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by Coulter, Tanya I., MRCPI and Chandra, Anita, PhD, FRCPath and Bacon, Chris M., PhD, FRCPath and Babar, Judith, MRCP, FRCR and Curtis, James, PhD and Screaton, Nick, FRCP, FRCR and Goodlad, John R., MD, FRCPath and Farmer, George, MD and Steele, Cathal Laurence, MB and Leahy, Timothy Ronan, MRCPI and Doffinger, Rainer, PhD, FRCPath and Baxendale, Helen, PhD, FRCPath and Bernatoniene, Jolanta, PhD and Edgar, J. David M., FRCP, FRCPath and Longhurst, Hilary J., PhD, FRCPath and Ehl, Stephan, MD, PhD and Speckmann, Carsten, MD and Grimbacher, Bodo, MD, PhD and Sediva, Anna, MD, PhD and Milota, Tomas, MD and Faust, Saul N., PhD, FRCPCH and Williams, Anthony P., PhD, FRCPath and Hayman, Grant, FRCP, FRCPath and Kucuk, Zeynep Yesim, MD and Hague, Rosie, MRCP, FRCPH and French, Paul, MD, MRCS, DipFMS, FRCPath and Brooker, Richard, FRCPCH and Forsyth, Peter, FRCPath and Herriot, Richard, FRCP, FRCPath and Cancrini, Caterina, MD, PhD and Palma, Paolo, MD, PhD and Ariganello, Paola, MD and Conlon, Niall, PhD, FRCPath and Feighery, Conleth, PhD, FRCPath and Gavin, Patrick J., MD and Jones, Alison, PhD, FRCPCH and Imai, Kohsuke, MD, PhD and Ibrahim, Mohammad A.A., PhD, FRCP, FRCPath and Markelj, Gašper, MD and Abinun, Mario, MD, PhD and Rieux-Laucat, Frédéric, PhD and Latour, Sylvain, PhD and Pellier, Isabelle, MD, PhD and Fischer, Alain, MD, PhD and Touzot, Fabien, MD, PhD and Casanova, Jean-Laurent, MD, PhD and Durandy, Anne, MD, PhD and Burns, Siobhan O., MD, PhD and Savic, Sinisa, PhD, FRCPath and Kumararatne, D.S., FRCPath, DPhil (Oxon) and Moshous, Despina, MD, PhD and Kracker, Sven, PhD and Vanhaesebroeck, Bart, PhD, FMedSci and Okkenhaug, Klaus, PhD and Picard, Capucine, MD, PhD and Nejentsev, Sergey, MD, PhD and Condliffe, Alison M., PhD, FRCP and Cant, Andrew James, MD, FRCP, FRCPH
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 597 - 606.e4
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in... 
Allergy and Immunology | Activated phosphoinositide 3-kinase δ syndrome | hematopoietic stem cell transplantation | phosphoinositide 3-kinase δ | immunodeficiency | phosphoinositide 3-kinase inhibitor | PIK3CD gene | bronchiectasis | p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency | Recurrence | Humans | Middle Aged | Child, Preschool | Infant | Male | Antibiotic Prophylaxis | Class I Phosphatidylinositol 3-Kinases/antagonists & inhibitors | Young Adult | Immunoglobulins, Intravenous/therapeutic use | Enzyme Inhibitors/therapeutic use | Lymphoproliferative Disorders/genetics | Adult | Female | Surveys and Questionnaires | Child | Respiratory Tract Infections/genetics | Mutation/genetics | Hematopoietic Stem Cell Transplantation | International Cooperation | Herpesviridae Infections/genetics | Animals | Adolescent | Survival Analysis | Mice | Immunologic Deficiency Syndromes/genetics | Cohort Studies | Activated phosphoinositide 3-kinase delta syndrome | IMMUNOLOGICAL FEATURES | HYPER-IGM SYNDROME | p110 delta-activating mutation causing senescent T cells | hematopoietic stem cell | COMMON VARIABLE IMMUNODEFICIENCY | PIK3CD | IMMUNOLOGY | lymphadenopathy | REFERENCE VALUES | P110-DELTA | phosphoinositide 3-kinase delta | P110 DELTA | B-CELL | ALLERGY | transplantation | MUTATIONS | Class I Phosphatidylinositol 3-Kinases - genetics | Herpesviridae Infections - mortality | Respiratory Tract Infections - genetics | Lymphoproliferative Disorders - therapy | Respiratory Tract Infections - mortality | Respiratory Tract Infections - therapy | Immunologic Deficiency Syndromes - mortality | Herpesviridae Infections - genetics | Immunologic Deficiency Syndromes - therapy | Lymphoproliferative Disorders - genetics | Mutation - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Lymphoproliferative Disorders - mortality | Herpesviridae Infections - therapy | Immunoglobulins, Intravenous - therapeutic use | Immunologic Deficiency Syndromes - genetics | Immune Deficiencies, Infection, and Systemic Immune Disorders | HSCT, Hematopoietic stem cell transplantation | BALF, Bronchoalveolar lavage fluid | CT, Computed tomography | APDS, Activated phosphoinositide-3 kinase δ syndrome | GOF, Gain of function | PI3K, Phosphoinositide 3-kinase | HSV, Herpes simplex virus | CMV, Cytomegalovirus | OR, Odds ratio | PPV, Pneumococcal polysaccharide vaccine | CNS, Central nervous system
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 1, pp. 210 - 218.e9
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) 2 (p110δ-activating mutations causing senescent T cells, lymphadenopathy, and immunodeficiency... 
Allergy and Immunology | and immunodeficiency | p110δ-activating mutations causing senescent T cells | hyper-IgM | adenopathy | p110δ | activated phosphoinositide 3-kinase δ syndrome | p85α | antibody deficiency | immunodeficiency | lymphadenopathy | phosphoinositide 3-kinase | Primary immunodeficiency | Class I Phosphatidylinositol 3-Kinases/genetics | RNA Splice Sites | Gene Frequency | Humans | Middle Aged | Immunologic Deficiency Syndromes/diagnosis | Child, Preschool | Genotype | Male | Young Adult | CD8-Positive T-Lymphocytes/immunology | Phenotype | T-Lymphocyte Subsets/immunology | Biopsy | Adolescent | Alleles | Adult | Female | Mutation | Child | Cohort Studies | p110 delta-activating mutations causing senescent T cells | CELLS | HUMAN IMMUNODEFICIENCY | KINASE | p85 alpha | IMMUNOLOGY | p110 delta | ALLERGY | MUTATIONS | activated phosphoinositide 3-kinase delta syndrome | T-Lymphocyte Subsets - immunology | Class I Phosphatidylinositol 3-Kinases - genetics | Immunologic Deficiency Syndromes - etiology | Immunologic Deficiency Syndromes - mortality | CD8-Positive T-Lymphocytes - metabolism | Immunologic Deficiency Syndromes - diagnosis | T-Lymphocyte Subsets - metabolism | CD8-Positive T-Lymphocytes - immunology | Life Sciences | Human health and pathology | Economics and Finance | Psychology | Santé publique et épidémiologie | Humanities and Social Sciences | Psychiatrics and mental health
Journal Article
Journal Article
Journal Article
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 03/2018, Volume 9
Activated phosphoinositide 3-kinase (PI3K) delta Syndrome (APDS), caused by autosomal dominant mutations in PIK3CD (APDS1) or PIK3R1 (APDS2), is a... 
registry | MUTATION | PIK3CD | PIK3R1 | IMMUNOLOGY | activated phosphoinositide 3-kinase delta syndrome | natural history | rapamycin | SIROLIMUS
Journal Article
by Jeong, JS and Kim, JS and Kim, SR and Lee, YC
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1661-6596, 07/2019, Volume 20, Issue 14, p. 3525
Journal Article
Clinical Immunology, ISSN 1521-6616, 2016, Volume 171, pp. 38 - 40
Highlights • Activated phosphoinositide 3-kinase δ syndrome may be complicated by refractory autoimmune hemolytic anemia. • Sirolimus presents a precision... 
