X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (1015) 1015
Publication (194) 194
Book Chapter (15) 15
Book Review (15) 15
Dissertation (13) 13
Conference Proceeding (7) 7
Government Document (2) 2
Book / eBook (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
pi3 kinase (580) 580
animals (502) 502
index medicus (448) 448
humans (428) 428
phosphatidylinositol 3-kinases - metabolism (302) 302
cell biology (258) 258
signal transduction (250) 250
biochemistry & molecular biology (236) 236
mice (193) 193
phosphorylation (172) 172
akt (168) 168
phosphatidylinositol 3-kinases - antagonists & inhibitors (158) 158
cancer (156) 156
apoptosis (145) 145
activation (142) 142
oncology (139) 139
age-1 pi3 kinase (134) 134
article (129) 129
proto-oncogene proteins c-akt - metabolism (119) 119
cell line, tumor (106) 106
signal transduction - drug effects (104) 104
female (102) 102
cells, cultured (99) 99
rats (98) 98
signal transduction - physiology (97) 97
expression (96) 96
phosphatidylinositol 3-kinase (93) 93
enzyme inhibitors - pharmacology (91) 91
male (91) 91
proteins (90) 90
insulin (85) 85
kinases (85) 85
pathway (83) 83
research (82) 82
transcription factor (81) 81
neurosciences (76) 76
mutation (75) 75
pi3-kinase (74) 74
signaling pathway (74) 74
c-elegans (73) 73
phosphatidylinositol 3-kinases - genetics (72) 72
phosphoinositide 3-kinase (71) 71
map kinase (70) 70
morpholines - pharmacology (70) 70
caenorhabditis elegans - genetics (68) 68
apoptosis - drug effects (66) 66
cell line (65) 65
pi3‐kinase (65) 65
caenorhabditis-elegans (64) 64
growth (64) 64
chromones - pharmacology (63) 63
immunology (63) 63
life-span (63) 63
physiological aspects (61) 61
genetics & heredity (60) 60
insulin - metabolism (60) 60
oxidative stress (60) 60
analysis (59) 59
genetic aspects (59) 59
biology (58) 58
developmental biology (56) 56
cells (55) 55
chemistry, medicinal (55) 55
protein kinase inhibitors - pharmacology (55) 55
caenorhabditis elegans (54) 54
blotting, western (53) 53
enzyme activation (53) 53
gene expression (53) 53
proto-oncogene proteins c-akt (53) 53
survival (53) 53
kinase (52) 52
pharmacology & pharmacy (52) 52
mtor (51) 51
proto-oncogene proteins - metabolism (51) 51
cell proliferation (50) 50
caenorhabditis elegans proteins - genetics (49) 49
cell proliferation - drug effects (49) 49
protein-serine-threonine kinases - metabolism (49) 49
pten (49) 49
caenorhabditis elegans proteins - metabolism (48) 48
gene-expression (48) 48
protein-kinase (48) 48
longevity (45) 45
biophysics (44) 44
mitogen-activated protein kinases - metabolism (44) 44
nf-kappa-b (44) 44
tumor cells, cultured (44) 44
aging (42) 42
receptor (42) 42
transcription factors - metabolism (42) 42
inhibition (41) 41
phosphorylation - drug effects (41) 41
protein (41) 41
androstadienes - pharmacology (40) 40
caenorhabditis elegans - physiology (40) 40
models, biological (40) 40
breast cancer (39) 39
in-vitro (39) 39
pi3k (39) 39
protein kinases (39) 39
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


FEBS Letters, ISSN 0014-5793, 08/2012, Volume 586, Issue 17, pp. 2740 - 2750
The molecular architectures of intracellular signaling networks are largely unknown. Understanding their design principles and mechanisms of processing... 
