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ACS MEDICINAL CHEMISTRY LETTERS, ISSN 1948-5875, 07/2018, Volume 9, Issue 7, pp. 612 - 617
Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyzes the formation of symmetric dimethylarginine in a number of... 
SM PROTEINS | PRMT5 | COMPLEX | CHEMISTRY, MEDICINAL | methyltransferase | inhibitor | PICLN | methylation | LYMPHOMA | splicing | RESIDUES | PRE-MESSENGER-RNA
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 164, pp. 317 - 333
Protein arginine methyltransferases 5 (PRMT5) represents an attractive drug target in epigenetic field for the treatment of leukemia and lymphoma. Here, a... 
PRMT5 inhibitors | N-Substituted 1,2,3,4-tetrahydroisoquinoline derivatives | Anti-tumor | SM PROTEINS | PRMT5 | METHYLATION | COMPLEX | CHEMISTRY, MEDICINAL | PICLN | GROWTH | IDENTIFICATION
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 07/2018, Volume 9, Issue 7, pp. 612 - 617
Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyzes the formation of symmetric dimethylarginine in a number of... 
PRMT5 | methyltransferase | splicing | inhibitor | methylation | SM PROTEINS | METHYLATION | COMPLEX | CHEMISTRY, MEDICINAL | PICLN | PRMTS | splicing methylation | LYMPHOMA | RESIDUES | PRE-MESSENGER-RNA
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 08/2017, Volume 114, Issue 34, pp. E7092 - E7100
TRPM6 and TRPM7 are members of the melastatin-related transient receptor potential (TRPM) subfamily of ion channels. Deletion of either gene in mice is... 
PRMT5 | CHANNEL FUNCTIONS | EMBRYONIC-DEVELOPMENT | PROTEIN | METHYLTRANSFERASE | PICLN | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | CANCER | kinase | ion channel | CRISPR-CAS9 NUCLEASES | TRPM7 | DIFFERENTIATION | TRPM6
Journal Article
Cell Reports, ISSN 2211-1247, 09/2016, Volume 16, Issue 12, pp. 3103 - 3112
The formation of macromolecular complexes within the crowded environment of cells often requires aid from assembly chaperones. PRMT5 and SMN complexes mediate... 
pICln | ribosome | snRNPs | assembly chaperone | PROTEIN | SPLICEOSOMAL SNRNPS | RNA | MEMBRANE | QUALITY-CONTROL | SMN COMPLEX | U7 SNRNPS | CELL BIOLOGY
Journal Article
Journal Article
NEUROBIOLOGY OF DISEASE, ISSN 0969-9961, 10/2016, Volume 94, pp. 245 - 258
The neuromuscular disorder, spinal muscular atrophy (SMA), results from insufficient levels of the survival motor neuron (SMN) protein. Together with Gemins... 
pICln | Unrip | motor neuron disease | DEAD-BOX PROTEIN | SPLICEOSOMAL SNRNPS | SMN complex | Strap | SURVIVAL-MOTOR-NEURON | CIRCUIT FUNCTION | NEUROSCIENCES | snRNP assembly | wmd | U1 SNRNP | Gemin2 | Gemin3 | DISEASE PHENOTYPE | trimethylguanosine synthase 1 | Tgs1 | MOUSE MODEL | spinal muscular atrophy | MELANOGASTER | GENE-PRODUCT | SCHIZOSACCHAROMYCES-POMBE
Journal Article
Journal Article
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 12/2001, Volume 21, Issue 24, pp. 8289 - 8300
Journal Article