Allergy and Immunology | Sirolimus | Autoimmune hemolytic anemia | Activated phosphoinositide 3-kinase δ syndrome | Activated phosphoinositide 3-kinase delta syndrome | GENOMICS | IMMUNOLOGY
Journal Article
ACS MEDICINAL CHEMISTRY LETTERS, ISSN 1948-5875, 11/2019, Volume 10, Issue 11, pp. 1554 - 1560
A medicinal chemistry effort focused on identifying a structurally diverse candidate for phosphoinositide 3-kinase delta (PI3K delta) led to the discovery of... 
Parsaclisib | CHEMISTRY, MEDICINAL | INCB050465 | phosphoinositide 3-kinase delta | INCB040093 | dezapelisib | PI3K delta
Journal Article
by Wang, Y and Wang, WJ and Liu, LY and Hou, J and Ying, WJ and Hui, XY and Zhou, QH and Liu, DR and Yao, HL and Sun, JQ and Wang, XC
JOURNAL OF CLINICAL IMMUNOLOGY, ISSN 0271-9142, 11/2018, Volume 38, Issue 8, pp. 854 - 863
PurposeWe aimed to report the clinical manifestations and immunological features of activated phosphatidylinositol 3-kinase syndrome 1 (APDS1) in a Chinese... 
primary immunodeficiency | PIK3CD | MUTATIONS | IMMUNOLOGY | PIK3CD gene | Activated phosphoinositide 3-kinase syndrome | MTOR | rapamycin | FEATURES | Medicine, Experimental | Medical research | B cells | T cells | Health aspects | Immunodeficiency
Journal Article
ISSN 0091-6749, 2016
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 03/2018, Volume 9, Issue MAR, p. 446
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 2012, Volume 38, Issue 4, pp. 381 - 391
Abstract Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by the production of autoantibodies against nuclear components.... 
Allergy and Immunology | Lyn tyrosine kinase | Autoimmune disease | Systemic lupus erythematosus | Phosphoinositide 3-kinase p110δ | Autoimmune disease therapy | B-CELL DEVELOPMENT | SYSTEMIC-LUPUS-ERYTHEMATOSUS | PHOSPHATIDYLINOSITOL 3-KINASE | TYROSINE KINASE | ALLERGIC AIRWAY INFLAMMATION | IMMUNOLOGY | NEGATIVE REGULATOR | MUTANT MICE | Phosphoinositide 3-kinase p110 delta | LYN(-/-) MICE | T-CELLS | LYN-DEFICIENT MICE | Kidney - pathology | Antibodies, Antinuclear - immunology | Hyperplasia | Autoimmune Diseases - mortality | Phosphatidylinositol 3-Kinases - metabolism | src-Family Kinases - deficiency | Autoimmune Diseases - genetics | Kidney - metabolism | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | T-Lymphocytes - metabolism | Myeloid Cells - immunology | Proto-Oncogene Proteins c-akt - metabolism | B-Lymphocytes - metabolism | Haploinsufficiency - genetics | Signal Transduction | Mice, Inbred C57BL | Autoimmune Diseases - immunology | Genotype | Receptors, Antigen, B-Cell - immunology | Mice, Knockout | Antibodies, Antinuclear - genetics | Phosphatidylinositol 3-Kinases - genetics | Animals | B-Lymphocytes - immunology | Alleles | Myeloid Cells - metabolism | T-Lymphocytes - immunology | Mice | Myeloid Cells - pathology | src-Family Kinases - genetics | Plasma Cells - cytology | Haploinsufficiency - immunology | Mitogen-Activated Protein Kinases - metabolism | Plasma Cells - immunology | Glomerulonephritis | Enzymes | Animal models | Immunoglobulins | Autoantibodies | Inflammation | Lymphocytes T | Kidney | phosphoinositides | 1-Phosphatidylinositol 3-kinase | Cell activation | haploinsufficiency | Lymphocytes B | Plasma cells | Lyn protein | Autoimmune diseases
Journal Article