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Free Radical Biology and Medicine, ISSN 0891-5849, 06/2016, Volume 95, pp. 278 - 292
Microvascular endothelial cells (CMECs) oxidative damage resulting from hypoxia/reoxygenation (H/R) injury is responsible for microcirculation perfusion... 
PI3K/Akt pathway | ROS | Survivin | Liraglutide | Calcium homeostasis | CMECs | Apoptosis
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 2015, Volume 146, pp. 53 - 60
The PI3K/Akt/mTOR pathway is the most frequently known activated aberrant pathway in human cancers. Pathologic activation can occur at multiple levels along... 
Isoforms | PI3K pathway | Review | PI3K inhibitors | PI3K/Akt/mTOR
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 10/2019, Volume 118
Osteoarthritis (OA) is involved in these pathophysiological changes of articular cartilage, subchondral bone and synovium. As a selective HDAC6 inhibitor,... 
ACY-1215 | Osteoarthritis | Osteoblasts | HDAC6 | PI3K/AKT
Journal Article
Biomedical Research (India), ISSN 0970-938X, 2018, Volume 29, Issue 12, pp. 2490 - 2494
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 03/2019, Volume 111, pp. 714 - 723
Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in which the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase... 
PTEN | Lactoferrin | Alzheimer’s disease | Neurodegeneration | PI3K/Akt
Journal Article
Chemical Biology and Drug Design, ISSN 1747-0277, 2019
Thrombotic diseases are major cause of cardiovascular diseases. This study was designed to investigate the effect of tachyplesin I on platelet aggregation and... 
anti-thrombosis | tachyplesin I | PI3K/Akt | platelet aggregation
Journal Article
FRONTIERS IN MOLECULAR NEUROSCIENCE, ISSN 1662-5099, 2011, Volume 4, pp. 51 - 51
The phosphatidylinositol 3-kinase (P13K)/AKT/mammalian target of rapamycin (mTOR) pathway is activated in the majority of human cancers. This pathway is known... 
nitric oxide | PI3K/AKT/mTOR | NEUROSCIENCES | angiogenesis | VEGF | angiopoietins | Angiogenesis | Nitric Oxide | Angiopoietins
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2019, Volume 517, Issue 3, pp. 445 - 451
Nutlin-3 shows a potent antitumor efficacy through downregulation of the cancerogenic ether à go-go 1 (Eag1) channel. However, the molecular mechanisms... 
Nutlin-3 | Anticancer | Eag1 | p53 | PI3K/AKT | Index Medicus
Journal Article
Experimental and Molecular Pathology, ISSN 0014-4800, 06/2019, Volume 108, pp. 80 - 88
Triptolide (TPL) is a potential anti-tumor natural compound. However, its role in nephroblastoma is poorly studied. Herein, we aimed to reveal the regulatory... 
Nephroblastoma | KLF4 | miR-193b-3p | PI3K/AKT/ERK | Triptolide
Journal Article
Neuroscience, ISSN 0306-4522, 08/2019, Volume 414, pp. 112 - 127
Inflammation may result in periventricular leukomalacia, which is the leading cause of preterm brain encephalopathy. Moreover, < omega >-3 polyunsaturated... 
< omega >-3 PUFA | neuroprotection | LPS | PI3K/AKT pathway | Index Medicus
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2011, Volume 672, Issue 1, pp. 45 - 55
Amyloid β-protein (Aβ), which is deposited in neurons as neurofibrillary tangles, is known to exert cytotoxic effects by inducing mitochondrial dysfunction.... 
Neuroprotection | Hyperoside | Amyloid β-protein (Aβ) | Mitochondria | PI3K/Akt
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2019, Volume 514, Issue 1, pp. 140 - 147
Long non-coding RNA (lncRNAs), which are increasingly identified to be dysregulated in cancers, has been verified to participate in tumorigenesis and cancer... 
LAD progression | TTN-AS1 | PTEN stabilization | PI3K/AKT pathway
Journal Article
Experimental Cell Research, ISSN 0014-4827, 07/2019, Volume 380, Issue 2, pp. 205 - 215
Oxidative stress plays an important role in the progression of cardiac diseases, including acute myocardial infarction, ischemia/reperfusion (I/R) injury and... 
Oxidative stress | Thyroid hormone | Mitochondrial function | PI3K/AKT signaling | Apoptosis
Journal Article
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 09/2019, Volume 672, pp. 108064 - 108064
S-equol is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora, which has strong anti-cancer... 
Breast cancer | miR-10a-5p | S-Equol | MCF-7 | PI3K/AKT | Index Medicus
Journal Article
Cellular Signalling, ISSN 0898-6568, 11/2019, Volume 63, pp. 109386 - 109386
High-mobility group A1 (HMGA1), an architectural transcription factor, participates in different human tumors' biological progression. HMGA1 overexpression is... 
HMGA1 | Uveal melanoma | microRNA-222 | PI3K/Akt/MMP9 | Index Medicus
Journal Article
Cell Cycle, ISSN 1538-4101, 10/2019, Volume 18, Issue 19, pp. 2538 - 2549
Insulin resistance (IR) is prevalent in women with polycystic ovary syndrome (PCOS). Improvement in insulin sensitivity remains one of the most effective... 
Polycystic ovary syndrome | H19 | metformin | sitagliptin | PI3K/AKT | Index Medicus
Journal Article
Cellular Signalling, ISSN 0898-6568, 02/2019, Volume 54, pp. 170 - 178
Human Glioblastoma is one deadly disease; the median survival time is reported to be 13.9 months after treatment. In the present study, we discovered that... 
DHX33 | PI3K/Akt/mTOR | Glioblastoma | RNA helicase | CELL BIOLOGY
Journal Article
Genomics, ISSN 0888-7543, 05/2019
Hepatocellular carcinoma (HCC) is a primary cause of cancer mortality. PAK1 plays key roles in many types of cancers. However, the role of PAK1 in HCC is not... 
Journal Article
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