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pifir model (31) 31
pharmacology & pharmacy (24) 24
analgesia (19) 19
pain (19) 19
antinociception (18) 18
rat (16) 16
animals (13) 13
chemistry, medicinal (13) 13
rats (13) 13
rats, wistar (13) 13
acetaminophen (12) 12
morphine (11) 11
male (10) 10
aspirin (9) 9
induced functional impairment (9) 9
synergism (9) 9
caffeine (8) 8
dose-response relationship, drug (8) 8
nsaids (8) 8
opioids (8) 8
pain - drug therapy (8) 8
drugs (7) 7
index medicus (7) 7
model (7) 7
uric acid (7) 7
disease models, animal (6) 6
pain - chemically induced (6) 6
dipyrone (5) 5
drug synergism (5) 5
endogenous opioids (5) 5
pharmacokinetics (5) 5
pharmacology (5) 5
analgesics - pharmacology (4) 4
analysis (4) 4
diazepam (4) 4
inhibition (4) 4
ketoprofen (4) 4
mechanism (4) 4
metamizol (4) 4
neurosciences (4) 4
nonsteroidal antiinflammatory drugs (4) 4
rodents (4) 4
tramadol (4) 4
area under curve (3) 3
arthritis (3) 3
arthritis - drug therapy (3) 3
drug therapy, combination (3) 3
efficacy (3) 3
elevated plus-maze (3) 3
enantiomers (3) 3
female (3) 3
integrative & complementary medicine (3) 3
ketorolac (3) 3
male-mice (3) 3
mice (3) 3
nitric oxide (3) 3
nociception (3) 3
pain measurement - drug effects (3) 3
paracetamol (3) 3
pifir (3) 3
plant sciences (3) 3
potentiation (3) 3
-ketoprofen (2) 2
7-nitroindazole (2) 2
[spi:other] engineering sciences/other (2) 2
acid (2) 2
analgesic interactions (2) 2
analgesics - administration & dosage (2) 2
analgesics, opioid - pharmacology (2) 2
analysis of variance (2) 2
anti-inflammatory agents, non-steroidal - administration & dosage (2) 2
anti-inflammatory agents, non-steroidal - pharmacology (2) 2
anxiety - drug therapy (2) 2
aspirin - pharmacology (2) 2
behavior, animal - drug effects (2) 2
behavioral sciences (2) 2
benzodiazepine receptors (2) 2
cyclic gmp (2) 2
cyclic gmp - physiology (2) 2
cyclooxygenase (2) 2
diazepam - pharmacology (2) 2
direct antagonism (2) 2
drug mixtures (2) 2
enzyme inhibitors - pharmacology (2) 2
flumazenil (2) 2
formalin test (2) 2
ibuprofen (2) 2
induced analgesia (2) 2
inflammation - chemically induced (2) 2
l-arginine (2) 2
l-name (2) 2
lamiaceae (2) 2
medicine, research & experimental (2) 2
metabolites (2) 2
methylene blue (2) 2
models (2) 2
motor activity - drug effects (2) 2
ng-nitroarginine methyl ester - pharmacology (2) 2
nitric oxide - physiology (2) 2
nitric oxide donors - pharmacology (2) 2
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1. Full Text Antinociceptive Activity of Metamizol Metabolites in a Rat Model of Arthritic Pain
by López‐Muñoz, Francisco Javier and Soria‐Arteche, Olivia and López, José Raúl Medina and Hurtado y de la Peña, Marcela and García, Ma. Concepción Lozada and Moreno‐Rocha, Luis Alfonso and Domínguez‐Ramírez, Adriana Miriam
Drug Development Research, ISSN 0272-4391, 08/2013, Volume 74, Issue 5, pp. 332 - 338
Preclinical Research The aim of the present study was to evaluate the antinociceptive activity of the main metamizol (MET) metabolites, 4‐methylaminoantipyrine... 
synthesis | metamizol | antinociception | PIFIR model | metabolites | CHEMISTRY, MEDICINAL | MECHANISM | DIPYRONE | MORPHINE | INHIBITION | ACETAMINOPHEN | PHARMACOKINETICS | PHARMACOLOGY & PHARMACY | INSIGHTS | PIFIR | Metabolites | Arthritis | Medical research
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2. Full Text Parallel anxiolytic-like and antinociceptive actions of diazepam in the anterior basolateral amygdala and dorsal periaqueductal gray
by Jiménez-Velázquez, Guadalupe and López-Muñoz, Francisco Javier and Fernández-Guasti, Alonso
Brain Research, ISSN 0006-8993, 2010, Volume 1349, pp. 11 - 20
Abstract Rationale : The antinociceptive actions of diazepam and other benzodiazepines are partly due to their anxiolytic-like properties. Objective : This... 
