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2010, Current topics in microbiology and immunology, ISBN 9783642148156, Volume 346, 347., v.
PI3K is at the forefront of drug development with the first clinical trials of PI3K pathway inhibitors in progress. This book offers an overview of some key... 
Protein kinases | Protein-tyrosine kinase | Inhibitors | Cell proliferation | Phosphoinositides | Cell death | Apoptosis | Phospholipases
Book
BBA - Proteins and Proteomics, ISSN 1570-9639, 2008, Volume 1784, Issue 1, pp. 159 - 185
Journal Article
Science, ISSN 0036-8075, 11/2013, Volume 342, Issue 6160, pp. 866 - 871
Journal Article
by Coulter, Tanya I., MRCPI and Chandra, Anita, PhD, FRCPath and Bacon, Chris M., PhD, FRCPath and Babar, Judith, MRCP, FRCR and Curtis, James, PhD and Screaton, Nick, FRCP, FRCR and Goodlad, John R., MD, FRCPath and Farmer, George, MD and Steele, Cathal Laurence, MB and Leahy, Timothy Ronan, MRCPI and Doffinger, Rainer, PhD, FRCPath and Baxendale, Helen, PhD, FRCPath and Bernatoniene, Jolanta, PhD and Edgar, J. David M., FRCP, FRCPath and Longhurst, Hilary J., PhD, FRCPath and Ehl, Stephan, MD, PhD and Speckmann, Carsten, MD and Grimbacher, Bodo, MD, PhD and Sediva, Anna, MD, PhD and Milota, Tomas, MD and Faust, Saul N., PhD, FRCPCH and Williams, Anthony P., PhD, FRCPath and Hayman, Grant, FRCP, FRCPath and Kucuk, Zeynep Yesim, MD and Hague, Rosie, MRCP, FRCPH and French, Paul, MD, MRCS, DipFMS, FRCPath and Brooker, Richard, FRCPCH and Forsyth, Peter, FRCPath and Herriot, Richard, FRCP, FRCPath and Cancrini, Caterina, MD, PhD and Palma, Paolo, MD, PhD and Ariganello, Paola, MD and Conlon, Niall, PhD, FRCPath and Feighery, Conleth, PhD, FRCPath and Gavin, Patrick J., MD and Jones, Alison, PhD, FRCPCH and Imai, Kohsuke, MD, PhD and Ibrahim, Mohammad A.A., PhD, FRCP, FRCPath and Markelj, Gašper, MD and Abinun, Mario, MD, PhD and Rieux-Laucat, Frédéric, PhD and Latour, Sylvain, PhD and Pellier, Isabelle, MD, PhD and Fischer, Alain, MD, PhD and Touzot, Fabien, MD, PhD and Casanova, Jean-Laurent, MD, PhD and Durandy, Anne, MD, PhD and Burns, Siobhan O., MD, PhD and Savic, Sinisa, PhD, FRCPath and Kumararatne, D.S., FRCPath, DPhil (Oxon) and Moshous, Despina, MD, PhD and Kracker, Sven, PhD and Vanhaesebroeck, Bart, PhD, FMedSci and Okkenhaug, Klaus, PhD and Picard, Capucine, MD, PhD and Nejentsev, Sergey, MD, PhD and Condliffe, Alison M., PhD, FRCP and Cant, Andrew James, MD, FRCP, FRCPH
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 597 - 606.e4
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in... 
Allergy and Immunology | Activated phosphoinositide 3-kinase δ syndrome | hematopoietic stem cell transplantation | phosphoinositide 3-kinase δ | immunodeficiency | phosphoinositide 3-kinase inhibitor | PIK3CD gene | bronchiectasis | p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency | Activated phosphoinositide 3-kinase delta syndrome | IMMUNOLOGICAL FEATURES | HYPER-IGM SYNDROME | p110 delta-activating mutation causing senescent T cells | hematopoietic stem cell | COMMON VARIABLE IMMUNODEFICIENCY | PIK3CD | IMMUNOLOGY | lymphadenopathy | REFERENCE VALUES | P110-DELTA | phosphoinositide 3-kinase delta | P110 DELTA | B-CELL | ALLERGY | transplantation | MUTATIONS | Recurrence | Class I Phosphatidylinositol 3-Kinases - genetics | Herpesviridae Infections - mortality | Humans | Middle Aged | Child, Preschool | Infant | Male | Antibiotic Prophylaxis | Respiratory Tract Infections - genetics | Lymphoproliferative Disorders - therapy | Young Adult | Respiratory Tract Infections - mortality | Respiratory Tract Infections - therapy | Immunologic Deficiency Syndromes - mortality | Adult | Female | Surveys and Questionnaires | Herpesviridae Infections - genetics | Child | Immunologic Deficiency Syndromes - therapy | Hematopoietic Stem Cell Transplantation | International Cooperation | Lymphoproliferative Disorders - genetics | Mutation - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Lymphoproliferative Disorders - mortality | Animals | Herpesviridae Infections - therapy | Immunoglobulins, Intravenous - therapeutic use | Adolescent | Survival Analysis | Immunologic Deficiency Syndromes - genetics | Mice | Cohort Studies | Index Medicus | Abridged Index Medicus | Immune Deficiencies, Infection, and Systemic Immune Disorders | HSCT, Hematopoietic stem cell transplantation | BALF, Bronchoalveolar lavage fluid | CT, Computed tomography | APDS, Activated phosphoinositide-3 kinase δ syndrome | GOF, Gain of function | PI3K, Phosphoinositide 3-kinase | HSV, Herpes simplex virus | CMV, Cytomegalovirus | OR, Odds ratio | PPV, Pneumococcal polysaccharide vaccine | CNS, Central nervous system
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2009, Volume 106, Issue 48, pp. 20371 - 20376
Journal Article
Blood, ISSN 0006-4971, 01/2014, Volume 123, Issue 2, pp. 239 - 248
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2015, Volume 290, Issue 13, pp. 8439 - 8446
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2007, Volume 406, Issue 3, pp. 511 - 518
Resveratrol, a polyphenol found in fruits, possesses chemopreventive and chemotherapeutic properties and has been shown to increase lifespan in yeast and... 
