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Journal Article
Oncotarget, ISSN 1949-2553, 05/2016, Volume 7, Issue 22, pp. 33440 - 33450
Journal Article
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 03/2015, Volume 74, Issue 3, pp. 569 - 578
Objectives We have previously shown that peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor, is essential for the normal growth... 
RAPAMYCIN | PIOGLITAZONE | DISEASE | GROWTH | ACTIVATED-RECEPTOR-GAMMA | DEGRADATION | AUTOPHAGY | RHEUMATOLOGY | PI3K/AKT/MTOR PATHWAY | EXPRESSION | AGONIST | Basic and Translational Research | Arthritis | 1507 | 1506 | Osteoarthritis | Chondrocytes
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 2015, Volume 72, Issue 2, pp. 221 - 236
The last decade has spawned an exciting new era of oncotherapy in dermatology, including the development of targeted therapies for metastatic melanoma and... 
Lambrolizumab | RAS | Ipilimumab | Panniculitis | Verrucal keratosis | Autoimmune dermopathies | PI3K-AKT-mTOR pathway | Seborrheic dermatitis | Temsirolimus | Pruritus | Dermatitis | Keratoacanthoma | Autoimmune adverse effects | Vitiligo | RAF inhibitors | Immunotherapy | Immune-related toxicities | mTOR inhibitor | B-RAF | Everolimus | PI3 kinase inhibitor | Squamous cell carcinoma | Dysgeusia | Selumetinib | Dual inhibitor | MEK inhibitors | Dabrafenib | Rapamycin | PD-1 inhibitor | Trametinib | Keratotic squamoproliferative lesion | Vemurafenib | AKT inhibitor | Loss of taste | Nivolumab | MAP kinase pathway | Hedgehog signaling pathway | Taste alteration | Vismodegib | Hair loss | Keratosis pilaris | pruritus | ADVANCED CANCER | lambrolizumab | nivolumab | dysgeusia | RENAL-CELL CARCINOMA | METASTATIC MELANOMA | ipilimumab | autoimmune adverse effects | AZD6244 ARRY-142886 | MAMMALIAN TARGET | vitiligo | TASTE PAPILLA DEVELOPMENT | BRAF INHIBITORS | vismodegib | hair loss | hedgehog signaling pathway | panniculitis | keratotic squamoproliferative lesion | keratoacanthoma | taste alteration | seborrheic dermatitis | VEMURAFENIB TREATMENT | DERMATOLOGY | trametinib | keratosis pilaris | everolimus | dermatitis | immunotherapy | autoimmune dermopathies | dabrafenib | verrucal keratosis | ADVANCED SOLID TUMORS | vemurafenib | selumetinib | loss of taste | temsirolimus | immune-related toxicities | dual inhibitor | rapamycin | squamous cell carcinoma | Drug Eruptions - etiology | Molecular Targeted Therapy - adverse effects | Skin Neoplasms - drug therapy | Photosensitivity Disorders - chemically induced | Humans | Carcinoma, Squamous Cell - chemically induced | Drug Eruptions - therapy | Skin Neoplasms - chemically induced | Photosensitivity Disorders - therapy | Immunotherapy - adverse effects | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Panniculitis - chemically induced | Signal Transduction - drug effects | Antineoplastic Agents - adverse effects | Drug Eruptions - diagnosis | Alopecia - chemically induced | Mitogen-Activated Protein Kinases - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 02/2012, Volume 19, Issue 2, pp. 284 - 294
Journal Article
Oncology Reports, ISSN 1021-335X, 11/2018, Volume 40, Issue 5, pp. 2977 - 2987
Recently, sphingolipid derivatives, such as ceramide and sphingosine-1-phosphate (S1P), have emerged as key modulators in apoptotic cell death and cell... 
Breast cancer | MTOR signaling | Sphingosine-1-phosphate receptor | Ceramide synthase | Sphingosine-1-phosphate | V-ATPASE | APOPTOSIS | sphingosine-1-phosphate receptor | PI3K/AKT/MTOR | ceramide synthase | breast cancer | ACYL-CHAIN LENGTH | SPHINGOLIPIDS | mTOR signaling | CERAMIDE SYNTHASES | BREAST-CANCER | THERAPY | ONCOLOGY | BIOSYNTHESIS | sphingosine-1-phosphate | Phosphorylation | Receptors, Lysosphingolipid - antagonists & inhibitors | Humans | Gene Expression Regulation, Neoplastic | Ceramides - biosynthesis | TOR Serine-Threonine Kinases - genetics | MCF-7 Cells | Lysophospholipids - biosynthesis | Oncogene Protein v-akt - genetics | Receptors, Lysosphingolipid - genetics | Female | Cell Proliferation - genetics | Triazines - pharmacology | Membrane Proteins - genetics | Morpholines - pharmacology | Phosphotransferases (Alcohol Group Acceptor) - genetics | Ceramides - genetics | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Lysophospholipids - genetics | Sphingosine - analogs & derivatives | Breast Neoplasms - genetics | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Sphingosine - biosynthesis | Sphingosine N-Acyltransferase - genetics | Breast Neoplasms - pathology | Sphingosine - genetics | Care and treatment | Development and progression | Sphingolipids | Genetic aspects | Cellular signal transduction | Health aspects | Immunoglobulins | Laboratories | Roles | Mammals | Gene expression | Kinases | Fatty acids | Proteins | Signal transduction | Cell growth | Medical prognosis | Cell cycle | Apoptosis
Journal Article
2015, ISBN 9782889194193
The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as... 
B cell | PI3K/AKT/mTOR | Signal Transduction | T cell | PI3K pathway inhibitors
eBook
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, p. e99272
Journal Article