Neurology | Anterior basolateral amygdala | Anxiety–nociception relationship | Dorsal periaqueductal gray | Pain-induced functional impairment in the rat (PIFIR) | Diazepam | Rat defensive burying behaviour | Anxiety-nociception relationship | BENZODIAZEPINE RECEPTORS | CONCURRENT NOCICEPTIVE STIMULATION | PERSISTENT PAIN | in the rat (PIFIR) | Pain-induced functional impairment | BRAIN-STEM | MALE-MICE | ELEVATED PLUS-MAZE | NEUROSCIENCES | INDUCED ANALGESIA | INDUCED HYPERALGESIA | ANIMAL-MODELS | ANXIETY-INDUCED ANTINOCICEPTION | Amygdala - drug effects | Rats, Wistar | Area Under Curve | Periaqueductal Gray - drug effects | Anti-Anxiety Agents - pharmacology | Rats | Male | Anxiety - drug therapy | Pain - chemically induced | Diazepam - pharmacology | Animals | Pain - drug therapy | Reaction Time - drug effects | Statistics, Nonparametric | Behavior, Animal - drug effects | Uric Acid - adverse effects | Disease Models, Animal | Analysis | Uric acid | Amygdala
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3. Full Text Pharmacokinetics and pharmacodynamics of metamizol in co‐administration with morphine under acute and chronic treatments in arthritic rats
by Carrillo‐Calzadilla, Patricia Esmeralda and López‐Muñoz, Francisco Javier and Moreno‐Rocha, Luis Alfonso and Medina‐López, José Raúl and Cortés‐Arroyo, Alma Rosa and Domínguez‐Ramírez, Adriana Miriam
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 06/2017, Volume 69, Issue 6, pp. 642 - 651
Objective To investigate the relationship between metamizol pharmacokinetics and the antinociceptive effect produced after subcutaneous administration of... 
pharmacokinetics | metamizol | pharmacodynamics | tolerance | morphine | PAG-MICROINJECTED DIPYRONE | METABOLITES | TRAMADOL | ENDOGENOUS OPIOIDS | ADMINISTERED MORPHINE | ANTINOCICEPTION | ENHANCEMENT | PHARMACOLOGY & PHARMACY | TOLERANCE DEVELOPMENT | ANALGESIA | PIFIR | Analgesics - pharmacology | Dipyrone - pharmacology | Morphine - pharmacology | Rats, Wistar | Drug Tolerance | Analgesics, Opioid - pharmacology | Rats | Male | Dose-Response Relationship, Drug | Drug Synergism | Drug Therapy, Combination - methods | Pain Measurement - methods | Animals | Pain - drug therapy | Potentiation | Drugs | Pharmacodynamics | Pain perception | Morphine | Pharmacology | Drug development | Pain | Metabolites | Drug tolerance | Rodents | Dipyrone | Pharmacokinetics
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4. Full Text Pharmacokinetics and pharmacodynamics of (S)-ketoprofen co-administered with caffeine: A preclinical study in arthritic rats
by Medina-López, Raúl and Vara-Gama, Nancy and Soria-Arteche, Olivia and Moreno-Rocha, Luis A and López-Muñoz, Francisco J
Pharmaceutics, ISSN 1999-4923, 03/2018, Volume 10, Issue 1, p. 20
The purpose of the present study was to determine whether caffeine modifies the pharmacokinetics and pharmacodynamics of (S)-ketoprofen following oral... 
Pharmacodynamics | Pharmacokinetics | PIFIR model | (S)-ketoprofen | Caffeine | EFFICACY | pharmacodynamics | ENANTIOMERS | INDUCED FUNCTIONAL IMPAIRMENT | PARACETAMOL | MODEL | ANTINOCICEPTION | caffeine | PAIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PLASMA-LEVELS | pharmacokinetics | PHARMACOLOGY & PHARMACY | Pain | Kinetics | Rodents
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5. Full Text Antinociceptive Effect and GC/MS Analysis of Rosmarinus officinalis L. Essential Oil from its Aerial Parts
by Martínez, Ana L and González-Trujano, Maria Eva and Pellicer, Francisco and López-Muñoz, Francisco J and Navarrete, Andrés
Planta Medica, ISSN 0032-0943, 04/2009, Volume 75, Issue 5, pp. 508 - 511
Abstract The rationale of this investigation was to examine the antinociceptive properties of the essential oil obtained from ROSMARINUS OFFICINALIS aerial... 
