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Oncogene, ISSN 0950-9232, 2019, Volume 38, Issue 25, pp. 5076 - 5090
Genomic alterations in cancer cells result in vulnerabilities that clinicians can exploit using molecularly targeted drugs, guided by knowledge of the tumour... 
MUTATIONS CONFER RESISTANCE | CLINICAL DEVELOPMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACQUIRED-RESISTANCE | CELL BIOLOGY | APOPTOTIC RESPONSE | ERK1/2 INHIBITOR | MEK INHIBITION | ONCOLOGY | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITION | PI3 KINASE | GENETICS & HEREDITY | TUMOR-GROWTH | COMBINED BRAF | Colorectal Neoplasms - genetics | Humans | MAP Kinase Kinase 1 - genetics | PTEN Phosphohydrolase - antagonists & inhibitors | Colorectal Neoplasms - drug therapy | Tumor Cells, Cultured | MAP Kinase Kinase 2 - genetics | Aniline Compounds - administration & dosage | Colorectal Neoplasms - metabolism | Molecular Targeted Therapy - methods | MAP Kinase Kinase 1 - antagonists & inhibitors | PTEN Phosphohydrolase - genetics | HCT116 Cells | PTEN Phosphohydrolase - metabolism | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Signal Transduction - genetics | Protein Kinase Inhibitors - administration & dosage | Drug Resistance, Neoplasm - genetics | MAP Kinase Signaling System - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | MAP Kinase Kinase 2 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Colorectal Neoplasms - pathology | Sulfonamides - administration & dosage | Usage | Colorectal cancer | Genetic aspects | Cellular signal transduction | Drug therapy, Combination | Research | Drug therapy | Risk factors | Colorectal carcinoma | MEK inhibitors | Extracellular signal-regulated kinase | MAP kinase | Tumor cell lines | Drug resistance | Cancer therapies | 1-Phosphatidylinositol 3-kinase | Signal transduction | Cell lines | Mutation | PTEN protein | Genotypes | Tumors | Cancer | Cell signalling | Molecular biology
Journal Article
FEBS Letters, ISSN 0014-5793, 08/2012, Volume 586, Issue 17, pp. 2740 - 2750
The molecular architectures of intracellular signaling networks are largely unknown. Understanding their design principles and mechanisms of processing... 
Intrinsic disorder | Macromolecular crowding | Signalosome | Molecular architecture | Signaling network | Signaling complex | SH3 domain | SH2 domain | Sic1 | hepatocyte growth-factor receptor | Frs | CDK | CRKL | growth factor receptor-bound protein 2 | T-cell receptor | GRIP1 | PI3K | signal transducer and activator of transcription 1 | eukaryotic linear motif | NFN hypothesis | glutamate receptor interacting protein 1 | ZBP1 | Dok | sarcoma kinase | CASK | p130Cas | CT-10 related kinase | NR2B | disrupted in schizophrenia 1 | sterile 5 protein | MALS | SLiM | cyclin-dependent kinase | epidermal growth factor | Src-homology 2 domain | Erk | MAPK/Erk kinase | JIP1 | cell division control protein 4 | IGFR | Abl | COP9 | Irs | cAMP | short linear motif | neuronal munc18-1 binding protein 1 | estrogen receptor beta 2 | caudal type homeobox 2 | PTB domain | San1 | N-methyl d-aspartate receptor subtype 2B | insulin receptor substrate | large multi-site docking | ADAP1 | ApoER2 | Cdc4 | NMR | cyclic adenosine monophosphate | constitutive photomorphogenesis protein 9 | N-terminal folding nucleation hypothesis | arf-GAP with dual PH domain-containing protein 1 | Grb2 | Src-homology 3 domain | LAT | breast cancer anti-estrogen resistance 1 | c-Jun-amino-terminal kinase-interacting protein 1 | Mint1 | extracellular signal-regulated kinase | Abelson tyrosine-protein kinase 1 | Crk-associated substrate | PI3 kinase | ELM | SH2 containing protein tyrosine phosphatase 2 | UTR | insulin-like growth factor 1 receptor | Pbs2 | linker for activation of T-cells | Ste5 | ErB2 | calcium/calmodulin-dependent serine protein kinase | apolipoprotein E receptor 2 | PH domain | sterile 11 protein | phosphatidylinositol (3,4,5)-triphosphate | Crk-like protein | Gab | untranslated region | Rack1 | atomic force microscopy | MEK | PIP3 | small angle X-ray scattering | Crk | cryo-electron microscopy | DLK | TCR | Src | AFM | pleckstrin homology domain | phosphotyrosine-binding domain | zip code-binding protein 1 | SHP2 | substrate/subunit/inhibitor of cyclin-dependent protein kinase 1 | receptor of activated protein kinase C 1 | c-Met | DAP-like kinase | DISC1 | cryo-EM | sir antagonist 1 | fibroblast growth factor receptor substrate | LMD | mammalian lin-seven protein | Ste11 | Cdx2 | EGF | STAT1 | docking protein 1 | Rev/Rex activation domain-binding protein | nuclear magnetic resonance | SAXS | Polymyxin B resistance protein 2 | Rab | Grb2-associated-binding protein | insulin receptor | BCAR1 | UNSTRUCTURED PROTEINS | SRC FAMILY KINASE | TYROSINE PHOSPHORYLATION | MAP-KINASE | PROTEIN-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROCESSIVE PHOSPHORYLATION | MESSENGER-RNA LOCALIZATION | CELL BIOLOGY | BIOPHYSICS | COP9 SIGNALOSOME | IN-VIVO | Fungal Proteins - chemistry | Neoplasms - metabolism | Computational Biology - methods | Signal Transduction | Humans | Gene Expression Regulation | Phosphoproteins - metabolism | Protein Interaction Mapping - methods | Insulin - metabolism | Receptor, Epidermal Growth Factor - metabolism | Animals | Models, Biological | Insulin Receptor Substrate Proteins | Receptor, Insulin - metabolism | Tyrosine | Atomic force microscopy | Epidermal growth factor | Phosphatases | Sarcoma | Soups | Fibroblast growth factors | Glutamate | Adenylic acid | T cells | Protein kinases | Protein binding
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 10/2017, Volume 56, Issue 10, pp. 2301 - 2316
Although GSK3β has been reported to have contrasting effects on the progression of different tumors, it's possible functions in esophageal squamous cell... 
