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Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 05/2017, Volume 15, Issue 5, pp. 983 - 997
Background: Synthetic phosphorothioate-modified CpG oligodeoxynucleotides (ODNs) show potent immunostimulatory properties that are widely exploited in clinical... 
P2Y12 purinoceptor | immunotherapy | CLEC | ODN | CPG | 2 protein | platelet activation | CLEC-2 protein | CPG-ODN | GLYCOPROTEIN-VI | SYK | THROMBOSIS | MOUSE | CLEC-2 | CANCER | OLIGONUCLEOTIDES | DNA | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Blood Platelets - immunology | Membrane Glycoproteins - metabolism | Humans | Lectins, C-Type - immunology | Receptors, Purinergic P2Y12 - drug effects | Male | Immunoreceptor Tyrosine-Based Activation Motif | Lectins, C-Type - metabolism | Time Factors | Platelet Membrane Glycoproteins - metabolism | Adjuvants, Immunologic - metabolism | Platelet Aggregation Inhibitors - pharmacology | Platelet Aggregation - drug effects | Lectins, C-Type - deficiency | Membrane Glycoproteins - immunology | Thrombosis - blood | Thrombosis - prevention & control | Blood Platelets - drug effects | Receptors, Purinergic P2Y12 - metabolism | Disease Models, Animal | Purinergic P2Y Receptor Antagonists - pharmacology | Cell Line | Mice, Inbred C57BL | Phosphorothioate Oligonucleotides - immunology | Thrombosis - immunology | Adjuvants, Immunologic - toxicity | Antibodies - pharmacology | Animals | Signal Transduction - drug effects | Blood Platelets - metabolism | Phosphorothioate Oligonucleotides - toxicity | Protein Binding | Phosphorothioate Oligonucleotides - metabolism | Mice | Platelet Activation - drug effects | Membrane Glycoproteins - deficiency
Journal Article
European Journal of Immunology, ISSN 0014-2980, 04/2018, Volume 48, Issue 4, pp. 605 - 611
Journal Article
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2018, Volume 16, Issue 26, pp. 4857 - 4863
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, pp. e108808 - e108808
CpG-oligodeoxynucleotides (CpG-ODN) are potent immune stimuli being developed for use as adjuvants in different species. Toll-like receptor 9 (TLR9) is the... 
MOTIFS | STRUCTURAL BIOLOGY | RECOGNITION | MULTIDISCIPLINARY SCIENCES | ADJUVANTS | TOLL-LIKE RECEPTORS | MECHANISMS | GENERATION | IDENTIFICATION | AGONISTS | BACTERIAL-DNA | Rabbits | Adjuvants, Immunologic - pharmacology | Cytokines - metabolism | Peptides - chemistry | Humans | Oligodeoxyribonucleotides - chemistry | Phosphates - chemistry | Spleen - drug effects | Peptides - pharmacology | Immunoglobulin M - metabolism | Animals | Spleen - metabolism | T-Lymphocytes - metabolism | Adjuvants, Immunologic - chemistry | Hemorrhagic Disease Virus, Rabbit - metabolism | Lymphocyte Activation - drug effects | Antibody Formation - drug effects | Base Sequence | HEK293 Cells | T-Lymphocytes - immunology | Oligodeoxyribonucleotides - pharmacology | Toll-Like Receptor 9 - metabolism | Immune response | Peptides | Oligodeoxynucleotides | T cells | Cells | Rabbit hemorrhagic disease | Disease | Laboratories | Oligonucleotides | Viruses | Lymphocytes T | Activation | Biology | Hemorrhagic disease | Mammalian cells | Antibody response | Proteins | Cell activation | Cell growth | Immunology | Splenocytes | Toll-like receptors | Phosphorothioate | Deoxyribonucleic acid--DNA | CpG islands | Immune system | Medical research | Antigens | Immunoglobulins | Cytokines | Adjuvants | TLR9 protein | Viral infections | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 2004, Volume 113, Issue 2, pp. 235 - 241
Background: Amb a 1-immunostimulatory phosphorothioate oligonucleotide conjugate (AIC) is a novel immunotherapeutic compound consisting of purified Amb a 1... 
rhinitis | ragweed | Amb a 1–immunostimulatory phosphorothioate oligonucleotide conjugate | immunotherapy | Amb a 1-immunostimulatory phosphorothioate oligonucleotide conjugate | Rhinitis | Ragweed | Immunotherapy | EOSINOPHILS | INCREASES | IMMUNOLOGY | amb a 1-immunostimulatory phosphorothioate | oligonucleotide conjugate | MUCOSA | GRASS-POLLEN IMMUNOTHERAPY | MESSENGER-RNA | ALLERGY | DNA | ASTHMA | EXPRESSION | LYMPHOCYTES | Rhinitis, Allergic, Seasonal - physiopathology | Oligonucleotides - chemistry | Thionucleotides - immunology | Antigens, Plant | Dose-Response Relationship, Immunologic | Humans | Middle Aged | Ambrosia - adverse effects | Male | Allergens - administration & dosage | Thionucleotides - administration & dosage | Allergens - immunology | Thionucleotides - chemistry | Inflammation - drug therapy | Plant Proteins - chemistry | Allergens - chemistry | Rhinitis, Allergic, Seasonal - etiology | Adult | Female | Eosinophilia - drug therapy | Cytokines - metabolism | Rhinitis, Allergic, Seasonal - drug therapy | Ambrosia - immunology | Plant Proteins - immunology | Treatment Outcome | Inflammation - immunology | Oligonucleotides - immunology | Biopsy | Nasal Mucosa - immunology | Plant Proteins - administration & dosage | Lymphocyte Count | Oligonucleotides - administration & dosage | Desensitization, Immunologic | Inflammation - physiopathology | Studies | Licenses | Seasons | Patients | Allergies
Journal Article
Journal Article
Plant Physiology, ISSN 0032-0889, 12/2011, Volume 157, Issue 4, pp. 1628 - 1641
Selective inhibition of gene expression by antisense oligodeoxynucleotides (ODNs) is widely applied in gene function analyses; however, experiments with ODNs... 
