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1. Full Text Sarcolemmal localisation of Na+/H+ exchange and Na+–HCO3− co‐transport influences the spatial regulation of intracellular pH in rat ventricular myocytes
by Garciarena, Carolina D and Ma, Yu‐ling and Swietach, Pawel and Huc, Laurence and Vaughan‐Jones, Richard D
The Journal of Physiology, ISSN 0022-3751, 05/2013, Volume 591, Issue 9, pp. 2287 - 2306
Key points •  Acid extrusion from ventricular myocytes typically occurs via Na+/H+ exchange (NHE1) and Na+–HCO3− co‐transporters (NBC). This maintains... 
PROTON MOBILITY | CELLS | PHYSIOLOGY | CA2 | CARDIAC MYOCYTES | HEART-FAILURE | ACIDOSIS | H+-ION MOBILITY | GUINEA-PIG | SARCOPLASMIC-RETICULUM | NA+-HCO3-COTRANSPORTER | NEUROSCIENCES | Guinea Pigs | Sarcolemma - physiology | Rats | Male | Rats, Sprague-Dawley | Sodium-Bicarbonate Symporters - metabolism | Sodium-Hydrogen Exchangers - metabolism | Heart Ventricles | Animals | Calcium - physiology | Myocytes, Cardiac - physiology | Electric Capacitance | Female | Hydrogen-Ion Concentration | Acids | Localization | Rodents | Cardiovascular
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2. Full Text The Effects of Puerarin on Rat Ventricular Myocytes and the Potential Mechanism
by Xu, Hao and Zhao, Manxi and Liang, Shenghui and Huang, Quanshu and Xiao, Yunchuan and Ye, Liang and Wang, Qinyi and He, Longmei and Ma, Lanxiang and Zhang, Hua and Zhang, Li and Jiang, Hui and Ke, Xiao and Gu, Yuchun
Scientific Reports, ISSN 2045-2322, 10/2016, Volume 6, Issue 1, p. 35475
Puerarin, a known isoflavone, is commonly found as a Chinese herb medicine. It is widely used in China to treat cardiac diseases such as angina, cardiac... 
CELLS | MYOCARDIAL-INFARCTION | MULTIDISCIPLINARY SCIENCES | BAICALIN | IMPROVES CARDIAC-FUNCTION | GUINEA-PIG | MESENTERIC-ARTERY | UNSTABLE ANGINA-PECTORIS | I-KS | POTASSIUM CHANNEL | KCNQ1 MUTATION | Cyclic AMP-Dependent Protein Kinases - metabolism | Heart Ventricles - cytology | Vasodilator Agents - pharmacology | Isoflavones - pharmacology | Rats | Dose-Response Relationship, Drug | Animals | Signal Transduction - drug effects | Adenosine Diphosphate - metabolism | Potassium Channels, Inwardly Rectifying - metabolism | Action Potentials - drug effects | Heart Ventricles - drug effects | Ventricular Function - drug effects | Protein kinase A | Arrhythmia | Potassium channels (inwardly-rectifying) | Cardiac muscle | Action potential | Angina | Myocytes | Velocity | Coronary artery disease | Depolarization | Rodents | Potassium channels (voltage-gated) | Infarction | Membrane potential | Ventricle | Cardiovascular diseases | Heart diseases | Isoflavones
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3. Full Text Caveolae in ventricular myocytes are required for stretch-dependent conduction slowing
by Pfeiffer, E.R and Wright, A.T and Edwards, A.G and Stowe, J.C and McNall, K and Tan, J and Niesman, I and Patel, H.H and Roth, D.M and Omens, J.H and McCulloch, A.D
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2014, Volume 76, pp. 265 - 274
Abstract Mechanical stretch of cardiac muscle modulates action potential propagation velocity, causing potentially arrhythmogenic conduction slowing. The... 