Pharmacology | PIFIR assay | receptors | Rosmarinus officinalis L | Antinociception | Endogenous opioids | Lamiaceae | 5-HT | CHEMISTRY, MEDICINAL | RODENTS | antinociception | LEAVES | 1,8-CINEOLE | ANALGESIC ACTIVITY | CINNAMOMUM-OSMOPHLOEUM | PLANT SCIENCES | PAIN | endogenous opioids | INTEGRATIVE & COMPLEMENTARY MEDICINE | MENTHOL | PHARMACOLOGY & PHARMACY | 5-HT1A receptors | Gas chromatography | Usage | Nociceptors | Physiological aspects | Rosemary | Chemical properties | Research | Health aspects | Essences and essential oils | Identification and classification | Mass spectrometry | Index Medicus
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6. Full Text Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents
by González-Trujano, M.E and Peña, E.I and Martínez, A.L and Moreno, J and Guevara-Fefer, P and Déciga-Campos, M and López-Muñoz, F.J
Journal of Ethnopharmacology, ISSN 0378-8741, 2007, Volume 111, Issue 3, pp. 476 - 482
The rationale of this investigation was to examine the antinociceptive effect of an ethanol extract of (RO) aerial parts, using three different experimental... 
Antinociception | Traditional medicine | PIFIR model | Writhing | Formalin test | Rosmarinus officinalis | CHEMISTRY, MEDICINAL | antinociception | RAT | MORPHINE | traditional medicine | FLAVONOIDS | PROSTAGLANDIN HYPERALGESIA | PLANT SCIENCES | writhing | PAIN | ROSEMARY | INTEGRATIVE & COMPLEMENTARY MEDICINE | PHARMACOLOGY & PHARMACY | MICE | RECEPTORS | formalin test | EXTRACT | Analgesics - pharmacology | Rats, Wistar | Plant Extracts - pharmacology | Tramadol - pharmacology | Male | Pain - chemically induced | Aspirin - administration & dosage | Dose-Response Relationship, Drug | Plant Extracts - administration & dosage | Arthritis - chemically induced | Inflammation - drug therapy | Pain - drug therapy | Anti-Inflammatory Agents - administration & dosage | Aspirin - pharmacology | Disease Models, Animal | Plant Components, Aerial | Anti-Inflammatory Agents - pharmacology | Analgesics - administration & dosage | Rats | Animals | Rosmarinus | Tramadol - administration & dosage | Arthritis - drug therapy | Mice | Pain Measurement | Plants, Medicinal | Acetic acid | Analysis | Models
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7. Full Text Anti-nociceptive and anti-inflammatory activities of the Agastache mexicana extracts by using several experimental models in rodents
by Adriana, González-Ramírez and María Eva, González-Trujano and Francisco, Pellicer and López-Muñoz Francisco, J
Journal of Ethnopharmacology, ISSN 0378-8741, 08/2012, Volume 142, Issue 3, pp. 700 - 705
is a plant that has long been used in large demand in Mexican folk medicine to treat pain, among others affections. Nevertheless, no scientific data confirming... 
