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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2015, Volume 290, Issue 30, pp. 18843 - 18854
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/2014, Volume 463, Issue 3, pp. 413 - 427
The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to... 
Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K) | Protein kinase inhibitor | Signal transduction inhibitor | N-Myc downstream-regulated gene-1 (NDRG1) | Protein Structure, Tertiary | Cell Line | Phosphorylation | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Class II Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Humans | Inositol Polyphosphate 5-Phosphatases | Class III Phosphatidylinositol 3-Kinases - metabolism | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Endosomes - metabolism | Amino Acid Motifs | Aminopyridines - pharmacology | Hydrophobic and Hydrophilic Interactions | Protein Binding | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | SGK3, serum- and glucocorticoid-regulated kinase-3 | signal transduction inhibitor | PI3K, phosphoinositide 3-kinase | ITC, isothermal titration calorimetry | SHIP1 | mTORC, mammalian target of rapamycin complex | EEA1, early endosome antigen 1 | INPP4B, inositol polyphosphate 4-phosphatase type II | TSC2, tuberous sclerosis complex 2 | phosphoinositide 3-kinase (PI3K) | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | DMEM, Dulbecco's modified Eagle's medium | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | IP1, inositol phosphate | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | PX, Phox homology | mammalian target of rapamycin (mTOR) | Accelerated Publication | PH, pleckstrin homology | PtdIns, phosphatidylinositol | PRAS40, proline-rich Akt substrate 40 kDa | protein kinase inhibitor | 2, Src homology 2-domain-containing inositol phosphatase 1 | Vps34, vacuolar protein sorting 34 | VSV-G, vesicular stomatitis virus glycoprotein
Journal Article
Journal of Cell Science, ISSN 0021-9533, 12/2009, Volume 122, Issue 23, pp. 4303 - 4310
Phosphatidylinositol 4-kinases (PI4Ks) catalyze the first committed step in the synthesis of phosphoinositides, important lipid regulators of signaling and... 
Zebrafish | PI3K | PI4K | FGF signaling | Limb development | EMBRYONIC-DEVELOPMENT | MKP3 | MAP-KINASE | OUTGROWTH | CELL BIOLOGY | HEMATOPOIESIS | PHOSPHOLIPASE-C-GAMMA-1 | GROWTH-FACTOR | RECEPTORS | EXPRESSION | VERTEBRATE LIMB
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, 02/2017, Volume 292, Issue 5, pp. 1691 - 1704
The class I PI3K family of lipid kinases plays an important role in integrin (IIb3) function, thereby supporting thrombus growth and consolidation. Here, we... 
GAP1IP4BP | GAP1(IP4BP) | PROTEIN-KINASE-C | ACTIVATION | PHOSPHORYLATION | THROMBUS FORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | Rasa3 | HUMAN PLATELETS | GAP1 FAMILY | Ras-related protein 1 (Rap1) | VON-WILLEBRAND-FACTOR | RAP1B | phosphatidylinositide 3-kinase (PI3K) | cell signaling | platelet | integrin | FIBRINOGEN
Journal Article
Structure, ISSN 0969-2126, 12/2018, Volume 26, Issue 12, pp. 1612 - 1625.e4
Phosphorylation of phosphoinositides by the class II phosphatidylinositol 3-kinase (PI3K) PI3K-C2α is essential for many processes, including neuroexocytosis... 
PX domain | C2 domain | PI3-kinase | protein-lipid interactions | phosphoinositides | SYSTEM | PI3K-C2-ALPHA | ACTIVATION | CHANNEL KCA3.1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESOLUTION | CELL BIOLOGY | 3-KINASE C2-ALPHA | BIOPHYSICS | PHOX-HOMOLOGY DOMAIN | PI3K | CLATHRIN | INSIGHTS
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2005, Volume 390, Issue 2, pp. 613 - 623
The mammalian signalling pathway involving class IPI3K (phosphoinositide 3-kinase), PTEN (phosphatidylinositol 3-phosphatase) and PKB (protein kinase B)/c-Akt... 
c-Akt | PTEN | Protein kinase B (PKB) | Phosphoinositide 3-kinase (PI3K) | Phosphorylation | Saccharomyces cerevisiae | LOCALIZATION | ACTIVATED PROTEIN-KINASE | BUDDING YEAST | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-CYCLE CONTROL | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | PHOSPHOINOSITIDE 3-KINASE | phosphoinositide 3-kinase (PI3K) | GENE | GROWTH | protein kinase B (PKB) | PTEN TUMOR-SUPPRESSOR | phosphorylation | Phosphatidylinositol Phosphates - metabolism | Saccharomyces cerevisiae - genetics | Saccharomyces cerevisiae - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | Saccharomyces cerevisiae - metabolism | Endocytosis | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | PTEN Phosphohydrolase - genetics | Gene Expression | Signal Transduction | Morpholines - pharmacology | PTEN Phosphohydrolase - metabolism | Mammals | Cell Division - drug effects | Protein Transport | Phosphatidylinositol 3-Kinases - genetics | Saccharomyces cerevisiae - cytology | Animals | Cytoskeleton - metabolism | Enzyme Activation | Index Medicus | CPY, carboxypeptidase Y | PI3K, phosphoinositide 3-kinase | PTEN, phosphatidylinositol 3-phosphatase | HA, haemagglutinin | ATM, ataxia telangiectasia | DNA-PKcs, the catalytic subunit of DNA-dependent protein kinase | ERK, extracellular-signal-regulated kinase | PDK1, 3-phosphoinositide-dependent protein kinase-1 | PKB, protein kinase B | PIP2, phosphatidylinositol 4,5-bisphosphate | PI(3,4)P2, phosphatidylinositol 3,4-bisphosphate | PH domain, pleckstrin homology domain | SH2 domain, Src homology 2 domain | PIKK, phosphatidylinositol kinase-related kinase | mTOR, mammalian target of rapamycin | PIP3, phosphatidylinositol 3,4,5-trisphosphate | MAPK, mitogen-activated protein kinase | PLCδ1, phospholipase δ1
Journal Article
2010, Current topics in microbiology and immunology, ISBN 9783642148156, Volume 346, 347., v.
PI3K is at the forefront of drug development with the first clinical trials of PI3K pathway inhibitors in progress. This book offers an overview of some key... 
Protein kinases | Protein-tyrosine kinase | Inhibitors | Cell proliferation | Phosphoinositides | Cell death | Apoptosis | Phospholipases
Book
Microbial cell (Graz, Austria), ISSN 2311-2638, 11/2018, Volume 5, Issue 12, pp. 545 - 554
Phosphatidylinositol 3-kinase (PI3K) is a key regulator of phosphoinositide-dependent signaling in mammalian cells and its dysfunction is related to multiple... 
p110α | kinase inhibitors | PI3K | eisosomes | fluorescent reporter | humanized yeast | heterologous expression | Saccharomyces cerevisiae | phosphoinositides | septins
Journal Article
BBA - Proteins and Proteomics, ISSN 1570-9639, 2008, Volume 1784, Issue 1, pp. 159 - 185
Journal Article