Cardiovascular | Cardiac mechanoelectric feedback | Caveolae | Capacitance | CARDIAC & CARDIOVASCULAR SYSTEMS | PRIMARY CULTURE | MEMBRANE | CARDIAC MYOCYTES | TISSUE | GUINEA-PIG | CARDIOMYOCYTES | CELL-CULTURES | CELL BIOLOGY | MUSCLE FIBERS | IN-VITRO MODEL | SURFACE | Heart Ventricles - cytology | Caveolin 3 - genetics | Heart Conduction System | Mice, Inbred C57BL | Cells, Cultured | Ventricular Function | Caveolae - physiology | Mice, Knockout | Action Potentials | Mechanotransduction, Cellular | Patch-Clamp Techniques | Animals | Myocytes, Cardiac - physiology | Ventricular Pressure | Caveolin 3 - metabolism | Myocytes, Cardiac - ultrastructure | Sarcolemma - metabolism | Cyclodextrins | cardiac mechanoelectric feedback | caveolae | capacitance
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4. Full Text Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes
by Aiba, Takeshi and Hesketh, Geoffrey G and Liu, Ting and Carlisle, Rachael and Villa-Abrille, Maria Celeste and O'Rourke, Brian and Akar, Fadi G and Tomaselli, Gordon F
Cardiovascular Research, ISSN 0008-6363, 2/2010, Volume 85, Issue 3, pp. 454 - 463
Aims Calmodulin (CaM) regulates Na+ channel gating through binding to an IQ-like motif in the C-terminus. Ca2+/CaM-dependent protein kinase II (CaMKII)... 
MOLECULAR-MECHANISM | BETA-ADRENERGIC STIMULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | Calcium | ALPHA-SUBUNIT | Na-channel | CAMKII | CARDIAC SODIUM-CHANNEL | EXCITABILITY | CA2 | Calmodulin | MODULATION | Ca2+/CaM-dependent protein kinase II | Action Potentials | Calmodulin - physiology | Cyclic AMP-Dependent Protein Kinases - physiology | Ion Channel Gating - physiology | Phosphorylation | Animals | Calcium - physiology | Guinea Pigs | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - physiology | Sodium Channels - physiology | CaM-dependent protein kinase II | Ca2 | Original
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5. Full Text Sex differences in mechanisms of cardiac excitation-contraction coupling in rat ventricular myocytes
by Farrell, Spring R and Ross, Jenna L and Howlett, Susan E
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 07/2010, Volume 299, Issue 1, pp. H36 - H45
Farrell SR, Ross JL, Howlett SE. Sex differences in mechanisms of cardiac excitation-contraction coupling in rat ventricular myocytes. Am J Physiol Heart Circ... 
Calcium transients | Gender | Calcium release | Calcium sparks | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | gender | SUPINE EXERCISE | GUINEA-PIG | GENDER-RELATED DIFFERENCES | calcium transients | REPOLARIZATION | INTRACELLULAR CA2 | HEART | FEMALE RATS | calcium release | PERIPHERAL VASCULAR DISEASE | calcium sparks | PROTEIN-KINASE-II | AGE | Myocardial Contraction | Excitation Contraction Coupling | Rats, Inbred F344 | Rats | Male | Action Potentials | Microscopy, Confocal | Animals | Sex Factors | Myocytes, Cardiac - metabolism | Female | Heart Ventricles - metabolism | Sarcoplasmic Reticulum - metabolism | Kinetics | In Vitro Techniques | Calcium Signaling | Heart | Excitation (Physiology) | Demographic aspects | Comparative analysis | Contraction
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6. Full Text Regulation of the Na+/Ca2+ exchanger by pyridine nucleotide redox potential in ventricular myocytes
by Liu, Ting and O'Rourke, Brian
Journal of Biological Chemistry, ISSN 0021-9258, 11/2013, Volume 288, Issue 44, pp. 31984 - 31992
The cardiac Na+/Ca2+ exchanger (NCX) is the major Ca2+ efflux pathway on the sarcolemma, counterbalancing Ca2+ influx via L-type Ca2+ current during... 
CELLS | ISCHEMIA/REPERFUSION INJURY | SELECTIVE INHIBITOR | DEPENDENT REGULATION | SODIUM-CALCIUM EXCHANGER | INDUCED HEART-FAILURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC SARCOLEMMAL VESICLES | NA+-CA2+ EXCHANGER | RAT-HEART | EXPRESSION | Guinea Pigs | Oxidation-Reduction | Calcium - metabolism | NADPH Oxidases - antagonists & inhibitors | Cells, Cultured | Enzyme Inhibitors - pharmacology | NADPH Oxidases - metabolism | Onium Compounds - pharmacology | Glycoproteins - pharmacology | Hydrogen Peroxide - metabolism | Catalase - metabolism | Myocardial Reperfusion Injury - metabolism | Myocytes, Cardiac - pathology | Myocardial Reperfusion Injury - pathology | Animals | Sodium-Calcium Exchanger - metabolism | Myocytes, Cardiac - metabolism | Heart Ventricles - metabolism | Homeostasis - drug effects | Heart Ventricles - pathology | NAD - metabolism | Sodium Calcium Exchange | NADH | Reactive Oxygen Species (ROS) | Ischemia | Membrane Biology | Excitation-Contraction Coupling | Metabolism
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7. Full Text Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species
by O'Hara, Thomas and Rudy, Yoram
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 03/2012, Volume 302, Issue 5, pp. H1023 - H1030
O'Hara T, Rudy Y. Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species. Am J Physiol... 
