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science & technology (318) 318
life sciences & biomedicine (289) 289
humans (187) 187
animals (185) 185
type c phospholipases - metabolism (183) 183
phosphorylation (155) 155
biochemistry & molecular biology (125) 125
isoenzymes - metabolism (114) 114
signal transduction (111) 111
phospholipase c gamma (103) 103
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mice (85) 85
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protein-tyrosine kinases - metabolism (61) 61
biological and medical sciences (59) 59
calcium - metabolism (56) 56
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molecular sequence data (52) 52
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enzyme activation (48) 48
phospholipase c gamma - metabolism (47) 47
tumor cells, cultured (46) 46
cells, cultured (44) 44
phospholipase c (40) 40
abridged index medicus (39) 39
amino acid sequence (39) 39
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fundamental and applied biological sciences. psychology (35) 35
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phosphoproteins - metabolism (34) 34
protein binding (34) 34
phospholipases (33) 33
phosphotyrosine (33) 33
t-lymphocytes - metabolism (33) 33
male (31) 31
type c phospholipases - genetics (31) 31
tyrosine - analogs & derivatives (29) 29
binding sites (28) 28
multidisciplinary sciences (28) 28
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medical sciences (27) 27
signal transduction - physiology (27) 27
adaptor proteins, signal transducing (26) 26
base sequence (25) 25
proteins - metabolism (25) 25
transfection (25) 25
blotting, western (24) 24
research (24) 24
isoenzymes - genetics (23) 23
phosphatidylinositols - metabolism (23) 23
t-lymphocytes - immunology (23) 23
epidermal growth factor - pharmacology (22) 22
lymphocyte activation (22) 22
phosphorylation - drug effects (21) 21
proto-oncogene proteins - metabolism (21) 21
type c phospholipases - physiology (21) 21
platelet-derived growth factor - pharmacology (20) 20
receptors, antigen, t-cell - metabolism (20) 20
tyrosine (20) 20
jurkat cells (19) 19
kinases (19) 19
phospholipase c gamma - genetics (19) 19
signal transduction - drug effects (19) 19
mutation (18) 18
physiological aspects (18) 18
receptor, epidermal growth factor - metabolism (18) 18
receptors, antigen, t-cell - physiology (18) 18
3t3 cells (17) 17
biophysics (17) 17
in vitro techniques (17) 17
inositol phosphates - metabolism (17) 17
molecular and cellular biology (16) 16
mutagenesis, site-directed (16) 16
precipitin tests (16) 16
proteins (16) 16
genetics & heredity (15) 15
phosphatidylinositol 3-kinases (15) 15
protein-tyrosine kinases - antagonists & inhibitors (15) 15
adaptor proteins, signal transducing - metabolism (14) 14
analysis (14) 14
cell membrane - metabolism (14) 14
cell physiology (14) 14
enzyme inhibitors - pharmacology (14) 14
gene expression (14) 14
medicine, research & experimental (14) 14
pc12 cells (14) 14
receptors (14) 14
recombinant fusion proteins - metabolism (14) 14
research & experimental medicine (14) 14
signal transduction - immunology (14) 14
time factors (14) 14
carrier proteins - metabolism (13) 13
gtpase-activating proteins (13) 13
membrane proteins - metabolism (13) 13
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neurosciences & neurology (13) 13
phospholipase (13) 13
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1. Full Text Phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial development
by Lawson, Nathan D and Mugford, Joshua W and Diamond, Brigid A and Weinstein, Brant M
Genes & development, ISSN 0890-9369, 06/2003, Volume 17, Issue 11, pp. 1346 - 1351