GSK3β | PI3‐kinase | esophageal cancer | STAT3 | PI3-kinase | CANCER-CELLS | SURVIVAL | ACTIVATION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | BREAST-CANCER | ONCOLOGY | GSK3 | SIGNALING PATHWAY | GSK3-BETA | EXPRESSION | EPIDEMIOLOGY | Up-Regulation | Phosphorylation | Prognosis | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Gene Expression Regulation, Neoplastic | Male | Esophageal Neoplasms - pathology | Lithium Chloride - pharmacology | Esophageal Neoplasms - metabolism | Female | STAT3 Transcription Factor - metabolism | Esophageal Squamous Cell Carcinoma | Cell Survival - drug effects | Tyrphostins - pharmacology | Glycogen Synthase Kinase 3 beta - metabolism | Disease Progression | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Survival Analysis | Cell Line, Tumor | Mice | Pyridines - pharmacology | Development and progression | Squamous cell carcinoma | Synthesis | Glycogen | Analysis | Esophageal cancer | Leukocyte migration | Lithium chloride | Kinases | Tissues | Metastases | Cell adhesion & migration | Xenografts | Inhibition | Data analysis | Stat3 protein | Glycogen synthase kinase 3 | Data processing | Pharmacology | siRNA | Esophagus | Molecular modelling | Inhibitors | Cell lines | Differentiation | Viability | In vitro methods and tests | Cell migration | Tumors | Esophageal Cancer | PI3-Kinase
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, p. e36800
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 07/2005, Volume 94, Issue 1, pp. 204 - 214
Integrity of the blood–brain barrier is essential for the normal functioning of CNS. Its disruption contributes to the pathobiology of various inflammatory... 
monocytes | PI3‐kinase | experimental autoimmune encephalomyelitis | lovastatin | nuclear factor‐κB | endothelial | Endothelial | Experimental autoimmune encephalomyelitis | Pl3-kinase | Lovastatin | Monocytes | Nuclear factor-κB | RHO-FAMILY GTPASES | REDUCTASE INHIBITOR | NITRIC-OXIDE SYNTHASE | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J | nuclear factor-kappa B | PI3-kinase | NEUROSCIENCES | ADHESION MOLECULE-1 | MULTIPLE-SCLEROSIS | E-SELECTIN | LEWIS RATS | Proto-Oncogene Proteins - antagonists & inhibitors | NF-kappa B - antagonists & inhibitors | Lovastatin - pharmacology | Protein-Serine-Threonine Kinases - physiology | Cells, Cultured | Cell Communication - physiology | Cell Adhesion - drug effects | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Monocytes - drug effects | Proto-Oncogene Proteins c-akt | Monocytes - enzymology | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Signal Transduction - drug effects | Cell Adhesion - physiology | Cell Communication - drug effects | NF-kappa B - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - physiology | Phosphatidylinositol 3-Kinases - physiology | Signal Transduction - physiology | Mice | Endothelial Cells - enzymology | Endothelial Cells - drug effects
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2007, Volume 17, Issue 9, pp. 2438 - 2442
4-Morpholin-4-ylpyrido[3′,2′:4,5]thieno[3,2- ]pyrimidine was discovered in our chemical library as a novel p110α inhibitor with an IC of 1.4 μM. By structural... 
p110α | Inhibitor | Anti-cancer agent | PI3 kinase | CHEMISTRY, MEDICINAL | anti-cancer agent | PTEN | CHEMISTRY, ORGANIC | PHOSPHOINOSITIDE 3-KINASE INHIBITORS | WORTMANNIN | FAMILY | BREAST-CANCER | ONCOGENE | inhibitor | PIK3CA GENE | PATHWAY | TUMOR-SUPPRESSOR | p110 alpha | MUTATIONS
Journal Article
Journal Article