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phospholipase c-gamma-1 (649) 649
humans (437) 437
animals (419) 419
phosphorylation (398) 398
biochemistry & molecular biology (351) 351
signal transduction (340) 340
activation (248) 248
cell biology (238) 238
immunology (221) 221
mice (192) 192
type c phospholipases - metabolism (179) 179
tyrosine phosphorylation (176) 176
antigen receptor (168) 168
index medicus (152) 152
tyrosine - metabolism (150) 150
rats (143) 143
protein-tyrosine kinases - metabolism (139) 139
signal-transduction (127) 127
cell line (122) 122
isoenzymes - metabolism (117) 117
calcium - metabolism (113) 113
molecular sequence data (109) 109
phospholipase c gamma (107) 107
c-gamma-1 (104) 104
cells, cultured (96) 96
amino acid sequence (92) 92
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enzyme activation (83) 83
phosphoproteins - metabolism (80) 80
expression (77) 77
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receptors, antigen, t-cell - metabolism (66) 66
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kinase (63) 63
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phosphatidylinositol 3-kinase (62) 62
protein binding (62) 62
transfection (62) 62
male (61) 61
protein (61) 61
cells (60) 60
phosphotyrosine (60) 60
female (59) 59
jurkat cells (58) 58
lymphocyte activation (58) 58
basophilic leukemia-cells (56) 56
zeta-chain (56) 56
blotting, western (54) 54
research (54) 54
kinetics (51) 51
cell antigen receptor (50) 50
base sequence (48) 48
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multidisciplinary sciences (47) 47
tyrosine - analogs & derivatives (47) 47
association (46) 46
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proteins - metabolism (44) 44
receptors, antigen, t-cell - physiology (44) 44
binding sites (43) 43
biophysics (43) 43
phospholipase c (43) 43
signal transduction - immunology (43) 43
growth-factor receptor (42) 42
c-gamma (41) 41
calcium (41) 41
mutation (41) 41
phospholipase c gamma - metabolism (41) 41
egf receptor (40) 40
genetics & heredity (40) 40
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kinases (38) 38
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adaptor proteins, signal transducing - metabolism (37) 37
gene expression (37) 37
molecular-cloning (37) 37
proto-oncogene proteins - metabolism (37) 37
binding (36) 36
pharmacology & pharmacy (36) 36
physiological aspects (36) 36
protein kinase c - metabolism (36) 36
hematology (35) 35
pc12 cells (35) 35
phosphorylation - drug effects (35) 35
tyrosine kinases (35) 35
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1. Full Text Phospholipase C gamma-1 mediated Akt-notch1 signaling is essential for intima formation
by Jianhui Zhuang and Dongyang Jiang and Wenhui Peng and Yuyan Lu and Qian Zhao and Lin Gao and Chen Chi and Xiangbing Xu and Chen Yan and Yawei Xu and Junbo Ge and Jinjiang Pang
Circulation, ISSN 0009-7322, 11/2015, Volume 132, Issue 19
Cell proliferation | Blood circulation disorders | Care and treatment | Dosage and administration | Phospholipases | Research
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2. Full Text Phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial development
by Lawson, Nathan D and Mugford, Joshua W and Diamond, Brigid A and Weinstein, Brant M
Genes and Development, ISSN 0890-9369, 06/2003, Volume 17, Issue 11, pp. 1346 - 1351
In this study, we utilize transgenic zebrafish with fluorescently labeled blood vessels to identify and characterize a mutant (y10) that displays specific... 