Intrinsic disorder | Macromolecular crowding | Signalosome | Molecular architecture | Signaling network | Signaling complex | SH3 domain | SH2 domain | Sic1 | hepatocyte growth-factor receptor | Frs | CDK | CRKL | growth factor receptor-bound protein 2 | T-cell receptor | GRIP1 | PI3K | signal transducer and activator of transcription 1 | eukaryotic linear motif | NFN hypothesis | glutamate receptor interacting protein 1 | ZBP1 | Dok | sarcoma kinase | CASK | p130Cas | CT-10 related kinase | NR2B | disrupted in schizophrenia 1 | sterile 5 protein | MALS | SLiM | cyclin-dependent kinase | epidermal growth factor | Src-homology 2 domain | Erk | MAPK/Erk kinase | JIP1 | cell division control protein 4 | IGFR | Abl | COP9 | Irs | cAMP | short linear motif | neuronal munc18-1 binding protein 1 | estrogen receptor beta 2 | caudal type homeobox 2 | PTB domain | San1 | N-methyl d-aspartate receptor subtype 2B | insulin receptor substrate | large multi-site docking | ADAP1 | ApoER2 | Cdc4 | NMR | cyclic adenosine monophosphate | constitutive photomorphogenesis protein 9 | N-terminal folding nucleation hypothesis | arf-GAP with dual PH domain-containing protein 1 | Grb2 | Src-homology 3 domain | LAT | breast cancer anti-estrogen resistance 1 | c-Jun-amino-terminal kinase-interacting protein 1 | Mint1 | extracellular signal-regulated kinase | Abelson tyrosine-protein kinase 1 | Crk-associated substrate | PI3 kinase | ELM | SH2 containing protein tyrosine phosphatase 2 | UTR | insulin-like growth factor 1 receptor | Pbs2 | linker for activation of T-cells | Ste5 | ErB2 | calcium/calmodulin-dependent serine protein kinase | apolipoprotein E receptor 2 | PH domain | sterile 11 protein | phosphatidylinositol (3,4,5)-triphosphate | Crk-like protein | Gab | untranslated region | Rack1 | atomic force microscopy | MEK | PIP3 | small angle X-ray scattering | Crk | cryo-electron microscopy | DLK | TCR | Src | AFM | pleckstrin homology domain | phosphotyrosine-binding domain | zip code-binding protein 1 | SHP2 | substrate/subunit/inhibitor of cyclin-dependent protein kinase 1 | receptor of activated protein kinase C 1 | c-Met | DAP-like kinase | DISC1 | cryo-EM | sir antagonist 1 | fibroblast growth factor receptor substrate | LMD | mammalian lin-seven protein | Ste11 | Cdx2 | EGF | STAT1 | docking protein 1 | Rev/Rex activation domain-binding protein | nuclear magnetic resonance | SAXS | Polymyxin B resistance protein 2 | Rab | Grb2-associated-binding protein | insulin receptor | BCAR1 | UNSTRUCTURED PROTEINS | SRC FAMILY KINASE | TYROSINE PHOSPHORYLATION | MAP-KINASE | PROTEIN-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROCESSIVE PHOSPHORYLATION | MESSENGER-RNA LOCALIZATION | CELL BIOLOGY | BIOPHYSICS | COP9 SIGNALOSOME | IN-VIVO | Fungal Proteins - chemistry | Neoplasms - metabolism | Computational Biology - methods | Signal Transduction | Humans | Gene Expression Regulation | Phosphoproteins - metabolism | Protein Interaction Mapping - methods | Insulin - metabolism | Receptor, Epidermal Growth Factor - metabolism | Animals | Models, Biological | Insulin Receptor Substrate Proteins | Receptor, Insulin - metabolism | Tyrosine | Atomic force microscopy | Epidermal growth factor | Phosphatases | Sarcoma | Soups | Fibroblast growth factors | Glutamate | Adenylic acid | T cells | Protein kinases | Protein binding
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 07/2005, Volume 94, Issue 1, pp. 204 - 214
Integrity of the blood–brain barrier is essential for the normal functioning of CNS. Its disruption contributes to the pathobiology of various inflammatory... 
monocytes | PI3‐kinase | experimental autoimmune encephalomyelitis | lovastatin | nuclear factor‐κB | endothelial | Endothelial | Experimental autoimmune encephalomyelitis | Pl3-kinase | Lovastatin | Monocytes | Nuclear factor-κB | RHO-FAMILY GTPASES | REDUCTASE INHIBITOR | NITRIC-OXIDE SYNTHASE | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J | nuclear factor-kappa B | PI3-kinase | NEUROSCIENCES | ADHESION MOLECULE-1 | MULTIPLE-SCLEROSIS | E-SELECTIN | LEWIS RATS | Proto-Oncogene Proteins - antagonists & inhibitors | NF-kappa B - antagonists & inhibitors | Lovastatin - pharmacology | Protein-Serine-Threonine Kinases - physiology | Cells, Cultured | Cell Communication - physiology | Cell Adhesion - drug effects | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Monocytes - drug effects | Proto-Oncogene Proteins c-akt | Monocytes - enzymology | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Signal Transduction - drug effects | Cell Adhesion - physiology | Cell Communication - drug effects | NF-kappa B - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - physiology | Phosphatidylinositol 3-Kinases - physiology | Signal Transduction - physiology | Mice | Endothelial Cells - enzymology | Endothelial Cells - drug effects
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 10/2017, Volume 56, Issue 10, pp. 2301 - 2316
Although GSK3β has been reported to have contrasting effects on the progression of different tumors, it's possible functions in esophageal squamous cell... 