Agastache mexicana (H. B. K.) Lint & Epling subsp. xolocotziana | Antinociception | Lamiaceae | Writhing test | PIFIR model | Formalin test | CHEMISTRY, MEDICINAL | RAT | MOUSE | Agastache mexicana (H. B. K.) Lint & Epling subsp xolocotziana | PAW FORMALIN TEST | PLANT SCIENCES | URSOLIC ACID | INHIBITION | INTEGRATIVE & COMPLEMENTARY MEDICINE | GLUTAMATE | TILIANIN | PHARMACOLOGY & PHARMACY | MICE | NOCICEPTION | ABDOMINAL CONSTRICTION | Analgesics - therapeutic use | Rats, Wistar | Solvents - chemistry | Stomach Ulcer - drug therapy | Rats | Acetates - chemistry | Male | Animals | Pain - drug therapy | Agastache | Anti-Inflammatory Agents - therapeutic use | Inflorescence - chemistry | Hexanes - chemistry | Mice | Phytotherapy | Methanol - chemistry | Plant Extracts - therapeutic use | Disease Models, Animal | Care and treatment | Pain | Anti-inflammatory drugs | Rodents | Analysis | Formaldehyde
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8. Full Text Enhancement of antinociception and caffeine by co-administration of ibuprofen in arthritic rats
by Lopez, JRM and Dominguez-Ramirez, AM and Cook, H and Bravo, G and Diaz-Reval, MI and Deciga-Campos, M and Lopez-Munoz, FJ
EUROPEAN JOURNAL OF PHARMACOLOGY, ISSN 0014-2999, 08/2006, Volume 544, Issue 1-3, pp. 31 - 38
It has been observed that caffeine improves antinociceptive efficacy of some non-steroidal antiinflammatory drugs (NSAIDs) in several experimental models,... 
ACID | antinociception | MORPHINE | analgesia | INDUCED FUNCTIONAL IMPAIRMENT | ibuprofen | MODEL | ASPIRIN | caffeine | PAIN | PHARMACOKINETICS | ACETAMINOPHEN | potentiation | DRUGS | PHARMACOLOGY & PHARMACY | ANALGESIC ADJUVANT | PIFIR model
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9. Full Text Participation of the GABA/benzodiazepine receptor and the NO-cyclicGMP pathway in the “antinociceptive-like effects” of diazepam
by Jiménez-Velázquez, Guadalupe and López-Muñoz, Francisco Javier and Fernández-Guasti, Alonso
Pharmacology, Biochemistry and Behavior, ISSN 0091-3057, 2008, Volume 91, Issue 1, pp. 128 - 133
The mechanism of action underlying the “analgesic activity” of diazepam remains unclear. In this study, the possible participation of the GABA/benzodiazepine... 
Flumazenil | L-NAME | Nitric oxide | Cyclic GMP | 7-nitroindazole | Antinociception | PIFIR model | L-arginine | Diazepam | Methylene blue
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10. Full Text Enhancement of antinociception by co-administration of ibuprofen and caffeine in arthritic rats
by López, José Raúl Medina and Domínguez-Ramírez, Adriana Miriam and Cook, Helgi Jung and Bravo, Guadalupe and Díaz-Reval, Ma. Irene and Déciga-Campos, Myrna and López-Muñoz, Francisco Javier
European Journal of Pharmacology, ISSN 0014-2999, 2006, Volume 544, Issue 1, pp. 31 - 38
It has been observed that caffeine improves antinociceptive efficacy of some non-steroidal antiinflammatory drugs (NSAIDs) in several experimental models,... 
Potentiation | Analgesia | Antinociception | PIFIR model | Ibuprofen | Caffeine | Analgesics - pharmacology | Caffeine - administration & dosage | Rats, Wistar | Rats | Ibuprofen - administration & dosage | Male | Dose-Response Relationship, Drug | Animals | Time Factors | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Arthritis - drug therapy | Drug Therapy, Combination | Central Nervous System Stimulants - administration & dosage | Disease Models, Animal | Morphine | Arthritis | Uric acid | Nonsteroidal anti-inflammatory drugs
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11. Full Text Enhancement of Antinociception but not Constipation by Combinations Containing Tramadol and Metamizole in Arthritic Rats
by López-Muñoz, Francisco Javier and Moreno-Rocha, Luis Alfonso and Bravo, Guadalupe and Guevara-López, Uriah and Domínguez-Ramírez, Adriana Miriam and Déciga-Campos, Myrna
Archives of Medical Research, ISSN 0188-4409, 2013, Volume 44, Issue 7, pp. 495 - 503
Background and Aims The use of a combination of analgesics could provide an optimal pain treatment with minimal side effects. Combinations of tramadol and some... 