Endothelial | Plcg1 | Zebrafish | Vegf | Artery | Vascular Endothelial Growth Factor A | Vascular Endothelial Growth Factors | Molecular Sequence Data | Type C Phospholipases - metabolism | Arteries - embryology | Male | Zebrafish - embryology | Arteries - cytology | Muscle, Smooth, Vascular - embryology | Lymphokines - genetics | Gene Expression Regulation, Developmental | Base Sequence | Phospholipase C gamma | Polymerase Chain Reaction | Female | Embryo, Nonmammalian - physiology | Recombinant Proteins - metabolism | Animals, Genetically Modified | RNA, Messenger - genetics | Intercellular Signaling Peptides and Proteins - genetics | DNA Primers | Muscle, Smooth, Vascular - cytology | Animals | Endothelial Growth Factors - genetics | Type C Phospholipases - genetics | Genetic Carrier Screening | Crosses, Genetic | Genetically modified animals | Developmental genetics | Gene mutations | Analysis | Genetic research | Physiological aspects | Genetic aspects | Research | Phospholipases | Genetic regulation | Arteries | Endothelium | Research Communications | zebrafish | artery | endothelial
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3. Full Text Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish
by Jing, Chang-Bin and Chen, Yi and Dong, Mei and Peng, Xiao-Lan and Jia, Xiao-E and Gao, Lei and Ma, Ke and Deng, Min and Liu, Ting-Xi and Zon, Leonard I and Zhu, Jun and Zhou, Yi and Zhou, Yong
Developmental Biology, ISSN 0012-1606, 02/2013, Volume 374, Issue 1, pp. 24 - 31
The regulation of hematopoiesis is generally evolutionarily conserved from zebrafish to mammals, including hematopoietic stem cell formation and blood cell... 
Zebrafish | Granulocytes | mpx | Phospholipase C gamma-1 (plcg1) | Mpx | EMBRYONIC-DEVELOPMENT | ERYTHROPOIESIS | NEUTROPHILS | TRANSCRIPTION FACTOR GFI-1 | DEVELOPMENTAL BIOLOGY | ISOZYMES | MYELOPOIESIS | HEMATOPOIETIC STEM-CELLS | IN-VIVO | PRIMITIVE HEMATOPOIESIS | DIFFERENTIATION | Granulocytes - cytology | Phosphorylation | RNA, Messenger - metabolism | Microscopy, Confocal - methods | Plasmids - metabolism | Cell Lineage | Phenotype | Animals | Mutagenesis | Gene Expression Regulation, Developmental | Hematopoiesis | Hematopoietic Stem Cells - cytology | Phospholipase C gamma - genetics | Cell Differentiation | Models, Genetic | Histones - metabolism | Mutation | Phospholipase C gamma - physiology | Genes | Hematopoietic stem cells | Phospholipases
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4. Full Text Trichostatin A reduced phospholipase C gamma-1 transcript and protein contents in MCF-7 breast cancer cells
by Drzewiecka, H and Jagodzinski, P.P
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 2011, Volume 66, Issue 1, pp. 1 - 5
Abstract It has recently been demonstrated that phospholipase C gamma-1 (PLCγ1) activation may contribute to breast carcinoma cell motility and their... 
Internal Medicine | Medical Education | MCF-7 breast cancer cells | TSA | Histone deacetylase inhibitors | PLCγ1 | MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | METASTASIS | C-GAMMA-1 | HISTONE-DEACETYLASE INHIBITOR | PROLIFERATION | PLC gamma 1 | INVASION | GROWTH | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | CARCINOMA | T-CELLS | Phospholipase C gamma - metabolism | Breast Neoplasms - pathology | Humans | Cell Line, Tumor | Half-Life | Female | Histone Deacetylase Inhibitors - pharmacology | Protein Synthesis Inhibitors - pharmacology | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Breast Neoplasms - drug therapy | Hydroxamic Acids - pharmacology | Protein biosynthesis | Breast cancer | Messenger RNA | Phospholipases | Analysis | Cancer cells | RNA
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5. Full Text Apicidin decreases phospholipase C gamma-1 transcript and protein in Hut-78 T lymphoma cells
by Dębicki, Szymon and Jagodzinski, Paweł P
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 2008, Volume 63, Issue 7, pp. 543 - 547
Abstract Phospholipase C gamma-1 (PLCγ1) phosphorylation is a key step in intracellular signal transduction in T cells. We used Hut-78 T lymphoma cells to... 