Endothelial | Plcg1 | Zebrafish | Vegf | Artery | Vascular Endothelial Growth Factor A | Vascular Endothelial Growth Factors | Molecular Sequence Data | Type C Phospholipases - metabolism | Arteries - embryology | Male | Zebrafish - embryology | Arteries - cytology | Muscle, Smooth, Vascular - embryology | Lymphokines - genetics | Gene Expression Regulation, Developmental | Base Sequence | Phospholipase C gamma | Polymerase Chain Reaction | Female | Embryo, Nonmammalian - physiology | Recombinant Proteins - metabolism | Animals, Genetically Modified | RNA, Messenger - genetics | Intercellular Signaling Peptides and Proteins - genetics | DNA Primers | Muscle, Smooth, Vascular - cytology | Animals | Endothelial Growth Factors - genetics | Type C Phospholipases - genetics | Genetic Carrier Screening | Crosses, Genetic | Genetically modified animals | Developmental genetics | Gene mutations | Analysis | Genetic research | Physiological aspects | Genetic aspects | Research | Phospholipases | Genetic regulation | Arteries | Endothelium | Index Medicus | Research Communications | zebrafish | artery | endothelial
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2. Full Text Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish
by Jing, Chang-Bin and Chen, Yi and Dong, Mei and Peng, Xiao-Lan and Jia, Xiao-E and Gao, Lei and Ma, Ke and Deng, Min and Liu, Ting-Xi and Zon, Leonard I and Zhu, Jun and Zhou, Yi and Zhou, Yong
Developmental biology, ISSN 0012-1606, 02/2013, Volume 374, Issue 1, pp. 24 - 31
Zebrafish | Granulocytes | mpx | Phospholipase C gamma-1 (plcg1) | Mpx | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Granulocytes - cytology | Phosphorylation | RNA, Messenger - metabolism | Microscopy, Confocal - methods | Plasmids - metabolism | Cell Lineage | Phenotype | Animals | Mutagenesis | Gene Expression Regulation, Developmental | Hematopoiesis | Hematopoietic Stem Cells - cytology | Phospholipase C gamma - genetics | Cell Differentiation | Models, Genetic | Histones - metabolism | Mutation | Phospholipase C gamma - physiology | Genes | Hematopoietic stem cells | Phospholipases | Index Medicus
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3. Full Text Phospholipase-C gamma-1 (PLCγ-1) is critical in hepatocyte growth factor induced in vitro invasion and migration without affecting the growth of prostate cancer cells
by Davies, Gaynor, Ph.D and Martin, Tracey A., Ph.D and Ye, Lin, M.D and Lewis-Russell, Jonathon M., M.D and Mason, Malcolm D., M.D and Jiang, Wen G., M.D
Urologic oncology, ISSN 1078-1439, 2008, Volume 26, Issue 4, pp. 386 - 391
Urology | Ribozyme | Prostate cancer | Migration | HGF/SF | Invasion | PLCγ-1 | Oncology | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Tumors of the urinary system | Urinary tract. Prostate gland | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Tumors | Cell Movement - drug effects | Prostatic Neoplasms - pathology | Transfection | Neoplasm Invasiveness | Humans | Cell Line, Tumor | Male | Cell Proliferation - drug effects | Hepatocyte Growth Factor - pharmacology | Phospholipase C gamma - physiology | Reverse Transcriptase Polymerase Chain Reaction | Index Medicus
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4. Full Text Trichostatin A reduced phospholipase C gamma-1 transcript and protein contents in MCF-7 breast cancer cells
by Drzewiecka, H and Jagodzinski, P.P
Biomedicine & pharmacotherapy, ISSN 0753-3322, 2011, Volume 66, Issue 1, pp. 1 - 5
Internal Medicine | Medical Education | MCF-7 breast cancer cells | TSA | Histone deacetylase inhibitors | PLCγ1 | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Phospholipase C gamma - metabolism | Breast Neoplasms - pathology | Humans | Cell Line, Tumor | Half-Life | Female | Histone Deacetylase Inhibitors - pharmacology | Protein Synthesis Inhibitors - pharmacology | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Breast Neoplasms - drug therapy | Hydroxamic Acids - pharmacology | Protein biosynthesis | Breast cancer | Messenger RNA | Phospholipases | Analysis | Cancer cells | RNA | Index Medicus
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5. Full Text Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening
by Sung-Hyun Kim and Sumin Yang and Key-Hwan Lim and Euiseng Ko and Hyun-Jun Jang and Mingon Kang and Pann-Ghill Suh and Jae-Yeol Joo
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 01/2021, Volume 118, Issue 3, p. 1
Splicing | Neurodegenerative diseases | High-throughput screening | mRNA | Genomes | Nucleotides | Gene sequencing | Phospholipase C | Deep learning | Learning | Phospholipase | Predictions | Mutation | Alzheimers disease | Alzheimer's disease | Index Medicus
