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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2007, Volume 104, Issue 2, pp. 612 - 617
Journal Article
2010, Current topics in microbiology and immunology, ISBN 9783642148156, Volume 346, 347., v.
PI3K is at the forefront of drug development with the first clinical trials of PI3K pathway inhibitors in progress. This book offers an overview of some key... 
Protein kinases | Protein-tyrosine kinase | Inhibitors | Cell proliferation | Phosphoinositides | Cell death | Apoptosis | Phospholipases
Book
by Coulter, Tanya I., MRCPI|Chandra, Anita, PhD, FRCPath|Bacon, Chris M., PhD, FRCPath|Babar, Judith, MRCP, FRCR|Curtis, James, PhD|Screaton, Nick, FRCP, FRCR|Goodlad, John R., MD, FRCPath|Farmer, George, MD|Steele, Cathal Laurence, MB|Leahy, Timothy Ronan, MRCPI|Doffinger, Rainer, PhD, FRCPath|Baxendale, Helen, PhD, FRCPath|Bernatoniene, Jolanta, PhD|Edgar, J. David M., FRCP, FRCPath|Longhurst, Hilary J., PhD, FRCPath|Ehl, Stephan, MD, PhD|Speckmann, Carsten, MD|Grimbacher, Bodo, MD, PhD|Sediva, Anna, MD, PhD|Milota, Tomas, MD|Faust, Saul N., PhD, FRCPCH|Williams, Anthony P., PhD, FRCPath|Hayman, Grant, FRCP, FRCPath|Kucuk, Zeynep Yesim, MD|Hague, Rosie, MRCP, FRCPH|French, Paul, MD, MRCS, DipFMS, FRCPath|Brooker, Richard, FRCPCH|Forsyth, Peter, FRCPath|Herriot, Richard, FRCP, FRCPath|Cancrini, Caterina, MD, PhD|Palma, Paolo, MD, PhD|Ariganello, Paola, MD|Conlon, Niall, PhD, FRCPath|Feighery, Conleth, PhD, FRCPath|Gavin, Patrick J., MD|Jones, Alison, PhD, FRCPCH|Imai, Kohsuke, MD, PhD|Ibrahim, Mohammad A.A., PhD, FRCP, FRCPath|Markelj, Gašper, MD|Abinun, Mario, MD, PhD|Rieux-Laucat, Frédéric, PhD|Latour, Sylvain, PhD|Pellier, Isabelle, MD, PhD|Fischer, Alain, MD, PhD|Touzot, Fabien, MD, PhD|Casanova, Jean-Laurent, MD, PhD|Durandy, Anne, MD, PhD|Burns, Siobhan O., MD, PhD|Savic, Sinisa, PhD, FRCPath|Kumararatne, D.S., FRCPath, DPhil (Oxon)|Moshous, Despina, MD, PhD|Kracker, Sven, PhD|Vanhaesebroeck, Bart, PhD, FMedSci|Okkenhaug, Klaus, PhD|Picard, Capucine, MD, PhD|Nejentsev, Sergey, MD, PhD|Condliffe, Alison M., PhD, FRCP|Cant, Andrew James, MD, FRCP, FRCPH
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 597 - 606.e4
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in... 