Internal Medicine | Medical Education | Histone deacetylase inhibitors | Apicidin | Hut-78 T lymphoma cells | MEDICINE, RESEARCH & EXPERIMENTAL | HISTONE DEACETYLASE INHIBITOR | ACTIVATION | DNA METHYLATION | ANTICANCER AGENTS | INVOLVEMENT | INDUCTION | SP1 SITES | ANTIGEN RECEPTORS | ANTIPROTOZOAL ACTIVITIES | PHARMACOLOGY & PHARMACY | EXPRESSION | Rabbits | Phosphorylation | Lymphoma, T-Cell | RNA, Messenger - genetics | Peptides, Cyclic - pharmacology | Signal Transduction - genetics | Blotting, Western | Phospholipase C gamma - biosynthesis | RNA, Messenger - biosynthesis | Animals | Phospholipase C gamma - genetics | Polymerase Chain Reaction | Cell Line, Tumor | Histone Deacetylase Inhibitors | Phospholipase C gamma - antagonists & inhibitors | Autoimmunity | Messenger RNA | Analysis | Protein biosynthesis | Lymphomas | Phospholipases | T cells
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6. Full Text PHOSPHOLIPASE-C-GAMMA-1 AND PHOSPHATIDYLINOSITOL-3 KINASE ARE THE DOWNSTREAM MEDIATORS OF THE PDGF RECEPTORS MITOGENIC SIGNAL
by VALIUS, M and KAZLAUSKAS, A
CELL, ISSN 0092-8674, 04/1993, Volume 73, Issue 2, pp. 321 - 334
Upon ligand-induced tyrosine phosphorylation, the platelet-derived growth factor (PDGF) receptor (PDGFR) beta subunit associates with PLC-gamma1, RasGAP, PI3K,... 
RAT-LIVER | GROWTH-FACTOR RECEPTOR | BOVINE BRAIN | TYROSINE PHOSPHORYLATION | 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-SYNTHESIS | GTPASE-ACTIVATING PROTEIN | SACCHAROMYCES-CEREVISIAE | ASSOCIATION | C-GAMMA | CELL BIOLOGY | GTPase-Activating Proteins | Signal Transduction | Mitosis | Protein-Tyrosine Kinases - metabolism | Humans | ras GTPase-Activating Proteins | Phosphotyrosine | Receptors, Platelet-Derived Growth Factor - physiology | Phosphatidylinositol 3-Kinases | Tyrosine - analogs & derivatives | Tyrosine - metabolism | Proteins - metabolism | DNA Mutational Analysis | DNA - biosynthesis | Enzyme Activation | Tumor Cells, Cultured | In Vitro Techniques | Platelet-Derived Growth Factor - physiology | Phosphotransferases - physiology | Type C Phospholipases - physiology
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7. Full Text INCREASE OF THE CATALYTIC ACTIVITY OF PHOSPHOLIPASE C-GAMMA-1 BY TYROSINE PHOSPHORYLATION
by NISHIBE, S and WAHL, MI and HERNANDEZSOTOMAYOR, SMT and TONKS, NK and RHEE, SG and CARPENTER, G
SCIENCE, ISSN 0036-8075, 11/1990, Volume 250, Issue 4985, pp. 1253 - 1256
Phospholipase C-gamma 1 (PLC-gamma 1), an isozyme of the phosphoinositide-specific phospholipase C family, which occupies a central role in hormonal signal... 
