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Biochemical Journal, ISSN 0264-6021, 08/2011, Volume 438, Issue 1, pp. 53 - 62
Genetic alterations in PI3K (phosphoinositide 3-kinase) signalling are common in cancer and include deletions in PTEN (phosphatase and tensin homologue deleted... 
Phosphoinositide 4-kinase (PI4K) | Pan-phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235; phosphoinositide 3-kinase α (PI3Kα) | PIK3CA | p110α E545k mutation | PIK3CA H1047R mutation | 3T3-L1 ADIPOCYTES | CATALYTIC SUBUNIT | BIOCHEMISTRY & MOLECULAR BIOLOGY | p110 alpha E545K mutation | phosphoinositide 4-kinase (PI4K) | pan-phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235 | BREAST-CANCER | INSULIN | P110-BETA | phosphoinositide 3-kinase alpha (PI3K alpha) | PIK3CA GENE | IN-VIVO | MUTATIONS | INHIBITORS | IA PI3K ISOFORMS | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Humans | Neoplasms, Experimental - prevention & control | Enzyme Inhibitors - therapeutic use | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Mice, Knockout | Neoplasms, Experimental - pathology | Tissue Distribution | Animals | Enzyme Inhibitors - pharmacokinetics | Signal Transduction - drug effects | Protein Isoforms | Mice | Neoplasms, Experimental - metabolism | Tumor Cells, Cultured | Homeodomain Proteins - physiology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | PI3K, phosphoinositide 3-kinase | BID, twice daily dosing | p110α E545K mutation | mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235; phosphoinositide 3-kinase α (PI3Kα) | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | pan-phosphoinositide 3kinase (PI3K) | PI4K, phosphoinositide 4-kinase | QD, once daily dosing | mTOR, mammalian target of rapamycin | TGI, tumour growth inhibition
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2009, Volume 422, Issue 1, pp. 23 - 35
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2010, Volume 427, Issue 1, pp. 69 - 78
More than 200 phosphorylated 14-3-3-binding sites in the literature were analysed to define 14-3-3 specificities, identify relevant protein kinases, and give... 
Evolution | 14-3-3 protein | Disrupted-in-schizophrenia 1 (DISC1) | calmodulin-dependent protein kinase | AGC protein kinase | NEURONAL MIGRATION | SIGNALING PATHWAYS | MEMBRANE H+-ATPASE | REGULATING 14-3-3 BINDING | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | EUKARYOTIC PROTEIN-KINASES | evolution | NUCLEAR-LOCALIZATION | EXOENZYME-S | STRUCTURAL BASIS | Ca2+/calmodulin-dependent protein kinase | disrupted-in-schizophrenia 1 (DISC1) | ENDOPLASMIC-RETICULUM | Protein Kinases - metabolism | Phosphorylation | Immunoprecipitation | Humans | RNA, Messenger - genetics | Cells, Cultured | Computational Biology | Kidney - cytology | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | 14-3-3 Proteins - metabolism | Nerve Tissue Proteins - metabolism | Kidney - metabolism | Carrier Proteins - metabolism | Protein Binding | Binding Sites | Dimerization | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | 14-3-3 Proteins - genetics | Index Medicus | Bcl-2-associated death promoter | AANAT, serotonin acetyltransferase | FOXO, Forkhead box O | KLC, kinesin light chain | CDK5, cyclin-dependent kinase 5 | HEK, human embryonic kidney | MARK, microtubule affinity-regulating kinase | AMPK, AMP-activated protein kinase | EST, expressed sequence tag | PKB, protein kinase B | RSK, ribosomal S6 kinase | CaMK, Ca2 | GLUT4, glucose transporter 4 | protein kinase G | GST, glutathione transferase | HDAC, histone deacetylase | HAP1A, Huntingtin-associated protein 1A | DIG, digoxigenin | PKC, protein kinase C | BAD, Bcl-XL | PP2A, protein phosphatase 2A | DSTT, Division of Signal Transduction Therapy | HA, haemagglutinin | AGC, protein kinase A | Ca2 | PI4K, phosphoinositide 4-kinase | DISC1, disrupted-in-schizophrenia 1 | protein kinase C family kinase | YAP1, yes-associated protein 1
Journal Article
Journal Article
Journal of Cell Science, ISSN 0021-9533, 12/2009, Volume 122, Issue 23, pp. 4303 - 4310
Phosphatidylinositol 4-kinases (PI4Ks) catalyze the first committed step in the synthesis of phosphoinositides, important lipid regulators of signaling and... 
