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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2011, Volume 21, Issue 18, pp. 5451 - 5456
A structural survey of pyrazolopyridine-pyridazinone phosphodiesterase (PDE) inhibitors was made with a view to optimization of their dual PDE3/4-inhibitory... 
Ibudilast | PDE3 inhibitors | Cyclic 3′,5′-nucleotide phosphodiesterase (PDE) | Respiratory disease | PDE4 inhibitors | Cyclic 3',5'-nucleotide phosphodiesterase (PDE) | Cyclic 3 ',5 '-nucleotide phosphodiesterase (PDE) | CHRONIC HEART-FAILURE | SLOW REACTING SUBSTANCE | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | IDENTIFICATION | OBSTRUCTIVE PULMONARY-DISEASE | ASTHMA | POSITIVE INOTROPIC AGENTS | HIGHLY POTENT | CARDIOTONIC AGENTS | Phosphodiesterase 3 Inhibitors - chemistry | Phosphodiesterase 3 Inhibitors - pharmacology | Pyrazoles - chemical synthesis | Pyridines - chemistry | Stereoisomerism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Structure-Activity Relationship | Phosphodiesterase 4 Inhibitors - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Dose-Response Relationship, Drug | Bronchodilator Agents - chemistry | Pyrazoles - chemistry | Drug Design | Molecular Structure | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Drug Evaluation, Preclinical | Pyrazoles - pharmacology | Phosphodiesterase 4 Inhibitors - chemistry | Guinea Pigs | Pyridines - chemical synthesis | Rats | Bronchodilator Agents - pharmacology | Bronchodilator Agents - chemical synthesis | Phosphodiesterase 4 Inhibitors - pharmacology | Phosphodiesterase 3 Inhibitors - chemical synthesis | Animals | Pyridines - pharmacology | Anti-inflammatory drugs | Pyridine
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2015, Volume 290, Issue 11, pp. 6763 - 6776
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 03/2012, Volume 20, Issue 5, pp. 1644 - 1658
(−)-6-(7-Methoxy-2-trifluoromethylpyrazolo[1,5- ]pyridin-4-yl)-5-methyl-4,5-dihydro-3-(2 )-pyridazinone (KCA-1490) is a dual PDE3/4 inhibitor that exhibits... 
Phosphodiesterase (PDE) | Fused bicyclic heteroaromatics | Dual PDE3/4 inhibitor | Asthma | COPD | CHEMISTRY, MEDICINAL | MANAGEMENT | RECEPTOR ANTAGONISTS | COMBINATION THERAPY | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INHALED CORTICOSTEROIDS | CHEMISTRY, ORGANIC | OBSTRUCTIVE PULMONARY-DISEASE | SMOOTH-MUSCLE | POSITIVE INOTROPIC AGENTS | CARDIOTONIC AGENTS | Phosphodiesterase 4 Inhibitors - chemistry | Anti-Inflammatory Agents - pharmacology | Phosphodiesterase 3 Inhibitors - chemistry | Phosphodiesterase 3 Inhibitors - pharmacology | Pyridines - chemistry | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Humans | Pyridines - chemical synthesis | Models, Molecular | Bronchodilator Agents - pharmacology | Structure-Activity Relationship | Bronchodilator Agents - chemical synthesis | Phosphodiesterase 4 Inhibitors - pharmacology | Phosphodiesterase 4 Inhibitors - chemical synthesis | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Bronchodilator Agents - chemistry | Phosphodiesterase 3 Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemistry | Bronchoconstriction - drug effects | Drug Design | Anti-Inflammatory Agents - chemical synthesis | Pyridines - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis | Anti-inflammatory drugs | Lung diseases, Obstructive
Journal Article
Journal Article
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 02/2016, Volume 1861, Issue 2, pp. 78 - 90
Increased synthesis of hyaluronic acid (HA) is often associated with increased metastatic potential and invasivity of tumor cells. 4-Methylumbelliferone (MU)... 
Ceramide | 4-Methylumbelliforone | NSMase2 | Hyaluronic acid | Anticancer | CANCER-CELLS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIRT1 | CELL BIOLOGY | ADHESION DYNAMICS | IN-VITRO | BIOPHYSICS | CALPAIN-MEDIATED PROTEOLYSIS | NEUTRAL SPHINGOMYELINASE 2 | PROSTATE-CANCER | MELANOMA-CELLS | EXPRESSION | Sirtuin 1 - metabolism | Sphingomyelin Phosphodiesterase - genetics | Calpain - metabolism | Apoptosis - drug effects | Neuroglia - pathology | Humans | Caspase 3 - metabolism | Gene Expression Regulation, Neoplastic | Calpain - genetics | Sirtuin 1 - genetics | Ceramides - biosynthesis | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Neuroglia - drug effects | Glucuronosyltransferase - genetics | Sphingomyelin Phosphodiesterase - metabolism | Caspase 3 - genetics | Antineoplastic Agents - pharmacology | Hyaluronan Synthases | Hymecromone - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Signal Transduction | Protein Phosphatase 2 - genetics | Tumor Suppressor Protein p53 - metabolism | Hyaluronic Acid - antagonists & inhibitors | Cell Movement - drug effects | Animals | Glucuronosyltransferase - metabolism | Hyaluronic Acid - metabolism | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Neuroglia - metabolism | Mice | Enzyme Activation | Ceramides | Calpain | Plant lipids | Tumor proteins | Tumors | Phosphatases | Metastasis | Mass spectrometry
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 02/2010, Volume 159, Issue 4, pp. 842 - 855
Background and purpose:  Apremilast is an orally administered phosphodiesterase-4 inhibitor, currently in phase 2 clinical studies of psoriasis and other... 