Internal Medicine | Antinociception | Metamizole | PIFIR model | Synergism | Constipation | Tramadol | MEDICINE, RESEARCH & EXPERIMENTAL | PAG-MICROINJECTED DIPYRONE | ENDOGENOUS OPIOIDS | PERIAQUEDUCTAL GRAY | MORPHINE | INVOLVEMENT | MODEL | ANALGESIC INTERACTION | SYNERGISTIC INTERACTION | PAIN | SURFACE | Arthritis, Experimental - drug therapy | Rats, Wistar | Dipyrone - administration & dosage | Analgesics - administration & dosage | Rats | Male | Tramadol - adverse effects | Constipation - chemically induced | Dipyrone - adverse effects | Dose-Response Relationship, Drug | Drug Synergism | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Pain - drug therapy | Tramadol - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Nociception - drug effects | Drug Therapy, Combination | Analgesics - adverse effects | Arthritis
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12. Full Text The antinociceptive efficacy of morphine, metamizol, or their combination in an experimental rat model with different levels of inflammatory pain
by López-Muñoz, Francisco Javier and Godínez-Chaparro, Beatriz and Huerta-Cruz, Juan Carlos and Guevara-López, Uriah and Domínguez-Ramírez, Adriana Miriam and Cortés-Arroyo, Alma Rosa
Pharmacology, Biochemistry and Behavior, ISSN 0091-3057, 2008, Volume 91, Issue 1, pp. 196 - 201
The purpose of this work was to evaluate the antinociceptive efficacy of an optimal morphine and metamizol combination on different levels of nociception... 
Nociception | Metamizol | Morphine | Pain | PIFIR model | Synergism | DIRECT ANTAGONISM | pain | TRAMADOL | ENDOGENOUS OPIOIDS | DIPYRONE | DICLOFENAC | INDUCED FUNCTIONAL IMPAIRMENT | ARTHRITIC NOCICEPTION | NEUROSCIENCES | morphine | metamizol | ACETAMINOPHEN | PHARMACOLOGY | synergism | BEHAVIORAL SCIENCES | PHARMACOLOGY & PHARMACY | ANALGESIC INTERACTIONS | Inflammation - chemically induced | Rats, Wistar | Rats | Analgesics, Opioid - therapeutic use | Male | Pain Measurement - drug effects | Pain - chemically induced | Dipyrone - therapeutic use | Dose-Response Relationship, Drug | Drug Synergism | Inflammation - complications | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Pain - drug therapy | Pain - etiology | Uric Acid | Aspirin - therapeutic use | Drug Therapy, Combination | Morphine - therapeutic use | Aspirin | Models | Salicylates | Polybrominated biphenyls | Index Medicus
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13. Full Text Participation of the GABA/benzodiazepine receptor and the NO-cyclicGMP pathway in the "antinociceptive-like effects" of diazepam
by Jiménez-Velázquez, Guadalupe and López-Muñoz, Francisco Javier and Fernández-Guasti, Alonso
Pharmacology Biochemistry and Behavior, ISSN 0091-3057, 11/2008, Volume 91, Issue 1, pp. 128 - 133
The mechanism of action underlying the "analgesic activity" of diazepam remains unclear. In this study, the possible participation of the GABA/benzodiazepine... 
Flumazenil | L-NAME | Cyclic GMP | Nitric oxide | 7-nitroindazole | Antinociception | PIFIR model | L-arginine | Diazepam | Methylene blue | nitric oxide | BENZODIAZEPINE RECEPTORS | antinociception | diazepam | NITRIC-OXIDE SYNTHASE | cyclic GMP | MALE-MICE | ELEVATED PLUS-MAZE | NEUROSCIENCES | GUANYLATE-CYCLASE | INDUCED PAW EDEMA | methylene blue | BRAIN GABA(A) RECEPTORS | INDUCED ANALGESIA | IN-VIVO | BEHAVIORAL SCIENCES | PHARMACOLOGY & PHARMACY | RAT-BRAIN | flumazenil | NG-Nitroarginine Methyl Ester - pharmacology | Nitric Oxide - biosynthesis | Cyclic GMP - physiology | Rats, Wistar | Enzyme Inhibitors - pharmacology | Rats | Male | Nitric Oxide - physiology | Pain Measurement - drug effects | Guanylate Cyclase - antagonists & inhibitors | Diazepam - pharmacology | Indazoles - pharmacology | Animals | Analgesics | Signal Transduction - drug effects | Arginine - pharmacology | Receptors, GABA-A - drug effects | Hypnotics and Sedatives - pharmacology | Nitric Oxide Donors - pharmacology | Nitric Oxide Synthase Type I - drug effects | Cyclic GMP - biosynthesis | Analysis | Guanosine | Polybrominated biphenyls | GABA | Uric acid | Guanylate cyclase | Dyes and dyeing
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14. Full Text Peripheral involvement of the nitric oxide–cGMP pathway in the indomethacin-induced antinociception in rat
by Ventura-Martínez, Rosa and Déciga-Campos, Myrna and Díaz-Reval, Ma. Irene and González-Trujano, Ma. Eva and López-Muñoz, Francisco J
European Journal of Pharmacology, ISSN 0014-2999, 2004, Volume 503, Issue 1, pp. 43 - 48
The role of nitric oxide (NO) in the antinociceptive effect of indomethacin was assessed in the pain-induced functional impairment model in the rat (PIFIR... 
