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Journal of hazardous materials, ISSN 0304-3894, 2018, Volume 357, pp. 355 - 362
•Pancreas is the main target organ of Cd toxicity.•Cd induces apoptosis via PPAR-γ/PI3K/Akt pathway in pancreas.•Se reduces Cd accumulation and antagonize Cd... 
PPAR-γ/PI3K/Akt pathway | Cadmium | Selenium | Chicken pancreas | Apoptosis | CELLS | ACTIVATED RECEPTOR-GAMMA | LIPID-PEROXIDATION | PPAR-gamma/PI3K/Akt pathway | DEFICIENCY | HEAT-SHOCK PROTEINS | ENVIRONMENTAL SCIENCES | ENGINEERING, ENVIRONMENTAL | INDUCED OXIDATIVE STRESS | ANTIOXIDANT | NITRIC-OXIDE | GENE-EXPRESSION | RETICULUM RESIDENT SELENOPROTEINS
Journal Article
Cell cycle (Georgetown, Tex.), ISSN 1551-4005, 2018, Volume 17, Issue 8, pp. 963 - 973
It is believed that the alteration of tissue microenvironment would affect cancer initiation and progression. However, little is known in terms of the... 
RNA-sequencing | PI3K-Akt signaling | Cancer progression | Breast cancer | Ras signaling | Apoptosis | CELLS | POLYOMA | CELL BIOLOGY | METASTATIC NICHE | GLUCOSE-METABOLISM | RESISTANCE | PI3K-AKT PATHWAY | PI3K/AKT SIGNALING PATHWAY | PROTEINS | TUMORIGENESIS
Journal Article
Cancer letters, ISSN 0304-3835, 2015, Volume 367, Issue 1, pp. 58 - 68
Abstract Glioblastoma multiforme (GBM) is the most frequent and most aggressive brain tumor in adults. The introduction of temozolomide (TMZ) has advanced... 
Hematology, Oncology and Palliative Medicine | NVP-BEZ235 | Cell cycle arrest | PI3K–AKT–mTOR | Temozolomide | Glioma | Apoptosis | PI3K-AKT-mTOR | AKT ACTIVATION | CYCLIN-A | PHOSPHATIDYLINOSITOL 3-KINASE/MAMMALIAN TARGET | PI3K/MTOR INHIBITOR | ADJUVANT TEMOZOLOMIDE | MALIGNANT GLIOMA | PI3K/AKT PATHWAY | ONCOLOGY | RAPAMYCIN INHIBITOR | GLIOBLASTOMA CELLS | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Brain Neoplasms - pathology | Caspase 3 - metabolism | Antineoplastic Agents, Alkylating - pharmacology | Male | Quinolines - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Dacarbazine - pharmacology | Glioma - pathology | Dacarbazine - analogs & derivatives | Inhibitory Concentration 50 | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Brain Neoplasms - enzymology | Glioma - enzymology | bcl-2-Associated X Protein - metabolism | Imidazoles - pharmacology | Brain Neoplasms - drug therapy | Mice, SCID | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | G1 Phase Cell Cycle Checkpoints - drug effects | Glioma - drug therapy | Drug Resistance, Neoplasm - drug effects | Antimitotic agents | Chemotherapy | Antineoplastic agents | Gliomas | Analysis | Cancer
Journal Article
Journal of orthopaedic research, ISSN 0736-0266, 2015, Volume 33, Issue 7, pp. 957 - 964
ABSTRACT Osteogenesis of mesenchymal stem cells (MSCs) is essential for bone repair. Recently, microRNAs have been proven to play an important role in the... 
osteogenesis | miR‐21 | PI3K/AKT/β‐catenin | mesenchymal stem cells | PI3K/AKT/β-catenin | miR-21 | Signal Transduction | Humans | Cell Differentiation | Phosphatidylinositol 3-Kinases - metabolism | MicroRNAs - physiology | beta Catenin - metabolism | Mesenchymal Stromal Cells - physiology | Osteogenesis
Journal Article
Journal Article
Ai zheng, ISSN 1000-467X, 2013, Volume 32, Issue 5, pp. 253 - 265
Journal Article
Molecular neurobiology, ISSN 1559-1182, 2017, Volume 55, Issue 7, pp. 6076 - 6093
Well-established studies have shown an elevated level of reactive oxygen species (ROS) that induces oxidative stress in the Alzheimer’s disease (AD) patient’s... 
Oxidative stress | Neurosciences | Pre- and postsynaptic protein markers | Neurobiology | Reactive oxygen species (ROS) | Memory functions | Cell Biology | Neurology | Biomedicine | Alzheimer’s disease (AD) | Nrf2/HO-1 pathway | Neurodegeneration | APP/PS1 | Anthocyanins | p-PI3K/Akt/GSK3β pathways | CELLS | ACTIVATION | ACID | Alzheimer's disease (AD) | COGNITIVE IMPAIRMENT | Pre and postsynaptic protein markers | NEUROSCIENCES | PROTECTS | GLYCOGEN-SYNTHASE KINASE-3-BETA | TRANSCRIPTION FACTOR NRF2 | NEUROINFLAMMATION | p-PI3K/Akt/GSK3 beta pathways | DYSFUNCTION | BRAIN | Memory Disorders - physiopathology | Heme Oxygenase-1 - metabolism | Alzheimer Disease - complications | Reactive Oxygen Species - metabolism | Memory Disorders - genetics | Humans | Nerve Degeneration - physiopathology | Male | Phosphatidylinositol 3-Kinases - metabolism | Memory Disorders - complications | Cell Nucleus - metabolism | Amyloid beta-Peptides - metabolism | Anthocyanins - therapeutic use | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Biomarkers - metabolism | Cell Line | Alzheimer Disease - physiopathology | Anthocyanins - pharmacology | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Alzheimer Disease - drug therapy | Mice, Transgenic | Nerve Degeneration - pathology | Animals | Memory Disorders - drug therapy | NF-E2-Related Factor 2 - metabolism | Oxidative Stress - drug effects | Alzheimer Disease - genetics | Dietary Supplements | Nerve Degeneration - drug therapy | Anthocyanin | Prevention | Legumes | Beans | Synthesis | Glycogen | Analysis | Heme | Dietary supplements | Mimosaceae | Alzheimer's disease | Neuroprotection | Brain | Reactive oxygen species | Memory | AKT protein | Kinases | Caspase-3 | Neurotoxicity | Pathways | Rodents | Neurodegenerative diseases | Markers | Glycogen synthase kinase 3 | Heme oxygenase (decyclizing) | Caspase | Poly(ADP-ribose) polymerase | Amyloid precursor protein | 1-Phosphatidylinositol 3-kinase | Neurological diseases | Oxygenase | Computer memory | Signaling | Poly(ADP-ribose) Polymerase 1 | Diet | Lymphocytes B | Mice | Alzheimers disease | Hippocampus | Apoptosis | Index Medicus
Journal Article
Molecular nutrition & food research, ISSN 1613-4125, 12/2017, Volume 61, Issue 12, pp. 1700433 - n/a
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2019, Volume 116, Issue 14, pp. 6868 - 6877
Journal Article
Phytomedicine (Stuttgart), ISSN 0944-7113, 2019, p. 153062
The isothiocyanate sulforaphane (SFN) has multiple protein targets in mammalian cells, affecting processes of fundamental importance for the maintenance of... 
mTOR | NRF2 | PI3K-AKT | Sulforaphane | HDAC6
Journal Article