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phospholipase c-gamma-2 (331) 331
index medicus (272) 272
animals (181) 181
humans (167) 167
mice (125) 125
biochemistry & molecular biology (123) 123
immunology (114) 114
signal transduction (107) 107
phosphorylation (106) 106
activation (96) 96
hematology (84) 84
tyrosine phosphorylation (75) 75
protein-tyrosine kinases - metabolism (67) 67
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abridged index medicus (56) 56
cell biology (50) 50
collagen (50) 50
phosphatidylinositol 3-kinase (50) 50
glycoprotein-vi (44) 44
blood platelets - metabolism (43) 43
collagen - pharmacology (42) 42
syk kinase (41) 41
b-lymphocytes - immunology (39) 39
calcium - metabolism (38) 38
type c phospholipases - metabolism (38) 38
receptors, antigen, b-cell - metabolism (37) 37
enzyme activation (36) 36
adaptor proteins, signal transducing (35) 35
collagen receptor (35) 35
intracellular signaling peptides and proteins (35) 35
syk (35) 35
tyrosine - metabolism (35) 35
b-lymphocytes - metabolism (34) 34
integrin alphabeta (34) 34
mice, knockout (34) 34
phosphoinositide 3-kinase (34) 34
signal transduction - physiology (34) 34
mice, inbred c57bl (33) 33
peripheral vascular disease (33) 33
brutons tyrosine kinase (32) 32
receptor (32) 32
adhesion (30) 30
blood platelets - drug effects (30) 30
cells, cultured (30) 30
antigen receptor (29) 29
cell line (28) 28
cross-linking (28) 28
phospholipase c gamma (28) 28
proteins (28) 28
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platelet activation - drug effects (27) 27
protein-tyrosine kinase (27) 27
receptors, antigen, b-cell - physiology (27) 27
enzyme precursors - metabolism (26) 26
protein (26) 26
receptor-gamma-chain (26) 26
medicine, research & experimental (25) 25
molecular sequence data (25) 25
platelet membrane glycoproteins - metabolism (25) 25
von-willebrand-factor (25) 25
in-vivo (24) 24
lymphocytes (24) 24
platelet aggregation - drug effects (24) 24
isoenzymes - metabolism (23) 23
nf-kappa-b (23) 23
phosphatidylinositol 3-kinases - metabolism (23) 23
platelets (23) 23
signal transduction - drug effects (23) 23
t-cell (23) 23
thrombus formation (23) 23
b-cell (22) 22
biophysics (22) 22
cell antigen receptor (22) 22
glycoprotein vi (22) 22
signal transduction - immunology (22) 22
tyrosine kinase (22) 22
aggregation (21) 21
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carrier proteins - metabolism (21) 21
chickens (21) 21
gamma-chain (21) 21
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phosphoproteins - metabolism (21) 21
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x-linked agammaglobulinemia (21) 21
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tyrosine (20) 20
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b-lymphocytes - enzymology (18) 18
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Alzheimer's Research & Therapy, ISSN 1758-9193, 12/2019, Volume 11, Issue 1, pp. 1 - 11
Background Recent Genome Wide Association Studies (GWAS) have identified novel rare coding variants in immune genes associated with late onset Alzheimer’s... 
Enzymes | Brain research | Disease | Neurodegeneration | Genes | Genomes | Arthritis | Mutation | Dementia | Immune system | Polymorphism | Neuroinflammation | Immune response | Genetic variants | Phospholipase C
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2012, Volume 287, Issue 6, pp. 3704 - 3709
Journal Article
Blood, ISSN 0006-4971, 03/2010, Volume 115, Issue 10, pp. 2008 - 2013
During platelet activation, phosphoinositide 3-kinases (PI3Ks) produce lipid second messengers participating in the regulation of functional responses. Here,... 
PHOSPHOLIPASE C-GAMMA-2 | STIMULATION | PATHWAY | ITAM | MEDIATED ACTIVATION | HEMATOLOGY | PEPTIDE
Journal Article
Nature Genetics, ISSN 1061-4036, 01/2017, Volume 49, Issue 2, pp. 256 - 261
Journal Article
by Zhu, LQ and Ly, H and Liang, YY
JOURNAL OF VIROLOGY, ISSN 0022-538X, 01/2014, Volume 88, Issue 1, pp. 417 - 424
Host signaling pathways and cellular proteins play important roles in the influenza viral life cycle and can serve as antiviral targets. In this study, we... 
