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by Wang, XF and Luo, GT and Zhang, KD and Cao, J and Huang, C and Jiang, T and Liu, BY and Su, LP and Qiu, ZJ
CANCER RESEARCH, ISSN 0008-5472, 08/2018, Volume 78, Issue 16, pp. 4586 - 4598
Exosomes are emerging as important mediators of the cross-talk between tumor cells and the micro-environment. However, the mechanisms by which exosomes... 
BIOMARKERS | CELLS | RNA | MECHANISM | ONCOLOGY | ROLES | PI3K-GAMMA | SUPPRESSION | EXPRESSION | PROGRESSION | LYMPHOCYTES
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 08/2004, Volume 173, Issue 4, pp. 2236 - 2240
Despite the established role for PI3Ks in cell migration, the PI3Ks involved in lymphocyte chemotaxis are poorly defined. In this study, we report that... 
MIGRATION | REQUIREMENTS | ACTIVATION | ENTRY | B-CELL | IMMUNOLOGY | PI3K-GAMMA
Journal Article
Nature Cell Biology, ISSN 1465-7392, 01/2007, Volume 9, Issue 1, pp. 86 - 91
The directional movement of cells in a gradient of external stimulus is termed chemotaxis and is important in many aspects of development and differentiated... 
SIGNAL-TRANSDUCTION | DICTYOSTELIUM | MIGRATION | COMPASS | GAMMA | ACTIVATION | ACTIN | CHEMOTAXIS | 3-KINASE | PI3K-GAMMA | CELL BIOLOGY
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 10, pp. 2193 - 2196
Phosphatidylinositol 3-kinase (PI3K) isoforms PI3K beta and PI3K gamma are implicated in platelet adhesion, activation, and aggregation, but their relative... 
RAP1B | ALPHA(IIB)BETA | ACTIVATION | PI3K | ISOFORM | MICE | IDENTIFICATION | PI3K-GAMMA | HEMATOLOGY | PHOSPHOINOSITIDE 3-KINASE | BETA
Journal Article
by Jia, H and Dai, GX and Su, WG and Xiao, K and Weng, JY and Zhang, ZL and Wang, Q and Yuan, TH and Shi, FY and Zhang, Z and Chen, W and Sai, Y and Wang, J and Li, X and Cai, Y and Yu, J and Ren, P and Venable, J and Rao, T and Edwards, JP and Bembenek, SD
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 10, pp. 4936 - 4948
An electronic density model was developed and used to identify a novel pyrrolotriazinone replacement for a quinazolinone, a commonly used moiety to impart... 
P110-DELTA | AUTOIMMUNE | CHEMISTRY, MEDICINAL | PI3K-DELTA | INFLAMMATION | DELTA | KINASE | PI3K-GAMMA | FAMILY
Journal Article
Cancer Research, ISSN 0008-5472, 09/2018, Volume 78, Issue 17, pp. 4929 - 4942
Therapies targeting immune checkpoints have shown great clinical potential in a subset of patients with cancer but may be hampered by a failure to reverse the... 
ACTIVATION | IMMUNE CELLS | ONCOLOGY | RESISTANCE | INNATE | TUMOR-ASSOCIATED MACROPHAGES | DIFFERENTIATION | PI3K-GAMMA | RECEPTORS | CANCER | LGR4 | Index Medicus
Journal Article
CURRENT BIOLOGY, ISSN 0960-9822, 03/2005, Volume 15, Issue 6, pp. 566 - 570
A variety of genetic and inhibitor studies have shown that phosphoinositide 3-kinase gamma (PI3K gamma) plays an essential role in a number of physiological... 
ROLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PI3K-GAMMA
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 02/2019, Volume 25, Issue 3, pp. 1098 - 1112
Purpose: Tumor-associated macrophages (TAMs) and the hyperactivation of the PI3K/AKT pathway are involved in the pathogenesis of Hodgkin lymphoma and affect... 
ACTIVATION | ONCOLOGY | IDELALISIB | MACROPHAGES | PYRUVATE-KINASE M2 | BRENTUXIMAB VEDOTIN | PHASE-II | PI3K-GAMMA | BLOCKADE | POLARIZATION | T-CELLS
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 12/2017, Volume 474, pp. 3903 - 3914
Phosphoinositide 3-kinases (PI 3-kinases) are regulated by a diverse range of upstream activators, including receptor tyrosine kinases (RTKs),... 