Cardiac action potential | Drug effects | Delayed rectifier current | Human cardiac model | RATE-DEPENDENCE | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | HEART-FAILURE | drug effects | human cardiac model | QT INTERVAL | GUINEA-PIG | MODEL | I-KS | REPOLARIZATION | ACTION-POTENTIAL DURATION | delayed rectifier current | PERIPHERAL VASCULAR DISEASE | cardiac action potential | ION CHANNELS | CANINE | Guinea Pigs | Sodium-Potassium-Exchanging ATPase - physiology | Ventricular Function - physiology | Models, Cardiovascular | Humans | Adrenergic beta-Agonists - pharmacology | Sodium - metabolism | Action Potentials - physiology | Animals | Myocytes, Cardiac - drug effects | Delayed Rectifier Potassium Channels - physiology | Myocytes, Cardiac - physiology | Computer Simulation | Isoproterenol - pharmacology | Dogs | Cardiac Electrophysiology | Sodium - physiology | Action Potentials - drug effects | Ventricular Function - drug effects | Drugs | Heart ventricles | Physiological aspects | Electrophysiology | Muscle cells | Comparative analysis | Health aspects
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8. DUAL EFFECT OF ETHANOL ON INWARD RECTIFIER POTASSIUM CURRENT I-K1 IN RAT VENTRICULAR MYOCYTES
by Bebarova, M and Matejovic, P and Pasek, M and Simurdova, M and Simurda, J
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, ISSN 0867-5910, 08/2014, Volume 65, Issue 4, pp. 497 - 509
Alcohol consumption may result in electrocardiographic changes and arrhythmias. Important role of modifications of the inward rectifier potassium current I-K1... 
ACTIVATION | PHYSIOLOGY | KIR2.1 | inward rectifier | RECTIFYING K+ CHANNEL | GUINEA-PIG | ALCOHOL-CONSUMPTION | CARDIOMYOCYTES | ethanol | rat ventricular myocytes | ATRIAL-FIBRILLATION | HEART | INHIBITION | dual effect | MEMBRANE-POTENTIALS | arrhythmia | rat ventricular action potential model
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9. Full Text Sex differences in SR Ca2+ release in murine ventricular myocytes are regulated by the cAMP/PKA pathway
by Parks, Randi J and Ray, Gibanananda and Bienvenu, Laura A and Rose, Robert A and Howlett, Susan E
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 10/2014, Volume 75, pp. 162 - 173
Previous studies have shown that ventricular myocytes from female rats have smaller contractions and Ca transients than males. As cardiac contraction is... 
Calcium transient | Calcium spark | Gender | Excitation–contraction coupling | Gain | Phosphodiesterase | Excitation-contraction coupling | PROTEIN-KINASE-A | BETA-ADRENERGIC STIMULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | CARDIAC MYOCYTES | GUINEA-PIG | GENDER-RELATED DIFFERENCES | CELL BIOLOGY | INTRACELLULAR CA2 | NUCLEOTIDE PHOSPHODIESTERASE ACTIVITY | FEMALE RATS | CALCIUM-RELEASE | RYANODINE-RECEPTOR
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10. Full Text Inhibition of Rapid Delayed Rectifier Potassium current ( IKr ) by Ischemia/Reperfusion and its recovery by Vitamin E in ventricular myocytes
by Chen, Yaoxu and Yin, Chunxia and Yang, Yingying and Fan, Zhuo and Shang, Jinling and Tan, Wen
Journal of Electrocardiology, ISSN 0022-0736, 2017, Volume 50, Issue 4, pp. 437 - 443
Abstract Ischemia/reperfusion (I/R) induce prolongation of QT interval and action potential duration (APD), which is a major cardiac electrical disorder in... 
