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases | p38 Mitogen-Activated Protein Kinases | Antibodies, Monoclonal - immunology | Protein-Serine-Threonine Kinases - metabolism | Jurkat Cells | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Protein Kinase C - antagonists & inhibitors | Chelating Agents - pharmacology | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors | Cell Adhesion | Egtazic Acid - pharmacology | T-Lymphocytes - cytology | Hyaluronan Receptors - immunology | Enzyme Activation | Receptor Aggregation | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Mitogen-Activated Protein Kinase 3 | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism
Journal Article
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 04/2004, Volume 94, Issue 7, pp. 960 - 966
ABSTRACT—Glycogen synthase kinase (GSK) inhibition produced by ischemic preconditioning has been previously shown to be regulated through... 
Phosphatidylinositol-3 kinase | Reperfusion | Glycogen synthase kinase | Target of rapamycin | Opioids | LOCALIZATION | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTECTION | PHOSPHORYLATION | phosphatidylinositol-3 kinase | PHOSPHATIDYLINOSITOL 3-KINASE | CELL-SURVIVAL | KINASE-3-BETA | INSULIN | P70S6 KINASE | INDUCED DELAYED CARDIOPROTECTION | glycogen synthase kinase | PERIPHERAL VASCULAR DISEASE | target of rapamycin | HEMATOLOGY | reperfusion | opioids | Glycogen Synthase Kinase 3 - physiology | Maleimides - pharmacology | Receptors, Retinoic Acid - physiology | Glycogen Synthase Kinase 3 beta | Male | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptors, Thyroid Hormone - antagonists & inhibitors | Aminophenols - pharmacology | Cardiotonic Agents - therapeutic use | Myocardial Infarction - pathology | Indoles - pharmacology | Benzamides - pharmacology | Chromones - pharmacology | Nuclear Receptor Subfamily 1, Group F, Member 3 | Morphine - pharmacology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Morpholines - pharmacology | Rats | Receptors, Retinoic Acid - antagonists & inhibitors | Cardiotonic Agents - pharmacology | Myocardial Infarction - metabolism | Receptors, Opioid, delta - drug effects | Piperazines - pharmacology | Rats, Sprague-Dawley | Receptors, Thyroid Hormone - physiology | Sirolimus - pharmacology | Animals | Androstadienes - pharmacology | Signal Transduction - drug effects | Narcotic Antagonists - pharmacology | Phosphatidylinositol 3-Kinases - physiology | Premedication
Journal Article
Journal Article
Biochimie, ISSN 0300-9084, 11/2012, Volume 94, Issue 11, pp. 2297 - 2307
DNA methylation is an epigenetic mechanism establishing long-term gene silencing during development and cell commitment, which is maintained in subsequent cell... 
5-Aza-2′-deoxycytidine | Decitabine | DNA methyltransferase inhibitor | NPM-ALK | Anaplastic large cell lymphoma | T-cell lymphoma | CHRONIC MYELOGENOUS LEUKEMIA | 5-Aza-2 '-deoxycytidine | MALIGNANT T-LYMPHOCYTES | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE MYELOID-LEUKEMIA | EPIGENETIC MODULATION | GENE-EXPRESSION | TUMOR-SUPPRESSOR | HEMATOPOIETIC MALIGNANCIES | DNA (Cytosine-5-)-Methyltransferase 1 | Humans | Enzyme Inhibitors - pharmacology | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Azacitidine - analogs & derivatives | Lymphoma, Large-Cell, Anaplastic - enzymology | Transcriptome - drug effects | DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors | Receptor Protein-Tyrosine Kinases - metabolism | DNA (Cytosine-5-)-Methyltransferases - metabolism | Xenograft Model Antitumor Assays | Azacitidine - pharmacology | Animals | Cell Line, Tumor | Female | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Lymphoma, Large-Cell, Anaplastic - pathology | Mice | Gene Expression Regulation, Neoplastic - drug effects | DNA Methylation - drug effects | Lymphoma, Large-Cell, Anaplastic - metabolism | Lymphoma, Large-Cell, Anaplastic - genetics | Medical colleges | Genes | Transferases | Genomics | DNA | Aluminum compounds | Genetic aspects | Non-Hodgkin's lymphomas | T cells | Methylation | Cancer | ALK, anaplastic lymphoma kinase | signal transducer and activator of transcription | PI3-K | DNMT1, DNA methyltransferase 1 | Research Paper | PBMCs, peripheral blood mononuclear cells | HE, hematoxylin and eosin | NPM-ALK, nucleophosmin-anaplastic lymphoma kinase | CML, chronic myeloid leukemia | COBRA, Combined Bisulfite Restriction Analysis | PLCγ, phospholipase Cγ | M.SssI, CpG methyltransferase | ALCL, anaplastic large cell lymphoma | AML, acute myeloid leukemia | AKT | STAT, Janus kinase | JAK | AKT, phosphatidylinositol-3 kinase | 5-Aza-CdR, 5-aza-2′-deoxycytidine | MAPK, mitogen-activated protein kinase
Journal Article
Journal Article
Molecular Medicine Reports, ISSN 1791-2997, 07/2016, Volume 14, Issue 1, pp. 797 - 803
Journal Article
Journal Article
Journal Article