Antinociception | Indomethacin | Rat | PIFIR model | Nitric oxide | nitric oxide | ACTIVATION | antinociception | rat | MECHANISM | NOCICEPTOR SENSITIZATION | indomethacin | PAIN | ROFECOXIB | PHARMACOLOGY & PHARMACY | CYCLIC GMP PATHWAY | HYPERALGESIA | KETOROLAC | PARTICIPATION | ANALGESIA | Cyclic GMP - physiology | Gout - psychology | Rats, Wistar | Nitric Oxide Synthase - antagonists & inhibitors | Nitroprusside - pharmacology | Pain - chemically induced | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Nitric Oxide Synthase Type I | Pain - drug therapy | Female | Nitric Oxide Donors - pharmacology | Disease Models, Animal | NG-Nitroarginine Methyl Ester - pharmacology | Nerve Tissue Proteins - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Nitric Oxide - physiology | Pain Measurement - drug effects | Gout - chemically induced | Indomethacin - pharmacology | Animals | Gout - complications | Uric Acid | Signal Transduction - physiology | Chronic Disease | Arginine - metabolism | Peripheral Nervous System - drug effects
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15. Full Text Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats
by Fernández-Guasti, A and Reyes, R and Martínez-Mota, L and López-Muñoz, F J
Psychopharmacology, ISSN 0033-3158, 7/2005, Volume 180, Issue 3, pp. 399 - 407
The effect of anxiety on nociception has been evaluated but not that of nociception on anxiety.The study was conducted to analyse the influence of nociception... 
Medicine | Rat burying behaviour | Elevated plus maze | Buspirone | Acetylsalicylic acid | PIFIR model | Diazepam | diazepam | ANXIETY | PSYCHIATRY | GUIDELINES | buspirone | MALE-MICE | elevated plus maze | ANTINOCICEPTION | rat burying behaviour | ELEVATED PLUS-MAZE | NEUROSCIENCES | acetylsalicylic acid | BURYING BEHAVIOR | FATTY-ACID LEVELS | PAIN | PHARMACOLOGY & PHARMACY | AGENTS | STRESS | Anti-Anxiety Agents - administration & dosage | Inflammation - chemically induced | Rats, Wistar | Diazepam - administration & dosage | Anxiety - physiopathology | Motor Activity - drug effects | Rats | Male | Anxiety - drug therapy | Pain - chemically induced | Maze Learning - drug effects | Dose-Response Relationship, Drug | Buspirone - administration & dosage | Animals | Analysis of Variance | Pain - physiopathology | Injections, Intra-Articular | Uric Acid | Behavior, Animal - drug effects | Anti-Anxiety Agents - therapeutic use | Aspirin - pharmacology | Diazepam - therapeutic use | Buspirone - therapeutic use | Inflammation - physiopathology
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16. Enhancement of (S)-ketoprofen antinociception by caffeine co-administration: Effects in an arthritic-pain animal model
by López-Muñoz, Francisco J and Vara-Gama, Nancy and Soria-Arteche, Olivia and Domínguez-Ramírez, Adriana M and Medina, Raúl
Latin American Journal of Pharmacy, ISSN 0326-2383, 2017, Volume 36, Issue 7, pp. 1349 - 1354
To find a possible synergistic antinociceptive interaction, several doses of (S)-ketoprofen and caffeine were administered in an arthritic-pain model. To... 
Antinociception | PIFIR model | (S)-ketoprofen | NSAIDs | Caffeine | SURGERY | antinociception | RAT | KETOPROFEN | INDUCED FUNCTIONAL IMPAIRMENT | PARACETAMOL | ASPIRIN | DEXKETOPROFEN | caffeine | PHARMACOLOGY & PHARMACY | ANALGESIA
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