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Nucleic Acids Research, ISSN 0305-1048, 2015, Volume 43, Issue 6, pp. 2993 - 3011
The ss-siRNA activity in vivo requires a metabolically stable 5 '-phosphate analog. In this report we used crystal structure of the 5 '-phosphate binding... 
RNA INTERFERENCE | TARGET | ANIMALS | PHOSPHONATE ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESTERS | CLEAVAGE | ANTISENSE OLIGONUCLEOTIDES | CHEMICAL-MODIFICATIONS | MAMMALIAN-CELLS | NUCLEIC-ACIDS | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2010, Volume 53, Issue 6, pp. 2562 - 2576
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 09/2018, Volume 83, Issue 18, pp. 10701 - 10708
A concise approach for the synthesis of the 5'-carba analogs of nucleoside 5'-phosphates from 2'-deoxy-5'-O-phthalimidonucleosides by a visible light-mediated... 
PHOSPHATE | HEPATITIS-C VIRUS | CHAIN TERMINATORS | ACIDS | CHEMISTRY, ORGANIC | PHOSPHONATE PRODRUGS | ANTIVIRAL ACTIVITY | HCV | POTENTIAL INHIBITORS
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 04/2016, Volume 55, Issue 17, pp. 5255 - 5258
The metabolic conversion of nucleoside analogues into their triphosphates often proceeds insufficiently. Rate‐limitations can be at the mono‐, but also at the... 
nucleoside analogues | biological activity | prodrugs | cell uptake | triphosphate | DIPHOSPHATE PRODRUGS | ACTIVATION | PHOSPHORYLATION | REVERSE-TRANSCRIPTASE | HUMAN-IMMUNODEFICIENCY-VIRUS | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | NUCLEOTIDES | METABOLISM | INHIBITORS | PRONUCLEOTIDES | Anti-HIV Agents - pharmacology | Polyphosphates - pharmacology | Humans | Nucleosides - pharmacokinetics | Cell Membrane Permeability | Prodrugs - chemistry | HIV - drug effects | Prodrugs - metabolism | Swine | Thymine Nucleotides - metabolism | Nucleosides - pharmacology | Nucleosides - metabolism | Anti-HIV Agents - metabolism | CD4-Positive T-Lymphocytes - virology | Thymine Nucleotides - pharmacology | Cell Line | Nucleosides - chemistry | Esterases - metabolism | Thymine Nucleotides - chemical synthesis | Thymine Nucleotides - chemistry | Polyphosphates - metabolism | Anti-HIV Agents - chemistry | Animals | Prodrugs - pharmacokinetics | Anti-HIV Agents - pharmacokinetics | HIV Infections - drug therapy | Polyphosphates - pharmacokinetics | Prodrugs - pharmacology | Polyphosphates - chemistry | Phosphates | Nucleosides | Enzymes | Metabolites | Liver | Phosphonates | Protease inhibitors | Antiretroviral drugs | Drugs | Prodrugs | Series (mathematics) | Fluorescence | Lymphocytes T | Thymidine | Permeability | Derivatives | Chemical compounds | Conversion | Bearing | Polymerase chain reaction | Chemistry | Esterase | Phosphate | Antiviral activity | Nucleoside analogs | Index Medicus
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 02/2014, Volume 2014, Issue 6, pp. 1333 - 1337
The first synthesis of new cyclic phosphonates (phostones), analogues of pentafuranoses containing a phosphorus atom in place of the anomeric carbon in the... 
Carbohydrates | Medicinal chemistry | Glyco­mimetics | Bioisosteres | Phosphorus heterocycles | Glycomimetics | D-XYLOSE | PHOSPHONATE | STEREOCHEMISTRY | CHEMISTRY, ORGANIC | 2-DEOXY-L-RIBOSE | 1,2-OXAPHOSPHOLANES | PROBES | Nuclear magnetic resonance spectroscopy | Sugars | Phosphonates | Monosaccharides | Organic chemistry | Chemical Sciences
Journal Article
Tetrahedron, ISSN 0040-4020, 12/2016, Volume 72, Issue 50, pp. 8294 - 8308
Journal Article
Arkivoc, ISSN 1551-7004, 11/2017, Volume 2018, Issue 1, pp. 1 - 49
Journal Article
Journal Article
European Journal of Inorganic Chemistry, ISSN 1434-1948, 06/2017, Volume 2017, Issue 23, pp. 2955 - 2967
A series of (aminomethylene)phosphonate (AMP) analogues, 8 – 14 , bearing one or two heterocyclic moieties (imidazolyl, pyridyl, and thiazolyl) on the... 
Heterocycles | NMR spectroscopy | Chelates | Aminomethylene phosphonate | Zinc | Nuclear magnetic resonance spectroscopy | Phosphonates | Binding | Stoichiometry | Stability | Synthesis | Affinity | Ligands | Forming | Titration | Stability constants | Spectrophotometry | Bearing
Journal Article
Journal Article