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photoclick chemistry (91) 91
chemistry, multidisciplinary (89) 89
index medicus (72) 72
click chemistry (49) 49
photoclick-chemistry (43) 43
functionalization (40) 40
in-vivo (35) 35
chemistry, organic (31) 31
proteins (31) 31
cycloaddition (29) 29
mammalian-cells (28) 28
living cells (25) 25
article (23) 23
azide-alkyne cycloaddition (22) 22
biochemistry & molecular biology (22) 22
fluorescence (21) 21
free click chemistry (21) 21
ligation (20) 20
humans (19) 19
cells (18) 18
polymer (17) 17
molecular structure (16) 16
chemical properties (15) 15
diels-alder reactions (15) 15
models, molecular (15) 15
tetrazole (15) 15
tetrazoles (15) 15
1,3-dipolar cycloaddition (14) 14
bioconjugation (14) 14
design (14) 14
photochemistry (14) 14
protein (14) 14
animals (13) 13
catalysis (13) 13
copper-free (13) 13
polymer science (13) 13
tetrazoles - chemistry (13) 13
bioorthogonal chemistry (12) 12
polymers (12) 12
proteins - chemistry (12) 12
amino acids (11) 11
analysis (11) 11
azides (11) 11
cyclization (11) 11
nitriles (11) 11
terminal alkynes (11) 11
zykloaddition (11) 11
alkenes - chemistry (10) 10
chemistry (10) 10
chemistry, medicinal (10) 10
cycloaddition reaction (10) 10
derivatives (10) 10
escherichia-coli (10) 10
fluorescent dyes - chemistry (10) 10
light (10) 10
peptides (10) 10
reactivity (10) 10
research (10) 10
azides - chemistry (9) 9
materials science, multidisciplinary (9) 9
photoactivatable diaryltetrazoles (9) 9
selective modification (9) 9
tetrazol (9) 9
transfer-rna synthetase (9) 9
unnatural amino-acids (9) 9
kinetics (8) 8
polymerization (8) 8
surface functionalization (8) 8
alkynes - chemistry (7) 7
amino acids - chemistry (7) 7
bioorthogonal reaction (7) 7
chemical reactions (7) 7
chemistry, physical (7) 7
imines - chemistry (7) 7
nanoparticles (7) 7
nanoscience & nanotechnology (7) 7
peptides - chemistry (7) 7
photochemical processes (7) 7
photoclick reaction (7) 7
photoclick reaction strategy (7) 7
probes (7) 7
recombinant proteins (7) 7
1,3-dipolar cycloaddition reaction (6) 6
1,3-dipolar cycloadditions (6) 6
amino-acids (6) 6
biomolecules (6) 6
copper (6) 6
cross-linking (6) 6
imines (6) 6
immobilization (6) 6
live mammalian-cells (6) 6
nitril (6) 6
nitriles - chemistry (6) 6
organic chemistry (6) 6
photochemie (6) 6
staudinger ligation (6) 6
surface properties (6) 6
synthesis (6) 6
1,3-dipolar cycloaddition reactions (5) 5
2,5-disubstituted tetrazoles (5) 5
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1. Full Text Transition metal-mediated bioorthogonal protein chemistry in living cells
by Yang, Maiyun and Li, Jie and Chen, Peng R
Chemical Society reviews, ISSN 0306-0012, 09/2014, Volume 43, Issue 18, pp. 6511 - 6526
Considerable attention has been focused on improving the biocompatibility of Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC), a hallmark of bioorthogonal... 
Transition Elements - chemistry | Bacteria - metabolism | Copper - chemistry | Proteins - metabolism | Click Chemistry | Transition Elements - metabolism | Alkynes - chemistry | Catalysis | Proteins - chemistry | Azides - chemistry | Cycloaddition Reaction | Palladium - chemistry
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2. Full Text Bioorthogonal chemistry: strategies and recent developments
by Ramil, Carlo P and Lin, Qing
Chemical Communications, ISSN 1359-7345, 10/2013, Volume 49, Issue 94, pp. 117 - 1122
The use of covalent chemistry to track biomolecules in their native environment-a focus of bioorthogonal chemistry-has received considerable interest recently... 