Cardiovascular | QT interval | Arrhythmia | IKr current | Vitamin E | Ischemia/reperfusion | current | DE-POINTES | CARDIAC & CARDIOVASCULAR SYSTEMS | VITRO MODEL | PROTEIN-KINASE | PROLONGS CARDIAC REPOLARIZATION | GUINEA-PIG | SIMULATED-ISCHEMIA | I-Kr current | K+ CHANNEL FUNCTION | ISCHEMIA-REPERFUSION INJURY | HEART | Guinea Pigs | Myocytes, Cardiac - cytology | Cells, Cultured | Male | ERG1 Potassium Channel - metabolism | Sulfates | Long QT Syndrome - physiopathology | Myocardial Reperfusion Injury - metabolism | Animals | Myocytes, Cardiac - drug effects | Electrocardiography | Myocytes, Cardiac - metabolism | ERG1 Potassium Channel - antagonists & inhibitors | Long QT Syndrome - drug therapy | Action Potentials - drug effects | Myocardial Reperfusion Injury - prevention & control | Disease Models, Animal | Vitamin E - pharmacology | Cardiac patients
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11. Full Text GW29-e0236 The Antiarrhythmic Effect of Guizhi Gancao Decoction in Different Serum Concentrations on Potassium Currents and Action Potentials in Guinea Pig Ventricular Myocytes and HEK293 Cells
by Xing, Zuoying and Zhu, Mingjun and Wang, Youping and Gao, Yuan and Li, Bin and Hu, Yucai and Chen, Peng and Song, Huanhuan and Wang, Yongxia
Journal of the American College of Cardiology, ISSN 0735-1097, 10/2018, Volume 72, Issue 16, p. C78
Heart | Cardiac arrhythmia | Cardiac muscle | Guinea pigs | Rodents | Ventricle | Myocytes | Potassium | Potassium currents
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12. Full Text Rapid Estrogen Receptor-Mediated Mechanisms Determine the Sexually Dimorphic Sensitivity of Ventricular Myocytes to 17β-Estradiol and the Environmental Endocrine Disruptor Bisphenol A
by Belcher, Scott M and Chen, Yamei and Yan, Sujuan and Wang, Hong-Sheng
Endocrinology, ISSN 0013-7227, 02/2012, Volume 153, Issue 2, pp. 712 - 720
Previously we showed that 17β-estradiol (E2) and/or the xenoestrogen bisphenol A (BPA) alter ventricular myocyte Ca2+ handing, resulting in increased cardiac... 
HEART | SMALL EXPOSURES | RAT | CONTRACTION | ENDOCRINOLOGY & METABOLISM | GUINEA-PIG | CEREBELLAR NEURONS | GENDER-DIFFERENCES | ISOLATED CARDIAC MYOCYTES | ER-ALPHA | BETA | Receptors, Estrogen - metabolism | Receptors, Estrogen - genetics | Benzhydryl Compounds | Calcium - metabolism | Calcium Signaling - physiology | Cells, Cultured | Estradiol - administration & dosage | Myocardial Contraction - drug effects | Rats | Male | Sex Characteristics | Rats, Sprague-Dawley | Mice, Knockout | Dose-Response Relationship, Drug | Animals | Endocrine Disruptors - pharmacology | Myocytes, Cardiac - drug effects | Myocytes, Cardiac - physiology | Female | Phenols - administration & dosage | Mice | Estradiol - pharmacology | Phenols - pharmacology | General Endocrinology
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13. Full Text Pinacidil, a KATP channel opener, stimulates cardiac Na+/Ca2+ exchanger function through the NO/cGMP/PKG signaling pathway in guinea pig cardiac ventricular myocytes
by Iguchi, K and Saotome, M and Yamashita, K and Hasan, P and Sasaki, M and Maekawa, Y and Watanabe, Y
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, ISSN 0028-1298, 08/2019, Volume 392, Issue 8, pp. 949 - 959
Pinacidil, a nonselective ATP-sensitive K+ (KATP) channel opener, has cardioprotective effects for hypertension, ischemia/reperfusion injury, and arrhythmia.... 