PATHWAYS | PHOSPHOLIPASE C-GAMMA-2 | REPLICATION | PROTEIN | INHIBITION | VIROLOGY | B-CELL | RESISTANCE | HOST | INFECTION | RECEPTORS
Journal Article
by Gu, C and Wang, L and Zurawski, S and Oh, S
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 07/2019, Volume 203, Issue 2, pp. 389 - 399
The types and magnitude of Ag-specific immune responses can be determined by the functional plasticity of dendritic cells (DCs). However, how DCs display... 
C-TYPE LECTINS | DENDRITIC CELLS | PATTERN-RECOGNITION RECEPTOR | CLEC10A CD301 | INHIBITORY RECEPTOR | ANTIGEN-PRESENTING CELLS | TNF-ALPHA | IMMUNOLOGY | PHOSPHOLIPASE C-GAMMA-2 PLC-GAMMA-2 | BETA-CATENIN | SYK TYROSINE KINASE
Journal Article
BLOOD, ISSN 0006-4971, 08/2012, Volume 120, Issue 6, pp. 1317 - 1326
Platelet adhesion and aggregation play a critical role in primary hemostasis. Uncontrolled platelet activation leads to pathologic thrombus formation and organ... 
PHOSPHOLIPASE C-GAMMA-2 | ACTIVATION | PROLYL ISOMERASE | CYCLOSPORINE-A | IN-VIVO | ADHESION MECHANISMS | ENDOTHELIAL-CELLS | ENDOPLASMIC-RETICULUM | PROTEINS | HEMATOLOGY | CIS-TRANS-ISOMERASES
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 10/2013, Volume 210, Issue 11, pp. 2257 - 2271
Myeloid-derived suppressor cells (MDSCs) favor tumor promotion, mainly by suppressing antitumor T cell responses in many cancers. Although the mechanism of T... 
BETA-CATENIN GENE | BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | PHOSPHOLIPASE C-GAMMA-2 | B-CELL | MECHANISM | IMMUNE SUPPRESSION | BONE-MARROW | HEMATOPOIETIC STEM-CELL | DIFFERENTIATION | IMMUNOLOGY | CD8(+) T-CELLS
Journal Article
BLOOD, ISSN 0006-4971, 01/2012, Volume 119, Issue 3, pp. 847 - 856
Integrin alpha 2 beta 1-mediated adhesion of human platelets to monomeric type I collagen or to the GFOGER peptide caused a time-dependent activation of PI3K... 
PHOSPHOLIPASE C-GAMMA-2 | GLYCOPROTEIN-VI | ACTIVATION | COLLAGEN | PROTEIN | ALPHABETA | TYROSINE KINASE | THROMBUS FORMATION | FOCAL ADHESION KINASE | HEMATOLOGY | PHOSPHOINOSITIDE 3-KINASE
Journal Article
BLOOD, ISSN 0006-4971, 10/2008, Volume 112, Issue 7, pp. 2780 - 2786
Immunoreceptor tyrosine-based activation motif (ITAM)-containing proteins have recently been demonstrated in macrophages and neutrophils to be required for... 
PHOSPHOLIPASE C-GAMMA-2 | COLLAGEN RECEPTOR | CYTOSKELETAL REORGANIZATION | THROMBUS FORMATION | PROTEIN-TYROSINE KINASE | BETA-CYTOPLASMIC DOMAINS | MONOCLONAL-ANTIBODIES | HEMATOLOGY | VON-WILLEBRAND-FACTOR | IMMUNOGLOBULIN-G | GLYCOPROTEIN VI
Journal Article
Journal Article
International Immunology, ISSN 0953-8178, 03/2019, Volume 31, Issue 3, pp. 157 - 166
The RNA-binding protein polypyrimidine tract-binding protein-1 (Ptbp1) binds to the pyrimidine-rich sequence of target RNA and controls gene expression via... 
RBPs | B-cell activation | Immunodeficiency | B-CELL DEVELOPMENT | PHOSPHOLIPASE C-GAMMA-2 | ACTIVATION | CROSS-LINKING | DNA REARRANGEMENT | GERMINAL CENTER | PROLIFERATION | IMMUNOLOGY | SIGLEC-G | MEMORY | immunodeficiency | EXPRESSION
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 11/2006, Volume 116, Issue 11, pp. 2869 - 2879
Excessive bone loss in arthritic diseases is mostly due to abnormal activation of the immune system leading to stimulation of osteoclasts. While phospholipase... 
RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | PHOSPHOLIPASE C-GAMMA-2 | ADAPTER PROTEINS | NUCLEAR-FACTOR | TYROSINE KINASE | BLOCKS OSTEOCLASTOGENESIS | RECEPTOR ACTIVATOR | NECROSIS-FACTOR-ALPHA | INFLAMMATORY ARTHRITIS | NF-KAPPA-B
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2012, Volume 366, Issue 4, pp. 330 - 338
Journal Article
BLOOD, ISSN 0006-4971, 02/2006, Volume 107, Issue 4, pp. 1405 - 1412
The extracellular matrix protein, laminin, supports platelet adhesion through binding to integrin alpha(6)beta(1) In the present study, we demonstrate that... 
ADHESION | ALPHA-2-BETA-1 | COLLAGEN | B-CELL | RECEPTOR GLYCOPROTEIN-VI | ALPHABETA | THROMBUS FORMATION | PHOSPHOLIPASE-C-GAMMA-2 | COUPLED RECEPTORS | HEMATOLOGY | AGGREGATION
Journal Article
BLOOD, ISSN 0006-4971, 09/2006, Volume 108, Issue 5, pp. 1509 - 1514
Mature megakaryocytes form structures called proplatelets that serve as conduits for platelet packaging and release at vascular sinusoids. Since the... 
BLOOD-PLATELETS | CYTOSKELETON | BONE-MARROW | PHOSPHOLIPASE-C-GAMMA-2 | FORMATION INVITRO | MEGAKARYOCYTE | MICE | TRANSCRIPTION FACTOR NF-E2 | THROMBOPOIETIN | HEMATOLOGY | HEMATOPOIETIC PROGENITORS
Journal Article
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, ISSN 1538-7933, 08/2005, Volume 3, Issue 8, pp. 1752 - 1762
This review summarizes recent developments in our understanding of the molecular basis of platelet activation by two distinct types of surface receptor, the... 
PHOSPHOLIPASE C-GAMMA-2 | GPVL integrin | Syk | COLLAGEN RECEPTOR | INTEGRIN ALPHA(IIB)BETA | THROMBUS FORMATION | collagen | MURINE PLATELETS | PROTEIN-TYROSINE KINASE | tyrosine kinases | Src kinases | RECEPTOR-GAMMA-CHAIN | GLYCOPROTEIN IB-ALPHA | CELL ADHESION MOLECULE-1 | PERIPHERAL VASCULAR DISEASE | BETA-CYTOPLASMIC DOMAINS | HEMATOLOGY
Journal Article
Immunity, ISSN 1074-7613, 2010, Volume 32, Issue 2, pp. 187 - 199
Early events of B cell activation after B cell receptor (BCR) triggering have been well characterized. However, little is known about the steady state of the... 
MOLIMMUNO | PHOSPHOLIPASE C-GAMMA-2 | UNDERGO HOP DIFFUSION | SINGLE-PARTICLE TRACKING | SYNAPSE FORMATION | TRANSLATIONAL DIFFUSION | IMMUNOLOGY | ANTIGEN RECEPTOR | PLASMA-MEMBRANE | CLASS-II | LATERAL DIFFUSION | SURFACE-IMMUNOGLOBULIN | CD79 Antigens - immunology | Cytoskeleton - immunology | Immunologic Capping - immunology | Actins - metabolism | Actins - immunology | Signal Transduction - immunology | Protein Engineering | Immunologic Capping - drug effects | Cytoskeletal Proteins - metabolism | Cell Membrane - metabolism | B-Lymphocytes - pathology | Thiazolidines - pharmacology | B-Lymphocytes - metabolism | Cell Membrane - drug effects | Mice, Inbred C57BL | Protein Structure, Tertiary - genetics | Signal Transduction - genetics | Mice, Knockout | CD79 Antigens - metabolism | B-Lymphocytes - drug effects | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | B-Lymphocytes - immunology | Cytoskeletal Proteins - immunology | Signal Transduction - drug effects | Cell Line, Tumor | Protein Binding | Cell Membrane - immunology | Mice | CD79 Antigens - genetics | Cytoskeleton - drug effects | Immunologic Capping - genetics | Microscopy, Fluorescence | Oncology, Experimental | Research | Cancer | Proteins | Studies | Medical research | Plasma | Phosphorylation | Microscopy | Rodents | Cytoskeleton | Cameras | Behavior | Kinases | Diffusion | Index Medicus
Journal Article