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JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 04/2019, Volume 37, Issue 11, pp. 932 - 932
Journal Article
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 10/2017, Volume 140, Issue 4, pp. 1152 - 1152
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2016, Volume 59, Issue 19, pp. 9228 - 9242
Aberrant signaling of phosphoinositide 3-kinase δ (PI3Kδ) has been implicated in numerous pathologies including hematological malignancies and rheumatoid... 
B-CELLS | CHEMISTRY, MEDICINAL | PI3K-DELTA | CAL-101 | AUTOIMMUNITY | IDELALISIB | PI3 KINASE | MECHANISMS | ARTHRITIS | CANCER | SELECTIVITY
Journal Article
by Jia, H and Dai, GX and Su, WG and Xiao, K and Weng, JY and Zhang, ZL and Wang, Q and Yuan, TH and Shi, FY and Zhang, Z and Chen, W and Sai, Y and Wang, J and Li, X and Cai, Y and Yu, J and Ren, P and Venable, J and Rao, T and Edwards, JP and Bembenek, SD
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 10, pp. 4936 - 4948
An electronic density model was developed and used to identify a novel pyrrolotriazinone replacement for a quinazolinone, a commonly used moiety to impart... 
P110-DELTA | AUTOIMMUNE | CHEMISTRY, MEDICINAL | PI3K-DELTA | INFLAMMATION | DELTA | KINASE | PI3K-GAMMA | FAMILY
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2018, Volume 61, Issue 24, pp. 11061 - 11073
A deconstruction of previously reported phosphoinositide 3-kinase δ (PI3Kδ) inhibitors and subsequent regrowth led to the identification of a privileged... 
TARGET | CHEMISTRY, MEDICINAL | EVOLUTION | SERIES | PI3K | PI3K-DELTA INHIBITORS | OPTIMIZATION | MECHANISMS | HIGHLY POTENT | LEAD
Journal Article
Annals of Oncology, ISSN 0923-7534, 2017, Volume 28, Issue 9, pp. 2169 - 2178
Background: Copanlisib is a pan-class I phosphatidylinositol 3-kinase inhibitor with predominant activity against the a-and delta-isoforms. Patients and... 
Malignant lymphoma | Copanlisib | Treatment | PI3K inhibitor | treatment | DLBCL | EFFICACY | NON-HODGKINS-LYMPHOMAS | IBRUTINIB | BAY 80-6946 | INTERNATIONAL WORKSHOP | PI3K-DELTA | ONCOLOGY | copanlisib | MANTLE CELL LYMPHOMA | IDELALISIB | CHRONIC LYMPHOCYTIC-LEUKEMIA | malignant lymphoma | Original | Editor's Choice
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 03/2019, Volume 202, Issue 5, pp. 1397 - 1405
In chronic lymphocytic leukemia (CLL), signaling through several prosurvival B cell surface receptors activates the PI3K signaling pathway. Idelalisib is a... 
RESPONSES | ACTIVATION | PI3K-DELTA | B-CELL | PHOSPHATIDYLINOSITOL 3-KINASE | EXPANSION | PHOSPHOINOSITIDE 3-KINASE P110-DELTA | CHRONIC LYMPHOCYTIC-LEUKEMIA | AKT | IMMUNOLOGY | CANCER
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 08/2019, Volume 62, Issue 15, pp. 6972 - 6984
4-(Pyrimidin-4-yl)morpholines are privileged pharmacophores for PI3K and PIKKs inhibition by virtue of the morpholine oxygen, both forming the key hydrogen... 
POTENT | CHEMISTRY, MEDICINAL | PROTEIN-KINASE | PI3K-DELTA INHIBITORS | 3-KINASE PI3K | IN-VIVO EVALUATION | DERIVATIVES | CANCER | MTOR
Journal Article
Xenobiotica, ISSN 0049-8254, 08/2019, Volume 49, Issue 8, pp. 953 - 960
1. Leniolisib is a novel oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor, currently in clinical development for the treatment of inflammatory and... 
CDZ173 | human ADME | fluorine NMR | phosphatidylinositol-3-kinase (PI3K) delta inhibitor | metabolite identification | Leniolisib
Journal Article
Blood, ISSN 0006-4971, 12/2018, Volume 132, Issue 23, pp. 2446 - 2455
Duvelisib (also known as IPI-145) is an oral, dual inhibitor of phosphatidylinositol 3-kinase delta and gamma (PI3K-delta,gamma) being developed for treatment... 
CLL | THERAPY | IDELALISIB | PI3K-DELTA,GAMMA | IBRUTINIB | CHRONIC LYMPHOCYTIC-LEUKEMIA | INHIBITOR | PI3K-GAMMA | COMBINATION | HEMATOLOGY | FLUDARABINE | Clinical Trials and Observations
Journal Article
Aging Cell, ISSN 1474-9718, 08/2015, Volume 14, Issue 4, pp. 644 - 658
Summary The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a... 