MULTIDISCIPLINARY SCIENCES | Phosphatidylinositol 4,5-Diphosphate | Phosphorylation | Phosphoric Diester Hydrolases - metabolism | Signal Transduction | Protein-Tyrosine Kinases - metabolism | Phosphotyrosine | Phosphatidylinositol Diacylglycerol-Lyase | Enzyme Activation - drug effects | Tyrosine - analogs & derivatives | ErbB Receptors | Immunosorbent Techniques | Tyrosine - metabolism | Diglycerides - metabolism | Isoenzymes - metabolism | Phosphatidylinositols - metabolism | Catalysis | Epidermal Growth Factor - pharmacology | Kinetics | Inositol 1,4,5-Trisphosphate - metabolism | Protein tyrosine kinase | Research | Phospholipases
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8. Full Text ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival
by Zhong, Wenbin and Yi, Qing and Xu, Bing and Li, Shiqian and Wang, Tong and Liu, Fupei and Zhu, Biying and Hoffmann, Peter R and Ji, Guangju and Lei, Pingsheng and Li, Guoping and Li, Jiwei and Li, Jian and Olkkonen, Vesa M and Yan, Daoguang
Nature Communications, ISSN 2041-1723, 09/2016, Volume 7, Issue 1, p. 12702
Metabolic pathways are reprogrammed in cancer to support cell survival. Here, we report that T-cell acute lymphoblastic leukemia (T-ALL) cells are... 
PHOSPHOLIPASE C-GAMMA-1 | INHIBITION | METABOLISM | PHOSPHORYLATION | PROTEIN-KINASE | MEMBRANE | MULTIDISCIPLINARY SCIENCES | FRIEND-CELLS | SIGNALS | THERAPEUTIC TARGETS
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9. Full Text Beta 2-integrin LFA-1 signaling through phospholipase C-gamma 1 activation
by S B Kanner and L S Grosmaire and J A Ledbetter and N K Damle
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/1993, Volume 90, Issue 15, pp. 7099 - 7103
One of the beta 2-integrins found on hematopoietic cells is lymphocyte function-associated antigen 1 (LFA-1), a lymphocyte/myeloid cell-specific receptor that... 
COSTIMULATORY SIGNAL | HUMAN NEUTROPHILS | MULTIDISCIPLINARY SCIENCES | CROSS-LINKING | LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1 | PROTEIN-TYROSINE KINASE | HUMAN T-CELLS | CD4+ LYMPHOCYTES-T | ADHESION MOLECULE-1 | FUNCTION-ASSOCIATED ANTIGEN-1 | TYROSINE-PHOSPHORYLATED PROTEIN | PHOSPHOTYROSINE | LEUKOCYTE INTEGRINS | SIGNAL TRANSDUCTION | CALCIUM RESPONSES | Phosphorylation | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Calcium - metabolism | Lymphocyte Activation | Humans | Phosphotyrosine | Type C Phospholipases - metabolism | Lymphocyte Function-Associated Antigen-1 - metabolism | Phosphoproteins - metabolism | CD4-Positive T-Lymphocytes - physiology | Tyrosine - analogs & derivatives | Tyrosine - metabolism | Enzyme Activation | Receptor Aggregation | In Vitro Techniques
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10. Full Text Vitamin D controls T cell antigen receptor signaling and activation of human T cells
by Von Essen, Marina Rode and Kongsbak, Martin and Schjerling, Peter and Olgaard, Klaus and Ødum, Niels and Geisler, Carsten
Nature Immunology, ISSN 1529-2908, 2010, Volume 11, Issue 4, pp. 344 - 349
Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low... 