Zebrafish | PI3K | PI4K | FGF signaling | Limb development | EMBRYONIC-DEVELOPMENT | MKP3 | MAP-KINASE | OUTGROWTH | CELL BIOLOGY | HEMATOPOIESIS | PHOSPHOLIPASE-C-GAMMA-1 | GROWTH-FACTOR | RECEPTORS | EXPRESSION | VERTEBRATE LIMB
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 2, pp. 145 - 156
As an important metabolic pathway, phosphatidylinositol metabolism generates both constitutive and signalling molecules that are crucial for plant growth and... 
Phospholipid | Signalling | Plant | PHOSPHATIDYLINOSITOL MONOPHOSPHATE KINASE | POLLEN-TUBE GROWTH | ARABIDOPSIS-THALIANA | MYOINOSITOL POLYPHOSPHATE 5-PHOSPHATASE | INOSITOL 1,3,4-TRISPHOSPHATE 5/6-KINASE | PHOSPHATIDIC-ACID ACCUMULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEGATIVE REGULATOR | plant | ROOT-HAIR DEVELOPMENT | phospholipid | ABSCISIC-ACID | D-ALPHA | signalling | Plant Proteins - genetics | Plants - metabolism | Oxidative Stress | Signal Transduction | Calcium - metabolism | Models, Biological | Gene Expression Regulation, Plant | Phosphatidylinositols - metabolism | Plant Proteins - metabolism | Phospholipids - metabolism | Inositol Phosphates - metabolism | Plant Roots - growth & development | Index Medicus | PLC, phospholipase C | LPP, lipid phosphate phosphatase | PI3K, phosphoinositide 3-kinase | 5PTase, inositol polyphosphate 5-phosphatase | AVR4, avirulence 4 | PIPK, phosphoinositide phosphate kinase | Review | ABA, abscisic acid | DGK, DAG kinase | AtIPK2, Arabidopsis thaliana inositol polyphosphate kinase 2 | SNX1, sorting nexin 1 | PDK1, phosphoinositide-dependent kinase 1 | ZmPLC1, Zea mays PLC1 | F-actin, filamentous actin | LOX2, lipoxygenase 2 | IAA, indoleacetic acid | OsPIPK, Oryza sativa phosphoinositide phosphate kinase | PA, phosphatidic acid | CTR1, constitutive triple response 1 | DAG, diacylglycerol | PIP5K, phosphoinositide phosphate 5-kinase | PP2A, protein phosphatase 2A | AtCP, actin-capping protein | RACK1, receptor for activated C-kinase 1 | IP3R, Ins(1,4,5)P3 receptor | PI4K, phosphoinositide 4-kinase | PLD, phospholipase D | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2010, Volume 425, Issue 1, pp. 159 - 168
Ca2+ entry through store-operated Ca2+ channels involves the interaction at ER-PM (endoplasmic reticulum-plasma membrane)junctions of STIM (stromal interaction... 