immunopharmacology | anti-inflammatory drugs | PDE inhibitor | chemokines | inflammation | skin pharmacology | anti‐inflammatory drugs | Skin pharmacology | Inflammation | Anti-inflammatory drugs | Immunopharmacology | Chemokines | TRANSCRIPTION FACTORS | DIFFERENTIAL EXPRESSION | ELEMENT-BINDING PROTEIN | NECROSIS-FACTOR-ALPHA | PERITONEAL-MACROPHAGES | PDE4 INHIBITORS | OBSTRUCTIVE PULMONARY-DISEASE | CYCLIC-AMP PHOSPHODIESTERASE | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | PLAQUE-TYPE PSORIASIS | Humans | Middle Aged | Thalidomide - pharmacology | RNA, Messenger - metabolism | Zymosan - metabolism | Thalidomide - analogs & derivatives | Ultraviolet Rays | Psoriasis - pathology | Time Factors | U937 Cells | Anti-Inflammatory Agents - administration & dosage | Skin Transplantation | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cytokines - genetics | Keratinocytes - enzymology | Disease Models, Animal | Psoriasis - immunology | Leukocytes, Mononuclear - drug effects | Psoriasis - drug therapy | Administration, Oral | Anti-Inflammatory Agents - pharmacology | Thalidomide - administration & dosage | Skin - enzymology | Keratinocytes - immunology | Killer Cells, Natural - enzymology | Keratinocytes - drug effects | Lipopolysaccharides - pharmacology | Killer Cells, Natural - drug effects | Mice | Transplantation, Heterologous | Dose-Response Relationship, Drug | Psoriasis - genetics | Enterotoxins - immunology | Leukocytes, Mononuclear - immunology | Inflammation Mediators - metabolism | Phosphodiesterase 4 Inhibitors | Killer Cells, Natural - immunology | Adult | Skin - pathology | Skin - immunology | Severity of Illness Index | Cytokines - metabolism | Phosphodiesterase Inhibitors - pharmacology | Mice, SCID | Gene Expression Regulation - drug effects | Phosphodiesterase Inhibitors - administration & dosage | Animals | Skin - radiation effects | Leukocytes, Mononuclear - enzymology | Cell Proliferation - drug effects | Psoriasis - enzymology | Skin - drug effects | Psoriasis | Tumor necrosis factor-TNF | Rodents | Research Papers
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 10/2010, Volume 30, Issue 10, pp. 1998 - 2004
Journal Article
FEBS Journal, ISSN 1742-464X, 03/2016, Volume 283, Issue 6, pp. 1107 - 1123
Novel structure of sphingomyelinase phosphodiesterase like 3a ( SMPDL 3a) revealed a conserved calcineurin like phosphodiesterase domain with a binuclear... 
calcineurin‐like phosphodiesterase | binuclear metallophosphodiesterase | acid sphingomyelinase like | Niemann–Pick disease | nucleotide hydrolase | Niemann-Pick disease | Nucleotide hydrolase | Binuclear metallophosphodiesterase | Acid sphingomyelinase like | Calcineurin-like phosphodiesterase | calcineurin-like phosphodiesterase | Cytidine Monophosphate - metabolism | Sphingomyelin Phosphodiesterase - genetics | Zinc - metabolism | Humans | Molecular Sequence Data | Substrate Specificity | Crystallography, X-Ray | Phylogeny | Disulfides - chemistry | Sphingomyelin Phosphodiesterase - metabolism | Niemann-Pick Diseases - enzymology | Conserved Sequence | Niemann-Pick Diseases - genetics | Amino Acid Sequence | Catalytic Domain | Sphingomyelin Phosphodiesterase - chemistry | Mutant Proteins - genetics | Models, Molecular | Mutant Proteins - metabolism | Glycosylation | Static Electricity | Sequence Homology, Amino Acid | Point Mutation | Mutant Proteins - chemistry | Protein Conformation | HYPOTHETICAL PROTEIN | ARABIDOPSIS-THALIANA | CRYSTAL-STRUCTURE | POLYKETIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TETRACENOMYCIN-F2 CYCLASE | PLANT POLYKETIDES | ALDOL CONDENSATION | AROMATIC POLYKETIDES | FUNCTIONAL-ANALYSIS | STREPTOMYCES-GLAUCESCENS | Enzymes | Hydrolases | Phospholipids | Nucleotides | Analysis | Lipids | Genetic disorders | Molecular biology
Journal Article
The EMBO Journal, ISSN 0261-4189, 04/2009, Volume 28, Issue 8, pp. 1043 - 1054
Journal Article
Oncogene, ISSN 0950-9232, 03/2015, Volume 34, Issue 12, pp. 1499 - 1509
Journal Article