CELLS | METASTASIS | ROLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOINOSITIDE 3-KINASE ISOFORMS | GROWTH | KINASE | P101 | P110-BETA SUBUNIT | PI3K-GAMMA
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 11/2006, Volume 8, Issue 11, pp. 1303 - 1309
Through their ability to regulate production of the key lipid messenger PtdIns(3,4,5)P-3, the class I phosphatidylinositol-3-OH kinases (PI(3)Ks) support many... 
RECRUITMENT | ACTIVATION | ROLES | CHEMOTAXIS | INFLAMMATION | TRANSDUCTION | PI3K-GAMMA | PHOSPHOINOSITIDE 3-KINASE | CELL POLARITY | CELL BIOLOGY
Journal Article
Blood, ISSN 0006-4971, 12/2018, Volume 132, Issue 23, pp. 2446 - 2455
Duvelisib (also known as IPI-145) is an oral, dual inhibitor of phosphatidylinositol 3-kinase delta and gamma (PI3K-delta,gamma) being developed for treatment... 
CLL | THERAPY | IDELALISIB | PI3K-DELTA,GAMMA | IBRUTINIB | CHRONIC LYMPHOCYTIC-LEUKEMIA | INHIBITOR | PI3K-GAMMA | COMBINATION | HEMATOLOGY | FLUDARABINE | Clinical Trials and Observations
Journal Article
by Zhang, B and Ye, HL and Ren, XF and Zheng, SY and Zhou, QB and Chen, CH and Lin, Q and Li, GL and Wei, LS and Fu, ZQ and Zhang, YT and Hu, CH and Li, ZH and Chen, RF
CANCER LETTERS, ISSN 0304-3835, 2019, Volume 459, pp. 204 - 215
Macrophage-targeted therapy offers new options for intractable pancreatic ductal adenocarcinoma (PDAC), which has a low 5-year survival rate. However, the... 
Biomarker | Integrin | ONCOLOGY | PATHWAY | Pancreatic ductal adenocarcinoma | Cancer stem cell | TUMOR-ASSOCIATED MACROPHAGES | Tumor-associated macrophage | PI3K-GAMMA | POLARIZATION | BETA
Journal Article
by Liu, LX
BLOOD, ISSN 0006-4971, 05/2008, Volume 111, Issue 9, pp. 4828 - 4828
Journal Article
by Sala, V and Li, MC and Ghigo, A
AGING-US, ISSN 1945-4589, 02/2019, Volume 11, Issue 4, pp. 1075 - 1076
Journal Article
EMBO MOLECULAR MEDICINE, ISSN 1757-4676, 07/2015, Volume 7, Issue 7, pp. 859 - 861
Attention-deficit/hyperactivity disorder (ADHD) is a developmental disorder characterized by hyperactivity, inattention, and impulsive behaviors and has... 
MEDICINE, RESEARCH & EXPERIMENTAL | ADHD | BEHAVIORAL FLEXIBILITY | PI3K-GAMMA
Journal Article
Philosophical Transactions of the Royal Society B: Biological Sciences, ISSN 0962-8436, 02/2019, Volume 374, Issue 1765, p. 20180151
Macropinocytosis is a prevalent and essential pathway inmacrophages where it contributes to anti-microbial responses and innate immune cell functions. Cell... 
Toll-like receptors | Rab GTPase | FRET | macropinocytosis | ruffles | phosphoinositides | RECRUITMENT | HOMEOSTASIS | PROTEIN | MECHANISMS | ENDOCYTOSIS | BIOLOGY | PI3K-GAMMA | MEMBRANE RUFFLES | PROMOTES | GTPASE
Journal Article
Journal Article
by Xu, AJ and Li, YM and Zhao, WS and Hou, F and Li, XJ and Sun, L and Chen, W and Yang, AT and Wu, SN and Zhang, B and Yao, JY and Wang, H and Huang, J
JOURNAL OF MOLECULAR MEDICINE-JMM, ISSN 0946-2716, 02/2018, Volume 96, Issue 2, pp. 119 - 133
Hepatic fibrosis is characterized by the activation of hepatic stellate cells (HSCs). Migration of the activated HSCs to the site of injury is one of the key... 
MEDICINE, RESEARCH & EXPERIMENTAL | PHP14 | ACTIVATION | PI3K gamma/AKT/Rac1 pathway | Migration | PROTEIN HISTIDINE PHOSPHATASE | SUBSTRATE | GENETICS & HEREDITY | Hepatic stellate cell | Liver fibrosis | FACTOR-BETA RECEPTOR | CANCER
Journal Article
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