Stromal interaction molecule 1 (STIM1) | Phosphoinositide | PtdIns(4,5)P | Endoplasmic reticulum calcium | Orai1 | PtdIns(3,4,5)P | Calcium signal | Store-operated calcium entry (SOCE) | endoplasmic reticulum calcium | CA2+ ENTRY | store-operated calcium entry (SOCE) | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN PLATELETS | DEPLETION | CHAIN KINASE INHIBITOR | calcium signal | ACTIVATES CRAC CHANNELS | PLASMA-MEMBRANE | phosphoinositide | PtdIns(3,4,5)P-3 | PtdIns(4,5)P-2 | stromal interaction molecule 1 (STIM1) | CLUSTERS | ORAI CHANNELS | STROMAL INTERACTION MOLECULE-1 | Calcium Channels - metabolism | Calcium - metabolism | Humans | Endoplasmic Reticulum - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Protein Transport - drug effects | Neoplasm Proteins - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | 1-Phosphatidylinositol 4-Kinase - metabolism | Phosphatidylinositol 4,5-Diphosphate - metabolism | Transfection | Adenosine Triphosphate - metabolism | Phosphatidylinositols - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | Chromones - pharmacology | Neoplasm Proteins - genetics | Calcium Channels - genetics | Stromal Interaction Molecule 1 | Membrane Proteins - genetics | Morpholines - pharmacology | 1-Phosphatidylinositol 4-Kinase - antagonists & inhibitors | ORAI1 Protein | Microscopy, Confocal | Androstadienes - pharmacology | Protein Binding | Luminescent Proteins - genetics | HeLa Cells | Kinetics | Inositol 1,4,5-Trisphosphate - metabolism | Luminescent Proteins - metabolism | Index Medicus | PLC, phospholipase C | PM, plasma membrane | STIM, stromal interaction molecule | RFP–ptase-dom, type IV 5-phosphatase domain fused to an RFP tag | PtdIns(4,5)P2 | HEK-293, human embryonic kidney | AM, fluo-4 acetoxymethyl ester | PI3K, phosphatidylinositol 3-kinase | RFP, red fluorescent protein | SOC, store-operated Ca2+ channel | storeoperated calcium entry (SOCE) | (E)CFP, (enhanced) cyan fluorescent protein | FRB, fragment of mammalian target of rapamycin that binds FKBP12 | GFP, green fluorescent protein | NA, numerical aperture | PtdIns(3,4,5)P3 | SOCE, store-operated Ca2+ entry | ICRAC, Ca2+ release-activated Ca2+ current | [Ca2+]i, intracellular free Ca2+ concentration | fluo-4 | PH, pleckstrin homology | PI4K, phosphatidylinositol 4-kinase | EYFP, enhanced yellow fluorescent protein | FKBP12, FK506-binding protein 12 | ER, endoplasmic reticulum
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2016, Volume 26, Issue 11, pp. 2706 - 2712
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2009, Volume 106, Issue 18, pp. 7577 - 7582
Journal Article
Journal Article
Frontiers in plant science, ISSN 1664-462X, 2017, Volume 8, p. 677
Specific cellular components including products of phosphatidylinositol (PI) metabolism play an important role as signaling molecules in stomatal responses to... 
Journal Article
Plant Molecular Biology, ISSN 0167-4412, 03/2006, Volume 60, Issue 5, pp. 729 - 746
In Arabidopsis thaliana and Oryza sativa, two types of PI 4-kinase (PI4Ks) have been isolated and functionally characterized. The α-type PI4Ks (~220 kDa)... 
Life Sciences | Biochemistry, general | Plant Pathology | GFP | membrane targeting | PI4K | signal transduction | PPC ( P lant P I4Ks C harged) region | Plant Sciences | yeast | Signal transduction | PPC (Plant PI4Ks Charged) region | Yeast | Membrane targeting | PPC (Plant PI4Ks Charged)region | ARABIDOPSIS-THALIANA | 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLASMA-MEMBRANE | PLANT SCIENCES | FUNCTIONAL EXPRESSION | SUSPENSION-CULTURE CELLS | PLECKSTRIN HOMOLOGY DOMAIN | INOSITOL TRISPHOSPHATE | PHOSPHATIDIC-ACID | ABSCISIC-ACID | STRESS | Arabidopsis - enzymology | Molecular Sequence Data | Green Fluorescent Proteins - genetics | Plant Epidermis - genetics | Plant Epidermis - metabolism | 1-Phosphatidylinositol 4-Kinase - metabolism | Onions - genetics | Biolistics - methods | Biological Transport | Plant Proteins - chemistry | Plants, Genetically Modified | Plant Epidermis - cytology | Cell Membrane - metabolism | Plant Proteins - metabolism | Phospholipids - metabolism | 1-Phosphatidylinositol 4-Kinase - genetics | 1-Phosphatidylinositol 4-Kinase - chemistry | Amino Acid Sequence | Green Fluorescent Proteins - metabolism | Tobacco - metabolism | Repetitive Sequences, Amino Acid - genetics | Oryza - enzymology | Onions - metabolism | Sequence Homology, Amino Acid | Microscopy, Confocal | Plant Proteins - genetics | Tobacco - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Onions - cytology | Index Medicus
Journal Article