Deacetylase | Phosphoinositide 3-kinase | Insulin signalling | Sirtuin | Resveratrol | Human primary myotube | human primary myotube | LIFE-SPAN | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | insulin signalling | SIRTUINS | MUSCLE-CELLS | SIRT1 | INSULIN-RECEPTOR | sirtuin | PATHWAY | GLUCOSE | PANCREATIC BETA-CELLS | MICE | deacetylase | resveratrol | phosphoinositide 3-kinase | Insulin - pharmacology | Phosphorylation | Signal Transduction | Humans | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Phosphatidylinositol 3-Kinases - metabolism | Muscle Fibers, Skeletal - metabolism | Stilbenes - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphoproteins - metabolism | Animals | Ribonucleotide Reductases - antagonists & inhibitors | Adenosine Triphosphate - metabolism | Insulin Receptor Substrate Proteins | Muscle Fibers, Skeletal - cytology | Mice | Proto-Oncogene Proteins c-akt - metabolism | Sirtuins - metabolism | Index Medicus | FOXO, forkhead box O | GST, glutathione S-transferase | PI, phosphoinositide | AMPK, AMP-activated protein kinase | COX-1, cyclo-oxygenase 1 | DAF-16, abnormal dauer formation protein-16 | PI3K, PI 3-kinase | LPA, lysophosphatidic acid | PS, 3-sn-phosphatidyl-L-serine | Hck, haemopoietic cell kinase | PGC-1α, peroxisome-proliferator-activated receptor γ co-activator-1α | PKB, protein kinase B | DMEM, Dulbecco's modified Eagle's medium | siRNA, short interfering RNA | SIR, silent information regulator | MAPK, mitogen-activated protein kinase | FCS, fetal calf serum | IRS, insulin receptor substrate
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2011, Volume 438, Issue 1, pp. 53 - 62
Genetic alterations in PI3K (phosphoinositide 3-kinase) signalling are common in cancer and include deletions in PTEN (phosphatase and tensin homologue deleted... 
Phosphoinositide 4-kinase (PI4K) | Pan-phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235; phosphoinositide 3-kinase α (PI3Kα) | PIK3CA | p110α E545k mutation | PIK3CA H1047R mutation | 3T3-L1 ADIPOCYTES | CATALYTIC SUBUNIT | BIOCHEMISTRY & MOLECULAR BIOLOGY | p110 alpha E545K mutation | phosphoinositide 4-kinase (PI4K) | pan-phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235 | BREAST-CANCER | INSULIN | P110-BETA | phosphoinositide 3-kinase alpha (PI3K alpha) | PIK3CA GENE | IN-VIVO | MUTATIONS | INHIBITORS | IA PI3K ISOFORMS | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Humans | Neoplasms, Experimental - prevention & control | Enzyme Inhibitors - therapeutic use | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Mice, Knockout | Neoplasms, Experimental - pathology | Tissue Distribution | Animals | Enzyme Inhibitors - pharmacokinetics | Signal Transduction - drug effects | Protein Isoforms | Mice | Neoplasms, Experimental - metabolism | Tumor Cells, Cultured | Homeodomain Proteins - physiology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | PI3K, phosphoinositide 3-kinase | BID, twice daily dosing | p110α E545K mutation | mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235; phosphoinositide 3-kinase α (PI3Kα) | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | pan-phosphoinositide 3kinase (PI3K) | PI4K, phosphoinositide 4-kinase | QD, once daily dosing | mTOR, mammalian target of rapamycin | TGI, tumour growth inhibition
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2011, Volume 17, Issue 2, pp. 206 - 211
Journal Article
Cancer Research, ISSN 0008-5472, 01/2009, Volume 69, Issue 2, pp. 565 - 572
Journal Article