GSK3β | PI3‐kinase | esophageal cancer | STAT3 | PI3-kinase | CANCER-CELLS | SURVIVAL | ACTIVATION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | BREAST-CANCER | ONCOLOGY | GSK3 | SIGNALING PATHWAY | GSK3-BETA | EXPRESSION | EPIDEMIOLOGY | Up-Regulation | Phosphorylation | Prognosis | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Gene Expression Regulation, Neoplastic | Male | Esophageal Neoplasms - pathology | Lithium Chloride - pharmacology | Esophageal Neoplasms - metabolism | Female | STAT3 Transcription Factor - metabolism | Esophageal Squamous Cell Carcinoma | Cell Survival - drug effects | Tyrphostins - pharmacology | Glycogen Synthase Kinase 3 beta - metabolism | Disease Progression | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Survival Analysis | Cell Line, Tumor | Mice | Pyridines - pharmacology | Development and progression | Squamous cell carcinoma | Synthesis | Glycogen | Analysis | Esophageal cancer | Leukocyte migration | Lithium chloride | Kinases | Tissues | Metastases | Cell adhesion & migration | Xenografts | Inhibition | Data analysis | Stat3 protein | Glycogen synthase kinase 3 | Data processing | Pharmacology | siRNA | Esophagus | Molecular modelling | Inhibitors | Cell lines | Differentiation | Viability | In vitro methods and tests | Cell migration | Tumors | Cancer | Esophageal Cancer | PI3-Kinase
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, p. e36800
The dysregulation of receptor protein tyrosine kinase (RPTK) function can result in changes in cell proliferation, cell growth and metastasis leading to... 
TYROSINE KINASE TYRO3 | APOPTOTIC CELLS | PI3 KINASE | BIOLOGY | SURVIVAL ACTIVITIES | FAMILY RECEPTORS | SMOOTH-MUSCLE-CELLS | TAM RECEPTORS | GROWTH-FACTOR | PROTEIN-S | ARREST-SPECIFIC GENE | Proto-Oncogene Proteins - metabolism | Cell Line | Up-Regulation | Phosphorylation | Cell Proliferation | Signal Transduction | Intercellular Signaling Peptides and Proteins - genetics | Rats | Proto-Oncogene Proteins - genetics | Phosphatidylinositol 3-Kinases - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | MAP Kinase Signaling System | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Transfection | Receptor Protein-Tyrosine Kinases - genetics | c-Mer Tyrosine Kinase | Tyrosine | Protein kinases | Mitogens | Analysis | Cell proliferation | Transformation | Immunoprecipitation | Kinases | Metastases | Axl protein | Skin cancer | Proteins | Signal transduction | Receptors | Cell activation | Cell growth | Rodents | Fibroblasts | Protein-tyrosine kinase receptors | Growth factors | Protein-tyrosine kinase | Immunoglobulins | Immune response | Melanoma | Extracellular signal-regulated kinase | MAP kinase | 1-Phosphatidylinositol 3-kinase | Polymerase chain reaction | Studies | Signaling | Molecular modelling | Inhibitors | Mutagenesis | Transformations (mathematics) | Receptor mechanisms | Tumors
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2007, Volume 17, Issue 9, pp. 2438 - 2442
4-Morpholin-4-ylpyrido[3′,2′:4,5]thieno[3,2- ]pyrimidine was discovered in our chemical library as a novel p110α inhibitor with an IC of 1.4 μM. By structural... 
p110α | Inhibitor | Anti-cancer agent | PI3 kinase | CHEMISTRY, MEDICINAL | anti-cancer agent | PTEN | CHEMISTRY, ORGANIC | PHOSPHOINOSITIDE 3-KINASE INHIBITORS | WORTMANNIN | FAMILY | BREAST-CANCER | ONCOGENE | inhibitor | PIK3CA GENE | PATHWAY | TUMOR-SUPPRESSOR | p110 alpha | MUTATIONS
Journal Article
Cellular Signalling, ISSN 0898-6568, 2011, Volume 23, Issue 10, pp. 1515 - 1527
Journal Article