AZIDE-ALKYNE CYCLOADDITION | 1,3-DIPOLAR CYCLOADDITIONS | CROSS-METATHESIS | DIELS-ALDER REACTIONS | PHOTOCLICK-CHEMISTRY | NONCANONICAL AMINO-ACIDS | PROTEIN MODIFICATION | IN-VIVO | FREE CLICK CHEMISTRY | CHEMISTRY, MULTIDISCIPLINARY | LIVING CELLS | Alkenes - chemistry | Animals | Metals - chemistry | Biochemistry - methods | Humans | Alkynes - chemistry | Catalysis | Azides - chemistry | Activation
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3. Full Text Advances in chemical protein modification
by Boutureira, Omar and Bernardes, Gonçalo J. L
Chemical Reviews, ISSN 0009-2665, 03/2015, Volume 115, Issue 5, pp. 2174 - 2195
SELECTIVE CYSTEINE MODIFICATION | AZIDE-ALKYNE CYCLOADDITION | CROSS-METATHESIS | PICTET-SPENGLER LIGATION | THIOL-ENE REACTION | PHOTOCLICK-CHEMISTRY | CLICK CHEMISTRY | DIRECTED TOSYL CHEMISTRY | MEDIATED PROTEIN | CHEMISTRY, MULTIDISCIPLINARY | SITE-SPECIFIC CONJUGATION | Transition Elements - chemistry | Transition Elements - chemical synthesis | Animals | Humans | Amino Acids - chemistry | Amino Acids - chemical synthesis | Proteins - chemistry | Proteins - chemical synthesis | Chemistry Techniques, Synthetic - methods | Post-translational modification | Amino acids | Research | Chemical properties | Transition metal compounds | Alkylation
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4. Full Text Orthogonal bioorthogonal chemistries
by Patterson, David M and Prescher, Jennifer A
Current Opinion in Chemical Biology, ISSN 1367-5931, 10/2015, Volume 28, pp. 141 - 149
Bioorthogonal reactions have long been used to examine individual biomolecules in living systems. Studies of multi-component networks demand not only reliable... 
CHEMICAL REPORTERS | PICTET-SPENGLER LIGATION | BIOPHYSICS | DIELS-ALDER REACTIONS | PHOTOCLICK-CHEMISTRY | CLICK CHEMISTRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | STRAIN-PROMOTED CYCLOADDITIONS | LIVE MAMMALIAN-CELLS | AZIDE-ALKYNE | LIVING CELLS | Animals | Proteins - metabolism | Biochemistry - methods | Humans | Models, Molecular | Molecular Imaging - methods | Alkynes - chemistry | Proteins - analysis | Azides - chemistry
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5. Full Text Transition metal-mediated bioorthogonal protein chemistry in living cells
by Yang, Maiyun and Li, Jie and Chen, Peng R
Chemical Society Reviews, ISSN 0306-0012, 8/2014, Volume 43, Issue 18, pp. 6511 - 6526
Considerable attention has been focused on improving the biocompatibility of Cu( i )-catalyzed azide-alkyne cycloaddition (CuAAC), a hallmark of bioorthogonal... 
AZIDE-ALKYNE CYCLOADDITION | CROSS-COUPLING REACTIONS | GENETIC-CODE | PHOTOCLICK-CHEMISTRY | TRANSFER-RNA SYNTHETASE | CLICK CHEMISTRY | RECOMBINANT PROTEINS | UNNATURAL AMINO-ACIDS | MAMMALIAN-CELLS | CHEMISTRY, MULTIDISCIPLINARY | RHODIUM CARBENOIDS
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6. Full Text Controlled Cell Adhesion on Poly(dopamine) Interfaces Photopatterned with Non‐Fouling Brushes
by Rodriguez‐Emmenegger, Cesar and Preuss, Corinna M and Yameen, Basit and Pop‐Georgievski, Ognen and Bachmann, Michael and Mueller, Jan O and Bruns, Michael and Goldmann, Anja S and Bastmeyer, Martin and Barner‐Kowollik, Christopher
Advanced Materials, ISSN 0935-9648, 11/2013, Volume 25, Issue 42, pp. 6123 - 6127
Bioinspired poly(dopamine) (PDA) films are merged with antifouling poly(MeOEGMA) brushes utilizing a nitrile imine‐mediated tetrazole‐ene cycloaddition... 