Allergy and Immunology | Activated phosphoinositide 3-kinase δ syndrome | hematopoietic stem cell transplantation | phosphoinositide 3-kinase δ | immunodeficiency | phosphoinositide 3-kinase inhibitor | PIK3CD gene | bronchiectasis | p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency | Activated phosphoinositide 3-kinase delta syndrome | IMMUNOLOGICAL FEATURES | HYPER-IGM SYNDROME | p110 delta-activating mutation causing senescent T cells | hematopoietic stem cell | COMMON VARIABLE IMMUNODEFICIENCY | PIK3CD | IMMUNOLOGY | lymphadenopathy | REFERENCE VALUES | P110-DELTA | CT | phosphoinositide 3-kinase delta | P110 DELTA | B-CELL | ALLERGY | transplantation | MUTATIONS | Recurrence | Class I Phosphatidylinositol 3-Kinases - genetics | Herpesviridae Infections - mortality | Humans | Middle Aged | Child, Preschool | Infant | Male | Antibiotic Prophylaxis | Respiratory Tract Infections - genetics | Lymphoproliferative Disorders - therapy | Young Adult | Respiratory Tract Infections - mortality | Respiratory Tract Infections - therapy | Immunologic Deficiency Syndromes - mortality | Adult | Female | Surveys and Questionnaires | Herpesviridae Infections - genetics | Child | Immunologic Deficiency Syndromes - therapy | Hematopoietic Stem Cell Transplantation | International Cooperation | Lymphoproliferative Disorders - genetics | Mutation - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Lymphoproliferative Disorders - mortality | Animals | Herpesviridae Infections - therapy | Immunoglobulins, Intravenous - therapeutic use | Adolescent | Survival Analysis | Immunologic Deficiency Syndromes - genetics | Mice | Cohort Studies | Index Medicus | Abridged Index Medicus | Immune Deficiencies, Infection, and Systemic Immune Disorders | HSCT, Hematopoietic stem cell transplantation | BALF, Bronchoalveolar lavage fluid | CT, Computed tomography | APDS, Activated phosphoinositide-3 kinase δ syndrome | GOF, Gain of function | PI3K, Phosphoinositide 3-kinase | HSV, Herpes simplex virus | CMV, Cytomegalovirus | OR, Odds ratio | PPV, Pneumococcal polysaccharide vaccine | CNS, Central nervous system
Journal Article
Cancer Research, ISSN 0008-5472, 11/2008, Volume 68, Issue 22, pp. 9221 - 9230
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 1, pp. 210 - 218.e9
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 1997, Volume 272, Issue 12, pp. 7873 - 7882
Phosphatidylinositol 3-kinase (PI 3-kinase) is stimulated by association with a variety of tyrosine kinase receptors and intracellular tyrosine-phosphorylated... 
SIGNAL-TRANSDUCTION | CELLS | ACTIVATION | RECEPTOR TYROSINE KINASES | GLUCOSE-TRANSPORTER | STIMULATED GLUT4 TRANSLOCATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INHIBITOR | PROTEINS | PHOSPHOINOSITIDE 3-KINASE | WORTMANNIN
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2011, Volume 438, Issue 1, pp. 53 - 62
Genetic alterations in PI3K (phosphoinositide 3-kinase) signalling are common in cancer and include deletions in PTEN (phosphatase and tensin homologue deleted... 
Phosphoinositide 4-kinase (PI4K) | Pan-phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235; phosphoinositide 3-kinase α (PI3Kα) | PIK3CA | p110α E545k mutation | PIK3CA H1047R mutation | 3T3-L1 ADIPOCYTES | CATALYTIC SUBUNIT | BIOCHEMISTRY & MOLECULAR BIOLOGY | p110 alpha E545K mutation | phosphoinositide 4-kinase (PI4K) | pan-phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235 | BREAST-CANCER | INSULIN | P110-BETA | phosphoinositide 3-kinase alpha (PI3K alpha) | PIK3CA GENE | IN-VIVO | MUTATIONS | INHIBITORS | IA PI3K ISOFORMS | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Humans | Neoplasms, Experimental - prevention & control | Enzyme Inhibitors - therapeutic use | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Mice, Knockout | Neoplasms, Experimental - pathology | Tissue Distribution | Animals | Enzyme Inhibitors - pharmacokinetics | Signal Transduction - drug effects | Protein Isoforms | Mice | Neoplasms, Experimental - metabolism | Tumor Cells, Cultured | Homeodomain Proteins - physiology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | PI3K, phosphoinositide 3-kinase | BID, twice daily dosing | p110α E545K mutation | mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235; phosphoinositide 3-kinase α (PI3Kα) | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | pan-phosphoinositide 3kinase (PI3K) | PI4K, phosphoinositide 4-kinase | QD, once daily dosing | mTOR, mammalian target of rapamycin | TGI, tumour growth inhibition
Journal Article
Journal Article
Journal Article