PHOSPHOLIPASE C-GAMMA-1 | REQUIREMENTS | IN-VITRO | TCR | IMMUNE-SYSTEM | PHOSPHORYLATION | PROTEIN-KINASE | DIFFERENTIAL ACTIVATION | MEDIATED ACTIVATION | DOWN-REGULATION | IMMUNOLOGY | Signal Transduction - immunology | Lymphocyte Activation - immunology | Phospholipase C gamma - immunology | In Situ Hybridization | Vitamin D - immunology | Receptors, Calcitriol - immunology | Humans | Cells, Cultured | Immunoblotting | Receptors, Antigen, T-Cell - immunology | Enzyme Activation - immunology | Phospholipase C gamma - biosynthesis | Antigen receptors, T cell | Receptors | Vitamin D | Physiological aspects | Calcifediol | Cellular signal transduction | Genetic aspects | Alfacalcidol | Research | T cells
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11. Full Text REGULATION OF PHOSPHOLIPASE-C-GAMMA-1 BY PROFILIN AND TYROSINE PHOSPHORYLATION
by GOLDSCHMIDTCLERMONT, PJ and KIM, JW and MACHESKY, LM and RHEE, SG and POLLARD, TD
SCIENCE, ISSN 0036-8075, 03/1991, Volume 251, Issue 4998, pp. 1231 - 1233
Epidermal growth factor and platelet-derived growth factor can stimulate the production of the second messenger inositol trisphosphate in responsive cells, but... 
BOVINE BRAIN | RECEPTOR | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | MULTIDISCIPLINARY SCIENCES | Tyrosine | Phosphatidylinositol 4,5-Diphosphate | Phosphorylation | ErbB Receptors - metabolism | Signal Transduction | Protein-Tyrosine Kinases - metabolism | Type C Phospholipases - metabolism | Epidermal Growth Factor - metabolism | Animals | Isoenzymes - metabolism | Profilins | Phosphatidylinositols - metabolism | Microfilament Proteins - metabolism | Kinetics | Contractile Proteins - metabolism | Inositol Phosphates - metabolism | Protein tyrosine kinase | Research | Phospholipases | Growth factors
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12. Full Text Transactivation domain of Kruppel-like factor 15 negatively regulates angiotensin II-induced adventitial inflammation and fibrosis
by Lu, YY and Li, XD and Zhou, HD and Shao, S and He, S and Hong, MN and Liu, JC and Xu, YL and Wu, YJ and Zhu, DL and Wang, JG and Gao, PJ
FASEB JOURNAL, ISSN 0892-6638, 05/2019, Volume 33, Issue 5, pp. 6254 - 6268
Kruppel-like factor (KLF) 15 has emerged as a critical regulator of fibrosis in cardiovascular diseases. However, the precise role that KLF15 and its... 
PHOSPHOLIPASE C-GAMMA-1 | MIGRATION | CONTRIBUTE | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | macrophage | vascular remodeling | KLF15 | Ang II | FIBROBLASTS | CELL BIOLOGY | adenovirus | DISEASE | BIOLOGY | DIFFERENTIATION | EXPRESSION
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13. Full Text LTD at mossy fiber synapses onto stratum lucidum interneurons requires TrkB and retrograde endocannabinoid signaling
by Pan, Enhui and Zhao, Zirun and McNamara, James O
Journal of neurophysiology, ISSN 0022-3077, 02/2019, Volume 121, Issue 2, pp. 609 - 619
Hippocampal mossy fiber axons simultaneously activate CA3 pyramidal cells and stratum lucidum interneurons (SLINs). the latter providing feedforward inhibition... 
interneuron | TrkB | synaptic plasticity | hippocampus | BDNF | PHOSPHOLIPASE C-GAMMA-1 | LOCALIZATION | PHYSIOLOGY | SYNAPTIC-TRANSMISSION | IDENTIFICATION | NEUROSCIENCES | ZINC | LONG-TERM DEPRESSION | FEEDFORWARD INHIBITION | BRAIN | PLASTICITY
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14. Full Text Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y 1086, c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity
by Cardoso, A.P and Pinto, M.L and Pinto, A.T and Oliveira, M.I and Pinto, M.T and Gonçalves, R and Relvas, J.B and Figueiredo, C and Seruca, R and Mantovani, A and Mareel, M and Barbosa, M.A and Oliveira, M.J
Oncogene, ISSN 0950-9232, 04/2014, Volume 33, Issue 16, pp. 2123 - 2133
The interactions between cancer cells and their microenvironment are crucial for malignant progression, as they modulate invasion-related activities.... 
