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Drug Development Research, ISSN 0272-4391, 08/2013, Volume 74, Issue 5, pp. 332 - 338
Preclinical Research The aim of the present study was to evaluate the antinociceptive activity of the main metamizol (MET) metabolites, 4‐methylaminoantipyrine... 
synthesis | metamizol | antinociception | PIFIR model | metabolites | CHEMISTRY, MEDICINAL | MECHANISM | DIPYRONE | MORPHINE | INHIBITION | ACETAMINOPHEN | PHARMACOKINETICS | PHARMACOLOGY & PHARMACY | INSIGHTS | PIFIR | Metabolites | Arthritis | Medical research
Journal Article
Journal Article
Pharmaceutics, ISSN 1999-4923, 03/2018, Volume 10, Issue 1, p. 20
The purpose of the present study was to determine whether caffeine modifies the pharmacokinetics and pharmacodynamics of (S)-ketoprofen following oral... 
Pharmacodynamics | Pharmacokinetics | PIFIR model | (S)-ketoprofen | Caffeine | EFFICACY | pharmacodynamics | ENANTIOMERS | INDUCED FUNCTIONAL IMPAIRMENT | PARACETAMOL | MODEL | ANTINOCICEPTION | caffeine | PAIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PLASMA-LEVELS | pharmacokinetics | PHARMACOLOGY & PHARMACY | Pain | Kinetics | Rodents
Journal Article
Journal Article
EUROPEAN JOURNAL OF PHARMACOLOGY, ISSN 0014-2999, 08/2006, Volume 544, Issue 1-3, pp. 31 - 38
It has been observed that caffeine improves antinociceptive efficacy of some non-steroidal antiinflammatory drugs (NSAIDs) in several experimental models,... 
ACID | antinociception | MORPHINE | analgesia | INDUCED FUNCTIONAL IMPAIRMENT | ibuprofen | MODEL | ASPIRIN | caffeine | PAIN | PHARMACOKINETICS | ACETAMINOPHEN | potentiation | DRUGS | PHARMACOLOGY & PHARMACY | ANALGESIC ADJUVANT | PIFIR model
Journal Article
Pharmacology, Biochemistry and Behavior, ISSN 0091-3057, 2008, Volume 91, Issue 1, pp. 128 - 133
The mechanism of action underlying the “analgesic activity” of diazepam remains unclear. In this study, the possible participation of the GABA/benzodiazepine... 
Flumazenil | L-NAME | Nitric oxide | Cyclic GMP | 7-nitroindazole | Antinociception | PIFIR model | L-arginine | Diazepam | Methylene blue
Journal Article
Journal Article
Journal Article
Pharmacology Biochemistry and Behavior, ISSN 0091-3057, 11/2008, Volume 91, Issue 1, pp. 128 - 133
Journal Article
Journal Article
Journal Article
Latin American Journal of Pharmacy, ISSN 0326-2383, 2017, Volume 36, Issue 7, pp. 1349 - 1354
To find a possible synergistic antinociceptive interaction, several doses of (S)-ketoprofen and caffeine were administered in an arthritic-pain model. To... 
Antinociception | PIFIR model | (S)-ketoprofen | NSAIDs | Caffeine | SURGERY | antinociception | RAT | KETOPROFEN | INDUCED FUNCTIONAL IMPAIRMENT | PARACETAMOL | ASPIRIN | DEXKETOPROFEN | caffeine | PHARMACOLOGY & PHARMACY | ANALGESIA
Journal Article