Leaves | BREAKTHROUGH TECHNOLOGIES | Carotenoids | Messenger RNA | Chloroplasts | RNA | Genes | Fluorescence | Greening | Plants | Nucleic acids | CAROTENOID BIOSYNTHESIS | RNASE-H | CHLOROPHYLL-A | ARABIDOPSIS-THALIANA | INHIBITION | MESSENGER-RNA | GENE-EXPRESSION | RETICULOCYTE LYSATE | TARGET VALIDATION | OLIGONUCLEOTIDES | PLANT SCIENCES | Chloroplast Proteins - genetics | Phosphorothioate Oligonucleotides - genetics | Oligodeoxyribonucleotides - chemical synthesis | Chlorophyll Binding Proteins - metabolism | Gene Knockdown Techniques | Triticum - metabolism | Cell Nucleus - metabolism | Biological Transport | Oligodeoxyribonucleotides - genetics | Photosystem II Protein Complex - genetics | Plant Proteins - metabolism | Chloroplasts - genetics | Oxidoreductases - genetics | Tobacco - metabolism | RNA, Messenger - genetics | Gene Expression Regulation, Plant - genetics | RNA, Plant - genetics | Phosphorothioate Oligonucleotides - chemical synthesis | Chloroplasts - metabolism | Arabidopsis - metabolism | Photosystem II Protein Complex - metabolism | Arabidopsis - genetics | Triticum - genetics | Plant Proteins - genetics | Oligonucleotides, Antisense - genetics | Chlorophyll Binding Proteins - genetics | Oligonucleotides, Antisense - chemical synthesis | Plant Leaves - genetics | Plant Leaves - metabolism | Tobacco - genetics | Carotenoids - metabolism | Chloroplast Proteins - metabolism | Proteins | Oligodeoxynucleotides | Plant genetics | Physiological aspects | Genetic aspects | Research | Gene expression
Journal Article
Antiviral Research, ISSN 0166-3542, 01/2013, Volume 97, Issue 1, pp. 49 - 59
Journal Article
Immunology, ISSN 0019-2805, 06/2013, Volume 139, Issue 2, pp. 166 - 178
Re‐expression of recombinase activating genes ( RAG ) in mature B cells may support autoreactivity by enabling revision of the B ‐cell receptor ( BCR ). Recent... 
cells | autoimmunity | G DNA | Toll receptors | Toll‐like receptors | cell receptor | Autoimmunity | Toll-like receptors | CpG DNA | B cells | B-cell receptor | SYSTEMIC-LUPUS-ERYTHEMATOSUS | V(D)J RECOMBINATION | PERIPHERAL-BLOOD | INDUCTION | IMMUNOLOGY | RAG EXPRESSION | PLASMACYTOID DENDRITIC CELLS | RECOMBINATION-ACTIVATING GENES | REEXPRESSION | LYMPHOCYTES | Cell Nucleus - immunology | Antigens, Nuclear - metabolism | Homeodomain Proteins - metabolism | Humans | Homeodomain Proteins - immunology | Receptors, Antigen, B-Cell - metabolism | Toll-Like Receptor 9 - agonists | DNA-Binding Proteins - metabolism | Toll-Like Receptor 9 - immunology | Signal Transduction - immunology | Cell Nucleus - metabolism | Flow Cytometry | Phosphorothioate Oligonucleotides - pharmacology | Interleukin-6 - metabolism | B-Lymphocytes - metabolism | Immunoglobulin lambda-Chains - immunology | DNA-Binding Proteins - immunology | Oligodeoxyribonucleotides - immunology | Cells, Cultured | Phosphorothioate Oligonucleotides - immunology | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Homeodomain Proteins - genetics | Receptors, Antigen, B-Cell - immunology | B-Lymphocytes - drug effects | Immunoglobulin lambda-Chains - metabolism | Antigens, Nuclear - genetics | B-Lymphocytes - immunology | Ku Autoantigen | Signal Transduction - drug effects | Autoantigens - immunology | Interleukin-6 - immunology | Oligodeoxyribonucleotides - pharmacology | Antigens, Nuclear - immunology | Microscopy, Fluorescence | Autoantigens | Immunoglobulins | Oligodeoxynucleotides | T cell receptors | Immune system | Original
Journal Article