macrophages | cancer cell invasion | tumor microenvironment | gastric cancer | invasion-related signaling pathways | colon cancer | PHOSPHOLIPASE C-GAMMA-1 | METASTASIS | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INFILTRATION | CELL BIOLOGY | INVASIVENESS | TUMOR-CELL MIGRATION | ONCOLOGY | INFLAMMATION | GROWTH | GENETICS & HEREDITY | CARCINOMA | PROGRESSION
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15. Full Text Timeline - Jurkat T cells and development of the T-cell receptor signalling paradigm
by Abraham, RT and Weiss, A
NATURE REVIEWS IMMUNOLOGY, ISSN 1474-1733, 04/2004, Volume 4, Issue 4, pp. 301 - 308
Twenty years of investigation have yielded a detailed view of the signalling machinery engaged by T-cell receptors (TCRs). Many of the fundamental insights... 
PHOSPHOLIPASE C-GAMMA-1 | CYTOPLASMIC FREE CALCIUM | SEVERE COMBINED IMMUNODEFICIENCY | SHORT-INTERFERING RNAS | PROTEIN-TYROSINE KINASE | IMMUNOLOGY | LYMPHOCYTE REGULATORY MOLECULES | NF-KAPPA-B | ANTIGEN RECEPTOR | MAMMALIAN-CELLS | 2-STIMULUS REQUIREMENT
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16. Full Text AXL Mediates Resistance to PI3Kα Inhibition by Activating the EGFR/PKC/mTOR Axis in Head and Neck and Esophageal Squamous Cell Carcinomas
by Elkabets, Moshe and Pazarentzos, Evangelos and Juric, Dejan and Sheng, Qing and Pelossof, Raphael A and Brook, Samuel and Benzaken, Ana Oaknin and Rodon, Jordi and Morse, Natasha and Yan, Jenny Jiacheng and Liu, Manway and Das, Rita and Chen, Yan and Tam, Angela and Wang, Huiqin and Liang, Jinsheng and Gurski, Joseph M and Kerr, Darcy A and Rosell, Rafael and Teixidó, Cristina and Huang, Alan and Ghossein, Ronald A and Rosen, Neal and Bivona, Trever G and Scaltriti, Maurizio and Baselga, José
Cancer Cell, ISSN 1535-6108, 04/2015, Volume 27, Issue 4, pp. 533 - 546
Phosphoinositide-3-kinase (PI3K)-α inhibitors have shown clinical activity in squamous cell carcinomas (SCCs) of head and neck (H&N) bearing mutations or... 
PHOSPHOLIPASE C-GAMMA-1 | RECEPTOR TYROSINE KINASES | PLUS CETUXIMAB | PIK3CA | ONCOLOGY | PATHWAY | GROWTH | PLATINUM-BASED CHEMOTHERAPY | TUMOR-CELLS | PROTEINS | EGFR | CELL BIOLOGY | TOR Serine-Threonine Kinases - metabolism | Carcinoma, Squamous Cell - metabolism | Humans | Receptor Protein-Tyrosine Kinases - physiology | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Head and Neck Neoplasms - metabolism | Protein Kinase C - metabolism | Antibodies, Monoclonal, Humanized - pharmacology | Esophageal Neoplasms - metabolism | Cetuximab | Esophageal Squamous Cell Carcinoma | Proto-Oncogene Proteins - metabolism | Signal Transduction | Proto-Oncogene Proteins - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Phosphatidylinositol 3-Kinases - genetics | Xenograft Model Antitumor Assays | Animals | Class I Phosphatidylinositol 3-Kinases | Receptor Protein-Tyrosine Kinases - genetics | Proto-Oncogene Proteins - physiology | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology
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17. Full Text Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma 1 in vascular smooth muscle cells
by M B Marrero and W G Paxton and J L Duff and B C Berk and K E Bernstein
Journal of Biological Chemistry, ISSN 0021-9258, 04/1994, Volume 269, Issue 14, pp. 10935 - 10939
The receptor for angiotensin II (Ang II) has recently been cloned; it is a receptor with seven transmembrane spanning domains that stimulates phosphoinositide... 