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6. Full Text REGULATION OF PHOSPHOLIPASE-C-GAMMA-1 BY PROFILIN AND TYROSINE PHOSPHORYLATION
by GOLDSCHMIDTCLERMONT, PJ and KIM, JW and MACHESKY, LM and RHEE, SG and POLLARD, TD
Science (American Association for the Advancement of Science), ISSN 0036-8075, 03/1991, Volume 251, Issue 4998, pp. 1231 - 1233
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Tyrosine | Phosphatidylinositol 4,5-Diphosphate | Phosphorylation | ErbB Receptors - metabolism | Signal Transduction | Protein-Tyrosine Kinases - metabolism | Type C Phospholipases - metabolism | Epidermal Growth Factor - metabolism | Animals | Isoenzymes - metabolism | Profilins | Phosphatidylinositols - metabolism | Microfilament Proteins - metabolism | Kinetics | Contractile Proteins - metabolism | Inositol Phosphates - metabolism | Protein tyrosine kinase | Research | Phospholipases | Growth factors | profilin | phospholipase C- gamma 1 | regulation | phosphorylation | Index Medicus
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7. Full Text Apicidin decreases phospholipase C gamma-1 transcript and protein in Hut-78 T lymphoma cells
by Dębicki, Szymon and Jagodzinski, Paweł P
Biomedicine & pharmacotherapy, ISSN 0753-3322, 2008, Volume 63, Issue 7, pp. 543 - 547
Internal Medicine | Medical Education | Histone deacetylase inhibitors | Apicidin | Hut-78 T lymphoma cells | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Rabbits | Phosphorylation | Lymphoma, T-Cell | RNA, Messenger - genetics | Peptides, Cyclic - pharmacology | Signal Transduction - genetics | Blotting, Western | Phospholipase C gamma - biosynthesis | RNA, Messenger - biosynthesis | Animals | Phospholipase C gamma - genetics | Polymerase Chain Reaction | Cell Line, Tumor | Histone Deacetylase Inhibitors | Phospholipase C gamma - antagonists & inhibitors | Autoimmunity | Messenger RNA | Analysis | Protein biosynthesis | Lymphomas | Phospholipases | T cells | Index Medicus
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8. Full Text PHOSPHOLIPASE-C-GAMMA-1 AND PHOSPHATIDYLINOSITOL-3 KINASE ARE THE DOWNSTREAM MEDIATORS OF THE PDGF RECEPTORS MITOGENIC SIGNAL
by VALIUS, M and KAZLAUSKAS, A
Cell (Cambridge), ISSN 0092-8674, 04/1993, Volume 73, Issue 2, pp. 321 - 334
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | GTPase-Activating Proteins | Signal Transduction | Mitosis | Protein-Tyrosine Kinases - metabolism | Humans | ras GTPase-Activating Proteins | Phosphotyrosine | Receptors, Platelet-Derived Growth Factor - physiology | Phosphatidylinositol 3-Kinases | Tyrosine - analogs & derivatives | Tyrosine - metabolism | Proteins - metabolism | DNA Mutational Analysis | DNA - biosynthesis | Enzyme Activation | Tumor Cells, Cultured | In Vitro Techniques | Platelet-Derived Growth Factor - physiology | Phosphotransferases - physiology | Type C Phospholipases - physiology | Index Medicus
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9. Full Text INCREASE OF THE CATALYTIC ACTIVITY OF PHOSPHOLIPASE C-GAMMA-1 BY TYROSINE PHOSPHORYLATION
by NISHIBE, S and WAHL, MI and HERNANDEZSOTOMAYOR, SMT and TONKS, NK and RHEE, SG and CARPENTER, G
Science (American Association for the Advancement of Science), ISSN 0036-8075, 11/1990, Volume 250, Issue 4985, pp. 1253 - 1256
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Phosphatidylinositol 4,5-Diphosphate | Phosphorylation | Phosphoric Diester Hydrolases - metabolism | Signal Transduction | Protein-Tyrosine Kinases - metabolism | Phosphotyrosine | Phosphatidylinositol Diacylglycerol-Lyase | Enzyme Activation - drug effects | Tyrosine - analogs & derivatives | ErbB Receptors | Immunosorbent Techniques | Tyrosine - metabolism | Diglycerides - metabolism | Isoenzymes - metabolism | Phosphatidylinositols - metabolism | Catalysis | Epidermal Growth Factor - pharmacology | Kinetics | Inositol 1,4,5-Trisphosphate - metabolism | Protein tyrosine kinase | Research | Phospholipases | Index Medicus
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10. Full Text Phospholipase C gamma-1 mediated Akt-notch1 signaling is essential for intima formation