nitrile imine‐mediated tetrazole‐ene cycloaddition (NITEC) | micropatterning | photoligation | poly(dopamine) | antifouling polymer brushes | nitrile imine-mediated tetrazole-ene cycloaddition (NITEC) | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | CLICK CHEMISTRY | BLOOD-PLASMA | MATERIALS SCIENCE, MULTIDISCIPLINARY | PROTEIN RESISTANCE | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | FUNCTIONALIZATION | ION MASS-SPECTROMETRY | PHOTOCLICK CHEMISTRY | 1,3-DIPOLAR CYCLOADDITION | POLYMER BRUSHES | COATINGS | SURFACE-CHEMISTRY | Polyethylene Glycols - metabolism | Recombinant Fusion Proteins - biosynthesis | Cell Line | Green Fluorescent Proteins - metabolism | Cell Adhesion Molecules - genetics | Acrylates - chemistry | Rats | Polyethylene Glycols - chemistry | Green Fluorescent Proteins - genetics | Phosphoproteins - genetics | Phosphoproteins - metabolism | Cell Adhesion | Cell Adhesion Molecules - metabolism | Indoles - metabolism | Animals | Acrylates - metabolism | Recombinant Fusion Proteins - genetics | Polymers - chemistry | Microfilament Proteins - metabolism | Indoles - chemistry | Microfilament Proteins - genetics | Silicon - chemistry | Polymers - metabolism | Phenols | Polymers | Adhesion
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7. Full Text Strain-promoted oxidation-controlled cyclooctyne-1,2-quinone cycloaddition (spocq) for fast and activatable protein conjugation
by Borrmann, A and Fatunsin, O and Dommerholt, J and Jonker, A.M and Lowik, D and Hest, J.C.M. van and Delft, F.L. van
Bioconjugate Chemistry, ISSN 1043-1802, 2015, Volume 26, Issue 2, pp. 257 - 261
A main challenge in the area of bioconjugation is to devise reactions that are both activatable and fast. Here, we introduce a temporally controlled reaction... 
AZIDE-ALKYNE CYCLOADDITION | CYCLOOCTYNES | DESIGN | PHOTOCLICK-CHEMISTRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | LIGATION | CHEMISTRY, ORGANIC | CHEMICAL-MODIFICATION | BIOORTHOGONAL CHEMISTRY | CHEMISTRY, MULTIDISCIPLINARY | AMINO-ACID | RECOMBINANT PROTEINS | LIVE MAMMALIAN-CELLS | Quinones - chemistry | Cyclization | Click Chemistry | Models, Molecular | Catechols - chemistry | Alkynes - chemistry | Proteins - chemistry | Azides - chemistry | Cycloaddition Reaction
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8. Full Text Genetically encoded tetrazine amino acid directs rapid site-specific in vivo bioorthogonal ligation with trans-cyclooctenes
by Seitchik, Jason L and Peeler, Jennifer C and Taylor, Michael T and Blackman, Melissa L and Rhoads, Timothy W and Cooley, Richard B and Refakis, Christian and Fox, Joseph M and Mehl, Ryan A
Journal of the American Chemical Society, ISSN 0002-7863, 02/2012, Volume 134, Issue 6, pp. 2898 - 2901
Bioorthogonal ligation methods with improved reaction rates and less obtrusive components are needed for site-specifically labeling proteins without catalysts.... 