ISOZYME | ACTIVATION | MOBILIZATION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCIUM | RECEPTOR | ALPHA | GROWTH-FACTOR | RESIDUES | C-GAMMA | Type C Phospholipases - drug effects | Angiotensin II - pharmacology | Cells, Cultured | Rats | Type C Phospholipases - metabolism | Platelet-Derived Growth Factor - pharmacology | Muscle, Smooth, Vascular - cytology | Tyrosine - metabolism | Animals | Isoenzymes - metabolism | Phospholipase C gamma | Isoenzymes - drug effects | Kinetics | Phosphorylation - drug effects | Muscle, Smooth, Vascular - enzymology | Muscle, Smooth, Vascular - drug effects
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18. Full Text The regulation of phospholipase C-gamma 1 by phosphatidic acid. Assessment of kinetic parameters
by G A Jones and G Carpenter
Journal of Biological Chemistry, ISSN 0021-9258, 10/1993, Volume 268, Issue 28, pp. 20845 - 20850
A survey of lipids revealed that the anionic phospholipid phosphatidic acid activates both control and tyrosine-phosphorylated PLC-gamma 1. The mechanism by... 
CELLS | DIACYLGLYCEROL | PROTEIN-KINASE-C | ACTIVATION | STIMULATION | TYROSINE PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | EPIDERMAL GROWTH-FACTOR | MIXED MICELLES | PHOSPHATIDYLCHOLINE | SIGNAL TRANSDUCTION | Phosphorylation | Tyrosine - metabolism | Allosteric Regulation | Cells, Cultured | Substrate Specificity | Type C Phospholipases - metabolism | Kinetics | Phosphatidic Acids - pharmacology
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19. Full Text FUNCTIONAL ACTIVATION OF THE T-CELL ANTIGEN RECEPTOR INDUCES TYROSINE PHOSPHORYLATION OF PHOSPHOLIPASE C-GAMMA-1
by WEISS, A and KORETZKY, G and SCHATZMAN, RC and KADLECEK, T
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 07/1991, Volume 88, Issue 13, pp. 5484 - 5488
Stimulation of the T-cell antigen receptor (TCR), which itself is not a protein-tyrosine kinase (PTK), activates a PTK and phospholipase C (PLC). Using the... 
PHOSPHATIDYL-INOSITOL PATHWAY | STIMULATION | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | INCREASES | PHOSPHATIDYLINOSITOL | PROLIFERATION | PDGF RECEPTOR | CD4 | CALCIUM | T-CELL ACTIVATION | PROTEIN KINASE P56LCK | SIGNAL TRANSDUCTION | ASSOCIATION
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20. Full Text Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLC gamma 1- and Ca2+-dependent apoptosis
by Baumann, S and Fas, SC and Giaisi, M and Muller, WW and Merling, A and Gulow, K and Edler, L and Krammer, PH and Li-Weber, M
BLOOD, ISSN 0006-4971, 02/2008, Volume 111, Issue 4, pp. 2354 - 2363
Herbs have successfully been used in traditional Chinese medicine for centuries. However, their curative mechanisms remain largely unknown. In this study, we... 
PHOSPHOLIPASE C-GAMMA-1 | HEPATOCELLULAR-CARCINOMA CELLS | MITOCHONDRIAL PERMEABILITY TRANSITION | CYCLOPHILIN-D | CA2+ MOBILIZATION | GENE-EXPRESSION | SCUTELLARIA-BAICALENSIS GEORGI | ENDOPLASMIC-RETICULUM | HYDROGEN-PEROXIDE | ANTICANCER DRUGS | HEMATOLOGY
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