by Jianhui Zhuang and Dongyang Jiang and Wenhui Peng and Yuyan Lu and Qian Zhao and Lin Gao and Chen Chi and Xiangbing Xu and Chen Yan and Yawei Xu and Junbo Ge and Jinjiang Pang
Circulation (New York, N.Y.), ISSN 0009-7322, 11/2015, Volume 132, Issue 19
Cell proliferation | Blood circulation disorders | Care and treatment | Dosage and administration | Phospholipases | Research
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11. Full Text Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma 1 in vascular smooth muscle cells
by M B Marrero and W G Paxton and J L Duff and B C Berk and K E Bernstein
The Journal of biological chemistry, ISSN 0021-9258, 04/1994, Volume 269, Issue 14, pp. 10935 - 10939
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Type C Phospholipases - drug effects | Angiotensin II - pharmacology | Cells, Cultured | Rats | Type C Phospholipases - metabolism | Platelet-Derived Growth Factor - pharmacology | Muscle, Smooth, Vascular - cytology | Tyrosine - metabolism | Animals | Isoenzymes - metabolism | Phospholipase C gamma | Isoenzymes - drug effects | Kinetics | Phosphorylation - drug effects | Muscle, Smooth, Vascular - enzymology | Muscle, Smooth, Vascular - drug effects | Index Medicus
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12. Full Text The regulation of phospholipase C-gamma 1 by phosphatidic acid. Assessment of kinetic parameters
by G A Jones and G Carpenter
The Journal of biological chemistry, ISSN 0021-9258, 10/1993, Volume 268, Issue 28, pp. 20845 - 20850
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Phosphorylation | Tyrosine - metabolism | Allosteric Regulation | Cells, Cultured | Substrate Specificity | Type C Phospholipases - metabolism | Kinetics | Phosphatidic Acids - pharmacology | Index Medicus
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13. Full Text NUCLEAR-MAGNETIC-RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA-1 COMPLEXED WITH A HIGH-AFFINITY BINDING PEPTIDE
by PASCAL, SM and SINGER, AU and GISH, G and YAMAZAKI, T and SHOELSON, SE and PAWSON, T and KAY, LE and FORMANKAY, JD
Cell (Cambridge), ISSN 0092-8674, 05/1994, Volume 77, Issue 3, pp. 461 - 472
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Structure, Tertiary | Amino Acid Sequence | Magnetic Resonance Spectroscopy | Receptors, Platelet-Derived Growth Factor - chemistry | Isoenzymes - genetics | Models, Molecular | Molecular Sequence Data | Type C Phospholipases - metabolism | Isoenzymes - chemistry | Type C Phospholipases - chemistry | Sequence Alignment | Isoenzymes - metabolism | Phospholipase C gamma | Phosphopeptides - chemical synthesis | Phosphopeptides - metabolism | Protein Binding | Type C Phospholipases - genetics | Binding Sites | Index Medicus
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14. Full Text Involvement of phospholipase C gamma 1 in mouse egg activation induced by a truncated form of the C-kit tyrosine kinase present in spermatozoa
by Sette, C and Bevilacqua, A and Geremia, R and Rossi, P
The Journal of cell biology, ISSN 0021-9525, 08/1998, Volume 142, Issue 4, pp. 1063 - 1074
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein tyrosine kinase | Spermatozoa | Mice | Phospholipases | Research | Cytoplasm
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15. Full Text BINDING OF SH2 DOMAINS OF PHOSPHOLIPASE-C-GAMMA-1, GAP, AND SRC TO ACTIVATED GROWTH-FACTOR RECEPTORS
by ANDERSON, D and KOCH, CA and GREY, L and ELLIS, C and MORAN, MF and PAWSON, T
Science (American Association for the Advancement of Science), ISSN 0036-8075, 11/1990, Volume 250, Issue 4983, pp. 979 - 982
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Genes, src - genetics | Phosphorylation | ErbB Receptors - metabolism | GTPase-Activating Proteins | ErbB Receptors - genetics | Receptors, Cell Surface - metabolism | Type C Phospholipases - metabolism | Sequence Homology, Nucleic Acid | Proteins - genetics | Receptors, Platelet-Derived Growth Factor | Proteins - metabolism | Type C Phospholipases - genetics | Receptors, Cell Surface - genetics | Cellular signal transduction | Growth factor receptors | Research | Protein binding | Index Medicus
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