CODE | DIELS-ALDER REACTIONS | PHOTOCLICK CHEMISTRY | SMALL MOLECULES | ESCHERICHIA-COLI | REACTIVITY | PROTEINS | FREE CLICK CHEMISTRY | CHEMISTRY, MULTIDISCIPLINARY | PEPTIDE | LIVING CELLS | Genetic Engineering - methods | Recombinant Proteins - metabolism | Green Fluorescent Proteins - metabolism | Tyrosine-tRNA Ligase - chemistry | Models, Chemical | Pyridines - chemistry | Molecular Conformation | Amino Acids - chemistry | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods | Cyclooctanes - chemistry | Escherichia coli - metabolism | Methanococcus - metabolism | Catalysis | Proteins - chemistry | Chemistry - methods | Amino acids | Chemical properties | Research | Structure | Cycloalkenes | Cells
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9. Full Text Two Rapid Catalyst-Free Click Reactions for in Vivo Protein Labeling of Genetically Encoded Strained Alkene/Alkyne Functionalities
by Kurra, Yadagiri and Odoi, Keturah A and Lee, Yan-Jiun and Yang, Yanyan and Lu, Tongxiang and Wheeler, Steven E and Torres-Kolbus, Jessica and Deiters, Alexander and Liu, Wenshe R
Bioconjugate Chemistry, ISSN 1043-1802, 09/2014, Volume 25, Issue 9, pp. 1730 - 1738
Detailed kinetic analyses of inverse electron-demand Diels-Alder cydoaddition and nitrilimine-alkene/alkyne 1,3-diploar cycloaddition reactions were conducted... 
DIELS-ALDER REACTIONS | PHOTOCLICK-CHEMISTRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | MAMMALIAN-CELLS | CHEMISTRY, MULTIDISCIPLINARY | TRANS-CYCLOOCTENE LIGATION | 1,3-DIPOLAR CYCLOADDITION REACTION | AMINO-ACID | COPPER(I)-CATALYZED AZIDE-ALKYNE | SUBSTITUTED PHENYLALANINE DERIVATIVES | TRANSFER-RNA-SYNTHETASE | LIVING CELLS | Staining and Labeling - methods | Alkenes - chemistry | Click Chemistry | Cyclooctanes - chemistry | Models, Molecular | Protein Conformation | Alkynes - chemistry | Catalysis | Kinetics | Proteins - chemistry | Escherichia coli Proteins - chemistry | Tyrosine - chemistry
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10. Full Text Advances of azide-alkyne cycloaddition-click chemistry over the recent decade
by Singh, Maya Shankar and Chowdhury, Sushobhan and Koley, Suvajit
Tetrahedron, ISSN 0040-4020, 09/2016, Volume 72, Issue 35, pp. 5257 - 5283
Display Omitted 
Azide-alkyne | 1,2,3-Triazoles | Organic synthesis | Click chemistry | Copper catalysis | CuAAC | SODIUM-AZIDE | 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES | COPPER NANOPARTICLES | ONE-POT SYNTHESIS | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | TERMINAL ALKYNES | CATALYZED 1,3-DIPOLAR CYCLOADDITION | PHOTOCLICK CHEMISTRY | N-SUBSTITUTED BENZOTRIAZOLES | IN-SITU
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11. Full Text Fluorescent polymers from non-fluorescent photoreactive monomers
by Mueller, Jan O and Voll, Dominik and Schmidt, Friedrich G and Delaittre, Guillaume and Barner-Kowollik, Christopher
Chemical communications (Cambridge, England), ISSN 1359-7345, 12/2014, Volume 50, Issue 99, pp. 15681 - 15684
A facile, fast and ambient-temperature avenue towards highly fluorescent polymers is introduced via polymerizing non-fluorescent photoreactive monomers based... 
Fluorescent Dyes - chemistry | Pyrazoles - chemistry | Ultraviolet Rays | Tetrazoles - chemistry | Imines - chemistry | Nitriles - chemistry | Fluorescence Resonance Energy Transfer | Polymerization | Polymers - chemistry | Kinetics | Cycloaddition Reaction
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12. Full Text A bioorthogonal ligation enabled by click cycloaddition of o-quinolinone quinone methide and vinyl thioether
by Li, Qiang and Dong, Ting and Liu, Xiaohui and Lei, Xiaoguang
Journal of the American Chemical Society, ISSN 0002-7863, 04/2013, Volume 135, Issue 13, pp. 4996 - 4999
There is an increasing interest in the use of bioorthogonal ligation to advance biomedical research through selective labeling of biomolecules in living... 