dasatinib | plasminogen‐activated inhibitor | dependence receptors | quercetin | ephrins | PI3K delta | p21 | Dasatinib | Dependence receptors | Ephrins | Plasminogen-activated inhibitor | Quercetin | P21 | ENDOTHELIAL DYSFUNCTION | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | EXPRESSION PROFILES | plasminogen-activated inhibitor | CELLULAR SENESCENCE | CANCER-THERAPY | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | LUNG-CANCER | SET ENRICHMENT ANALYSIS | GENE-EXPRESSION | IONIZING-RADIATION | TUMOR-GROWTH | Carotid Arteries - drug effects | Endonucleases - genetics | Plasminogen Activator Inhibitor 2 - genetics | Transcriptome | Gene Expression Profiling | Adipocytes - drug effects | Aging - genetics | Osteoporosis - metabolism | Ephrins - metabolism | Plasminogen Activator Inhibitor 2 - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Osteoporosis - genetics | Intervertebral Disc - pathology | Fibroblasts - metabolism | Endothelial Cells - metabolism | Intervertebral Disc - chemistry | Fibroblasts - pathology | Mesenchymal Stem Cells - pathology | Mice, Knockout | Dasatinib - pharmacology | Osteoporosis - pathology | Ephrins - genetics | Fibroblasts - drug effects | Mice | Endothelial Cells - pathology | bcl-X Protein - metabolism | Aging - metabolism | Aging - drug effects | bcl-X Protein - genetics | Cellular Senescence - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Endonucleases - metabolism | DNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Mesenchymal Stem Cells - drug effects | Mesenchymal Stem Cells - metabolism | Heart - physiopathology | Cellular Senescence - genetics | Osteoporosis - prevention & control | DNA-Binding Proteins - genetics | Adipocytes - pathology | Aging - pathology | Phosphatidylinositol 3-Kinases - genetics | Animals | Quercetin - pharmacology | Adipocytes - metabolism | Heart - drug effects | Carotid Arteries - pathology | Intervertebral Disc - drug effects | Drug Combinations | Endothelial Cells - drug effects | Original
Journal Article
AMERICAN JOURNAL OF HEMATOLOGY, ISSN 0361-8609, 11/2018, Volume 93, Issue 11, pp. 1318 - 1326
Duvelisib (IPI-145), an oral, dual inhibitor of phosphoinositide-3-kinase (PI3K)- and -, was evaluated in a Phase 1 study in advanced hematologic malignancies,... 
CLL | MODELS | IDELALISIB | PI3K-DELTA,GAMMA | IMMUNE-RESPONSES | INFLAMMATION | PHOSPHOINOSITIDE 3-KINASE P110-DELTA | PROLIFERATION | CELL CYTOKINE PRODUCTION | DIFFERENTIATION | HEMATOLOGY
Journal Article
Journal Article
Clinical Lymphoma, Myeloma and Leukemia, ISSN 2152-2650, 03/2019, Volume 19, Issue 3, pp. 135 - 141
Copanlisib is a phosphoinositol 3-kinase (PI3K) inhibitor approved for the third-line treatment of follicular non-Hodgkin lymphoma. Although the drug is... 
Hypertension | Follicular lymphoma | Hyperglycemia | Copanlisib | PI3K | PI3K-DELTA | ONCOLOGY | INHIBITOR | HEMATOLOGY
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 2019, Volume 37, Issue 11, pp. 912 - 922
PURPOSE Indolent non-Hodgkin lymphoma (iNHL) remains largely incurable and often requires multiple lines of treatment after becoming refractory to standard... 
PROLONGS SURVIVAL | PREDNISONE | MITOXANTRONE | PI3K | ONCOLOGY | CYCLOPHOSPHAMIDE | PI3K-DELTA,GAMMA | RITUXIMAB | VINCRISTINE | FOLLICULAR LYMPHOMA | INHIBITOR | Life Sciences | Hematology | Human health and pathology
Journal Article
by Xie, CY and He, Y and Zhen, MY and Wang, YL and Xu, YP and Lou, LG
CANCER SCIENCE, ISSN 1349-7006, 07/2017, Volume 108, Issue 7, pp. 1476 - 1484
The PI3K isoform (PIK3CD), also known as P110, is predominately expressed in leukocytes and has been implicated as a potential target in the treatment of... 
CAL-101 | PROTEIN | ISOFORM | CANCER | B-CELLS | PHOSPHOINOSITIDE 3-KINASE DELTA | P110-DELTA | PI3K signaling | PI3K-DELTA | PI3K | ONCOLOGY | puquitinib | PATHWAY | SELECTIVE INHIBITORS | CHRONIC LYMPHOCYTIC-LEUKEMIA | Acute myeloid leukemia
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 02/2019, Volume 78, Issue 2, pp. 249 - 260
Background The phosphatidylinositol 3-kinase delta isoform (PI3K delta) belongs to an intracellular lipid kinase family that regulate lymphocyte metabolism,... 
autoimmune diseases | treatment | B cells | autoantibodies | sjøgren's syndrome | PI3K-DELTA INHIBITOR | P110-DELTA | STROMAL CELL | TERTIARY LYMPHOID STRUCTURES | MALIGNANT-LYMPHOMA | B-CELL DEPLETION | CHRONIC LYMPHOCYTIC-LEUKEMIA | RHEUMATOLOGY | SALIVARY-GLANDS | MALT LYMPHOMA | T-CELLS
Journal Article
Annals of Oncology, ISSN 0923-7534, 2017, Volume 28, Issue 9, pp. 2047 - 2049
Journal Article
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