Pinacidil | SENSITIVE POTASSIUM CHANNELS | CELLS | Nonselective KATP channel opener | ACTIVATION | SUPEROXIDE | Na+/Ca2+ exchange current (I-NCX) | K-ATP CHANNELS | PROTEIN-KINASE-G | Patch-clamp technique | Cardiac myocytes | FREE-RADICALS | SMOOTH-MUSCLE | CA2 | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | Heart | Reactive oxygen species | Arrhythmia | Guanosine | Myocytes | Glycine | Kinases | Guanylate cyclase | Calcium influx | Proteins | Signal transduction | Mitochondria | Na+/Ca2+-exchanging ATPase | Reperfusion | Ischemia | Cyclic GMP | Fura-2 | Glibenclamide | Phosphodiesterase | Hypertension | Automation | Calcium (intracellular) | Cardiac muscle | NG-Nitroarginine methyl ester | Signaling | Inhibitors | Sodium | Protein kinase | Guinea pigs | Nitric oxide | Sildenafil | Ventricle | NCX1 protein | Potassium | Calcium ions
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14. Full Text Nucleotides maintain the activity of Cav1.2 channels in guinea-pig ventricular myocytes
by Liu, Shu-yuan and Xu, Jian-jun and Minobe, Etsuko and Gao, Qing-hua and Feng, Rui and Zhao, Mei-mi and Guo, Feng and Yang, Lei and Hao, Li-ying and Kameyama, Masaki
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 05/2015, Volume 460, Issue 3, pp. 813 - 818
The activity of Cav1.2 Ca channels is maintained in the presence of calmodulin and ATP, even in cell-free patches, and thus a channel ATP-binding site has been... 
Nucleotide | Binding site | Cav1.2 | ATP | Ca2+ channel | channel | POTASSIUM CHANNELS | PHOSPHORYLATION | TRANSPORTERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC MYOCYTES | CA2+ CHANNELS | HEART | BIOPHYSICS | CALCIUM-CHANNELS | CALMODULIN KINASE-II | MODULATION | Heart Ventricles - cytology | Animals | Guinea Pigs | Calcium Channels - metabolism | Muscle, Smooth, Vascular - metabolism | Heart Ventricles - metabolism | Nucleotides - physiology | Muscle, Smooth, Vascular - cytology | Calmodulin | Nucleotides | Index Medicus
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15. Full Text Effects of Astragaloside IV on Action Potentials and Ionic Currents in Guinea-Pig Ventricular Myocytes
by Zhao, Meimi and Zhao, Jinsheng and He, Guilin and Sun, Xuefei and Huang, Xueshi and Hao, Liying
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2013, Volume 36, Issue 4, pp. 515 - 521
Astragaloside IV (AS-IV) is one of the main active constituents of Astragalus membranaceus, which has various actions on the cardiovascular system. However,... 
patch clamp | ion channel | action potential | cardiac myocyte | astragaloside IV | Patch clamp | Action potential | Cardiac myocyte | Astragaloside IV | Ion channel | HOMOCYSTEINE | APOPTOSIS | CARDIAC-ARRHYTHMIA | ISCHEMIA | SARCOPLASMIC-RETICULUM | IN-VITRO | PHASE ENDOTHELIAL DYSFUNCTION | A549 CELLS | PHARMACOLOGY & PHARMACY | CHANNEL ACTIVITY | MEMBRANACEUS | Calcium Channels - physiology | Drugs, Chinese Herbal | Heart Ventricles - cytology | Animals | Guinea Pigs | Myocytes, Cardiac - drug effects | Triterpenes - pharmacology | Myocytes, Cardiac - physiology | Potassium Channels - physiology | In Vitro Techniques | Action Potentials - drug effects | Saponins - pharmacology
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16. Full Text Acidosis in models of cardiac ventricular myocytes
by Edmund J Crampin and Nicolas P Smith and A. Elise Langham and Richard H Clayton and Clive H Orchard
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, ISSN 1364-503X, 05/2006, Volume 364, Issue 1842, pp. 1171 - 1186
transients during acidosis. These interactions are incorporated into a dynamical model of pH regulation in the myocyte to simulate respiratory acidosis in the... 
Protons | Action potentials | Orchards | Myocardium | Cell membranes | Physiological regulation | Respiratory acidosis | Acidosis | Modeling | Cardiac ventricular myocyte | Intracellular calcium handling | Mathematical model | pH regulation | cardiac ventricular myocyte | MULTIDISCIPLINARY SCIENCES | INTRACELLULAR PH | SARCOPLASMIC-RETICULUM | GUINEA-PIG | intracellular calcium handling | MATHEMATICAL-MODEL | PANCREATIC DUCTAL EPITHELIUM | SYSTOLIC CA2 | CONTRACTION | acidosis