FUNCTIONALIZATION | CELLS | PHOTOCLICK CHEMISTRY | BIOCONJUGATION | REACTIVITY | DIELS-ALDER LIGATION | LIVING SYSTEMS | GENERATION | COPPER-FREE | PROTEINS | CHEMISTRY, MULTIDISCIPLINARY | Vinyl Compounds - chemistry | Biotinylation | Click Chemistry | Humans | Sulfides - chemistry | Cell Membrane Permeability | Molecular Imaging | Indolequinones - chemistry | Cycloaddition Reaction | Paclitaxel - chemistry | Quinolones - chemistry | Fluorescein | Molecular Structure | HeLa Cells | Spin coupling | Chemical reaction, Rate of | Analysis | Quinone | Imaging systems | Chemical properties | Structure | Methods
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13. Full Text Photoinducible bioorthogonal chemistry: A spatiotemporally controllable tool to visualize and perturb proteins in live cells
by Lim, Reyna K. V and Lin, Qing
Accounts of Chemical Research, ISSN 0001-4842, 09/2011, Volume 44, Issue 9, pp. 828 - 830
Visualization in biology has been greatly facilitated by the use of fluorescent proteins as in-cell probes. The genes coding for V these wavelength-tunable... 
NITRILE-IMINES | PHOTOCLICK CHEMISTRY | BIOSYNTHETIC ROUTE | QUANTUM YIELDS | IN-VIVO | NEWLY SYNTHESIZED PROTEINS | FUSION PROTEIN | 1,3-DIPOLAR CYCLOADDITION REACTIONS | 1.3-DIPOLARE CYCLOADDITIONEN | MAMMALIAN-CELLS | CHEMISTRY, MULTIDISCIPLINARY | Alkenes - chemistry | Proteins - metabolism | Tetrazoles - chemistry | Click Chemistry | Escherichia coli | Humans | Nitriles - chemistry | Proteins - chemistry | Protein biosynthesis | Amino acids | Usage | Research | Methods | Visual perception | Proteins | Coding | Genes | Cells (biology) | Fluorescence | Tools | Biology | Monitoring
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14. Full Text Contemporary Photoligation Chemistry: The Visible Light Challenge
by Offenloch, Janin T and Gernhardt, Marvin and Blinco, James P and Frisch, Hendrik and Mutlu, Hatice and Barner‐Kowollik, Christopher
Chemistry – A European Journal, ISSN 0947-6539, 03/2019, Volume 25, Issue 15, pp. 3700 - 3709
Catalyst‐free and bond‐forming light‐induced reactions have seen an unprecedented renaissance in the realm of soft matter materials science due to their... 
red-shifting | action plots | photochemistry | polymer chemistry | DESIGN | UP-CONVERSION | REACTIVITY | DIMERIZATION | CHEMISTRY, MULTIDISCIPLINARY | PHOTOREDOX CATALYSIS | FUNCTIONALIZATION | PLATFORM | PHOTOCLICK CHEMISTRY | CYCLOADDITIONS | Light | Analysis | Biodegradation | Anthracene | Catalysts | U.V. radiation | Materials science | Photochemicals | Organic chemistry | Pyrene | Ultraviolet radiation | Atmospheric chemistry | Environmental degradation | Controllability | Absorption spectra | Catalysis
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15. Full Text Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction
by Lang, Kathrin and Davis, Lloyd and Torres-Kolbus, Jessica and Chou, Chungjung and Deiters, Alexander and Chin, Jason W
Nature Chemistry, ISSN 1755-4330, 04/2012, Volume 4, Issue 4, pp. 298 - 304
The site-specific incorporation of bioorthogonal groups via genetic code expansion provides a powerful general strategy for site-specifically labelling... 
GREEN FLUORESCENT PROTEIN | PHOTOCLICK CHEMISTRY | RECOMBINANT PROTEINS | CLICK CHEMISTRY | IN-VIVO | ESCHERICHIA-COLI | UNNATURAL AMINO-ACIDS | PYRROLYSINE ANALOG | MAMMALIAN-CELLS | CHEMISTRY, MULTIDISCIPLINARY | LIVING CELLS | Cell Line | Fluorescent Dyes - chemistry | Green Fluorescent Proteins - metabolism | Lysine - analogs & derivatives | Norbornanes - chemistry | Humans | Green Fluorescent Proteins - genetics | Proteins - genetics | Amino Acids - metabolism | Proteins - metabolism | Lysine - metabolism | Rhodamines - chemistry | Amino Acyl-tRNA Synthetases - metabolism
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